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Visual outcomes after three different surgical procedures for correction of refractive error in patients with thin corneas

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 970-977页

作者： Hye Seong Hwang hyun jeong lee Seong Jun lee Jae-hyung Kim Department of Ophthalmology Chungbuk National UniversityCheongjuChunbguk 28644Republic of Korea Korean Minjok Leadership Academy HoengseongGangwon 25268Republic of Korea Nuri Eye Clinic Daejeon 35234Republic of Korea Seoul Daabom Eye Center CheoungjuChungbuk 28644Republic of Korea

AIM:To investigate and compare the visual and refractive outcomes of small incision lenticule extraction(SMILE),laser assisted sub-epithelial keratomileusis(LASEK),and LASEK combined with corneal collagen cross-linking(LASEKCXL)surgery in patients with less than 500μm of central corneal thickness(CCT).METHODS:The retrospective medical records review was conducted on the patients with CCT less than 500μm treated with SMILE,LASEK,and *** was a total of 172 eyes,76 eyes were in the SMILE group,53 eyes in the LASEK group,and 43 eyes in the LASEK-CXL *** distance visual acuity(UDVA),spherical equivalent refraction(SE),and corneal haze were followed up in the three groups for 12 ***:At 12 mo postoperatively,there were no statistically significant differences in UDVA and in the absolute value of SE between the three *** predictability within±0.50 D in the SMILE group(85.5%)was significantly higher than in both the LASEK group(64.2%,P<0.01)and the LASEK-CXL group(69.8%,P=0.04).The efficacy index and safety index were not significantly different among the three *** haze at 12 mo postoperatively was higher in the LASEK-CXL group(27.9%)than in the SMILE group(2.6%,P<0.01)and in the LASEK group(7.5%,P<0.01).CONCLUSION:In patients with CCT less than 500μm,SMILE,LASEK,and LASEK-CXL appear to be effective for myopic *** them,SMILE surgery shows the highest predictability.

关键词： small incision lenticule extraction thin cornea laser assisted sub-epithelial keratomileusis collagen-cross linking visual acuity myopia

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Is endoscopic submucosal dissection safe for papillary adenocarcinoma of the stomach?

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World Journal of Gastroenterology 2015年第13期21卷 3944-3952页

作者： hyun jeong lee Gwang Ha Kim Do Youn Park Bong Eun lee Hye Kyung Jeon Joon hyung Jhi Geun Am Song Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research Institute Pusan National University Hospital Busan 602-739South Korea Department of Pathology Pusan National University School of MedicineBusan 602-739South Korea

AIM: To identify the clinicopathological predictors of lymph node(LN) metastasis and evaluate the outcomes of endoscopic submucosal dissection(ESD) in papillary adenocarcinoma-type early gastric cancers(EGCs).METHODS: From January 2005 to May 2013, 49 patients who underwent surgical operation and 24 patients who underwent ESD for papillary adenocarcinomatype EGC were enrolled to identify clinicopathological characteristics and predictive factors of LN metastasis and to evaluate the outcomes of ESD for papillary adenocarcinoma-type ***: Most papillary adenocarcinoma-type EGCs were located in the lower third of the stomach and had an elevated macroscopic shape. The overall prevalence of LN metastasis was 18.3%(9/49). The presence of lymphovascular invasion was found to be a predictor of LN metastasis(P = 0.016). According to current indication criteria of ESD, 6 and 11 of the 49 patients had absolute and expanded indications for ESD, respectively. Two patients(11.8%) with expanded indication for ESD had LN metastasis. Of the 24 patients who underwent ESD, 13(54%) achieved out-of-ESD indication, with 9 of those 13 patients undergoing surgical operation due to non-curative resection. CONCLUSION: The use of ESD should be carefully considered for papillary adenocarcinoma-type EGC with suspected ESD indication after pre-treatment work-up because of the higher frequency of LN metastasis and additional surgeries.

