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Exercise improves the effects of testosterone replacement therapy and the durability of response after cessation of treatment： a pilot randomized controlled trial

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Asian Journal of Andrology 2017年第5期19卷 602-607页

作者： Dae-Yeon cho jeong Kyun Yeo Seung Ik cho Jae Eun Jung Sang Jin Yang Doo Hwan Kong jeong Ku Ha Jin Goo Kim Min Gu Park Inje University Sanggye Paik Hospital Department of Urology Seoul Korea Inje University Seoul Paik Hospital Department of Urology Seoul Korea KonKuk University Medical Center Department of Orthopedics Seoul Korea Inje University Seoul Paik Hospital Department of Orthopedics Sports Medical Center Seoul Korea

The effects of the combination of exercise and TRT on symptoms of late-onset hypogonadism （LOH） and the durability of response after cessation of TRT were investigated. A total of fifty patients with erectile dysfunction （ED） who had a sedentary lifestyle and low serum total testosterone （T） levels were enrolled and followed for 20 weeks. Patients were randomly divided into two groups; all of them received T gel for 12 weeks and it was discontinued for 8 weeks. Patients assigned to Group II were offered a supervised exercise program for 20 weeks. Measurement of serological testing was performed and self-assessment questionnaires and Global Assessment Question （GAQ） were asked. Baseline characteristics and the initial symptom scores showed no significant difference between the two groups. Serum total T levels and the symptom scores were increased at 12 weeks in both groups, and Group II showed better results with statistical significance. There was a decrease in T levels and worsening of symptom scores at week 20 compared to week 12 in both groups, and Group II showed better results with statistical significance. On the GAQ, Group II showed higher ratio of ＂yes＂ at week 12 and the same tendency was sustained at week 20 with significant difference between two groups. The combination of exercise and TRT showed significant improvements in serum T levels and LOH symptoms compared to TRT alone. In addition, these improvements were maintained in the combination group with continuous exercise, even after cessation of TRT.

关键词： erectile dysfunction exercise hypogonadism testosterone

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Spatial Modeling of the Highest Daily Maximum Temperature in Korea via Max-stable Processes

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Advances in Atmospheric Sciences 2013年第6期30卷 1608-1620页

作者： Youngsaeng LEE Sanghoo YOON Md.Sharwar MURSHED Maeng-Ki KIM ChunHo cho Hee-jeong BAEK jeong-Soo PARK Department of Statistics Chonnam National University School of Mathematics University of Southampton Department of Business Administration Northern University Bangladesh Department of Atmospheric Science Kongju National University Climate Research Laboratory National Institute of Meteorological ResearchKMA Seoul Korea

This paper examines the annual highest daily maximum temperature （DMT） in Korea by using data from 56 weather stations and employing spatial extreme modeling. Our approach is based on max-stable processes （MSP） with Schlather＇s characterization. We divide the country into four regions for a better model fit and identify the best model for each region. We show that regional MSP modeling is more suitable than MSP modeling for the entire region and the pointwise generalized extreme value distribution approach. The advantage of spatial extreme modeling is that more precise and robust return levels and some indices of the highest temperatures can be obtained for observation stations and for locations with no observed data, and so help to determine the effects and assessment of vulnerability as well as to downscale extreme events.

关键词： extreme climate extremal coefficient generalized extreme value distribution prediction re- turn level spatial extremes

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17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α

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Acta Pharmaceutica Sinica B 2016年第5期6卷 504-509页

作者： Sung-joon cho Miaoran Ning Yanyan Zhang Leah H.Rubin Hyunyoung jeong Department of Biopharmaceutical Sciences College of PharmacyUniversity of Illinois at Chicago Department of Pharmacy Practice College of PharmacyUniversity of Illinois at Chicago Department of Psychiatry University of Illinois at Chicago

