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Depolarization mitigated in ferroelectric Hf_(0.5)Zr_(0.5)O_(2)ultrathin films(<5 nm)on Si substrate by interface engineering

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Journal of Advanced Ceramics 2024年第3期13卷 282-292页

作者： Se hyun Kim Younghwan lee Dong hyun lee Geun Hyeong Park hyun Woo jeong Kun Yang Yong Hyeon Cho Young Yong Kim Min Hyuk Park Department of Materials Science and Engineering College of EngineeringSeoul National UniversitySeoul 08826Republic of Korea Research Institute of Advanced Materials College of EngineeringSeoul National UniversitySeoul 08826Republic of Korea Inter-university Semiconductor Research Center College of EngineeringSeoul National UniversitySeoul 08826Republic of Korea Pohang Accelerator Laboratory Pohang University of Science&TechnologyPohang 790784Republic of Korea

(Hf,Zr)O_(2)offers considerable potential for next-generation semiconductor devices owing to its nonvolatile spontaneous polarization at the ***,scaling this material to sub-5 nm thickness poses several challenges,including the formation of an interfacial layer and high trap *** particular,a low-k SiO_(2)interfacial layer is naturally formed when(Hf,Zr)O_(2)films are directly grown on a Si substrate,leading to high depolarization fields and rapid reduction of the remanent *** address these issues,we conducted a study to significantly improve ferroelectricity and switching endurance of(Hf,Zr)O_(2)films with sub-5 nm thicknesses by inserting a TiO_(2)interfacial *** deposition of a Ti film prior to Hf_(0.5)Zr_(0.5)O_(2)film deposition resulted in a high-k TiO_(2)interfacial layer and prevented the direct contact of Hf_(0.5)Zr_(0.5)O_(2)with *** findings show that the high-k TiO_(2)interfacial layer can reduce the SiO_(2)/Si interface trap density and the depolarization field,resulting in a switchable polarization of 60.2μC/cm^(2)for a 5 nm thick Hf_(0.5)Zr_(0.5)O_(2)***,we propose that inserting a high-k TiO_(2)interfacial layer between the Hf_(0.5)Zr_(0.5)O_(2)film and the Si substrate may offer a promising solution to enhancing the ferroelectricity and reliability of(Hf,Zr)O_(2)grown on the Si substrate and can pave the way for next-generation semiconductor devices with improved performance.

关键词： ferroelectric charge trapping hafnia depolarization

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Semantics-oriented approach for information interoperability and governance:towards user-centric enterprise architecture management

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第4期11卷 227-240页

作者： Imran GHANI Choon Yeul lee Sung hyun JUHN Seung Ryul jeong School of Business IT Kookmin University

Enterprise architecture (EA) efforts focus on business, technology, data, and application architecture, and their integration. However, less attention has been given to one of the most critical EA elements, i.e., users (EA audiences). As a result, existing EA management systems (EAMS) have become old, large, content-centric document-repositories that are unable to provide meaningful information of use to the enterprise users and aligned with their needs and functional scope. We argue that a semantic technology based mechanism focusing on enterprise information and user-centricity has the potential to solve this problem. In this context, we present a novel ontology-based strategy named the user-centric semantics-oriented EA (U-SEA) model. Based on this model, we have developed a user-centric semantics-oriented enterprise architecture management (U-SEAM) system. Our approach is generic enough to be used in a wide variety of user-centric EAM applications. The results obtained show computational feasibility to integrate and govern enterprise information and to reduce complexity with respect to interoperability between enterprise information and users.

关键词： Enterprise architecture management system (EAMS) Ontology Recommender system User-centric Semantic Web Framework

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Pharmacokinetic comparison with different assays for simultaneous determination of cis-,trans-cefprozil diastereomers in human plasma

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Journal of Pharmaceutical Analysis 2021年第3期11卷 351-363页

作者： Seung-hyun jeong Ji-Hun Jang Hea-Young Cho Yong-Bok lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-Do13488Republic of Korea

