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Superior antibody and membrane protein‑specific T‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang howard h.W.Wong Leo c.h.Tsang Sara chaothai Tsz chun Kwan John K.c.Li Karl c.K.chan Leo L.h.Luk jens.n c.h.ho Wing Yan Li Amos M.T.Lee Jennifer h.Y.Lam Sau Man chan Wilfred h.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public health The University of Hong KongHong KongChina hKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(ncT04800133)investigated the superiority of antibody and T-cell responses of full-dose coronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-cc versus ID-cc)and post-dose 3(IMccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SnM[sum of individual(S),nucleocapsid protein(n),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+cD4^(+),SnM-specific IL-2^(+)cD8^(+),S-specific IL-2^(+)cD8^(+),n-specific IL-2^(+)cD4^(+),n-specific IL-2^(+)cD8^(+)and M-specific IL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to IM-cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRnT90),PRnT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)cD4^(+),interferon-γ+cD8^(+)and IL-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-cc,ID-cc,IM-ccc and ID-ccc,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine

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high na-ion conductivity andmechanical integrity of anion-exchanged polymeric hydrogel electrolytes for flexible sodium ion hybrid energy storage

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SusMat 2024年第1期4卷 140-153页

作者： JungWoo hong harpalsinh h.Rana Jeong hee Park Jun Su Kim Sang Joon Lee Gun Jang Tae hoon Kang Kang ho Shin Sang ha Baek Wooseok Yang Kwang ho Kim Ju-hyuk Lee ho Seok Park School of chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea clean Energy Research center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea KIST-SKKU carbon-neutral Research center Sungkyunkwan University(SKKU)SuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea cOSMOS LAB/92 Jomaru-ro 385beon-gilBucheon-siRepublic of Korea SKKU Advanced Institute of nano Technology(SAInT) Sungkyunkwan UniversitySuwonRepublic of Korea Department of health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

The polymeric gel electrolytes are attractive owing to their higher ionic conductivities than those of dry polymer electrolytes and lowered water activity for enlarged potential ***,the ionic conductivity and mechanical strength of the na-ion conducting polymeric gel electrolytes are limited by below 20 mS cm−1 and 2.2 ***,we demonstrate na-ion conducting and flexible polymeric hydrogel electrolytes of the chemically coupled poly(diallyldimethylammonium chloride)-dextrin-n,n′-methylene-bisacrylamide film immersed in naclO_(4) solution(ex-DDA-Dex+naclO_(4))for flexible sodium-ion hybrid capacitors(f-nIhc).In particular,the anion exchange reaction and synergistic interaction of ex-DDA-Dex with the optimum clO_(4)−enable to greatly improve the ionic conductivity up to 27.63 mS cm−1 at 25◦c and electrochemical stability window up to 2.6 V,whereas the double networking structure leads to achieve both the mechanical strength(7.48 MPa)and softness of hydrogel ***,the f-nIhcs with the ex-DDA-Dex+naclO_(4) achieved high specific and high-rate capacities of 192.04 F g^(−1)at 500 mA g^(−1)and 116.06 F g^(−1)at 10000 mA g^(−1),respectively,delivering a large energy density of 120.03Wh kg^(−1)at 906Wkg^(−1)and long cyclability of 70%over 500 cycles as well as demonstrating functional operation under mechanical stresses.

关键词： anion exchange chemistry flexible energy storage hybrid energy storage hydrogel electrolytes renewable electrolytes sodium storage

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Development and application of photocatalytic coating for roadside nO_(x) mitigation in hong Kong

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chinese chemical Letters 2024年第3期35卷 153-157页

作者： Xinwei Li Pengge Wang Shuwen han Yu huang Wingkei ho Steven Sai hang ho Shun-cheng Lee Meng Wang Department of civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Loess and Quaternary Geology(SKLLQG)and Key Laboratory of Aerosol chemistry and Physics Institute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China Department of Science and Environmental Studies The Education University of Hong KongHong KongChina Division of Atmospheric Sciences Desert Research InstituteRenoNV 89512United States

