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Understanding the creep behaviors and mechanisms of Mg-Gd-Zn alloys via machine learning

Journal of Magnesium and Alloys 2024年第8期12卷 3281-3291页

作者： Shuxia Ouyang Xiaobing Hu Qingfeng Wu jeong ah lee Jae Heung lee Chenjin Zhang Chunhui Wang Hyoung Seop Kim Guangyu Yang Wanqi Jie Graduate Institute of Ferrous and Eco Materials Technology(GIFT) Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Xi’an Rare Metal Materials lnstitute Co.Ltd Xi’an 710016China Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea DepartmentAdvanced Institute for Materials Research(WPI-AIMR) Tohoku UniversitySendai 980-8577Japan Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul 03722South Korea

Mg-Gd-Zn based alloys have better creep resistance than other Mg alloys and attract more attention at elevated ***,the multiple alloying elements and various heat treatment conditions,combined with complex microstructural evolution during creep tests,bring great challenges in understanding and predicting creep *** this study,we proposed to predict the creep properties and reveal the creep mechanisms of Mg-Gd-Zn based alloys by machine *** the one hand,the minimum creep rates were effectively predicted by using a support vector regression *** complex and nonmonotonic effects of test temperature,test stress,alloying elements,and heat treatment conditions on the creep properties were *** the other hand,the creep stress exponents and creep activation energies were calculated by machine learning to analyze the variation of creep mechanisms,based on which the constitutive equations of Mg-Gd-Zn based alloys were *** study introduces an efficient method to comprehend creep behaviors through machine learning,offering valuable insights for the future design and selection of Mg alloys.

关键词： Mg-Gd-Zn based alloys Machine learning Creep rate Creep mechanism Constitutive equation

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Ru/NiMnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第1期100卷 397-408页

作者： Md ahasan Habib Shusen Lin Mehedi Hasan Joni Sumiya Akter Dristy Rutuja Mandavkar Jae-Hun jeong Jihoon lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NiMnB spherical cluster pillar （SCP）,denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic *** Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 M KOH,making them highly competitive with state-of-the-art ***,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 M KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

关键词： Potassium hydroxide

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Relation between preoperative hyperopia and surgical outcome in infantile esotropia

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1963-1967页

作者： Haeng Jin lee jeong-ah Kim Seong-Joon Kim Young Suk Yu Department of Ophthalmology Seoul National University College of Medicine Seoul Artificial Eye Center Seoul National University Hospital Clinical Research Institute

AIM: To evaluate the relation between preoperative hyperopia and surgical outcomes of infantile esotropia in patients younger than 24 months of ***: Medical records of patients who underwent bilateral medial rectus muscle recession for infantile esotropia between November 1, 2002 and December 1, 2011 were retrospectively reviewed. Patients were divided into two groups according to the degree of preoperative hyperopia. Group I had less than +3.0 diopter(D) of hyperopia and group II had between +3.0 and +5.0 D of hyperopia. Postoperative alignments were evaluated 1 wk, 3, 6 mo, and 1 y after surgery. Following the 1-year postoperative visit, patients were monitored yearly. Relationships between preoperative factors including hyperopia and postoperative outcomes were evaluated. RESULTS: Forty-six patients were included, with 33 patients in group I and 13 patients in group II. The preoperative mean refractive error was +0.88 D in group I and +3.45 D in group II. Surgical outcomes were not significantly different between groups at any postoperative time point examined. Cumulative probability of surgical success, prevalence of inferior oblique overaction, dissociated vertical deviation, and re-operation rate were not significantly different between ***: Preoperative moderate hyperopia(less than +5.0 D) did not affect the surgical outcome of infantile esotropia. Therefore, the surgical correction of esotropia should be considered when the angle of esodeviation is unchanged following hyperopia correction, even in children with moderate hyperopia.

关键词： infantile esotropia hyperopia medial rectus muscle recession

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Synthesis of crosslinked polystyrene particles by seeded batch polymerization with monomer absorption

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 153-159页

作者： Ki-Chang lee Han-ah WI Department of Polymer Science and Engineering Engineering Research Institute Gyeongsang National University

A highly crosslinked, monodispersed polystyrene（PS） particle was prepared by a seeded batch dispersion polymerization with a monomer absorption method. Prior to polymerization, 1,9 lam monodispersed PS seed particles were treated under an optimum condition of monomer absorption. The effects of divinylbenzebe（DVB） concentration and polymerization temperature were examined for styrene（in PS seed）/styrene（in the second stage） mass ratio of 1：1 in the medium range of EtOH/water mass ratio of 100/0-80/20 and 2.3 μm uniform crosslinked PS particles containing 15%-20% （mass fraction） DVB were prepared at 60-70 ℃. The results show that monomer absorption before the second stage of polymerization is more effective to prepare highly crosslinked monodispersed PS particles.

