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Superior antibody and membrane protein‑specific T‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang howard h.W.Wong Leo c.h.Tsang Sara chaothai Tsz chun Kwan John K.c.Li Karl c.K.chan Leo L.h.Luk jenson c.h.ho Wing Yan Li Amos M.T.Lee Jennifer h.Y.Lam Sau Man chan Wilfred h.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public health The University of Hong KongHong KongChina hKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(NcT04800133)investigated the superiority of antibody and T-cell responses of full-dose coronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-cc versus ID-cc)and post-dose 3(IMccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+cD4^(+),SNM-specific IL-2^(+)cD8^(+),S-specific IL-2^(+)cD8^(+),N-specific IL-2^(+)cD4^(+),N-specific IL-2^(+)cD8^(+)and M-specific IL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to IM-cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)cD4^(+),interferon-γ+cD8^(+)and IL-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-cc,ID-cc,IM-ccc and ID-ccc,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine

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AVAILABILITY OF ROcK PhoSPhATE TO PLANT GROWTh IN RED EARTh

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Science china Mathematics 1954年第1期 65-79页

作者： c.K.LEE c.h.ho R.K.LU T.K.hU Institute of Soil Studies Academia Sinica Institute of Soil Studies Academia Sinica

One of the main factors causing large areas of red and yellow earthregions in southern china remaining idle is due to their serious *** present,these soils occurring on rolling hills and mountainousregions are subjected to severe erosion as a consequence of untimely defore-station and fuel *** programs for reclamation of theseidle lands based on the principle of reforestation and grass-rotation system

关键词： Ph bone AVAILABILITY OF ROcK PhoSPhATE TO PLANT GROWTh IN RED EARTh rock ROcK OFR

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连续缩聚直接纺丝和间歇缩聚螺杆挤压熔纺的优劣谈

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聚酯工业 1989年第3期2卷 52-60页

作者： c.h.ho kinston 张清

聚酯在工业上有价值的成纤特性,在1941年由英国的加尔科印染者协会的温菲尔德和狄克逊做了首次描述。他们的发明后来转让给Du Pont和IcI公司。1953年,Du Pont公司开始大规模工业化生产“达克纶”聚酯,生产厂是金斯顿(Kinston),北卡罗林... 详细信息

聚酯在工业上有价值的成纤特性,在1941年由英国的加尔科印染者协会的温菲尔德和狄克逊做了首次描述。他们的发明后来转让给Du Pont和IcI公司。1953年,Du Pont公司开始大规模工业化生产“达克纶”聚酯,生产厂是金斯顿(Kinston),北卡罗林纳(North carolina)工厂。两年后,英国的IcI公司在威尔顿(Wilton)工厂投产了称为“特丽纶”的聚酯。

关键词：聚合物熔体聚合物降解工厂投产温菲尔德低聚物熔纺卡罗林狄克逊热降解纺丝工艺

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Fish-on-chips:unveiling neural processing of chemicals in small animals through precise fluidic control

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Neural Regeneration Research 2024年第11期19卷 2351-2353页

作者： Samuel K.h.Sy ho Ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li Ka Shing Institute of health Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Electrical and Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanced Biomedical Instrumentation center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret K.L.cheung Research center for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-chuen Research center of Brain Degenerative Diseases in chinese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald choa Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in ***,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal ***,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain ***,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much *** is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.

