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IRG1 induced by heme oxygenase- 1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production

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Cellular & Molecular Immunology 2016年第2期13卷 170-179页

作者： Md Jamal Uddin Yeonsoo Joe Seul-Ki Kim Sun Oh jeong Stefan W Ryter Hyun-Ock Pae Hun Taeg Chung School of Biological Sciences University of Ulsan Korea Department of Microbiology and Immunology Wonkwang University School of Medicine Korea Joan and Sanford I. Weill Department of Medicine New York-Presbyterian Hospital Weill Cornell Medical College New York USA

The immunoresponsive gene 1 （IRG 1） protein has crucial functions in embryonic implantation and neurodegeneration. IRG1 promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species （ROS）. The cytoprotective protein heme oxygenase-1 （ho-1）, which generates endogenous carbon monoxide （CO）, is expressed in the lung during Lipopolysaccharide （LPS） tolerance and cross tolerance. however, the detailed molecular mechanisms and functional links between IRG1 and ho-1 in the innate immune system remain unknown. In the present study, we found that the CO releasing molecule-2 （CORM-2） and chemical inducers of ho- 1 increased I RG 1 expression in a time- and dose-dependent fashion in RAW264.7 cells. Furthermore, inhibition of ho-1 activity by zinc protoporphyrin IX （ZnPP） and ho-1 siRNA significantly reduced expression of IRG1 under these conditions. In addition, treatment with CO and ho-1 induction significantly increased A20 expression, which was reversed by ZnPP and ho-1 siRNA. LPS-stimulated TNF-a was significantly decreased, whereas IRG1 and A20 were increased by CORM-2 application and ho-1 induction, which in turn were abrogated by ZnPP. Interestingly, siRNA against IRG1 and A20 reversed the effects of CO and ho-1 on LPS-stimulated TNF-a production. Additionally, CO and ho-1 inducers significantly increased IRG1 and A20 expression and downregulated TNF-a production in a LPS-stimulated sepsis mice model. Furthermore, the effects of CO and ho-1 on TNF-α production were significantly reversed when ZnPP was administered. In conclusion, CO and ho-1 induction regulates IRG1 and A20 expression, leading to inhibition of inflammation in vitroand in an in vivomice model.

关键词： A2O anti-inflammatory effects carbon monoxide ho-1 IRG1

中韩研究型大学本科生全球化能力和经历的比较研究--基于南京大学与首尔大学的问卷调查

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大学教育科学 2013年第6期6卷 98-109页

作者：吕林海郑钟昊龚放南京大学教育研究院韩国首尔大学国际大学院

培养学生的全球化能力是今日大学所应承担的重要责任,也是世界发达国家推进大学国际化发展的内在动因。基于对中国南京大学与韩国首尔大学的问卷调查和比较,可以发现,两校本科生在全球化理解能力上没有明显差异,而在全球化交往能力上,... 详细信息

培养学生的全球化能力是今日大学所应承担的重要责任,也是世界发达国家推进大学国际化发展的内在动因。基于对中国南京大学与韩国首尔大学的问卷调查和比较,可以发现,两校本科生在全球化理解能力上没有明显差异,而在全球化交往能力上,南京大学低年级本科生要显著强于首尔大学,但在高年级阶段,这种差异并不存在。而就全球化经历的比较来看,首尔大学为学生提供的全球化学术经历和交往经历,要更加丰富和充裕。聚类分析和回归分析则进一步表明,全球化经历与全球化能力之间存在着明显的联系,并且全球化的交往经历会更显著地影响学生的两种全球化能力的发展。对于中国大学的国际化发展来说,在国家层面,应深刻考量"全球化人才"培养的重要价值;在大学层面,应通过资金和政策的支持来推进"全球化人才"的培养;在学生层面,应帮助学生建立"全球化人才"的身份意识,并鼓励学生参与到各种全球化经历之中。

关键词：全球化能力全球化经历南京大学首尔大学

大学生的全球化能力和经历:中国与世界一流大学的比较——基于南京大学、首尔大学和伯克利加州大学的问卷调查

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清华大学教育研究 2013年第4期34卷 100-107页

作者：吕林海郑钟昊龚放南京大学教育研究院首尔大学国际大学院

为大学生提供更加丰富的全球化经历,培养大学生的全球化能力,是大学国际化发展的重要方面。通过对南京大学、首尔大学和伯克利加州大学的问卷调查,研究发现,伯克利加州大学学生在全球化能力和全球化经历等方面,都显著优于中韩两校。中... 详细信息

为大学生提供更加丰富的全球化经历,培养大学生的全球化能力,是大学国际化发展的重要方面。通过对南京大学、首尔大学和伯克利加州大学的问卷调查,研究发现,伯克利加州大学学生在全球化能力和全球化经历等方面,都显著优于中韩两校。中韩之间的比较则表明,在全球化能力上,首尔大学先弱后强,低年级阶段所存在的显著差异,在高年级阶段则完全消失;在全球化经历上,首尔大学在各个维度上都明显好于南京大学。聚类分析则证明,全球化经历和全球化能力之间存在着明显的聚合相关关系。在定量调查的基础上,结合对学生的深度访谈,文章指出,促进学生的双向流动、增设区域研究中心和相关课程、提升校内全球化活动的丰富度和精深度、引导学生树立"全球化人才"的身份意识、完善大学国际化的支持和管理机制,是促进学生全球化能力发展的重要方面。