The purpose of this study was to compare pharmacokinetic(PK)parameters obtained using two newly developed assays,HPLC-UV and UPLC-ESI-MS/*** of assay and results obtained therefrom are very important in PK studies and can have a major impact on the PK-based clinical dose and usage *** this study,we developed two new methods that are most commonly used in biosample analysis and focused on PK parameters obtained from *** HPLC-UV equipped with a Luna-C8 column using UV detector,cefprozil diastereomers were separated using water containing 2%(V/V)acetic acid and acetonitrile as a mobile *** UPLC-ESI-MS/MS equipped with a HALO-C18 column,cefprozil diastereomers were separated using 0.5%(V/V)aqueous formic acid containing 5 mM ammoniumformate buffer and methanol as a mobile *** showed high resolution,sensitivity,and selectivity without interference by plasma *** intra-and inter-day precisions(CV,%)were within 8.88%for HPLC-UV and UPLC-ESI-MS/*** of both methods was 95.67%-107.50%.These two analytical methods satisfied the criteria of international guidance and could be successfully applied to PK *** of PK parameters between two assays confirmed that there is a difference in the predicted minimum plasma concentrations at steady state,which may affect clinical dose and usage ***,we confirmed possible correlation between PK parameters and various biochemical parameters after oral administration of 1000 mg cefprozil to humans.

关键词： Cefprozil diastereomers Comparison HPLC-UV UPLC-ESI-MS/MS Pharmacokinetic parameter Biochemical parameters

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Severe mediastinitis and pericarditis after endobronchial ultrasoundguided transbronchial needle aspiration:A case report

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World Journal of Clinical Cases 2021年第34期9卷 10723-10727页

作者： jeong Suk Koh Yoon Joo Kim Da hyun Kang jeong Eun lee Song-I lee Department of Pulmonary and Critical Care Medicine Chungnam National University HospitalDaejeon 35015South Korea

BACKGROUND Endobronchial ultrasound-guided transbronchial needle aspiration(EBUS-TBNA)is a safe and minimally invasive diagnostic tool for mediastinal and hilum ***,infectious complications may occur after *** these,mediastinitis and pericarditis are *** SUMMARY A 67-year-old woman was referred to our hospital due to paratracheal lymph node enlargement on chest computed tomography(CT).EBUS-TBNA was performed on the lymph node lesions,and prophylactic oral antibiotics were *** days after EBUS-TBNA,the patient visited the emergency room with a high fever and chest *** test results revealed leukocytosis with a left shift and elevated C-reactive protein level(25.7 mg/dL).Chest CT revealed the formation of a mediastinal abscess in the right paratracheal lymph node and pericardial and bilateral pleural *** patient received intravenous antibiotic treatment,cardiac drainage through pericardiocentesis,and surgical *** patient recovered favorably and was discharged 31 d after the *** Mediastinitis and pericarditis after EBUS-TBNA are rare but should be considered even after the use of prophylactic antibiotics.

关键词： Endoscopic ultrasound-guided fine needle aspiration Complication Mediastinitis Pericarditis Antibiotics Case report

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Is there correlation between pancreatic enzyme and radiological severity in acute pancreatitis?

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World Journal of Gastroenterology 2008年第15期14卷 2401-2405页

作者： Yeon Soo Kim Byung Seok lee Seok hyun Kim Jae Kyu Seong hyun Yong jeong Heon Young lee Departments of Internal Medicine Daejeon St. Mary's Hospital Medical College of the Catholic University of Korea Korea Department of Internal Medicine Chungnam National University Hospital Daejeon 301721 Korea

AIM: To investigate the correlation between the changes of pancreatic enzyme, the biochemical markers and the clinical results according to the Balthazar computer tomography (CT) grade. METHODS: Between July 2004 and July 2005, we reviewed the charts of 119 patients who were admitted to our hospital with acute pancreatitis. RESULTS: Eighty-three patients (69.7%) were male, and the mean age of the patients was 57 ± 15.7 years. The biliary pancreatitis patients had an older mean age. Forty-nine patients (41.1%) had biliary pancreatitis and forty-six (38.6%) had alcoholic pancreatitis. Group 3 patients had a longer duration of pain (2.51 ± 1.16 vs 3.17 ± 1.30 vs 6.56 ± 6.13, P < 0.001), a longer period of fasting (7.49 ± 4.65 vs 10.65 ± 5.54 vs 21.88 ± 13.81, P < 0.001) and a longer hospital stay (9.17 ± 5.34 vs 14.63 ± 8.65 vs 24.47 ± 15.52, P < 0.001) than the other groups. On the univariate analysis, the factors that affected the radiological grade were the leukocyte count at admission (P = 0.048), the hemoglobin (P = 0.016) and total bilirubin concentrations (P = 0.023), serum lipase (P = 0.009), the APACH Ⅱ scores at admission (P = 0.017), the APACH Ⅱ scores after 24 h (P = 0.031), the C-reactive protein (CRP) titer (P = 0.0001) and the follow up CRP titer (P = 0.003). But the CRP level (P = 0.001) and follow up CRP titer (P = 0.004) were only correlated with the radiological grade on multivariate analysis. According to the ROC curve, when we set the CRP cut off value at 83 mg/L, the likelihoodratio for a positive test was 3.84 and the likelihood ratio for a negative test was 0.26 in group 3. CONCLUSION: In conclusion, our study suggests that the CRP with the radiological severity may be used to estimate the severity of acute pancreatitis.