A facile chemical method for the development of photocatalytic coating products was proposed based on practical application perspective for the hong Kong roadside nitrogen oxides(nO_(x))***_(2)-based photocatalytic coating Pc-c film with crystallized size of around 5–6 nm was synthesized with the peptization of h_(2)O_(2).The Pc-c coating possesses a super-hydrophilicity surface and is proven to have a nO_(x)degradation rate of 46.8%with an optimum ph level of *** addition,the Pc-c coating presents a promising photocatalytic nO_(x)degradation compared with other commercially available coating products and P25 when applied on two building materials of poly-methyl methacrylate(PMMA)and concrete surface.A weather resistance simulation and a 180-day on-site field trial were carried out the attenuation effects of photocatalytic coating applied in outdoor *** on epidemiological estimation and field investigation,hospital admissions for respiratory diseases(hARD)and mortality cases(Mc)could be reduced with the application of Pc-c coating along the street *** work demonstrates the feasibility of air pollution control measures for the local roadside nO_(x)using photocatalytic technology,offering promising health benefits with environmental remediation.

关键词： Photocatalysis coating nO_(x) mitigation hong Kong Roadside

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Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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Photonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI ThALÍA DOMÍnGUEZ BUcIO hAO LIU JOSÉMAnUEL LUQUE GOnZÁLEZ FRAncIScO JURADO-ROMERO ALEJAnDRO ORTEGA-MOÑUX GLEnn chURchILL JAMES c.GATES JAMES hILLIER nIKOLAOS KALFAGIAnnIS DAnIELE MELATI jens h.SchMID ILARIA cRISTIAnI PAVEL chEBEn J.GOnZALO WAnGÜEMERT-PÉREZ ÑIGO MOLInA-FERnÁnDEZ FREDERIc GARDES cOSIMO LAcAVA PERIKLIS PETROPOULOS Optoelectronics Research centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telecommunication Research Institute(TELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain School of Science and Technology Nottingham Trent UniversityNottingham NG118NSUK Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece centre de nanosciences et de nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and Photonics Research center National Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same *** allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multiplexing and de-multiplexing functionalities *** system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering pump modal

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Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients

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Asian Journal of Andrology 2024年第3期26卷 233-238页

作者： Daniele castellani Vineet Gauhar Khi Yung Fong Mario Sofer Moisés Rodríguez Socarrás Azimdjon n Tursunkulov Lie Kwok Ying Sarvajit Biligere ho Yee Tiong Dean Elterman Abhay Mahajan Mark Taratkin Sorokin nikolai Ivanovich Tanuj Pal Bhatia Dmitry Enikeev nariman Gadzhiev Mohammed Taif Bendigeri Jeremy Yuen-chun Teoh Marco Dellabella Fernando Gómez Sancha Bhaskar Kumar Somani Thomas Reinhard William herrmann Urology Unit IRCCS INRCAAncona 60127Italy Urology Unit Marche University HospitalLe Marche Polytechnic UniversityAncona 60126Italy Department of Urology Ng Teng Fong General HospitalSingapore 609606Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Urology Tel Aviv Sourasky Medical CenterAffiliated to the Sackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel Department of Urology and Robotic Surgery ICUA-Clínica CEMTROMadrid 28701Spain Urology Division Akfa Medline HospitalTashkent 100211Uzbekistan Advanced Urology Gleneagles HospitalSingapore 258499Singapore Department of Urology National University HospitalSingapore 119228Singapore Divisionof Urology Department of SurgeryUniversity of TorontoOntarioToronto M5G 2C4Canada Department of Urology Mahatma Gandhi Mission’s Medical College and HospitalAurangabad 431003India Institute for Urology and Reproductive health Sechenov UniversityMoscow119435Russian Federation Department of Urologyand Andrology Lomonosov Moscow State UniversityMoscow 119992Russian Federation Department of Urology Sarvodaya Hospital and Research CentreFaridabadHaryana 121006India Department of Urology Medical University of ViennaVienna 1090Austria Department of Urology Saint-Petersburg State University HospitalSaint-Petersburg 199034Russian Federation Department of Urology Asian Institute of Nephrology and UrologyHyderabad 500082India S.h.ho Urologycentre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong Kong 96H2+Q9China Department of Urology University Hospitals Southampton NHS TrustSouthampton SO166YDUnited Kingdom Department of Urology Cantonal Hospital Thurgau AGFraunfeld 8500Switzerland