关键词：全球化能力全球化经历大学国际化

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为创造更多就业机会韩国新总统支持市场经济

商业周刊（中文版） 2022年第4期 28-29页

作者： jeong-ho Lee Youkyung Lee Shinhye Kang 程玺(译) 不详

3月10日的选举是韩国历史上最为势均力敌的总统大选之一,检察官出身的尹锡悦(Yoon Sukyeol)以不到1个百分点的优势击败了执政的共同民主党候选人、京畿道前知事李在明。现年61岁的尹锡悦曾任韩国检察总长,是个政治新人和外交新手。他在2... 详细信息

3月10日的选举是韩国历史上最为势均力敌的总统大选之一,检察官出身的尹锡悦(Yoon Sukyeol)以不到1个百分点的优势击败了执政的共同民主党候选人、京畿道前知事李在明。现年61岁的尹锡悦曾任韩国检察总长,是个政治新人和外交新手。他在2019年被文在寅任命为最高检察官,帮助文在寅兑现了“追查权贵”的承诺。

关键词：民主党候选人总统大选检察官文在寅检察总长就业机会京畿道市场经济

Esophageal mucosal metastasis from adenocarcinoma of the distal stomach

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World Journal of Gastroenterology 2013年第23期19卷 3699-3702页

作者： Sung-ho Ki Seok jeong In Suh Park Don Haeng Lee Jung Il Lee Kye Sook Kwon Hyung Gil Kim Yong Woon Shin Division of Gastroenterology Department of Internal Medicine Pohang St. Mary's HospitalPohang 790-825 South Korea Division of Gastroenterology Department of Internal Medicine Inha University School of MedicineIncheon 400-711 South Korea Department of Pathology Inha University School of MedicineIncheon 400-711 South Korea Center for Advanced Medical Education by BK21 Project Inha University School of Medicine Utah-Inha DDS and Advanced Therapeutics Research CenterIncheon 400-711 South Korea

Dissemination of gastric cancer may usually occur by direct spread through the perigastric tissues to adjacent organ, lymphatic spread, and hematogenous spread. We report a rare case of gastric cancer with mucosal metastastic lesion on the upper esophagus that was diagnosed by endoscopy and endosonography. A biopsy of the esophageal mass was performed and the pathologic findings with immunohistochemical stain for Mucin-5AC are proved to be identical to that of gastric adenocarcinoma, suggesting metastasis from main lesion of the gastric cancer. The lesion could not be explained by lymphatic or hematogenous spread,and its metastasis mechanism is considered to be different from previous studies. We suggest that the gastroesophageal reflux of cancer cells could be one of the possible metastatic pathways for metastasis of esophagus from an adenocarcinoma of the stomach.

关键词： Stomach cancer Neoplasm metastasis Esophagus

Large-Scale Production of Microalgal Lipids Containing High Levels of Docosahexaenoic Acid upon Fermentation of <i>Aurantiochytrium</i>sp. KRS101

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Food and Nutrition Sciences 2013年第9期4卷 1-5页

作者： Won-Kyung hong Anna Yu Baek-Rock Oh Jang Min Park Chul ho Kim Jung-hoon Sohn Akihiko Kondo jeong-Woo Seo Applied Microbiology Research Center Bio-Materials Research Institute Korea Research Institute of Bioscience and Biotechnology (KRIBB) Jeongeup South Korea Department of Chemical Science and Engineering Graduate School of Engineering Kobe University Kobe Japan. Systems and Synthetic Biology Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon South Korea

In this study, large-scale production of microalgal lipid containing high levels of docosahexaenoic acid (DHA) by fermentation of Aurantiochytrium sp. KRS101 was performed. The microalgal strain yielded productivity of docosahex-aenoic acid (DHA) productivity of 1.08 and 1.6 g/L/d by fermentation at 300-L and 5000-L scale stirrer-type bioreactor. The productivity was significantly enhanced upto 5.6 g/L/d by fermentation at 6000-L scale airlift-type bioreactor, probably due to the reduced shearing force. The microalgal lipid could be efficiently recovered by safe extraction methods such as ethanol extraction, hot water extraction or supercritical fluid extraction, promising commercial potential of the microalgal DHA-rich lipid in the food and feed industry.

