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Artificial Nanoscale Erythrocytes from Clinically Relevant Compounds for Enhancing Cancer Immunotherapy

Nano-Micro Letters 2020年第7期12卷 156-174页

作者： Wenquan Ou Kang Sik Nam Dae hoon Park Jungho Hwang Sae Kwang Ku Chul Soon Yong Jong Oh Kim jeong hoon Byeon College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea College of Korean Medicine Daegu Haany UniversityGyeongsan 38610Republic of Korea School of Mechanical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea

Because of enhanced e cacy and lower side e ects,cancer immunotherapies have recently been extensively investigated in clinical trials to overcome the limitations of conventional cancer *** engineering attempts have been made to build nanosystems even including stimulus nanomaterials for the e cient delivery of antigens,adjuvants,or anticancer drugs to improve immunogenic cancer cell death,this requires huge R&D e orts and investment for clinically relevant findings to be approved for translation of the *** this end,in this study,an air–liquid two-phase electrospray was developed for stable bubble pressing under a balance between mechanical and electrical parameters of the spray to continuously produce biomimetic nanosystems consisting of only clinically relevant compounds[paclitaxel-loaded fake blood cell Eudragit particle(Eu-FBCP/PTX)]to provide a conceptual leap for the timely development of translatable chemo-immunotherapeutic *** was pursued as the e cacy of systems for delivering anticancer agents that has been mainly influenced by nanosystem shape because of its relevance to transporting behavior to organs,blood circulation,and cell–membrane *** resulting Eu-FBCP/PTX nanosystems exhibiting phagocytic and micropinocytic uptake behaviors can confer better e cacy in chemo-immunotherapeutics in the absence and presence of anti-PD-L1 antibodies than similar sized PTX-loaded spherical Eu particles(Eu-s/PTX).

关键词： Cancer immunotherapies Air–liquid two-phase electrospray Paclitaxel-loaded fake blood cell Eudragit particle Translatable chemo-immunotherapeutic nanosystems Anti-PD-L1 antibodies

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Comparison of magnetic properties of DNA-cetyltrimethyl ammonium complex with those of natural DNA

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Science China Chemistry 2012年第5期55卷 814-821页

作者： kwon Young-Wan CHOI Dong hoon JIN Jung-Il LEE Chang hoon KOH Eui Kwan GROTE James G. Department of Chemistry Korea University Seoul 136-701 Korea Department of Polymer Science & Engineering Chosun University Gwangju 501-759 Korea Korea Basic Science Institute-Seoul Branch Korea University Seoul 136-701 Korea US Air Force Research Laboratory Materials and Manufacturing Directorate AFRL/MLPS Wright-Patterson Air Force Base Ohio USA

We prepared the DNA-cetyltrimethyl ammonium complex, as well as the same complex intercalated with stable organic free radicals, and studied their magnetic properties by electron magnetic resonance (EMR) spectroscopy and by measuring the magnetization on a superconducting quantum interference device (SQUID). The UV-vis and CD spectra of DNA-quaternary alkyl ammonium complex (DNA--Q+) in organic solvent clearly demonstrated that it retained the double helical B-form conformation. The interhelical spacing of double strand DNA (dsDNA) increased when the counter ions (Na+) of phosphate groups of the natural DNA were replaced with the long alkyl quaternary ammonium groups. The inter-helical distance of DNA-cetyltrimethyl ammonium (CTMA) was 39.1  as confirmed by X-ray diffractometry. In general, the magnetization of the DNA-CTMA complex solid was found to be significantly lower than that of natural DNA. Moreover, intercalation of the complex with stable organic free radicals did not improve magnetization, which again was in marked contrast to natural DNA. EMR spectroscopic behavior of the complex in the solid state also was quite different from that of natural DNA: The unique broad EMR signal of natural DNA in the low field region with g-value greater than 10 disappeared in the DNA-CTMA complex.

关键词： natural DNA DNA-CTMA DNA-CTMA-PTMI magnetic property electron magnetic resonance (EMR) superconducting quantum interference device (SQUID)

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Flow characteristics of aluminum coated boron steel in hot press forming

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中国有色金属学会会刊：英文版 2009年第4期19卷 913-916页

作者： jeong-Hwan JANG Jae-Ho LEE Bye ong-Don JOO Young-hoon MOON School of Mechanical Engineering Pusan National University

The flow characteristics of aluminum coated boron steel in hot press forming were ***,the effects of aluminum coated layer on press forming were analyzed during deep *** results show that aluminum coated boron steel exhibits a high sensitivity on temperature and strain *** coating layer appears in surface flaking in a temperature range of 700-800 ℃,but smooth surface is formed above 900 ℃.

