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Treatment of a patient with severe cerebral malaria during the COVID-19 pandemic in China:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4419-4426页

作者： Yan-Fang Zhu Wen-Jing Xia Wei Liu Ju-min Xie Department of Critical Care Medicine Huangshi Hospital of TCM(Infectious Disease Hospital)Huangshi 435000Hubei ProvinceChina Hubei Key Laboratory of Renal Disease Occurrence and Intervention Medical SchoolHubei Polytechnic UniversityHuangshi 435003Hubei ProvinceChina

BACKGROUND On June 30,2021,China received certification from the World Health Organization for malaria ***,this certification does not signify the absence of malaria within *** to the increasing frequency of international exchanges and collaborations,the threat of imported malaria persists in ***,the prevention and control of imported malaria have become a primary focus for our country to maintain its malaria elimination *** SUMMARY Herein,we present a case report of a 53-year-old Chinese man who worked in Africa for nearly two *** was diagnosed with malaria in the Democratic Republic of the Congo between November 19 and November 23,*** receiving effective treatment with oral antimalarial drugs,his condition improved,allowing him to return to *** was later admitted to our hospital on January 12,2023,during the coronavirus disease 2019 pandemic in Huangshi,*** a thorough evaluation of the patient's symptoms,clinical signs,imaging and laboratory test results,and epidemiological data,he was rapidly diagnosed with severe cerebral *** patient underwent successful treatment through a series of intensive care unit *** The successful treatment of this imported case of severe cerebral malaria provides a valuable reference for managing patients with similar malaria infections and has significant clinical implications.

关键词： Pernicious malaria Severe cerebral malaria Imported patients Traditional Chinese medicine Angong niuhuang Pill Case report

Investigating the molecular mechanism of Chelidonii Herba against liver cancer using network pharmacology and molecular docking validation

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Integrative Medicine Discovery 2024年第22期8卷 1-12页

作者： ming-Zhi Yang Zi-Xuan Yang Zhang Yu Ju-min Xie Hubei Key Laboratory of Renal Disease Occurrence and Intervention Medical SchoolHubei Polytechnic UniversityHuangshi 435003China

Background:The molecular mechanism of Chelidonii Herba in treating hepatocellular carcinoma was investigated using network pharmacology and molecular docking ***:The main active components of Chelidonii Herba were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database,and the targets of these active ingredients were identified using the SwissTargetPrediction *** related to liver cancer were sourced from GeneCards,Therapeutic Targets Database,and Online Mendelian Inheritance in Man *** targets between the active components of Chelidonii Herba and liver cancer were determined using the jvenn online *** protein interaction network was analyzed via STRING database and visualized using Cytoscape *** targets were identified and further analyzed within the protein interaction *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted for the intersection targets using the DAVID database to correlate gene *** bubble diagrams for Gene Ontology enrichment analysis and circular diagrams for Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were generated using CNSknowall and SangerBox online *** docking and visualization were performed using AutoDockTools 1.5.7 and PyMOL 2.5.7 software,*** survival and pan-cancer analysis of core targets were conducted using the GEPIA2 online ***:Twelve active components of Chelidonii Herba were identified through screening.A total of 103 intersection targets and 12 core targets were found between these active constituents of Chelidonii Herba and liver *** Herba may exert its effects on liver cancer through these 12 core *** signaling pathways are implicated,including chemical carcinogen-receptor activation,endocrine resistance,HIF-1 signaling pathway,and proteoglycans in ***

关键词： Chelidonii Herba liver cancer network pharmacology molecular docking

Recurrence of intratendinous ganglion due to incomplete excision of satellite lesion in the extensor digitorum brevis tendon: A case report

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World Journal of Clinical Cases 2022年第36期10卷 13373-13380页

作者： jeong Jin park Hyun Gyu Seok Hongfei Yan Chul Hyun park Department of Orthopaedic Surgery Yeungnam University HospitalDaeguKoreaDaegu 42415South Korea Department of Orthopaedic Surgery College of MedicineYeungnam UniversityDaegu 42415South Korea