关键词： crosslinked polystyrene particle seeded batch dispersion polymerization monomer absorption divinylbenzene (DVB)

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Neutrophil-to-lymphocyte ratio and carbohydrate antigen 19-9 as prognostic markers for advanced pancreatic cancer patients receiving first-line chemotherapy

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 915-928页

作者： Kabsoo Shin Eun-Kyo Jung Se Jun Park Sangwoon jeong In-Ho Kim Myung-ah lee Division of Medical Oncology Department of Internal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Catholic Cancer Research Institute College of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND A decline in serum carbohydrate antigen 19-9(CA19-9)levels during systemic chemotherapy is considered as a prognostic marker for patients with advanced pancreatic ***-to-lymphocyte ratio(NLR)has been extensively studied as a simple and useful indicator of prognosis in various cancers including pancreatic *** To assess the prognostic significance of NLR and CA19-9 in patients with advanced pancreatic adenocarcinoma received first-line chemotherapy according to CA19-9 *** We retrospectively analyzed patients diagnosed with advanced pancreatic cancer who received first-line chemotherapy between January 2010 and July 2017 at the Catholic University of Seoul ***’s *** were divided according to CA19-9 positivity(CA19-9-positive vs-negative groups)and pre-and posttreatment NLR *** determine cut-off value of NLR and CA19-9 reduction,time-dependent receiver operating characteristic curve was *** evaluated overall survival(OS)and progression-free survival(PFS)for each group using Kaplan-Meier method,and we performed multivariate analyses on the entire *** We included 271 patients in this ***-off value of NLR and CA19-9 reduction was determined as 2.62 and 18%.Multivariate analysis showed that post-treatment NLR<2.62 and reduction of≥18%of baseline CA19-9 were significantly associated with OS and ***-treatment NLR≥2.62 showed hazard ratio(HR)of 2.47[95%confidence interval(CI):1.84-3.32,P<0.001]and CA19-9 decline(≥18%)showed HR of 0.51(95%CI:0.39-0.67,P<0.001)for *** CA19-9-positive patients were divided into groups according to CA19-9 response(responder vs non-responder)and post-treatment NLR(<2.62 vs≥2.62),CA19-9 responder and post-treatment NLR<2.62 group showed better survival than CA19-9 non-responder and post-treatment NLR≥2.62 group(OS 11.0 mo vs 3.9 mo,P<0.001;PFS 6.3 mo vs 2.0 mo,P<0.001).The combination of CA19-9 decline and post-treatment NLR showed a significant c

关键词： Pancreatic adenocarcinoma Serum carbohydrate antigen 19-9 Neutrophil-tolymphocyte ratio Multivariate analysis Prognosis Chemotherapy

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Techniques for overcoming atretic changes of the portal vein in living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 311-317页

作者： jeong-Moo lee Kwang-Woong lee Department of Surgery Seoul National University College of Medicine101 Daehak-roJongno-guSeoul 03080Korea

Background:Spontaneous diversion of the portal flow through collateral vessels into the systemic circulation is frequently observed in liver transplant recipients with severe portal *** induces main portal vein atretic change and modifies flow into the collateral even after donor graft *** atretic changes make liver transplantation *** this article we described several methods for overcoming this challenge by appropriate surgical ***:Three anastomotic techniques for living donor liver transplantation were performed in patients with atretic changes in the portal ***:The three techniques were(1)venoplasty to widen the diameter by using the recipient’s portal vein,and the diameter of the recipient’s portal vein was enlarged using their own portal vein stump patch;(2)conduit with cryopreserved vessels,and we dissected around the superior mesenteric vein and splenic vein junction and a conduit was built using the cryopreserved vessels;and(3)left gastric varix to portal vein anastomosis,if the recipients had large gastric varix and variceal wall was sufficiently thick for ***:Selection of optimal methods for portal vein anastomosis is essential in patients with atrophic change on the portal *** these methods are used aptly,they can be considered as favorable methods for overcoming each situation.