UDP-glucuronosyltransferase 1A9(UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous *** data have shown increased elimination of UGT1A9 substrates in pregnant women or oral contraceptive users,but the role of estrogen in the regulation of UGT1A9 expression remains *** this study,we investigated the effect of 17β-estradiol(E2) on UGT1A9 expression and the role of ERα in the transcriptional regulation of UGT1A9.E2 significantly increased UGT1A9 promoter activity in Hep G2 cells in the presence of ERα.UGT1A9 induction by E2 was abrogated by antiestrogen ICI182,780 in Hep G2 cells that constitutively express ERα.Results from transient transfection of ERα mutants into Hep G2 cells demonstrated that mutation at DNA-binding domain of ERα abrogates increased UGT1A9 promoter activity by *** and mutation assays of UGT1A9 promoter revealed a putative ERE located within -2262/-1987 *** of healthy human liver tissues revealed significantly higher UGT1A9 expression in women as compared to ***,these findings provide a mechanistic basis for the previous clinical reports and may shed a light on identifying sources for inter-individual variability in UGT1A9-mediated drug metabolism.

关键词： UGT1A9 17β-Estradiol Estrogen receptor Drug metabolism Sex difference

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Preparation and characterization of solidified SMEDDS containing flurbiprofen by spray drying method

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 108-109页

作者： Yoo-jeong Jang Kwan Hyung cho College of Pharmacy Inje University

Flurbiprofen, a non-steroidal anti-inflammatory agent, is used to treat rheumatoid arthritis and sore throat (1)However, it gave poor water solubility, and various solubilization technique such as self-microemulsifying drug delivery system(SMEDDS) has been used to improve the solubility, dissolution and oral bioavailability [2].The objective of this work was to develop redispersible solidified SMEDDS containing water-insoluble flurbiprofen with enhanced solubility.

关键词： Flurbiprofen Solidified SMEDDS Solubilization

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Thin-Wall Aluminum Die-Casting Technology for Development of Notebook Computer Housing

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Journal of Materials Science & Technology 2008年第1期24卷 65-69页

作者： Chang-Seog Kang Jae-Ik cho Chang- Yeol jeong Se- Weon choi Young-Chan Kim Korea Institute of Industrial Technology Gwangju Korea

Silicon-based aluminum casting alloys are known to be one of the most widely used alloy systems mainly due to their superior casting characteristics and unique combination of mechanical and physical properties. However,manufacturing of thin-walled aluminum die-casting components,less than 1.0 mm in thickness,is generally known to be very difficult task to achieve aluminum casting alloys with high ***,in this study,the optimal die-casting conditions for producing 297 mm×210 mm×0.7 mm thin-walled aluminum component was examined experimentally by using 2 different gating systems,tangential and split type,and vent ***,computational solidification simulation was also *** results showed that split type gating system was preferable gating design than tangential type gating system at the point of view of soundness of casting and distortion generated after *** was also found that proper vent design was one of the most important factors for producing thin-wall casting components because it was important for the fulfillment of the thin-wall cavity and the minimization of the casting distortion.

关键词： Aluminum Thin-wall die-casting Notebook computer housing Cold chamberdie-casting machine

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Docurity: A New Cryptographic Primitive for Collaborative Cloud Systems

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Intelligent Automation & Soft Computing 2023年第6期36卷 3725-3742页

作者： Byeori Kim Minseong choi Taek-Young Youn jeong Hyun Yi Haehyun cho Soongsil University Seoul06978Korea Dankook University Yongin16890Korea

Recently,there has been a sudden shift from using traditional office applications to the collaborative cloud-based office suite such as Microsoft Office *** cloud-based systems allow users to work together on the same docu-ment stored in a cloud server at once,by which users can effectively collaborate with each ***,there are security concerns unsolved in using cloud *** of the major concerns is the security of data stored in cloud ser-vers,which comes from the fact that data that multiple users are working together cannot be stored in encrypted form because of the dynamic characteristic of cloud *** this paper,we propose a novel mode of operation,DL-ECB,for AES by which we can modify,insert,and delete the ciphertext based on changes in ***,we can use encrypted data in collaborative cloud-based *** demonstrate that the DL-ECB mode can preserve the confidential-ity,integrity,and auditability of data used in collaborative cloud systems from adversaries,we implement and evaluate the prototype of the DL-ECB mode.

