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Spatial distribution and comparative evaluation of phosphorus release rate in benthic sediments of an estuary dam

International Journal of Sediment Research 2022年第3期37卷 355-369页

作者： Yongsik Song Yong-hoon jeong Chang-Min Shin Dong-Heui Kwak Geosystem Research Corporation Department of Civil Engineering Jeonbuk National University Department of Bio-Convergence Science Jeonbuk National University Water Quality Assessment Research Division National Institute of Environmental Research Department of Bioactive Materials Science Jeonbuk National University

A series of experiments and simulations were performed to ascertain the rate at which phosphorus is released using a water quality model in Saemangeum Lake, an artificially constructed lake located in an estuary. The general inflow of seawater once a day contributed to the formation of a halocline in the lake water, which caused variation in the vertical concentration of dissolved oxygen. The halocline was mainly observed in the deep downstream regions of Saemangeum Lake that are close to the open sea. In contrast, the shallower regions upstream, which are under the influence of pollutant-loading from upstream rivers, exhibited high concentrations of chemical oxygen demand, total phosphorus, and Chl-a,resulting in lower water quality than the downstream regions. Laboratory experiments investigating the release of phosphorus at five representative locations showed that the upstream release flux, where the halocline was weaker, was higher than that downstream, where the initial level of phosphorus sedimentation was high. In particular, a need for an accurate evaluation method for the release of phosphorus at each site was suggested as slight differences were obtained depending on the estimation method used at each representative location. The results of the phosphorus release experiments led to the use of time-weighted integration(TWI), terminated time evaluation, and statistical mean value; the Environmental Fluid Dynamics Code-National Institute of Environment Research model, a widely used water quality model for studying retention watersheds, was applied to the simulation of hydraulic and water quality characteristics for the Saemangeum Lake and its surrounding waters. The result of the water quality simulation indicated the highest reproducibility for release-time TWI so that TWI values were more useful in predicting phosphorus concentrations and the subsequent management of water quality.

关键词： Eutrophication Phosphorus release Salinity Sediments Water quality simulation Environmental Fluid Dynamics Code–National Institute of Environment Research model (EFDC-NIER)

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Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats

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Chinese Journal of Integrative Medicine 2018年第6期24卷 460-466页

作者： kwon-Yeon Weon Min Gi Kim Soyoung Shin Tae Hwan Kim Sang hoon Joo Eunsook Ma Seok Won jeong Sun Dong Yoo Yu Seok Youn Beom Soo Shin College of Pharmacy Catholic University of Daegu School of Pharmacy Sungkyunkwan University College of Pharmacy Wonkwang University

Objective： To evaluate the potential pharmacokinetic interactions of the anticancer agent gefitinib （Iressae） and the oriental medications Guipi Decoction （归脾汤, GPD, Guibi-tang in Korean） and Bawu Decoction （八物汤, BWD, Palmul-tang in Korean）. Methods： Methylceliulose （MC, control）, GPD （1,200 mg/kg）, or BWD （6,000 mg/kg） was orally administered to rats either as a single dose or multiple doses prior to gefitinib administration. To examine the effects of a single dose of the herbal medicines, gefitinib （10 mg/kg） was orally administered after 5 min or 1 h of MC or the herbal medicine pretreatments. To examine the effects of the multiple doses of the herbal medicines, gefltinib （10 mg/kg） was orally administered following 7 consecutive days of the administration of MC or each herbal medicine. The plasma concentrations of gefitinib were determined with liquid chromatography-tandem mass spectrometry assay. The plasma concentration-time profiles of gefitinib were analyzed with a noncompartmental analysis. Results： Gefitinib was rapidly absorbed and showed a mono- exponential decline with an elimination half-life of 3.7-4.1 h. The pharmacokinetics of gefitinib was not affected by GPD pretreatment. However, a significantly lower maximum plasma concentration （Crux, P〈0.05） and area under the curve （P〈0.05）, and a delayed time to reach Cmax （Tmax, P〈0.01） were observed in both single- and multiple- dose BWD-pretreated rats compared with the control rats. Conclusions： BWD and not GPD might delay and interfere with gefitinib absorption. Further evaluations of the clinical significance of these findings are needed.