关键词： Gastric cancer Papillary adenocarcinoma Endoscopic

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Long-primed germinal centres with enduring affinity maturation and clonal migration

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四川生理科学杂志 2022年第9期44卷 1618-1618页

作者： jeong hyun lee Center for Infectious Disease and Vaccine Research La Jolla Institute for Immunology La Jolla CA USA Consortium for HIV/AIDS Vaccine Development The Scripps Research Institute La Jolla CA USA IAVI Neutralizing Antibody Center The Scripps Research Institute La Jolla CA USA Department of Medicine Division of Infectious Diseases and Global Public Health University of California San Diego La Jolla CA USA Department of Immunology and Microbiology The Scripps Research Institute La Jolla CA USA Department of Integrative Structural and Computational Biology The Scripps Research Institute La Jolla CA USA Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA USA Emory National Primate Research Center and Emory Vaccine Center Emory University School of Medicine Atlanta GA USA Ragon Institute of Massachusetts General Hospital Massachusetts Institute of Technology and Harvard University Cambridge MA USA Department of Biological Engineering Massachusetts Institute of Technology Cambridge MA USA Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA USA Howard Hughes Medical Institute Chevy Chase MD USA Tulane National Primate Research Center Tulane School of Medicine Covington LA USA Department of Surgery Laboratory for AIDS Vaccine Research & Development Duke University Medical Center Duke University Durham NC USA

Germinal centres are the engines of antibody evolution. Here, using human immunodeficiency virus (HIV) Env protein immunogen priming in rhesus monkeys followed by a long period without further immunization, we demonstrate germinal centre B (BGC) cells that last for at least 6 months. A 186-fold increase in BGC cells was present by week 10 compared with conventional immunization. Single-cell transcriptional profiling showed that both light- and dark-zone germinal centre states were sustained. Antibody somatic hypermutation of BGC cells continued to accumulate throughout the 29-week priming period, with evidence of selective pressure. Env-binding BGC cells were still 49-fold above baseline at 29 weeks, which suggests that they could remain active for even longer periods of time. High titres of HIV-neutralizing antibodies were generated after a single booster immunization. Fully glycosylated HIV trimer protein is a complex antigen, posing considerable immunodominance challenges for B cells1,2. Memory B cells generated under these long priming conditions had higher levels of antibody somatic hypermutation, and both memory B cells and antibodies were more likely to recognize non-immunodominant epitopes. Numerous BGC cell lineage phylogenies spanning more than the 6-month germinal centre period were identified, demonstrating continuous germinal centre activity and selection for at least 191 days with no further antigen exposure. A long-prime, slow-delivery (12 days) immunization approach holds promise for difficult vaccine targets and suggests that patience can have great value for tuning of germinal centres to maximize antibody responses.

关键词： sustained centre holds

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Concomitant therapy achieved the best eradication rate for Helicobacter pylori among various treatment strategies

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World Journal of Gastroenterology 2015年第1期21卷 351-359页

作者： hyun jeong lee Jin Il Kim Jin Soo lee Eun Jung Jun Jung-Hwan Oh Dae Young Cheung Woo Chul Chung Byung-Wook Kim Sung Soo Kim Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 150-713South Korea

AIM: To compare the Helicobacter pylori(***) eradication rate of clarithromycin-based triple therapy,metronidazole-based triple therapy,sequential therapy and concomitant ***: A total of 680 patients infected with *** were divided into 4 groups and each group was treated with a different eradication ***-based triple therapy was applied to the first group [rabeprazole,amoxicillin and clarithromycin(PAC) group: proton pump inhibitor(PPI),amoxicillin,clarithromycin],whereas the second group was treated with metronidazole-based triple therapy [rabeprazole,amoxicillin and metronidazole(PAM) group: PPI,amoxicillin,metronidazole].The third group was treated with rabeprazole and amoxicillin,followed by rabeprazole,clarithromycin and metronidazole(sequential group).The final group was simultaneously treated with rabeprazole,amoxicillin clarithromycin and metronidazole(concomitant therapy group).In the case of a failure to eradicate ***,second-line quadruple and third-line eradication therapies were ***: The per protocol(PP) analysis was performed on 143,139,141 and 143 patients in the PAC,PAM,sequential and concomitant groups,*** excluded patients who did not receive a C13-urea breath test(22,20,23 and 22 patients,respectively) and patients with less than an 80% compliance level(5,11,6 and 5 patients,respectively).The eradication rates were 76.2%(109/143) in the PAC group,84.2%(117/139) in the PAM group,84.4%(119/141) in the sequential group and 94.4%(135/143) in the concomitant group(P = 0.0002).All 14 patients who failed second-line therapy were treated with thirdline eradication *** these 14 patients,6 infections were successfully eradicated with the thirdline *** PP and intention-to-treat analysis showed an eradication rate of 42.9%(6/14).In the PAC group,3 of 4 patients were successfully cured(3/4,75%); 2 of 2 patients in the PAM group(2/2,100%) and 1 of 5 patients in the seque

