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Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients

World Journal of Gastroenterology 2015年第5期21卷 1457-1467页

作者： jeong mo bae Tae Hun Lee Nam-Yun Cho Tae-You Kim Gyeong Hoon Kang Laboratory of Epigenetics Cancer Research InstituteSeoul National University College of MedicineSeoul 110-799South Korea Department of Pathology Seoul National University College of MedicineSeoul 110-799South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 110-799South Korea

AIM:To investigate the clinicopathologic characteristics and prognostic implications associated with loss of CDX2 expression in colorectal cancers(CRCs).METHODS:We immunohistochemically evaluated CDX2 expression in 713 CRCs and paired our findings to clinicopathologic and molecular characteristics of each *** included cytokeratin 7 and CK20 expression,microsatellite instability,Cp G island methylator phenotype,and KRAS and BRAF mutation *** and multivariate survival analysis was performed to reveal the prognostic value of CDX2 ***:CDX2 expression was lost in 42(5.9%) ***,loss of CDX2 expression was associated with proximal location,infiltrative growth,advanced T,N,M and overall *** microscopic examination,loss of CDX2 expression was associated with poor differentiation,increased number of tumor-infiltrating lymphocytes,luminal serration and mucin *** of CDX2 expression was also associated with increased CK7 expression,decreased CK20 expression,Cp G island methylator phenotype,microsatellite instability and BRAF *** a univariate survival analysis,patients with loss of CDX2 expression showed worse overall survival(P < 0.001) and progression-free survival(P < 0.001).In a multivariate survival analysis,loss of CDX2 expression was an independent poor prognostic factor of overall survival [hazard ratio(HR) = 1.72,95%CI:1.04-2.85,P = 0.034] and progression-free survival(HR = 1.94,95%CI:1.22-3.07,P = 0.005).CONCLUSION:Loss of CDX2 expression is associated with aggressive clinical behavior and can be used as a prognostic marker in CRCs.

关键词： CDX2 CpG island methylator phenotype Microsatellit

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Annexin A10 expression in colorectal cancers with emphasis on the serrated neoplasia pathway

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World Journal of Gastroenterology 2015年第33期21卷 9749-9757页

作者： jeong mo bae Jung Ho Kim Ye-Young Rhee Nam-Yun Cho Tae-You Kim Gyeong Hoon Kang Laboratory of Epigenetics Cancer Research InstituteSeoul National University College of Medicine Department of Pathology Seoul National University College of Medicine Department of Internal Medicine Seoul National University College of Medicine

AIM: To validate the utility of Annexin A10 as a surrogate marker of the serrated neoplasia pathway in invasive colorectal cancers(CRCs).METHODS: A total of 1133 primary CRC patients who underwent surgical resection at Seoul National University Hospital between January 2004 and December 2007 were *** of Annexin A10 was evaluated by immunohistochemistry using tissue microarray and paired to our findings on clinicopathologic and molecular characteristics of each *** G island methylator phenotype was determined by Methy Light assay and microsatellite instability was determined by high performance liquid *** and BRAF mutation status was evaluated by direct sequencing and allele-specific *** and stage-specific survival analyses were performed to reveal the prognostic value of Annexin A10 ***: Annexin A10 expression was observed in 66(5.8%) of the 1133 *** A10 expression was more commonly found in females and was associated with proximal location,ulcerative gross type,advanced T category,N category and TNM *** with Annexin A10 expression showed an absence of luminal necrosis,luminal serration and mucin *** with Annexin A10 expression were associated with Cp G island methylator phenotype,microsatellite instability and BRAF *** survival analysis,Annexin A10 expression was associated with poor overall survival and progression-free survival,especially in stage Ⅳ ***: Annexin A10 expression is associated with poor clinical behavior and can be used a supportive surrogate marker of the serrated neoplasia pathway in invasive CRCs.

关键词： Annexin A10 Serrated neoplasia pathway CpG island

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun jeong Lee Su Bin Lim Department of Biochemistry&molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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On Uniform Decay for Transmission Problem of Kirchhoff Type Viscoelastic Wave Equation

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Acta Mathematica Sinica,English Series 2010年第7期26卷 1197-1206页

作者： jeong Ja bae Department of Mathematics Dongeui University

In this paper we consider the large time behavior of solutions to an n-dimensional transmission problem for two Kirchhoff type viscoelastic wave equations, that is, the wave propagation over bodies consisting of two physically different types of materials. One component is a simple elastic part while the other is a viscoelastic component endowed with a long range memory. We show that the dissipation produced by the viscoelastic part is strong enough to produce exponential or polynomial decay of the solution

关键词： existence of solution uniform decay wave equation boundary value problem a priori estimates

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ON TRANSMISSION PROBLEM FOR KIRCHHOFF TYPE WAVE EQUATION WITH A LOCALIZED NONLINEAR DISSIPATION IN BOUNDED DOMAIN

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Acta Mathematica Scientia 2012年第3期32卷 893-906页

作者： jeong Ja bae Department of Mathematics Dongeui UniversityPusan 614-714Korea

In this article, we consider the global existence and decay rates of solutions for the transmission problem of Kirchhoff type wave equations consisting of two physi- cally different types of materials, one component is a Kirchhoff type wave equation with nonlinear time dependent localized dissipation which is effective only on a neighborhood of certain part of the boundary, while the other is a Kirchhoff type wave equation with nonlinear memory.