关键词： Atretic portal vein Liver transplantation Anastomosis

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Digital exchange attributes and the risk of closure

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Blockchain(Research and Applications) 2023年第2期4卷 136-145页

作者： Seung ah lee George Milunovich Department of Actuarial Studies and Business Analytics Macquarie UniversitySydneyNSW2109Australia

Presently,there are over 500 cryptocurrency exchanges worldwide and more than 19,700 different *** the fact that cryptocurrency trading is possible via private peer-to-peer transactions,more than 90%of trading occurs on organised exchanges,which provide convenience and ***,centralised cryptocurrency exchanges are regarded as high-value targets by criminals and are often victims of *** this paper,we investigate the risk of cryptocurrency exchange closures and develop predictive models to forecast which markets will close down and which ones will remain active using publicly available *** models perform well and reach a high level of classification *** trading volume,the availability of public information on exchange staff,exchange lifetime,and several cybersecurity features are identified as key attributes in predicting exchange ***,our models do not account for all sources of risk,e.g.,potential fraud and mismanagement of client funds committed by the exchanges themselves,and market participants are encouraged to carefully consider where and how they store their digital assets.

关键词： Cryptocurrency markets Digital exchange Closure Classification Predictive models

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Crystal plasticity finite element simulations on extruded Mg-10Gd rod with texture gradient

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Journal of Magnesium and Alloys 2024年第8期12卷 3409-3430页

作者： Jaeseong lee Dirk Steglich Youngung jeong Department of Materials Convergence and System Engineering Changwon National University25 Changwondaehak-roChangwonRepublic of Korea Helmholtz-Zentrum Hereon Institute of Material Systems ModelingD-21502 GeesthachtGermany School of Materials Science and Engineering Changwon National University25 Changwondaehak-roChangwonRepublic of Korea

The mechanical properties of an extruded Mg-10Gd sample, specifically designed for vascular stents, are crucial for predicting its behavior under service conditions. Achieving homogeneous stresses in the hoop direction, essential for characterizing vascular stents, poses challenges in experimental testing based on standard specimens featuring a reduced cross section. This study utilizes an elasto-visco-plastic self-consistent polycrystal model(ΔEVPSC) with the predominant twinning reorientation(PTR) scheme as a numerical tool, offering an alternative to mechanical testing. For verification, various mechanical experiments, such as uniaxial tension, compression, notched-bar tension, three-point bending, and C-ring compression tests, were conducted. The resulting force vs. displacement curves and textures were then compared with those based on the ΔEVPSC model. The computational model's significance is highlighted by simulation results demonstrating that the differential hardening along with a weak strength differential effect observed in the Mg-10Gd sample is a result of the interplay between micromechanical deformation mechanisms and deformation-induced texture evolution. Furthermore, the study highlights that incorporating the axisymmetric texture from the as-received material incorporating the measured texture gradient significantly improves predictive accuracy on the strength in the hoop direction. Ultimately, the findings suggest that the ΔEVPSC model can effectively predict the mechanical behavior resulting from loading scenarios that are impossible to realize experimentally, emphasizing its valuable contribution as a digital twin.

关键词： Crystal plasticity Texture Finite element C-ring Three-point bending

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Tonsil-derived stem cells as a new source of adult stem cells

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World Journal of Stem Cells 2019年第8期11卷 506-518页

作者： Kyung-ah Cho Hyun Jung lee Hansaem jeong Miri Kim Soo Yeon Jung Hae Sang Park Kyung-Ha Ryu Seung Jin lee Byeongmoon jeong Hyukjin lee Han Su Kim Department of Microbiology College of Medicine Ewha Womans University Seoul 07985 South Korea Department of Chemistry and Nano Science Ewha Womans University Seoul 03760 South Korea College of Pharmacy Graduate School of Pharmaceutical Sciences Ewha Womans University Seoul 03760 South Korea Department of Otorhinolaryngology College of Medicine Ewha Womans University Seoul 07985 South Korea Department of Otorhinolaryngology College of Medicine Hallym University Chuncheon 24252 South Korea Department of Pediatrics College of Medicine Ewha Womans University Seoul 07985 South Korea

Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the identification and isolation of tonsil-derived stem cells (T-SCs) from waste surgical tissue following tonsillectomies in relatively young donors (i.e., under 10 years old). As such, TSCs offer several advantages, including superior proliferation and a shorter doubling time compared to bone marrow-derived mesenchymal stem cells (MSCs). T-SCs also exhibit multi-lineage differentiation, including mesodermal, endodermal (e.g., hepatocytes and parathyroid-like cells), and even ectodermal cells (e.g., Schwann cells). To this end, numbers of researchers have evaluated the practical use of T-SCs as an alternative source of autologous or allogenic MSCs. In this review, we summarize the details of T-SC isolation and identification and provide an overview of their application in cell therapy and regenerative medicine.

关键词： Stem cell Tonsil-derived stem cell Differentiation Endoderm Mesoderm Ectoderm Cell therapy

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