关键词： Aurantiochytrium sp. Heterotrophic Microalga Large-Scale Cultivation Lipid Docosahexaenoic Acid

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韩国元山岛海底出水高丽青瓷的科学分析

合肥学院学报（自然科学版） 2014年第2期24卷 89-96页

作者：朱善银 Gyu-ho KIM Yong-hwa jeong 安徽博物院文物科技保护中心合肥230061 韩国国立公州大学自然科学院韩国国立海洋文化财研究所水下发掘科

利用物理和化学方法对韩国元山岛海底出水14件高丽青瓷样品进行科学分析检测.结果表明,此海域出水青瓷来自两个产地,优质青瓷原料产地推定为康津,粗质青瓷原料推定为扶安,且优质青瓷原料的组成成分比粗质青瓷稳定;两种青瓷瓷胎属于高硅... 详细信息

利用物理和化学方法对韩国元山岛海底出水14件高丽青瓷样品进行科学分析检测.结果表明,此海域出水青瓷来自两个产地,优质青瓷原料产地推定为康津,粗质青瓷原料推定为扶安,且优质青瓷原料的组成成分比粗质青瓷稳定;两种青瓷瓷胎属于高硅质瓷胎,瓷釉均选用草木灰作为助熔剂,均属于钙釉;物性分析上,两种青瓷的烧制工艺特征明显.这些特性可为推定出水高丽青瓷原料产地及烧制工艺提供依据,也可作为研究我国境内出土高丽青瓷的分析比较对象,为研究我国古代制瓷技术的对外传播历史提供重要科学资料.

关键词：高丽青瓷元山岛出水文物 X射线荧光分析

Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry

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Journal of Geriatric Cardiology 2020年第11期17卷 680-693页

作者： Myunhee Lee Dae-Won Kim Mahn-Won Park Kyusup Lee Kiyuk Chang Wook Sung Chung Tae hoon Ahn Myung ho jeong Seung-Woon Rha Hyo-Soo Kim Hyeon Cheol Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae Kwon-Bae Kim Young Jo Kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-hoon Jung 无 KAMIR-NIH registry investigators Division of Cardiology Daejeon St.Mary’s hospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Division of Cardiology Seoul St.Mary’s hospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Gachon University Gil Medical CenterIncheonSouth Korea Chonnam National University hospital GwangjuSouth Korea d Korea University Korea University Guro hospital SeoulSouth Korea Seoul National University hospital SeoulSouth Korea Sungkyunkwan Universtiy Samsung Medical CenterSeoulSouth Korea Chungnam National University hospital DaejeonSouth Korea Chungbuk National University hospital CheongjuSouth Korea Kyungpook National University hospital DaeguSouth Korea Keimyung University Dongsan Medical Center DaeguSouth Korea Yeungnam University hospital DaeguSouth Korea Pusan National University hospital BusanSouth Korea Wonkwang University hospital IksanSouth Korea Chonbuk National University hospital JeonjuSouth Korea Institute of Toxicology DaejeonSouth Korea 不详

Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention(PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction(AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health(KAMIR-NIH) between November 2011 and December 2015 were classified into male(n = 8021, 75.9%) and female(n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events(MACCE) in women with those in men after AMI by using propensity score(PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction(NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population(30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585;1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328;TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P = 0.215, HR = 1.255, 95% CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up.

关键词： Acute myocardial infarction Asian population Gender difference Percutaneous coronary intervention

Individual having a parent with early-onset gastric cancer may need screening at younger age

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World Journal of Gastroenterology 2015年第15期21卷 4592-4598页

作者： Hee-Won Kwak Il Ju Choi Chan Gyoo Kim Jong Yeul Lee Soo-jeong Cho Bang Wool Eom hong Man Yoon Jungnam Joo Keun Won ryu Young-Woo Kim Center for Gastric Cancer National Cancer Center Biometric Research Branch National Cancer Center

AIM: To evaluate whether individuals with gastric cancer(GC) are diagnosed earlier if they have firstdegree relatives with ***: A total of 4282 patients diagnosed with GC at National Cancer Center hospital from 2002 to 2012 were enrolled in this retrospective study. We classified the patients according to presence or absence of first-degree family history of GC and compared age at diagnosis and clinicopathologic characteristics. In addition, we further classified patients according to specific family member with GC(father, mother, sibling, or offspring) and compared age at GC diagnosis among these patient groups. Baseline characteristics were obtained from a prospectively collected database. Information about the family member's age at GC diagnosis was obtained by ***: A total of 924 patients(21.6%) had a firstdegree family history of GC. The mean age at GC diagnosis in patients having paternal history of GC was 54.4 ± 10.4 years and was significantly younger than in those without a first-degree family history(58.1 ± 12.0 years, P however, this finding was not observed in patients who had an affected mother(57.2 ± 10.0 years) or sibling(62.2 ± 9.8 years). Among patients with family member having early-onset GC(hose with an affected father, 48.6 ± 10.4 years for those with an affected mother, and 57.4 ± 11.5 years for those with an affected sibling. Thus, patients with a parent diagnosed before 50 years of age developed GC 10.4 or 9.5 years earlier than individuals without a family history of GC(both P <0.001).CONCLUSION: Early-onset GC before age of 50 was associated with parental history of early-onset of GC. Individual having such family history need to start screening earlier.

关键词： Gastric cancer Family history Family member Age at diagnosis Screening