关键词：热压成型流动特性铝涂层硼钢表面剥落温度范围冲压成形高灵敏度

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Dynamic deformation behavior and microstructural evolution during high-speed rolling of Mg alloy having non-basal texture

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Journal of Materials Science & Technology 2019年第4期35卷 473-482页

作者： Sang-hoon Kim jeong Hun Lee Chong Soo Lee Jonghun Yoon Sung Hyuk Park School of Materials Science and Engineering Kyungpook National University Ulsan Regional Division Korea Institute of Industrial Technology Graduate Institute of Ferrous Technology Pohang University of Science and Technology Department of Mechanical Engineering Hanyang University

The dynamic deformation behaviors and resultant microstructural variations during high-speed rolling(HSR) of a Mg alloy with a non-basal texture are investigated. To this end, AZ31 alloy samples in which the basal poles of most grains are predominantly aligned parallel to the transverse direction(TD) are subjected to hot rolling with different reductions at a rolling speed of 470 m/min. The initial grains with a TD texture are favorable for {10–12} twinning under compression along the normal direction(ND); as a result, {10–12} twins are extensively formed in the material during HSR, and this consequently results in a drastic evolution of texture from the TD texture to the ND texture and a reduction in the grain size. After the initial grains are completely twinned by the {10–12} twinning mechanism, {10–11} contraction twins and {10–11}-{10–12} double twins are formed in the {10–12} twinned grains by further *** the contraction twins and double twins have crystallographic orientations that are favorable for basal slip during HSR, dislocations easily accumulate in these twins and fine recrystallized grains nucleate in the twins to reduce the increased internal strain energy. Until a rolling reduction of 20%, {10–12}twinning is the main mechanism governing the microstructural change during HSR, and subsequently,the microstructural evolution is dominated by the formation of contraction twins and double twins and the dynamic recrystallization in these twins. With an increase in the rolling reduction, the average grain size and internal strain energy of the high-speed-rolled(HSRed) samples decrease and the basal texture evolves from the TD texture to the ND texture more effectively. As a result, the 80% HSRed sample, which is subjected to a large strain at a high strain rate in a single rolling pass, exhibits a fully recrystallized microstructure consisting of equiaxed fine grains and has an ND basal texture without a TD texture component.

关键词： Magnesium alloy High-speed rolling Texture Dynamic recrystallization Twinning

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Characteristics of Atmospheric Circulation Associated with Cold Surge Occurrences in East Asia:A Case Study During 2005/06 Winter

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Advances in Atmospheric Sciences 2008年第5期25卷 791-804页

作者： Tae-Won PARK Jee-hoon jeong Chang-Hoi HO Seong-Joong KIM School of Earth and Environmental Sciences Seoul National University Seoul Korea Department of Earth Sciences University of Gothenburg Gothenburg Sweden Korea Polar Research Institute Incheon Korea

The characteristics of the upper-level circulation and thermodynamical properties for the period when two distinct cold surges broke out over East Asia during the 2005/06 winter are investigated. From early December 2005 to early January 2006, exceptionally cold weather lasted for approximately one month due to two successive cold surges that took place on 2 December 2005 and 2 January 2006, respectively. This study reveals that both involve the upper-tropospheric circulation, which induces the amplification and expansion of the surface Siberian high toward East Asia, but arose from different causes： the former is caused by the upper-level blocking originated from the North Pacific and the latter is caused by the upper-level wave train across the Eurasian Continent. In particular, it is suggested that the lower-tropospheric anomalous wind caused by upper-level circulation anomalies and a steep meridional temperature gradient amplified by phase-locked annual cycle combined to induce very strong cold advection in East Asia, which resulted in exceptionally cold weather that lasted for several weeks. The present results emphasize that the characteristics of the upper-tropospheric circulation can be considered as important precursors to cold surge occurrences in East Asia.