关键词： herb-drug interaction pharmacokinetics gefitinib Guipi Decoction Bawu Decoction

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Successful treatment of intracardiac air embolism using intracardiac catheter aspiration

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Journal of Geriatric Cardiology 2017年第2期14卷 151-154页

作者： Ae-Young Her Yong hoon Kim Da Hye Moon Ji Hyun Kim Jae hoon jeong Sung-Hyun Park Jin Seon jeong Division of Cardiology Department of Internal Medicine Kangwon National University School of Medicine Chuncheon South Korea Department of Internal Medicine Kangwon National University Hospital Chuncheon South Korea

Intracardic air embolism is uncommon, however it is a serious condition which frequently leads to catastrophic complications during or after invasive procedures resulting in significant morbidity and mortality. For a successful re- suscitation of patients with intracardiac air embolism, hy- perbaric oxygen therapy is critical.~~2~ Still, due to a hyper- baric chamber＇s unavailability at many hospitals and con- cerns about patient movement resulting in further embolism during transport, such treatment method is gradually dimin- ishing.

关键词： Aspiration Catheter Intracardiac air embolism

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Neuroprotective effect of the ethanol extract of Artemisia capillaris on transient forebrain ischemia in mice via nicotinic cholinergic receptor

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Chinese Journal of Natural Medicines 2018年第6期16卷 428-435页

作者： Huiyoung kwon Ji Wook Jung Young Choon Lee Jong hoon Ryu Dong Hyun Kim Department of Medicinal Biotechnology College of Health SciencesDong-A UniversityBusan 49315Republic of Korea Department of Herbal Medicinal Pharmacology College of Herbal Bio-industryDaegu Haany UniversityKyungsan 38610Republic of Korea Institute of Convergence Bio-Health Dong-A UniversityBusan 49315Republic of Korea Department of Life and Nanopharmaeeutical Sciences Kyung Hee UniversityKyung Hee UniversitySeou102447Republic of Korea Department of Oriental Pharmaceutical Science College of PharmacyKyung Hee UniversityKyung Hee UniversitySeoul 02447Republic of Korea Kyung Hee East-West Pharmaceutical Research Institute Kyung Hee UniversityKyung Hee UniversitySeoul 02447Republic of Korea

Artemisia capillaris Thunberg is a medicinal plant used as a traditional medicine in many cultures. It is an effective remedy for liver problems including hepatitis. Recent pharmacological reports have indicated that Artemisia species can exert various neurological effects. Previously, we reported a memory-enhancing effect of Artemisia species. However, the mechanisms underlying the neuroprotective effect of A. capillaris(AC) are still unknown. In the present study, we investigated the effect of an ethanol extract of AC on ischemic brain injury in a mouse model of transient forebrain ischemia. The mice were treated with AC for seven days, beginning one day before induction of transient forebrain ischemia. Behavioral deficits were investigated using the Y-maze. Nissl and Fluoro-jade B staining were used to indicate the site of injury. To determine the underlying mechanisms for the drug, we measured acetylcholinesterase activity. AC(200 mg·kg-1) treatment reduced transient forebrain ischemia-induced neuronal cell death in the hippocampal CA1 region. The AC-treated group also showed significant amelioration in the spontaneous alternation of the Y-maze test performance, compared to that in the untreated transient forebrain ischemia group. Moreover, AC treatment showed a concentration-dependent inhibitory effect on acetylcholinesterase activity in vitro. Finally, the effect of AC on forebrain ischemia was blocked by mecamylamine, a nonselective nicotinic acetylcholine receptor antagonist. Our results suggested that in a model of forebrain ischemia, AC protected against neuronal death through the activation of nicotinic acetylcholine receptors.

