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FOLFIRINOX vs gemcitabine/nab-paclitaxel for treatment of metastatic pancreatic cancer: Single-center cohort study

World Journal of Gastrointestinal Oncology 2020年第2期12卷 182-194页

作者： In Rae Cho Huapyong Kang Jung Hyun Jo Hee Seung Lee Moon Jae Chung jeong Youp Park Seung Woo Park Si Young Song Chansik An Mi-suk Park Seungmin Bang Department of Internal Medicine International Saint Mary’s HospitalCatholic Kwandong University College of MedicineIncheon 22711South Korea Department of Medicine Yonsei University Graduate School50-1 Yonsei-roSeoul 03722South Korea Division of Gastroenterology Department of Internal MedicineYonsei University College of Medicine50-1 Yonsei-roSeoul 03722South Korea Department of Radiology Yonsei University College of Medicine50-1 Yonsei-roSeoul 03722South Korea

BACKGROUND FOLFIRINOX and gemcitabine plus nab-paclitaxel(Gem+nabPTX)were recently introduced for metastatic pancreatic cancer ***,studies that compared these two regimens and studies in Asian populations are *** To compare the treatment outcomes of FOLFIRINOX and Gem+nabPTX regimen for metastatic pancreatic cancer treatment in Korean *** Patients with metastatic or recurrent pancreatic cancer treated with FOLFIRINOX(n=86)or Gem+nabPTX(n=81)as the first-line since January 2015 were identified using the Severance Hospital Pancreatic Cancer Cohort *** efficacy,treatment-related adverse events and economic aspects were *** Patients in the FOLFIRINOX group were significantly younger(54 vs 65 years;P<0.001)and had better performance statuses at *** median overall survival(10.7 vs 12.1 mo;P=0.157),progression-free survival(8.0 vs 8.4 mo;P=0.134),and objective response rates(33.7%vs 46.9%;P=0.067)were not significantly different when compared with Gem+nabPTX ***≥3 neutropenia and gastrointestinal adverse events were more common in the FOLFIRINOX *** drug costs of both regimens were *** Treatment efficacy and economic burdens were comparable between the two ***,the details of adverse event were ***+nabPTX regimen might be considered preferentially in certain conditions.

关键词： Pancreatic cancer Chemotherapy FOLFIRINOX Gemcitabine Nabpaclitaxel Survival

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Enterovenous fistulization: A rare complication of Crohn's disease

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World Journal of Gastroenterology 2011年第47期17卷 5227-5230页

作者： jeong Woo Lim Kyung-Jo Kim Byong Duk Ye jeong-Sik Byeon Seung-Jae Myung suk-Kyun Yang Jin Ho Kim Division of Gastroenterology Department of Internal Medicine University of Ulsan College of Medicine Asan Medical Center

The presence of hepatic portal venous gas (HPVG) is associated with numerous diseases, and has been regarded as a serious, even catastrophic condition. However, anecdotal reports mention that some patients with inflammatory bowel disease (IBD), who developed HPVG after diagnostic examinations of the colon, were successfully managed with antibiotic therapy and have followed benign courses. In contrast, among IBD patients, the development of HPVG is rarely caused by enterovenous fistula. We describe a 32-year-old man with Crohn's ileocolitis who presented with hypotension and fever associated with HPVG, as well as superior mesenteric vein thrombosis, possibly caused by enterovenous fistula, who was successfully managed by surgery. We also review the literature concerning portal venous gas associated with Crohn's disease.

关键词： Crohn's disease Enterovenous fistula Portal venous gas

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Signet-ring cell carcinoma arising from a fundic gland polyp in the stomach

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World Journal of Gastroenterology 2014年第47期20卷 18044-18047页

作者： Yong Seol jeong Sung Eun Kim Mi-Jung Kwon Jae Yong Seo Hyun Lim Ji Won Park Ho suk Kang Sung Hoon Moon Jong Hyuk Kim Choong Kee Park Department of Internal Medicine University of Hallym College of MedicineHallym University Sacred Heart Hospital Department of Pathology University of Hallym College of MedicineHallym University Sacred Heart Hospital

Fundic gland polyps(FGPs)are currently the most common type of gastric polyps and are usually ***,although rare,gastric adenocarcinoma of FGP has been recently proposed as a new variant of gastric *** we report the first case of a49-year-old woman with focal signet ring cell carcinoma that arose from an FGP of the *** tumor was completely excised by endoscopic snare *** should therefore be evaluated for malignant changes although they occur rarely,if the FGP has an erosive or irregular surface.