关键词： Helicobacter pylori Eradication Drug resistance Co

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Seven synchronous early gastric cancer with 28 lymph nodes metastasis

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World Journal of Gastroenterology 2013年第44期19卷 8141-8145页

作者： Hyeonjin Seong Jin Il Kim hyun jeong lee hyun Jin Kim hyung Joon Cho Hye Kang Kim Dae Young Cheung Dong Jin Kim Wook Kim Tae-Jung Kim Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul 150-713 South Korea Department of Surgery College of Medicine The Catholic University of Korea Seoul 150-713South Korea Department of Hospital Pathology College of Medicine The Catholic University of Korea Seoul 150-713South Korea

An 85 year male patient complaining epigastric discomfort was *** the esophagogastroduodenoscopy,three early gastric cancer(EGCa)lesions had been identified and these were diagnosed as adenocarcinoma with poorly differentiated cell *** patient underwent *** the post-operative mapping,however,additional 4 EGCa lesions were found,and the patient was diagnosed with 7 synchronous *** of the 7 EGCa lesions,6 had shown invasion only to the mucosal layer and one had shown invasion into the 1/3layer of *** spite of such superficial invasions,28 of 48 lymph nodes had been identified as *** multiple lesions of EGCa do not increase the risk of lymph node metastasis,but if their differentiations are poor or if they have lympho-vascular invasion,multiple lymph node metastases could incur even if the depth of invasion is limited to the mucosal layer or the upper portion of the submucosal layer.

关键词： Early gastric cancer Synchronous Metastasis Lymph node Endoscopy

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CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease: multi-institutional case series

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1231-1237页

作者： Roh-Eul Yoo Sun-Won Park Jung Hyo Rhim Ji Eun Kim Soo Chin Kim Ji-Young Choe Ho-Kyung Choung Sang In Khwarg Ji-hoon Kim jeong hyun lee Bo Eun lee Yeonah Kang Department of Radiology Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Radiology Seoul National University HospitalSeoul 03080Republic of Korea Department of Radiology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061Republic of Korea Department of Pathology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061Republic of Korea Department of Pathology Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Radiology Asan Medical CenterSeoul 05505Republic of Korea Department of Pathology Hallym University Sacred Heart HospitalAnyang14068Republic of Korea Department of Ophthalmology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061Republic of Korea Department of Ophthalmology Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Radiology Ulsan University College of MedicineSeoul 05505Republic of Korea Department of Radiology Inje University Haeundae Paik HospitalBusan 47392Republic of Korea

AIM:To report CT and MR imaging findings of ocular adnexal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease(IgG4-MALT lymphoma),a rare but clinically important complication of ocular adnexal IgG4-related ***:We retrospectively reviewed all cases of histologically confirmed ocular adnexal IgG4-related disease at three ter tiary and one secondary referral centers,between February 2003 and December *** cases of histopathologically diagnosed IgG4-MALT lymphoma were *** and MR images were analyzed by consensus of two experienced head and neck ***:Lacrimal glands were the main site of involvement in all seven *** lesions typically showed well-demarcated margins,iso-to hyperattenuation on precontrast CT,T2 hypo-to isointensity,T1 isointensity,and homogenous internal architecture with homogenous enhancement *** were mostly hyperdense and isointense to normal extraocular muscles on postcontrast CT and MR images,***:Unlike in typical ocular adnexal IgG4-related disease,T2 isointensity and hyperattenuation on precontrast CT images were noted in some IgG4-MALT lymphoma *** the findings may be nonspecific,the possibility of accompanying MALT lymphoma may need to be considered,when ocular adnexal lesions in patients clinically suspected of having IgG4-related disease are refractory to glucocorticoids and show T2 isointensity and hyperattenuation on precontrast CT for the optimal management of the ***,this is a case series of a very rare complication of ocular adnexal IgG4-related disease,and thus caution is warranted to generalize the conclusion.