关键词： Artemisia capillaris Transient forebrain ischemia Acetylcholinesterase Nicotinic acetylcholine receptor

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Theoretical Simulation of Surface Evolution Using the Random Deposition and Surface Relaxation for Metal Oxide Film in Atomic Layer Deposition

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Journal of Materials Science & Technology 2010年第4期26卷 371-374页

作者： Ji-hoon Ahn Se-Hun kwon Jin-Hyock Kim Ja-Yong Kim Sang-Won Kang Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology373-1Kusong-dongYusong-guTaejon 305-701Korea Hynix Semiconductor Incorporated San 136-1Ami-riBubal-eubIcheon-siKyongki-do467-701Korea

Atomic layer deposition （ALD） has become an essential deposition method for forming nanometer scale thin films in the microelectronics industry, and its applications have been extended to multi-component thin films, as well as to single metal oxide films. In order to investigate the development of the surface structure of ultra-thin film qualitatively as well as quantitatively, ALD processes are simulated with a molecular scale. For this simulation, the film materials are deposited on a imaginary substrate that consists of small lattice. The deposition behaviors are described by using random deposition （RD） model or random deposition with surface relaxation （RDSR） model as the ALD growth mode, and the proposed model was applied to the deposition of SrO-TiO2 thin films. Through this work, growth characteristics such as surface morphology, deposited film coverage can be predicted.

关键词： Atomic layer deposition Random deposition SrO-TiO2

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Effects of granulation process variables on the physical properties of dosage forms by combination of experimental design and principal component analysis

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Asian Journal of Pharmaceutical Sciences 2019年第3期14卷 287-304页

作者： Prakash Thapa Du Hyung Choi Min Soo Kim Seong hoon jeong College of Pharmacy Dongguk UniversityGyeonggi10326Republic of Korea Department of Pharmaceutical Engineering Inje UniversityGyeongnam50834Republic of Korea College of Pharmacy Pusan National UniversityBusan46241Republic of Korea

The current study was to understand how process variables of high shear wet granulations affect physical properties of granules and tablets. The knowledge gained was intended to be used for Quality-by-Design based process design and optimization. The variables were selected based on the risk assessment as impeller speed, liquid addition rate, and wet massing time. Formulation compositions were kept constant to minimize their influence on granules properties. Multiple linear regression models were built providing understanding of the impact of each variable on granule hardness, Carr’s index, tablet tensile strength, surface mean diameter of granules, and compression behavior. The experimental results showed that the impact of impeller speed was more dominant compared to wet massing time and water addition rate. The results also revealed that quality of granules and tablets could be optimized by adjusting specific process variables(impeller speed 1193 rpm, water spray rate 3.7 ml/min, and wet massing time 2.84 min). Overall desirability was 0.84 suggesting that the response values were closer to the target one. The SEM image of granules showed that spherical and smooth granules produced at higher impeller speed, whereas rough and irregular shape granules at lower speed. Moreover, multivariate data analysis demonstrated that impeller speed and massing time had strong correlation with the granule and tablet properties. In overall, the combined experimental design and principal component analysis approach allowed to better understand the correlation between process variables and granules and tablet attributes.

关键词： Experimental design Principal component analysis High shear granulation Process parameter

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Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

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Chinese Journal of Integrative Medicine 2022年第9期28卷 802-808页

作者： Bo-Ra Jeon Muhammad Irfan Seung Eun Lee jeong hoon Lee Man Hee Rhee Laboratory of Physiology and Cell Signaling College of Veterinary MedicineKyungpook National UniversityDaegu41566Republic of Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal Science(NIHHS)Eumseong27709Republic of Korea

Objective:To examine the antiplatelet and antithrombotic activity of Rumex acetosella ***:Standard light aggregometry was used for platelet aggregation,intracellular calcium mobilization assessed using Fura-2/AM,granule secretion(ATP release)by luminometer,and fibrinogen binding to integrin α_(Ⅱb)β_(3) detected using flow *** blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase(MAPK)and phosphoinositide 3-kinase(PI3K)/Akt ***:Rumex acetosella displayed the ability to inhibit platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin α_(Ⅱb)β_(3).Rumex acetosella has also down-regulated MAPK and PI3K/Akt phosphorylation(all P<0.01).Conclusion:Rumex acetosella extract exhibits antiplatelet activity via modulating GPVI signaling,and it may protect against the development of platelet-related cardiovascular diseases.

关键词： antiplatelet ethnomedicine integrinα_(Ⅱb)β_(3) mitogen-activated protein kinase Rumex acetosella L.