关键词： dealing precise sizes

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Interactive effect of dietary vitamin E and inorganic mercury on growth performance and bioaccumulation of mercury in juvenile olive flounder, Paralichthys olivaceus treated with mercuric chloride

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Animal Nutrition 2017年第3期3卷 276-283页

作者： Mohammad Moniruzzaman Jun-ho Lee Jin-hyeok Lee Seonghun Won Jim h.Damusaru Sungchul c.Bai Department of Marine Bio-materials and Aquaculture Feeds & Foods Nutrition Research CenterPukyong National University

A 6-week feeding trial was carried out to evaluate the effects of dietary vitamin E(DL-a-tocopheryl acetate, TA) on growth and mercury(hg) accumulation in juvenile olive flounder(Paralichthys olivaceus)treated with mercuric chloride(hgcl_2). Vitamin E and hgcl_2 were added to the semi-purified basal *** semi-purified diets in a 2 × 3 factorial design were formulated to contain 2 levels of hg(0 or 20 mg hgcl_2/kg diet) and 3 levels of vitamin E(0, 100, or 200 mg TA/kg diet). Experimental fish(n = 360,9.99 ± 0.15 g) were randomly allocated into 30-L tanks at a density of 20 fish per tank with 3 replicates in each treatment and were fed twice a day. At the end of the feeding trial, dietary hg depressed the growth performances in terms of weight gain(WG), specific growth rate(SGR), feed efficiency(FE) and protein efficiency ratio(PER) in fish, while fish fed the diets supplemented with vitamin E showed significant growth improvement in both presence and absence of hgcl_2 in the diets(P cted in fish fed the experimental diets. Whole body compositions of fish such as lipid and moisture contents were influenced by dietary vitamin E supplementation. Total hg contents of muscle, liver and kidney tissues were significantly reduced in fish fed diets supplemented with vitamin E(Phile the two-way ANOVA showed that increasing hg concentration has resulted in a reduction in vitamin *** body fatty acids of fish like eicosapentaenoic acid(EPA) and docosahexaenoic acid(DhA) contents were decreased by dietary hg. however, supplementation of dietary vitamin E improved the a-linolenic acid(ALA) and EPA contents in fish. Our results suggest that dietary supplementation of vitamin E has potential effects on growth improvement and ameliorating inorganic hg bioaccumulation in juvenile olive flounder.

关键词： Vitamin E Mercury Growth Bioaccumulation Olive flounder

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Perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes

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Regenerative Biomaterials 2022年第1期9卷 424-433页

作者： chien-Liang ho Lynn L.h.huang Shyh-Jou Shieh Institute of clinical Medicine College of MedicineNational Cheng Kung University138 Sheng-Li RoadTainan 70403TaiwanChina Division of Plastic and Reconstructive Surgery Department of SurgeryNational Cheng Kung University HospitalCollege of MedicineNational Cheng Kung University138 Sheng-Li RoadTainan 70403TaiwanChina Research center of Excellence in Regenerative Medicine National Cheng Kung University1 University RoadTainan 70101TaiwanChina Department of Biotechnology and Bioindustry Sciences College of Bioscience and BiotechnologyNational Cheng Kung University1 University RoadTainan 70101Taiwan International center for Wound Repair and Regeneration National Cheng Kung University1 University RoadTainan 70101TaiwanChina School of Medicine National Cheng Kung University1 University RoadTainan 70101TaiwanChina

Autologous chondrocytes(c cells)are effective sources of cell therapy for engineering cartilage tissue to repair chondral defects,such as degenerative *** expansion of cells with c cell characteristics has become a major challenge due to inadequate donor sites and poor proliferation of mature c *** perichondrial progenitor cells(P cells)from the cambium layer of the perichondrium possessed significantly higher mesenchymal stem cell markers than c *** the transwell co-culture system,P cells increased the passaging capacity of c cells from P6 to P9,and the cell number increased 128 *** system increased the percentage of Alcian blue-positive c cells from 40%in P6 to 62%in P9,contributing about 198 times more Alcian blue-positive c cells than the control group.c cells co-cultured with P cells also exhibited higher proliferation than c cells cultured with P cellconditioned *** results were obtained in nude mice that were subcutaneously implanted with c cells,P cells or a mixture of the two cell types,in which the presence of both cells enhanced neocartilage formation in ***,P cells enhanced the proliferation of c cells in a dose–dependent manner and prolonged the longevity of mature c cells for clinical applications.