关键词： Acute pancreatitis Computed tomography C-reactive protein

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Contemporary trends in radical prostatectomy and predictors of recovery of urinary continence in men aged over 70 years:comparisons between cohorts aged over 70 and less than 70 years

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Asian Journal of Andrology 2020年第3期22卷 280-286页

作者： Young Ju lee Jin-Woo Jung Sangchul lee Sang Wook lee jeong hyun Kim Sung Kyu Hong Seok-Soo Byun Sang Eun lee Seong Jin jeong Departme nt of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Catholic Kwan dong Univerisity International St.Mary's HospitalIncheon 22711Korea Department of Urology Kangwon National University School of MedicineChuncheon 24341Korea.

We evaluated contemporary trends in radical prostatectomy(RP)in men aged>70 years and investigated associations of selected variables with recovery of urinary continence(UC)in two age groups:>70 and70 years[n=610]vs70 years gradually increased up to 30.0%,and the rate of robot-assisted RP and neurovascular bundle(NVB)saving increased continually to 80.0%and 67.4%of older patients,*** the rate of recovery of UC within 12 months(3 months)in patients aged>70 years was lower than that in those aged S70 years(81.5%[52.6%]vs 88.6%[60.9%],respectively;both P70 ***,unlike younger patients,only variables(age and MUL),possibly associated with the inhere nt fun ction of the urinary sphi ncter,were predictors of recovery of UC in patients aged>70 years.

关键词： elderly predictor prostate cancer radical prostatectomy urinary incontinence

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Development and validation of a clinical nomogram predicting bladder outlet obstruction via routine clinical parameters in men with refractory nonneurogenic lower urinary tract symptoms

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Asian Journal of Andrology 2019年第5期21卷 486-492页

作者： Young Ju lee Jung Keun lee Jung Jun Kim Hak Min lee Jong Jin Oh Sangchul lee Sang Wook lee jeong hyun Kim Seong Jin jeong Department of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Kangwon National University School of MedicineChuncheon 24341Korea

We aimed to develop and validate a clinical nomogram predicting bladder outlet obstruction(BOO)solely using routine clinical parameters in men with refractory nonneurogenic lower urinary tract symptoms(LUTS).A total of 750 eligible patient ≥50 years of age who had previously not responded(International Prostate Symptom Score[IPSS]improvement2 cmH20 ml^-1 s^-1.A stepwise multivariable logistic regression analysis was conducted to determine the predictors of BOO,and^-coefficients of the final model were selected to create a clinical *** final multivariable logistic regression model showed that age,IPSS,maximum urinary flow rate,postvoid residual volume,total prostate volume,and transitional zone index were significant for predicting BOO;these candidates were used to develop the final *** discrimination performance of the nomogram was 88.3%(95%Cl:82.7%-93.0%,P<0.001),and the nomogram was reasonably we 11-fitted to the ideal line of the calibration *** nt split-sample validation revealed 80.9%(95%Cl:75.5%-84.4%,P<0.001)*** proposed BOO nomogram based solely on routine clinical parameters was accurate and validated *** nomogram may be useful in determining further treatment,primarily focused on prostatic surgery for BOO,without impeding the detection of possible BOO in men with LUTS that is refractory to empirical medications.

关键词： benign prostatic hyperplasia bladder outlet obstruction lower urinary tract symptoms no mogram urodynamics

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Acute lower extremity arterial thrombosis after intraocular foreign body removal under general anesthesia: A case report and review of literature

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World Journal of Clinical Cases 2021年第27期9卷 8232-8241页

作者： Soeun Jeon jeong-Min Hong Hyeon jeong lee Eunsoo Kim hyunju lee Yesul Kim hyun-Su Ri Jae Jung lee Department of Anesthesia and Pain Medicine Pusan National UniversitySchool of MedicineBusan 49241South Korea Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Anesthesia and Pain Medicine Kyungpook National UniversitySchool of MedicineDaegu 41944South Korea Department of Ophthalmology College of MedicinePusan National UniversitySchool of MedicineYangsan 50612South Korea