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An advanced segmentation using area and boundary tracing technique in extraction of lungs region

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Journal of Central South University 2014年第10期21卷 3811-3820页

作者： Kiran THAPALIYA Sang-Woong LEE Jae-Young PYU Heon jeong Goo-Rak kwon Department of Information and Communication Engineering Chosun University School of Computer Engineering Chosun University Deparment of Fire Administration Chodang University

A new method is presented for the segmentation of pulmonary parenchyma. The proposed method is based on the area calculation of different objects in the image. The main purpose of the proposed algorithm is the segment of the lungs images from the computer tomography(CT) images. The original image is binarized using the bit-plane slicing technique and among the different images the best binarized image is chosen. After binarization, the labeling is done and the area of each label is calculated from which the next level of binarized image is obtained. Then, the boundary tracing algorithm is applied to get another level of binarized image. The proposed method is able to extract lung region from the original images. The experimental results show the significance of the proposed method.

关键词： bit-plane slicing technique connected component labeling area tracing boundary tracing

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Delayed gait recovery in a stroke patient

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Neural Regeneration Research 2013年第16期8卷 1514-1518页

作者： jeong Pyo Seo Mi Young Lee Yong Hyun kwon Sung Ho Jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Department of Physical Therapy College of Health and Therapy Daegu Haany University Department of Physical Therapy Yeungnam College of Science & Technology

We report on a stroke patient who showed delayed gait recovery between 8 and 11 months after the onset of intracerebral hemorrhage. This 32-year-old female patient underwent craniotomy and drainage for right intracerebral hemorrhage due to rupture of an arteriovenous malformation. Brain MR images revealed a large leukomalactic lesion in the right fronto-parietal cortex. Diffusion tensor tractography at 8 months after onset revealed that the right corticospinal tract was severely injured. At this time, the patient could not stand or walk despite undergoing rehabilitation from 2 months after onset. It was believed that severe spasticity of the left leg and right ankle was largely responsible, and thus, antispastic drugs, antispastic procedures （alcohol neurolysis of the motor branch of the tibial nerve and an intramuscular alcohol wash of both tibialis posterior muscles） and physical therapy were tried to control the spasticity. These measures relieved the severe spasticity, with the result that the patient was able to stand at 3 months. In addition, the improvements in sensorimotor function, visuospatial function, and cognition also seemed to contribute to gait recovery. As a result, she gained the ability to walk independently on even floor with a left ankle foot orthosis at 11 months after onset. This case illustrates that clinicians should attempt to find the cause of gait inability and to initiate intensive rehabilitation in stroke patients who cannot walk at 3-6 months after onset.

关键词： neural regeneration brain injury stroke diffusion tensor imaging sequelae gait walk motor recovery corticospinal tract rehabilitation intracerebral hemorrhage grants-supported paper neuroregeneration

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Numerical simulation for dendrite growth in directional solidification using LBM-CA(cellular automata)coupled method

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Journal of Materials Science & Technology 2020年第14期47卷 15-24页

作者： Wonjoo Lee Yuhyeong jeong Jae-Wook Lee Howon Lee Seong-hoon Kang Young-Min Kim Jonghun Yoon Department of Mechanical Design Engineering Hanyang University222Wangsimni-roSeongdong-guSeoul 04763Republic of Korea Materials Deformation Department Korea Institute of Materials Science797 ChangwondaeroSeongsan-guChangwon-siGyeongnam-do 51508Republic of Korea Department of Mechanical Engineering Hanyang University55 Hanyangdaehak-roSangnok-guAnsan-siGyeonggi-do 15588Republic of Korea

To predict the dendrite morphology and microstructure evolution in the solidification of molten metal,numerically,lattice Boltzmann method(LBM)-cellular automata(CA)model has been developed by integrating the LBM to solve the mass transport by diffusion and convection during solidification and the CA to determine the phase transformation with respect to the solid fraction based on the local equilibrium *** is successfully validated with analytic solutions such as Lipton-Glicksman-Kurz(LGK)model in static melt,and Oseen-Ivantsov solution under the fluid flow conditions in terms of tip radius and velocity of the dendrite *** proposed LBM-CA model does not only describe different types of dendrite formations with respect to various solidification conditions such as temperature gradient and growth rate,but also predict the primary dendrite arm spacing(PDAS)and the secondary dendrite arm spacing(SDAS),quantitatively,in directional solidification(DS)experiment with Ni-based superalloy.

关键词： Cellular automata(CA) Lattice Boltzmann method(LBM) Dendritic growth Directional solidification

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