关键词： Fundic gland polyp Signet ring cell

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The Application of Maturity Method on Whitetopping Construction

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Journal of Civil Engineering and Architecture 2011年第3期5卷 233-240页

作者： Jung Jong suk Park Yong Boo Jun Myoung Hoon Sohn jeong Rak Department of Construction Technology Research Senior Research Land ＆ Housing Research Institute Daejeon City 305-731South Korea

The primary objective of this study was to assess the use of the maturity method to determine the joint sawing window and the traffic opening time on whitetopping construction in Korea. To determine joint sawing time, it was necessary to find the minimum strength not to cause raveling and to identify the time to the occurrence of drying shrinkage. This study found that the minimum compressive strength for joint sawing was 4.41MPa （45kg/cm2） and drying shrinkage occurred just after the concrete temperature reached at the peak. To develop the relationship between compressive strength and maturity values, thermachron i-buttons were inserted into the top and mid-depth of the fresh concrete in the test slabs. The results of the laboratory tests indicated that the Arrhenius equation better fitted the relationship between the compressive strength and maturity values than did the Nurse-Saul equation. However, the Nurse-Saul function estimated in-place strength quite well in this study. Therefore, the Nurse-Saul equation was used to determine the joint sawing window and the traffic opening time for whitetopping construction.

关键词： Maturity Nurse-Saul function Arrhenius equation whitetopping

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A CIS/2-based Standard Processing Model for Steel Beam Design

A CIS/2-based Standard Processing Model for Steel Beam Desig...

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The Sixth World Congress on Computational Mechanics in Conjunction with the Second Asian-Pacific Congress on Computational MechanicsⅠ

作者： E-Doo Kim Sang-Ho Shin Yeon-suk jeong School of Architecture University of Ulsan Mugeo 2-dong Nam-gu Seoul 680-749 Korea School of Civil and Environmental Engineering Yonsei University 134 Sinchon-dong Seodaemungu Seoul 120-749

Regulations for structural design play a significant role in structural engineering, providing requirements for design and construction of structures in terms of safety, serviceability, and durability[1]. To use the design codes correctly, engineers need to have a lot of experience and spend much time and efforts to design their structures and check the results with the regulations. Although many structural design programs have been developed and used in structural design, these programs are only valid to the specific code from which their algorithms were derived, and the revisions are difficult to be implemented into the programs without supports of developers.

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Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Phlebovirus in Domesticated Deer in South Korea

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Virologica Sinica 2019年第5期34卷 501-507页

作者： Min-Ah Yu Kwang-Min Yu Su-Jin Park Young-ll Kim Norbert John Robles Young-Jae Si Eun-Ha Kim Hyeok-ll Kwon Hye Won jeong Min-suk Song Seok-Yong Kim Young Ki Choi Department of Microbiology College of Medicine and Medical Research InstituteChungbuk National UniversityCheongju 28644Republic of Korea Zoonotic Infectious Diseases Research Center Chungbuk National UniversityCheongju 28644Republic of Korea Department of Internal Medicine College of Medicine and Medical Research InstituteCheongju 28644Republic of Korea Department of Internal Medicine Chungbuk National University HospitalCheongju 28644Republic of Korea

Severe fever with thrombocytopenia syndrome phlebovirus(SFTSV)has a wide host *** only has it been found in humans,but also in many wild and domesticated *** infection of breeding deer on farms is a particularly worrisome public health concern due to the large amount of human contact and the diverse use of deer products,including raw *** investigate the prevalence of breeding domesticated deer,we examined the SFTSV infection rate on deer farms in South Korea from 2015 to *** the 215 collected blood samples,0.9%(2/215)were found to be positive for viral RNA by PCR,and sequence analysis showed the highest homology with the KADGH human *** SFTSVspecific recombinant N and Gn protein-based ELIS As revealed that 14.0%(30/215)and 7.9%(17/215)of collected blood specimens were positive for SFTSV *** results demonstrate that the breeding farm deer are exposed to SFTSV and could be a potential infection source for humans through direct contact or consumption of byproducts.

关键词： Severe fever with thrombocytopenia syndrome phlebovirus(SFTSV) Breeding deer•Seroprevalence South Korea

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Antioxidant Effect of Polysaccharide Extracted From Dendrobium Medical Plants

Antioxidant Effect of Polysaccharide Extracted From Dendrobi...

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The International Meeting of the Society for Free Radical Research(SFRR)-Asia & the Third International Symposium on Natural Antioxidants-Molecular Mechanisms and Health Effects(ISNA)

作者： Young-ok Song jeong-chae Lee Yong-suk Jang Division of Biological Sciences and The Research Center for Bioactive Materials Chonbuk National University Chonju 561-756 Korea

The Dendrobium Medical Plants are Chinese traditional herbas, which have been used as adjuvant therapeutic agents for long time. Clinical experiments showed that they could increase the immune ability of human beings and delay tumor progression. But the active substance and the mechanism are not clear untill now. The purposes of this paper are to extract the polysaccharide (PSC) and to determine its antioxidant property.