关键词： Existence of solution uniform decay transmission problem Kirchhoff type wave equation boundary value problem localized dissipation

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Ru/NiMnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第1期100卷 397-408页

作者： Md Ahasan Habib Shusen Lin Mehedi Hasan Joni Sumiya Akter Dristy Rutuja Mandavkar Jae-Hun jeong Jihoon Lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NiMnB spherical cluster pillar （SCP）,denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic *** Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 M KOH,making them highly competitive with state-of-the-art ***,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 M KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

关键词： Advanced electrocatalyst High current Corrosion resistance Industrial requirement

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GLOBAL EXISTENCE FOR THE NONHOmoGENEOUS QUASILINEAR WAVE EQUATION WITH A LOCALIZED WEAKLY NONLINEAR DISSIPATION IN EXTERIOR DOMAINS

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Acta Mathematica Scientia 2009年第5期29卷 1203-1215页

作者： jeong Ja bae Department of Mathematics University of Ulsan

It is proved that the global existence for the nonhomogeneous quasilinear wave equation with a localized weakly nonlinear dissipation in exterior domains.

关键词： quasilinear wave equation localized weakly nonlinear dissipation exterior domains

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Saccharomyces boulardii as a single trigger of food protein-induced enterocolitis syndrome: Seven case reports

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World Journal of Clinical Cases 2025年第6期13卷 35-40页

作者： Jin-Bok Hwang Hyo-jeong Jang Department of Pediatrics Keimyung University School of MedicineDongsan Medical CenterDaegu 42601South Korea

BACKGROUND Food protein-induced enterocolitis syndrome(FPIES)is the most serious type of non-immunoglobulin E(IgE)-mediated food allergic reaction manifesting as sepsis-like symptom,which can lead to *** boulardii(***),a probiotic prescribed frequently in clinical settings,has been reported to trigger FPIES in an infant with soy-triggered *** this report,we describe a new clinical FPIES in which *** was the sole triggering factor of acute FPIES adverse reaction in seven healthy *** SUMMARY Seven FPIES cases triggered by only *** were gathered from 2011 to the *** of the patients had previously experienced any allergic reaction to cow’s milk,soy,or complementary *** age of the patients was 4-10-months old,and the symptoms of FPIES developed after ingestion of ***,which is mostly prescribed for the treatment of gastroenteritis or antibiotic-associated *** patients experienced severe repetitive vomiting 1-3 hours after *** *** lethargy,marked pallor,and cyanosis were also *** IgE-mediated hypersensitivity developed in any *** was followed by initial intense vomiting in approximately 5-10 hours after *** ingestion,and only one case showed bloody,purulent,and foul-smelling *** patients stabilized quickly,mostly within 6 *** got all improved within 24 hours after discontinuation of *** *** can be the sole trigger of acute FPIES and be prescribed cautiously even in healthy children without FPIES.

关键词： Food protein-induced enterocolitis syndrome Food hypersensitivity Saccharomyces boulardii Probiotics Child Case report

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ON TRANSMISSION PROBLEM FOR VISCOELASTIC WAVE EQUATION WITH A LOCALIZED A NONLINEAR DISSIPATION

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Acta Mathematica Scientia 2013年第2期33卷 362-374页

作者： jeong Ja bae Seong Sik KIM Department of Mathematics Dongeui UniversityPusan 614-714Korea

In this article, we consider the global existence and decay rates of solutions for the transmission problem of Kirchhoff type wave equations consisting of two physically different types of materials, one component being a Kirchhoff type wave equation with time dependent localized dissipation which is effective only on a neighborhood of certain part of boundary, while the other being a Kirchhoff type viscoelastic wave equation with nonlinear memory

关键词： Existence of solution uniform decay transmission problem boundary valueproblem localized dissipation

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Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue lymphoma

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World Journal of Gastroenterology 2014年第11期20卷 2751-2759页

作者： jeong bae Park Ja Seol Koojeong Department of Internal Medicine College of MedicineDongguk UniversityGyeongju 780-350South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan HospitalAnsan 425-707South Korea

Gastrointestinal lymphoma is the most common type of extranodal lymphoma,and most commonly affects the *** zone B-cell lymphoma of the mucosa-associated lymphoid tissue(MALT)and diffuse large B-cell lymphoma are the most common histologic types of gastric *** its increasing incidence,diagnosis of gastric lymphoma is difficult at an earlier stage due to its nonspecific symptoms and endoscopic findings,and,thus,a high index of suspicion,and multiple,deep,repeated biopsies at abnormally and normally appearing sites in the stomach are *** addition,testing for Helicobacter pylori(***)infection and endoscopic ultrasonography to determine the depth of tumor invasion and involvement of regional lymph nodes is essential for predicting response to *** eradication and for assessment of disease *** addition,*** infection and MALT lymphoma development are associated,and complete regression of low-grade MALT lymphomas after *** eradication has been *** and/or chemotherapy can be used in cases that show poor response to *** eradication,negativity for *** infection,or high-grade lymphoma.

关键词： Mucosa-associated lymphoid tissue Lymphoma Helicobacter pylori Eradication Remission

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