关键词： chondrocytes cell proliferation perichondrial progenitor cells paracrine effect neocartilage formation

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Neurovascular ageing:transcriptomic readout and implications on therapeutic targeting in Alzheimer’s disease

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Neural Regeneration Research 2021年第12期16卷 2411-2412页

作者： Zhongqi Li Bonaventure Ip Vincent c.T.Mok ho Ko Division of Neurology Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong Kong Special Administrative RegionChina Li Ka Shing Institute of health Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina(Li ZKo H)Margaret K.L.Cheung Research Centre for Management of ParkinsonismThe Chinese University of Hong KongHong Kong Special Administrative RegionChina chow Yuk ho Technology centre for Innovative Medicine The Chinese University of Hong KongHong Kong Special Administrative RegionChina Gerald choa Neuroscience centre School of Biomedical SciencesDepartment of PsychiatryPeter Hung Pain Research InstituteFaculty of MedicineThe Chinese University of Hong KongHong Kong Special Administrative RegionChina

Ageing is one of the greatest risk factors for neurodegenerative *** the complex biological changes in ageing increase the brain’s susceptibility to neurodegeneration remains incompletely *** into neurodegenerative disorders has shifted from a neuron-centric approach,to the contributing roles of age-related neurovascular and glial cell dysfunction.

关键词： incomplete susceptibility ageing

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controllable optical emission wavelength in all-inorganic halide perovskite alloy microplates grown by two-step chemical vapor deposition

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Nano Research 2020年第11期13卷 2939-2949页

作者： Mohammad K.hossain Pengfei Guo Wayesh Qarony Yuen h.Tsang chaoping Liu Sai W.Tsang Johnny c.ho Kin M.Yu Department of Physics City University of Hong KongKowloonHong Kong SARChina Department of Physics Comilla UniversityKotbariCumilla3506Bangladesh Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong SARChina Department of Applied Physics The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina college of Physics and Optoelectronics Taiyuan University of TechnologyTaiyuan030024China Research center for Advanced Optics and Photoelectronics Department of PhysicsCollege of ScienceShantou UniversityShantou515063China Key Laboratory of Intelligent Manufacturing Technology of MOE Shantou UniversityShantou515063China

All-inorganic halide perovskites(IhP),csPbX_(3)(X=cl,Br,I)exhibiting efficient optical emissions within the spectral range of 410 to 730 nm are potential candidates for many optoelectronic *** alloying of these IhPs is expected to achieve tunable emission wavelength covering the entire visible ***,we developed a two-step chemical vapor deposition(cVD)process for growing quaternary IhP csPbX_(3)(X=cl/Br and Br/I)*** exploiting the fast diffusion of halide anions in IhPs,the alloy composition can be precisely controlled by the growth time of the respective layers once the growth of the individual ternary IhP is *** complexities in the multi-parameter optimization in the conventional cVD growth of quaternary alloys can be *** this process,we synthesized single crystalline,homogeneous and thermally stable csPbcl3_((1−X))Br_(3x)and csPbBr3_((1−X))I_(3x)perovskites alloy microplates and demonstrated continuously tunable emission covering the spectrum from 428 to 715 nm by varying the halide compositions in the *** alloy microplates also exhibit room temperature amplified spontaneous emissions(ASE)along with strong photonic discharges from the microplate’s edges and hence are potentially useful as a gain medium as well as optical cavities for emissions with wavelengths covering the visible spectrum.