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Interplay between ABA and GA Modulates the Timing of Asymmetric Cell Divisions in the Arabidopsis Root Ground Tissue

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Molecular Plant 2016年第6期9卷 870-884页

作者： Shin Ae Lee Sejeong Jang Eun Kyung Yoon Jung-Ok Heo Kwang suk Chang Ji Won Choi Souvik Dhar Gyuree Kim jeong-Eun Choe Jae Bok Heo Chian Kwon Jae-Heung Ko Yong-Sic Hwang Jun Lim Department of Systems Biotechnology Konkuk University Seour 05029 Korea Department of Molecular Biotechnology Dong-A University Busan 49201 Korea Department of Molecular Biology Dankook University Yongin 16890 Korea Department of Plant and Environmental New Resources Kyung Hee University Yongin 17104 Korea These authors contributed equally to this article. Present address: The Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR United Kingdom Present address: Department of Life Science Research Institute for Natural Sciences Hanyang University Seoul 04763 Korea

In multicellular organisms, controlling the timing and extent of asymmetric cell divisions （ACDs） is crucial for correct patterning. During post-embryonic root development in Arabidopsis thaliana, ground tissue （GT） maturation involves an additional ACD of the endodermis, which generates two different tissues： the endo- dermis （inner） and the middle cortex （outer）. It has been reported that the abscisic acid （ABA） and gibberellin （GA） pathways are involved in middle cortex （MC） formation. However, the molecular mechanisms under- lying the interaction between ABA and GA during GT maturation remain largely unknown. Through transcriptome analyses, we identified a previously uncharacterized C2H2-type zinc finger gene, whose expression is regulated by GA and ABA, thus named GAZ （GA- AND ABA-RESPONSIVE ZINC FINGER）. Seedlings ectopically overexpressing GAZ （GAZ-OX） were sensitive to ABA and GA during MC formation, whereas GAZ-SRDX and RNAi seedlings displayed opposite phenotypes. In addition, our results indicated that GAZ was involved in the transcriptional regulation of ABA and GA homeostasis. In agreement with pre- vious studies that ABA and GA coordinate to control the timing of MC formation, we also confirmed the unique interplay between ABA and GA and identified factors and regulatory networks bridging the two hor- mone pathways during GT maturation of the Arabidopsis root.

关键词： ABA GA GRAS ground tissue root development transcription factor

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Freeze-Thaw Effect on Coarse Sand Coated Interface between FRP and Concrete

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Engineering（科研） 2013年第10期5卷 807-815页

作者： Keunhee Cho Sung Yong Park Sung Tae Kim jeong-Rae Cho Byung-suk Kim Infrastructure Research Department Korea Institute of Construction Technology Goyang South Korea

This paper examines the effect of freezing and thawing on the coarse sand coating chosen to achieve the composition of FRP and concrete in FRP-concrete composite deck. Push-out test specimens with dimensions of 100 × 100 × 450 mm were subjected to repeated freeze-thaw cycles under wet conditions ranging from -18℃± 2℃ to 4℃ ± 2℃. The failure strength of the interface and the deformation of FRP at failure exhibited by the specimens that experienced 300 freezing-thawing cycles showed a difference of merely 5% compared to those of the specimens that were not subjected to freeze-thaw. This indicates that coarse sand coating is not affected by freezing-thawing cycles and the FRP-concrete composite deck owns sufficient applicability in terms of durability against freezing-thawing.

关键词： Freeze-Thaw Coarse Sand Coating Interface Failure FRP Concrete

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Fatigue Performance of Precast FRP-Concrete Composite Deck with Long Span

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Engineering（科研） 2011年第11期3卷 1115-1123页

作者： Keunhee Cho jeong-Rae Cho Sung Tae Kim Byung-suk Kim Sung Yong Park 不详

The fatigue performance of precast FRP-concrete composite (PFC) deck is evaluated. This type of deck enables a reduction of the weight by 30% compared to conventional reinforced concrete decks owing to the composition of a hollow FRP panel with concrete. Therefore, the application of such deck in cable-stayed bridge will reduce effectively the weight of the superstructure leading also to substantial savings in the materials required for the superstructure and substructure and, therefore, achieve significant improvement of the economic efficiency. Static, pulsating fatigue and rolling fatigue tests were carried out on 4 m × 4 m precast FRP-concrete composite decks. All the specimens did not fail even after 2 million fatigue cycles, and the subsequent static tests conducted on these specimens verified that all the design criteria were satisfied. These experimental results demonstrated that the PFC deck developed in this research secures sufficient performances for future applications for cable-stayed bridges.

关键词： FRP Concrete Composite Deck Long Span Fatigue Performance

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