BACKGROUND Intratendious ganglions are rare lesions, especially on the foot and ankle. Although several studies have presented the intratendinous ganglion of the foot and ankle, there are only few reported cases, and no cases of recurrence or secondary surgery have been *** SUMMARY We present the case of a 32-year-old man with an intratendinous ganglion of the second extensor digitorum brevis(EDB) tendon that recurred after ganglion excision. Magnetic resonance imaging(MRI) performed before the first surgery was reviewed to analyze the causes of the recurrence. We confirmed that there was a lack of satellite detection. After recurrence, MRI revealed an extratendinous lesion, tenosynovitis, and intratendinous ganglion of the second EDB tendon. Since the second EDB tendon can compensate for the extrinsic muscle, en bloc resection was performed alone. In addition, meticulous excision and synovectomy were performed for extra-tendinous lesions and tenosynovitis, respectively. The patient returned to daily life without any functional problems or *** If removal of the affected tendon is not fatal, en bloc resection should first be considered to prevent incomplete excision and intraoperative leakage. When planning surgical excision, it is necessary to evaluate the presence of satellite lesions along the course of the affected tendon.

关键词： Intratendinous ganglion Recurrence Surgical excision En bloc resection Case report

Risk of ischaemic stroke in patients with transient global amnesia: a propensity-matched cohort study

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Stroke & Vascular Neurology 2022年第2期7卷 101-107页

作者： Sang Hun Lee Keon-Yeup Kim jeong-Woo Lee So-jeong park Jin-Man Jung Department of Neurology Korea University Ansan HospitalKorea University College of MedicineAnsanRepublic of Korea Data Science Team Hanmi Pharm.Co.LtdSeoulRepublic of Korea Korea University Zebrafish Translational Medical Research Center AnsanRepublic of Korea

Background The exact pathophysiological mechanism of transient global amnesia(TGA)is *** is debatable whether TGA is a risk factor for ***,here we investigated the possibility of TGA as a risk factor for stroke in a real-world setting using large-scale nationwide health claims *** We used health claims data from the Korean National Health Insurance Service(NHIS).Patients diagnosed with TGA between 2007 and 2013 were *** initially extracted patients without TGA who were preferentially matched for age and sex with the patients with TGA at a ratio of 10:1 from the whole ***,we performed 1:2 propensity score matching analysis to balance the baseline characteristics between the two *** the propensity score-matched dataset,we performed multivariable Cox regression analysis to investigate the association between TGA and stroke type,including ischaemic,haemorrhagic and all stroke *** Patients with TGA(n=14673)were selected from the NHIS *** extracting from the whole database(n=140486)and propensity score matching their data at a 1:2 ratio,a total of 10448 and 20442 patients were finally assigned to the TGA and control groups,*** multivariable Cox regression analysis demonstrated that the TGA group had a higher risk of ischaemic stroke and all types of stroke(adjusted HR=1.194;95%CI:1.043 to 1.368;and HR=1.197;95%CI:1.056 to 1.357,respectively).Conclusions Analysis of the nationwide claims database showed that TGA could be an important risk factor for stroke,especially for ischaemic stroke.

关键词： patients matched transient

Precise control of surface oxygen vacancies in ZnO nanoparticles for extremely high acetone sensing response

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Journal of Advanced Ceramics 2022年第5期11卷 769-783页

作者： Jihyun LEE Youngmoon CHOI Byoung Joon park jeong Woo HAN Hyun-Sook LEE Jong Hyeok park Wooyoung LEE Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical and Biological Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul 03722Republic of Korea