关键词： cold surge Siberian high East Asia East Asian winter monsoon upper-tropospheric circulation

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Identification and comparison of the local physicochemical structures of transition metal-based layered double hydroxides for high performance electrochemical oxygen evolution reactions

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Journal of Energy Chemistry 2023年第12期87卷 89-97,I0004页

作者： Min Sung Kim Bipin Lamichhane Ju-Hyeon Lee Jin-Gyu Bae jeong Yeon Heo Hyeon jeong Lee Shyam Kattel Ji hoon Lee School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea KNU Advanced Material Research Institute Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Department of Physics Florida A&M UniversityTallahasseeFlorida 32307United States

Layered double hydroxides(LDHs) have attracted considerable attention as a cost effective alternative to the precious iridium-and ruthenium-based electrocatalysts for an oxygen evolution reaction(OER),a bottleneck of water electrolysis for sustainable hydrogen *** their excellent OER performance,the structural and electronic properties of LDHs,particularly during the OER process,remain to be poorly *** this study,a series of LDH catalysts is investigated through in situ X-ray absorption fine structure analyses and density functional theory(DFT) *** experimental results reveal that the LDH catalyst with equal amounts of Ni and Fe(NF-LDH) exhibits the highest OER activity and catalytic life span when compared with its counterparts having equal amounts of Ni and Co(NC-LDH)and Ni only(Ni-LDH).The NF-LDH shows a markedly enhanced OER kinetics compared to the NC-LDH and the Ni-LDH,as proven by the lower overpotentials of 180,240,and 310 mV,respectively,and the Tafel slopes of 35.1,43.4,and 62.7 mV dec^(-1),*** DFT calculations demonstrate that the lowest overpotential of the NF-LDH is associated with the active sites located at the edge planes of NF-LDH in contrast to those located at the basal planes of Ni-LDH and *** current study pinpoints the active sites on various LDHs and presents strategies for optimizing the OER performance of the LDH catalysts.

关键词： Layered double hydroxides Oxygen evolution reaction In situ X-ray analyses Density functional theory Catalytic active sites

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Diurnal Variations of Summer Precipitation in the Beijing Area and the Possible Effect of Topography and Urbanization

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Advances in Atmospheric Sciences 2011年第4期28卷 725-734页

作者：殷水清李维京 Deliang CHEN Jee-hoon jeong 郭文利 State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University Beijing 100875 School of Geography Beijing Normal University Beijing 100875 Beijing Climate Center China Meteorological Administration Beijing 100081 Department of Earth Sciences University of Gothenburg Gothenburg 40530 Sweden Beijing Regional Climate Center Beijing Meteorological Bureau Beijing 100089

The present study examined the diurnal variations of summer precipitation in the Beijing area by usingsubdaily precipitation and wind observations. A combined effect of topography and urbanization on thecharacteristics of diurnal variations was suggested. It was shown that stations located in the plain areaexhibited typical night rain peaks, whereas those in the mountainous area exhibited clear afternoon peaks ofprecipitation diurnal variations. The precipitation peaks were associated with wind fields around the Beijingarea, which were found to be highly modulated by mountain-valley circulation and urban-country *** lower-tropospheric wind exhibited a clear diurnal shift in its direction from north at 0800 LST to southat 2000 LST, which reflected mountain-valley circulation. The transitions from valley to mountain windand the opposite generally happened after sunset and sunrise, respectively, and both occurred earlier for thestations located closer to mountains. By comparing the diurnal variations of precipitation at stations in anortheast suburb, an urban area, and a southwest suburb, it was revealed that the northeast suburb grouphad the highest normalized rainfall frequency, but the southwest group had the lowest from late afternoon tolate evening. On the contrary, in the early morning from about 0200 to 1000 LST, the southwest group andurban group had the highest normalized rainfall frequency. This pattern might originate from the combinedeffects of mountain-valley topography and urbanization.

关键词： diurnal variations precipitation mountain-valley circulation urban effect Beijing area

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Long-term clinical outcome between beta-blocker with ACEI or ARB in patients with NSTEMI who underwent PCI with drug-eluting stents

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Journal of Geriatric Cardiology 2019年第3期16卷 280-290页

作者： Yong hoon Kim Ae-Young Her Eun-Seok Shin Myung Ho jeong Division of Cardiology Department of Internal MedicineKangwon National University School of MedicineChuncheonSouth Korea Division of Cardiology Department of Internal MedicineUlsan Medical CenterUlsan HospitalUlsanSouth Korea Chonnam National University Hospital GwangjuSouth Korea