BACKGROUND Surgery,which is a major risk factor for venous thrombosis,has rarely been considered a risk factor for arterial *** studies have suggested that venous and arterial thromboses share common risk factors and have a bidirectional ***,there is a growing interest in the risk of arterial thrombosis after *** report a case of acute bilateral lower extremity arterial thromboses that developed after a prolonged *** SUMMARY A 59-year-old man was hospitalized for intraocular foreign body removal *** was a heavy-drinking smoker and had untreated hypertension and varicose veins in both *** operation was unexpectedly prolonged,lasting 4 h and 45 *** after emergence from general anesthesia,the patient complained of extreme pain in both *** the surgical drape was removed,cyanosis was evident in both feet of the *** pulse was not palpable,and continuous-wave Doppler signals were inaudible in the bilateral dorsalis pedis and posterior tibial *** tomography angiography confirmed acute bilateral thrombotic occlusion of the popliteal arteries,proximal anterior tibial arteries,and tibioperoneal *** pulse returned in both lower limbs after 6 h of heparin *** patient was discharged on postoperative day 26 without any *** Acute lower extremity arterial thrombosis can occur after *** should pay particular attention to patients with risk factors for thrombosis.

关键词： Thromboembolism Thrombosis Arterial thrombosis Arterial occlusive diseases Peripheral occlusive artery disease Case report

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Delayed gait recovery in a stroke patient

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Neural Regeneration Research 2013年第16期8卷 1514-1518页

作者： jeong Pyo Seo Mi Young lee Yong hyun Kwon Sung Ho Jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Department of Physical Therapy College of Health and Therapy Daegu Haany University Department of Physical Therapy Yeungnam College of Science & Technology

We report on a stroke patient who showed delayed gait recovery between 8 and 11 months after the onset of intracerebral hemorrhage. This 32-year-old female patient underwent craniotomy and drainage for right intracerebral hemorrhage due to rupture of an arteriovenous malformation. Brain MR images revealed a large leukomalactic lesion in the right fronto-parietal cortex. Diffusion tensor tractography at 8 months after onset revealed that the right corticospinal tract was severely injured. At this time, the patient could not stand or walk despite undergoing rehabilitation from 2 months after onset. It was believed that severe spasticity of the left leg and right ankle was largely responsible, and thus, antispastic drugs, antispastic procedures （alcohol neurolysis of the motor branch of the tibial nerve and an intramuscular alcohol wash of both tibialis posterior muscles） and physical therapy were tried to control the spasticity. These measures relieved the severe spasticity, with the result that the patient was able to stand at 3 months. In addition, the improvements in sensorimotor function, visuospatial function, and cognition also seemed to contribute to gait recovery. As a result, she gained the ability to walk independently on even floor with a left ankle foot orthosis at 11 months after onset. This case illustrates that clinicians should attempt to find the cause of gait inability and to initiate intensive rehabilitation in stroke patients who cannot walk at 3-6 months after onset.

关键词： neural regeneration brain injury stroke diffusion tensor imaging sequelae gait walk motor recovery corticospinal tract rehabilitation intracerebral hemorrhage grants-supported paper neuroregeneration

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Effects of Polymeric Stabilizers on the Synthesis of Gold Nanoparticles

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Journal of Materials Science & Technology 2014年第2期30卷 107-111页

作者： Eun Jung Kim jeong hyun Yeum Jin hyun Choi Department of Advanced Organic Materials Science and Engineering Kyungpook National University Department of Bio-fibers and materials Science Kyungpook National University

Gold nanoparticles （AuNPs） stabilized with sodium alginate （SA）, glycol chitosan （GC）, polyvinyl alcohol （PVA）, and polyethyleneimine （PEI） were synthesized in aqueous solutions at room temperature. Different sizes and size distributions of AuNPs were obtained according to the polymeric stabilizers. The mean particle diameters of AuNPs synthesized with GC and PVA as stabilizers were about 5.1 and 5.3 nm, respectively, while those of AuNPs stabilized with SA and PEI were 8.4 and 10.8 nm, respectively. When SA was used, relatively large particles aggregated to form large clusters. In the case of GC, a number of small particles built up large clusters. When PVA was used, the size and the number of nanoperticles were estimated small with a low weight content of Au. For this reason, the PVA-stabilized AuNPs formed clusters with a small hydrodynamic size. The AuNPs synthesized in the aqueous solution of PEI without a reducing agent, sodium borohydride, were uniform in size and formed the smallest nanoclusters （67.4 nm）. In this case, the highest Au content was obtained. Sufficiently grown nanoparticles with a high Au content and a limited hydrodynamic size are considered to be suitable for a variety of applications.

关键词： Gold nanoparticles Sodium alginate Glycol chitosan Polyvinyl alcohol Polyethyleneimine

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