ZnO has been studied intensely for chemical sensors due to its high sensitivity and fast ***,we present a simple approach to precisely control oxygen vacancy contents to provide significantly enhanced acetone sensing performance of commercial ZnO nanopowders.A combination of H_(2)O_(2)treatment and thermal annealing produces optimal surface defects with oxygen vacancies on the ZnO nanoparticles(NPs).The highest response of~27,562 was achieved for 10 ppm acetone in 0.125 MH_(2)O_(2)treated/annealed ZnO NPs at the optimal working temperature of 400℃,which is significantly higher than that of reported so far in various acetone sensors based on metal oxide semiconductors(MOSs).Furthermore,first-principles calculations indicate that pre-adsorbed O formed on the surface of H_(2)O_(2)treated ZnO NPs can provide favorable adsorption energy,especially for acetone detection,due to strong bidentate bonding between carbonyl C atom of acetone molecules and pre-adsorbed O on the ZnO *** study demonstrates that controlling surface oxygen vacancies by H_(2)O_(2)treatment and re-annealing at optimal temperature is an effective method to improve the sensing properties of commercial MOS materials.

关键词： gas sensors acetone metal oxide semiconductors(MOSs) ZnO nanoparticles(NPs) H_(2)O_(2)treatment

Case mistaken for leukemia after mRNA COVID-19 vaccine administration:A case report

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World Journal of Clinical Cases 2022年第33期10卷 12268-12277页

作者： Seul Bi Lee Chi Young park Sang-Gon park Hee jeong Lee Department of Internal Medicine Hemato-oncologyChosun University HospitalGwangju 501-717South Korea

BACKGROUND Following the global outbreak of coronavirus disease 2019(COVID-19),unlike other vaccines,COVID-19 vaccines were developed and commercialized in a relatively short period of *** large-scale administration of this vaccine in a short time-period led to various unexpected side effects,including severe cytopenia and thrombosis with thrombocytopenia *** many reports on adverse reactions,vaccination was necessary to prevent the spread of COVID-19;thus,it is essential to understand and discuss various cases of adverse reactions after *** SUMMARY A 77-year-old woman was administered the second dose of Pfizer mRNA COVID-19 *** vaccination she experienced fever,myalgia,and *** were subsequently administered for several days,but there was no improvement in the *** patient showed severe thrombocytopenia and *** and abdominopelvic computed tomography showed no infection related findings,but splenomegaly and cirrhotic liver features were observed.A large number of immature cells were observed in the peripheral blood smear;thus,bone marrow examination was performed for acute ***,there were no *** patient recovered after administration of hepatotoxins and transfusion treatment for cytopenia and was diagnosed with an adverse reaction to COVID-19 *** Adverse reactions of vaccination could be mistaken for hematologic malignancies including *** report a patient with leukocytosis following COVID-19 vaccination.

关键词： COVID-19 Vaccine mRNA Leukocytosis Adverse reaction Case report

Segmented tomographic evaluation of structural degradation of carbon support in proton exchange membrane fuel cells

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Journal of Energy Chemistry 2022年第11期31卷 359-367,I0010页

作者： Jung A.Hong min-Hyoung Jung Sung Yong Cho Eun-Byeol park Daehee Yang Young-Hoon Kim Sang-Hyeok Yang Woo-Sung Jang Jae Hyuck Jang Hyo June Lee Sungchul Lee Hu Young jeong Young-min Kim Department of Energy Science Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Fuel Cell Core Parts Development Cell Hyundai Mobis Co.Ltd.Uiwang 16082Republic of Korea Electron Microscopy&Spectroscopy Team Korea Basic Science Institute(KBSI)Daejeon 34133Republic of Korea Graduate School of Semiconductor Materials and Devices Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

The variation of the three-dimensional(3D)structure of the membrane electrode of a fuel cell during proton exchange cycling involves the corrosion/compaction of the carbon *** increasing degradation of the carbon structure continuously reduces the electrocatalytic performance of proton exchange membrane fuel cells(PEM-FCs).This phenomenon can be explained by performing 3D tomographic analysis at the ***,conventional tomographic approaches which present limited experimental feasibility,cannot perform such evaluation and have not provided sufficient structural information with statistical significance thus ***,a reliable methodology is required for the 3D geometrical evaluation of the carbon ***,we propose a segmented tomographic approach which employs pore network analysis that enables the visualization of the geometrical parameters corresponding to the porous carbon structure at a high *** approach can be utilized to evaluate the 3D structural degradation of the porous carbon structure after cycling in terms of local surface area,pore size distribution,and their 3D *** geometrical parameters of the carbon body were demonstrated to be substantially reduced owing to the cycling-induced *** information enables a deeper understanding of the degradation phenomenon of carbon supports and can contribute to the development of stable PEM-FC electrodes.