Background Because limited comparative data are available,we decided to compare 2-year major clinical outcomes between beta-blockers (BB) with angiotensin converting enzyme inhibitors (ACEI) and BB with angiotensin receptor blockers (ARB) therapy in patients with non-ST-segment elevation myocardial infarction (NSTEMI) after percutaneous coronary intervention (PCI) with drug-eluting stents (DES).Methods A total 11,288 NSTEMI patients who underwent PCI with DES were enrolled and they were divided into two groups,the BB with ACEI group (n = 7600) and the BB with ARB group (n = 3688).The major clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death,recurrent myocardial infarction (re-MI),total revascularization [target lesion revascularization (TLR),target vessel revascularization (TVR),non-TVR] rate during the 2-year follow-up *** After propensity score-matched (PSM) analysis,two PSM groups (3317 pairs,n = 6634,C-statistic = 0.695) were *** the cumulative incidences of all-cause death,cardiac death,TLR,and non-TVR were similar between the two groups,MACE (HR = 0.832,95% CI: 0.704?0.982,P = 0.030),total revascularization rate (HR = 0.767,95% CI: 0.598?0.984,P = 0.037),and TVR rate (HR = 0.646,95% CI: 0.470?0.888,P = 0.007) were significantly lower in the BB with ACEI group after *** In this study,we suggest that the combination of BB with ACEI may be beneficial for reducing the cumulative incidences of MACE,total revascularization rate,and TVR rather than the BB with ARB after PCI with DES in NSTEMI patients.

关键词： Angiotensin converting enzyme inhibitor Angiotensin receptor blocker Beta-blocker Myocardial infarction

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Current Usage of Terminologies Related to Acupotomy: A Literature Research and Standardization Suggestion

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Chinese Journal of Integrative Medicine 2019年第2期25卷 147-150页

作者： Sang-hoon Yoon Yoon-Sik Kim Hee-Guen Jo Chan-Young kwon Chung-Yeon Medical Institute Department of Clinical Korean Medicine Graduate SchoolKyung Hee University Yanggu Public Health Center

Objective: To investigate the current usage of terminologies related to acupotomy through systematic search and analyze the pros and cons of each for proposing a standard terminology. Methods: Seven medical journal databases were searched including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Oriental Medicine Advanced Searching Integrated System, KoreaMed, and Korean studies Information Service System using 10 candidate terminologies as searching terms. All studies published from their inception to July 26, 2017 were collected. Articles were included if the title stated one of the 10 candidate terminologies consistent with the definition of acupotomy. Priorly established frequency and consistency of each candidate terminology from medical databases were calculated and evaluated. Moreover, the pros and cons of each were analyzed to propose a standard terminology. Results: A total of 112 studies in English databases, 1,129 studies in Chinese database, and 44 studies in Korean databases were included. The most frequently used terminologies were needle knife(35.71%), acupotomy(48.54%) and acupotomy(90.90%) in English, Chinese and Korean database, respectively. Overall, acupotomy and needle knife were the most frequently used. Others like acupotomology, needle scalpel, miniscalpel acupuncture and miniscalpel needle were used within 10% of the total searched literature. Acupotome, stiletto needle, sword like needle, and Xiaozhendao were rarely used. Acupotomy had the advantages of high frequency and consistency but lacked representativeness. Needle knife also showed a high frequency, but the consistency was poor. Though miniscalpel acupuncture and miniscule needle were used less frequently, they had advantages of inclusiveness and clarity. Conclusions: A debate for standardization of the terminology is necessary. This preliminary research can provide a basic outline for the standardization consensus process, and

关键词： acupuncture Chinese medicine acupotomy terminology

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Risks of non-conservative design according to ASME B31.1 for high-temperature piping subjected to long-term operation in the creep range

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Nuclear Science and Techniques 2019年第5期30卷 59-69页

作者： Hyeong-Yeon Lee Seok-kwon Son Min-Gu Won Ji-Young jeong Korea Atomic Energy Research Institute National Fusion Research Institute School of Mechanical Engineering Sungkyunkwan University

This study investigates the risks of non-conservative piping design according to ASME B31.1 for hightemperature piping subjected to long-term operation at high temperature in a creep regime based on a sensitivity analysis of the hold time. Design evaluations of hightemperature piping were conducted over a range of hold times in the creep regime according to ASME B31.1,which implicitly considers the creep effects, and the French high-temperature design code of the RCC-MRx, which explicitly considers the creep effects. Conservatisms were quantified among the codes in terms of the hold times. In the case of B31.1, the design evaluation results do not change depending on the hold time at high temperature,whereas in the case of RCC-MRx, they do. It was shown that the design limits of RCC-MRx were exceeded when the hold time exceeded certain values, whereas those of B31.1 were satisfied regardless of the hold times. Thus, the design evaluations according to B31.1 did not consistently yield conservative results and might lead to non-conservative results in the case of long-term operations in the creep range.

关键词： ASME B31.1 Creep Hold time Hightemperature piping RCC-MRx Sensitivity analysis

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