关键词： CT IgG4-related disease MR ocular adnexal mucosa-associated lymphoid tissue lymphoma

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Effect of Eucommia ulmoides on Longitudinal Bone Growth Rate in Rats

Effect of Eucommia ulmoides on Longitudinal Bone Growth Rate...

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第十四届全国中药和天然药物学术研讨会

作者： hyun Soo Kim hyun jeong lee Donghun lee Jungbin Song Hocheol Kim Kyung Hee University

＜正＞Eucommia ulmoides is one of the popular tonic herbs to treat of back pain and bone fracture and reinforce muscles and bones in the traditional Korean *** study was performed to investigate the effect of *** on longitudinal bone growth ***（30 and 100 mg/kg,p.o.）was orally administered to adolescent female rats twice per

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Combination therapy for predominantly cystic thyroid nodules（PCTNs）:Ethanol ablation（EA） followed by Radiofrequency ablation（RFA）

Combination therapy for predominantly cystic thyroid nodules...

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2009年世界肿瘤介入学术大会

作者： Jung Hwan Baek Yoon Suk Kim jeong hyun lee Ducky lee Asan Medical Center

＜正＞Objectives:To evaluate the efficacy and safety of combination therapy in the treatment of PCTNs Methods:Between January 2005 and February 2006,137 patients who had benign single compressive predominantly cystic thyroid nodules（PCTNs）underwent ethanol ablation（EA）.All PCTNs were larger than 2 cm in the largest diameter and had a cystic portion more than 50%.Of these,27 patients(22 women,5men;age range,21～60 years;mean,38+10

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Polymyxin B Alleviates Angiotensin II-Induced Stress Fiber Formation and Cellular Hypertrophy

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Pharmacology & Pharmacy 2014年第9期5卷 903-910页

作者： Kwang-Seok Oh jeong hyun lee Byung Koo Oh Jihye Mun Byung Kil Park Byung Ho lee Research Center for Drug Discovery Technology Korea Research Institute of Chemical Technology Daejeon South Korea Research Center for Drug Discovery Technology Korea Research Institute of Chemical Technology Daejeon South Korea Department of Medicinal and Pharmaceutical Chemistry University of Science and Technology Daejeon South Korea Research Center for Drug Discovery Technology Korea Research Institute of Chemical Technology Daejeon South Korea Graduate School of New Drug Discovery and Development Chungnam National University Daejeon South Korea

Polymyxin B is widely used antibiotic in the clinic for resistant Gram-negative infections. In addition, polymyxin B-immobilized hemoperfusion cartridge has been used for endotoxin removal therapy in patients with septic shock. The aim of this study was to investigate the anti-fibrotic and anti-cellular hypertrophic effects of polymyxin B, and further to explore its possible mechanism. Polymyxin B (3, 10 μM) significantly inhibited stress fiber formation induced by angiotensin II (Ang II) in rat heart-derived H9c2 cells. Furthermore, polymyxin B (1 - 10 μM) showed a potent inhibitory effect on Ang II-induced cellular hypertrophy in H9c2 cells. Under the mechanism study, the inhibitory activities of polymyxin B against kinases involved in cellular hypertrophy such as AKT1, CAMK, GRK5, GSK3β, MLCK, PKC, PKD2, AMPK, ROCK2, p70S6K, SGK1were evaluated. Polymyxin B possesses a potent G protein related kinase 5 (GKR5) inhibitory activity with IC50 value of 1.1 μM, and has an ATP non-competitive inhibitory mode. Taken together, these results indicate that polymyxin B alleviates Ang II-induced stress fiber formation and cellular hypertrophy, and propose that one mechanism underlying these effects involves inhibition of the GRK5 pathway.

关键词： Polymyxin B GRK5 Angiotensin II Actin Stress Fiber Cellular Hypertrophy

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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