关键词： Electron tomography Fuel cell Proton exchange membrane Membrane electrode assembly Carbon corrosion

Corrugated surface microparticles with chitosan and levofloxacin for improved aerodynamic performance

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Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 146-158页

作者： Chang-Soo Han Ji-Hyun Kang Eun hye park Hyo-Jung Lee So-jeong jeong Dong-Wook Kim Chun-Woong park College of Pharmacy Chungbuk National UniversityCheongju 28160Republic of Korea School of Pharmacy Jeonbuk National UniversityJeonju 54896Republic of Korea College of Pharmacy Wonkwang UniversityIksan 54538Republic of Korea

Corrugated surface microparticles comprising levofloxacin(LEV),chitosan and organic acid were prepared using the 3-combo spray drying *** amount and the boiling point of the organic acid affected the degree of *** this study,we tried to improve the aerodynamic performance and increase aerosolization by corrugated surface microparticle for lung drug delivery efficiency as dry powder ***175 L20 prepared with 175 mmol propionic acid solution was corrugated more than HMF175 L20 prepared with 175 mmol formic acid *** ACI and PIV results showed a significant increase in aerodynamic performance of corrugated *** FPF value of HMP175 L20 was 41.3%±3.9%compared with 25.6%±7.7%of HMF175 *** microparticles also showed better aerosolization,decreased x-axial velocity,and variable *** dissolution of drug formulationswas observed in *** administered to the lungs achieved higher LEV concentrations in the lung fluid than high doses administered *** modification in the polymer-based formulation was achieved by controlling the evaporation rate and improving the inhalation efficiency of DPIs.

关键词： Chitosan Organic acid Levofloxacin Corrugated surface Aerodynamic performance

Long-term antibiotic use and risk of hepatocellular carcinoma later in life: a nationwide cohort study of 9.8 million participants

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Cancer Communications 2023年第10期43卷 1174-1177页

作者： Seogsong jeong Sun Jae park minseo Kim Young Jun park Seulggie Choi Jooyoung Chang Ji Soo Kim Yun Hwan Oh Ahryoung Ko Sang min park Department of Biomedical Sciences Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea Department of Biomedical Informatics CHA University School of MedicineSeongnamSouth Korea Department of Medicine College of MedicineJeonbuk National UniversityJeonjuSouth Korea Medical Research Center Genomic Medicine InstituteSeoul National UniversitySeoulSouth Korea Department of Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea International Healthcare Center Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea Department of Family Medicine Chung-Ang University Gwangmyeong HospitalChung-Ang University College of MedicineGwangmyeongSouth Korea Department of Family Medicine Seoul National University HospitalSeoulSouth Korea

Dear Editor,Antibiotics are considered indispensable in numerous treatments against infectious ***,their over-prescription and widespread use are emerging as important global issues,as they lead to resistant bacteria,reducing the efficacy of antibiotics[1].The defined daily doses per 1,000 habitants per day for antibiotics in South Korea is 28,which is much higher than the average of Organization for Economic Co-operation and Development countries[1].In animal studies,antibiotic tigecycline was found to inhibit the proliferation and induce apoptosis of hepatocellular carcinoma(HCC)cells[2].In addition,isoprenoid antibiotic was found to suppress the growth and invasion of HCC by targeting the signal transducer and activator of the transcription 3 signaling cascade[3].Despite evidence of the beneficial effects of antibiotics against HCC,evidence regarding their effects on the longterm development of HCC is *** regarding the incidence of HCC is provided in the Supplementary file.

关键词： doses invasion nationwide