关键词： chemical vapor deposition inorganic perovskites quaternary alloys emission spectrum amplified spontaneous emissions(ASE)

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Effects of dispersoid preforming via multistep sintering of oxide dispersion-strengthened cocrFeMnNi high-entropy alloy

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Journal of Materials Science & Technology 2023年第9期140卷 187-200页

作者： Seunghyeok chung Ji ho Shin ho Jin Ryu Department of Nuclear and Quantum Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea central Research Institute Korea Hydro and Nuclear Power Co.Ltd.(KHNP)Daejeon 34101Republic of Korea

Dispersoid formation and microstructural evolution in an oxide dispersion-strengthened cocrFeMnNi high-entropy alloy(hEA)using a newly designed multistep sintering process are *** proposed multistep sintering consists of a dispersoid preforming heat treatment of as-milled 0.1 wt%Y_(2)O_(3)-cocrFeMnNi high-entropy alloy powders at 800℃,followed by sintering at 800–1000℃ under uniaxial *** the conventional single-step sintered bulk,the coarsened Bcc Y_(2)O_(3)dispersoids mainly form with an incoherent interface with the hEA *** contrast,finer Fcc Y_(2)O_(3)dispersoids,an atypical form of Y_(2)O_(3),are formed in the matrix region after multistep *** of Fcc Y_(2)O_(3)disper-soids is initiated on the favorable facet,the{111}plane of the austenitic matrix,with the formation of a semi-coherent interface with the matrix during the dispersoid preforming heat treatment and it maintains its refined size even after *** is found that dispersoid preforming prior to sintering appears promising to control the finer dispersoid formation and refined grain structure.

关键词： Oxide dispersion strengthening high-Entropy alloy Multistep sintering Dispersoid preforming Microstructure evolution Interfacial structure

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candida albicans aspects of binary titanium alloys for biomedical applications

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Regenerative Biomaterials 2020年第2期7卷 213-220页

作者： Shuyang chen James K.h.Tsoi Peter c.S.Tsang Yeong-Joon Park ho-Jun Song Jukka P.Matinlinna Dental Materials Science Division of Applied Oral Sciences&Community Dental CareFaculty of DentistryThe University of Hong KongPrince Philip Dental Hospital34 Hospital RoadHong Kong SARPeople’s Republic of China Department of Prosthodontics Tianjin Stomatological HospitalNo.75Dagu RoadHeping DistrictTianjin 300041People’s Republic of China Division of Restorative Dental Sciences Faculty of DentistryThe University of Hong KongPrince Philip Dental Hospital34 Hospital RoadHong Kong SARPeople’s Republic of China and 4 Department of Dental Materials and MRc for hard-tissue Biointerface School of DentistryChonnam National UniversityGwangju 61186Republic of Korea

Titanium and its alloys are widely used in biomedical devices,***,due to its biocompati-bility and osseointegration *** fact,fungal(candida spp.)infection has been identified as one of the key reasons causing the failure of the device that is inevitable and impactful to the ***,this study evaluated the surface morphology,surface chemical composition and candida albicans adhesion on specimens of 16 binary Tialloys(-5 wt%of any one of the alloy elements:Ag,AI,Au,co,cr,cu,Fe,In,Mn,Mo,Nb,Pd,Pt,Sn,V and Zr)compared with cp-Ti,targeting to seek for the binary Ti-alloys which has the lowest *** *** albicans cultures were grown on the specimens for 48 h,and colony forming units(cFUs)and real-time polymerase chain reaction(RT-PcR)were used to evaluate the biofilm formation *** electron mi-croscopy and confocal laser scanning microscopy confirmed the formation of *** biofilm on all specimens'surfaces,such that cFU results showed Ti-Mo,Ti-Zr,Ti-AI and Ti-V have less *** formed on the surfaces than ***-PcR showed Ti-Zr and Ti-cu have significantly higher *** DNA concentrations than Ti-AI and Ti-V(Phereas Ti-cu has even showed a statistically higher concentration than Ti-Au,Ti-co,Ti-In and Ti-Pt(Phis study confirmed that Ti-Mo,Ti-Zr,Ti-AI and Ti-V have lower the occurrence of *** which might be clinically advantageous for medical devices,but Ti-cu should be used in caution.

关键词： titanium binary titanium alloy c.albicans,fungal infection medical devices

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