关键词： Cloud collaboration mode of operation auditability of ciphertext

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Clinical characteristics of asymptomatic Terson syndrome in the patients with aneurysmal subarachnoid hemorrhage

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International Journal of Ophthalmology(English edition) 2020年第2期13卷 292-300页

作者： Hae Min Kang Jin Mo cho So Yeon Kim jeong Hoon choi Department of Ophthalmology Catholic Kwandong UniversityInternational St.Mary’s HospitalIncheon 22711Republic of Korea Department of Neurosurgery Catholic Kwandong UniversityInternational St.Mary’s HospitalIncheon 22711Republic of Korea Department of Ophthalmology Choikang Eye ClinicSeoul 01110Republic of Korea

●AIM:To investigate clinical characteristics of asymptomatic Terson syndrome and its clinical impact in patients with aneurysmal subarachnoid hemorrhage(SAH).●METHODS:This retrospective,interventional study included 31 patients with aneurysmal SAH,and the medical records were *** addition to baseline characteristics of the study population such as age,sex,and underlying medical history,multi-modal imaging analysis,including fluorescein angiography(FA),spectral domain optical coherence tomography(SD-OCT),were also *** Coma Scale(GCS),Hunt-Hess(HH)grade,and Fisher scale at the time of admission,and functional outcome by using modified Rankin Scale(mRS)at 6 mo were compared.●RESULTS:Of the 31 patients,10 patients(32.3%)were diagnosed with Terson *** the patients with Terson syndrome did not report visual symptoms at the time of ophthalmologic *** showed microvascular changes of retinal capillaries and varying degrees of disc ***-OCT allowed intuitive anatomical localization of multi-layered retinal hemorrhages and assessment of ellipsoid zone *** patients with Terson syndrome showed significantly worse GCS(P=0.047)and HH grade(P=0.025)than those without,except Ficher scale(P=0.385).There was no significant difference in the mRS(P=0.250)at 6 *** baseline factors,the HH grade was the only significant factor associated with Terson syndrome(B=1.079,P=0.016).●CONCLUSION:In our study,32.3%of the patients have Terson syndrome without visual *** baseline HH grade is significantly correlated with Terson syndrome,and there is no significant difference in the functional outcome between the patients with and without Terson *** syndrome may develop without any visual symptoms as shown in our study,and ophthalmologic screening may be recommended to prevent further visual deterioration especially in the patients with poor HH grade at the time of aneurysmal SAH.

关键词： cerebral aneurysm subarachnoid hemorrhage Terson syndrome

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Health behaviors of Korean adults with hepatitis B:Findings of the 2016 Korean National Health and Nutrition Examination Survey

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World Journal of Gastroenterology 2018年第28期24卷 3163-3170页

作者： Yu-Hyeon Yi Yun-Jin Kim Sang-Yeoup Lee Byung-Mann cho Young-Hye cho jeong-Gyu Lee Department of Family Medicine Pusan National University School of Medicine Medical Research Institute Pusan National University Hospital Busan Tobacco Control Center Pusan National University Hospital Department of Medical Education Pusan National University School of Medicine Family Medicine Clinic Pusan National University Yangsan Hospital Department of Preventive Medicine and Occupational Medicine Pusan National University School of Medicine

AIM To assess the frequencies of five health-related behaviors(smoking, alcohol consumption, body weight, sleep dura-tion, and physical activity) in Korean adults with chronic hepatitis *** Data were obtained from the 2016 Korean National Health and Nutrition Examination Survey. In total, 5887 subjects(2568 males, 3319 females) over 19 years old were enrolled in this study. Interviews were performed to obtain information on demographic characteristics and medical conditions. A self-administered questionnaire and medical examination were used to assess the smoking history, alcohol use, physical activity, sleep duration, and body weight of the subjects. Chronic hepatitis B was diagnosed based on detection of hepatitis B surface antigen(HBs Ag). The subjects were categorized into HBs Ag positive and negative groups, and a complex sampling analysis was conducted to compare the health behaviors between these *** Among males, the current smoking rate in the HBs Ag positive group was higher than that in the negative group(45.5% vs 38.5%). In the positive group, the rates of monthly and high-risk alcohol use were 70.4% and 17.6% in males and 45.9% and 3.8% in females, respectively. The rate of alcohol use was similar between the two groups [P = 0.455(males) and P = 0.476(females)]. In the HBs Ag positive group, 32.3% and 49.9% of males and 26.5% and 49.6% of females were overweight and physically inactive, respectively. High-risk alcohol consumption and physical inactivity were significantly associated with self-perceived health *** Our data demonstrate that a large proportion of Korean adults with chronic hepatitis B have poor health behaviors. Further studies are needed to confirm our results.

关键词： Health behavior Self-perceived health status Hepatitis Health risk behavior Health status

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Cu^+-incorporated TiO_2 overlayer on Cu_2O nanowire photocathodes for enhanced photoelectrochemical conversion of CO_2 to methanol

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Journal of Energy Chemistry 2018年第1期27卷 264-270页

作者： Kangha Lee Seokwon Lee Hyunjin cho Sunil jeong Whi Dong Kim Sooho Lee Doh C.Lee Department of Chemical and Biomolecular Engineering(BK21+program) KAIST Institute for the NanocenturyKorea Advanced Institute of Science and Technology(KAIST)

In this paper, we report photoelectrochemical（PEC） conversion of carbon dioxide（CO_2） using photocathodes based on Cu_2O nanowires（NWs） overcoated with Cu~＋-incorporated crystalline TiO_2（TiO_2–Cu~＋）shell. Cu_2O NW photocathodes show remanent photocurrent of 5.3% after 30 min of PEC reduction of CO_*** coating Cu_2O with TiO_2–Cu~＋ overlayer, the remanent photocurrent is 27.6%, which is an increase by5.2 fold. The charge transfer resistance of Cu_2O/TiO_2–Cu~＋ is 0.423 k/cm2, whereas Cu_2O photocathode shows resistivity of 0.781 k/cm2 under irradiation. Mott–Schottky analysis reveals that Cu~＋ species embedded in TiO_2 layer is responsible for enhanced adsorption of CO_2 on TiO_2 surface, as evidenced by the decrease of capacitance in the Helmholtz layer. On account of these electrochemical and electronic effects by the Cu~＋ species, the Faradaic efficiency（FE） of photocathodes reaches as high as 56.5% when TiO_2–Cu~＋ is added to Cu_2O, showing drastic increase from 23.6% by bare Cu_2O photocathodes.

关键词： Photoelectrochemical CO2 reductionMethanol generation Copper oxide Titanium dioxide Cu+ catalyst

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Protective Effect of Brassica napus *** against Inflammation Response in RAW 264.7 Cells

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Chinese Journal of Integrative Medicine 2021年第4期27卷 273-279页

作者： Su-Hyeon cho Song Rae Kim Myeong Seon jeong Miri choi SeonJu Park Kil-Nam Kim Chuncheon Center Korea Basic Science InstituteChuncheon(24341)Republic of Korea

Objective:To demonstrate the anti-inflammatory activity of Brassica napus ***(BNH)in lipopolysaccharide(LPS)-stimulated RAW 264.7 ***:Composition analysis of BNH was conducted via gas chromatography-mass spectrometry after BNH were *** nitric oxide(NO)production was measured using the Griess *** E2(PGE2)production was evaluated with enzyme-linked immunosorbent *** effects of BNH on LPS-induced pro-inflammatory enzymes including inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2)were evaluated using Western blot ***,phosphorylation of nuclear factor-kappa B(N F-k B)and nuclear translocation of N F-k B p65 were evaluated with Western blot analysis and immunofluorescence staining,***:Compared with LPS-stimulated cells,BNH markedly decreased the generation of NO and PGE_(2)in LPS-stimulated RAW 264.7 cells(P<0.01 or P<0.05).Moreover,BNH inhibited protein levels of iNOS and COX-2(P<0.01).Phosphorylation of NF-k B and nuclear translocation of NF-k B p65 was significantly inhibited by BNH(P<0.01 or P<0.05).Conclusion:The anti-inflammatory activities of BNH were mediated via blockage of the N F-k B signaling pathways in LPS-stimulated RAW 264.7 cells.

关键词： Brassica napus L. inflammation lipopolysaccharide RAW 264.7 cells hydrosols

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