We aim to evaluate the incidence of incontinence following laser endoscopic enucleation of the prostate(EEP)comparing en-bloc(Group 1)versus 2-lobe/3-lobe techniques(Group 2).We performed a retrospective review of patients undergoing EEP for benign prostaticenlargement in 12 centers between January 2020 and January *** were presented as median and interquartile range(IQR).Univariable and multivariable logistic regression analysis was performed to evaluate factors associated with stress urinary incontinence(SUI)and mixed urinary incontinence(MUI).There were 1711 patients in Group 1 and 3357 patients in Group *** in Group 2were significantly younger(68[62–73]years vs 69[63–74]years,P=0.002).Median(interquartile range)prostate volume(PV)wassimilar between the groups(70[52–92]ml in Group 1 vs 70[54–90]ml in Group 2,P=0.774).There was no difference in preoperativeInternational Prostate Symptom Score,quality of life,or maximum flow ***,morcellation,and total surgical time weresignificantly shorter in Group *** 1 month,overall incontinence rate was 6.3%in Group 1 versus 5.3%in Group 2(P=0.12),and urge incontinence was significantly higher in Group 1(55.1%vs 37.3%in Group 2,Pnths,the overall rate ofincontinence was 1.7%in Group 1 versus 2.3%in Group 2(P=0.06),and SUI was significantly higher in Group 2(55.6%vs 24.1%in Group 1,P=0.002).At multivariable analysis,PV and IPSS were factors significantly associated with higher odds of transient SUI/***,surgical time,and no early apical release technique were factors associated with higher odds of persistent SUI/MUI.

关键词： benign prostatic hyperplasia en-bloc enucleation endoscopic enucleation of the prostate laser therapy stress urinaryincontinence urge urinary incontinence

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Ultra compact and high resolution spectrometer based on optical transmission through submicron interferometer array

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中国光学与应用光学 2010年第1期3卷 38-44页

作者： YAnG T LI c c ho h P Jiangsu Key Laboratory for Organic Electronics ＆ Information Displays Nanjing University of Posts and Telecommunications Nanjing（ 210000 ） China Department of Electronic Engineering Centre for Advanced Research in Photonics The Chinese University of Hong Kong Shatin N. T. Hong Kong SAR China

We present an ultra compact and high resolution free space optical spectrometer and demonstrate it by using FDTD simulations. The miniature interferometer-based spectrometer is a series of submicron phase objects on a polymethyl methacrylate(PMMA) film with a ccD as the detector. The spectrum is obtained by solving a system of simultaneous linear equations. The Tikhonov regularization method is used to achieve a resolution at the picometer level. compared with conventional spectrometers, the proposed device is low-cost and easy to fabricate due to its simple structure. Furthermore, its compact feature renders the device ideal for miniaturization and integration as the systems in microfluidics architectures and lab-on-chip designs.

关键词：光学材料高分辨率探测器光谱仪

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constructing collective Signature Schemes Using Problem of Finding Roots Modulo

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computers, Materials & continua 2022年第7期72卷 1105-1122页

作者： Tuan nguyen Kim Duy ho ngoc nikolay A.Moldovyan School of computer Science Duy Tan UniversityDa NangVietnam Department of Information Technology Ha NoiVietnam ITMO University St.PetersburgRussia

Digital signature schemes are often built based on the difficulty of the discrete logarithm problems,of the problem of factor analysis,of the problem of finding the roots modulo of large primes or a combination of the difficult problems mentioned *** this paper,we use the new difficult problem,which is to find the wth root in the finite ground field GF(p)to build representative collective signature schemes,but the chosen modulo p has a special structure distinct p=nt_(0)t_(1)t_(2)+1,where n is an even number and t_(0),t_(1),t_(2) are prime numbers of equal magnitude,about 80 *** characteristics of the proposed scheme are:i)The private key of each signer consists of 2 components(K_(1),K_(2)),randomly selected,but the public key has only one component(Y)calculated by the formula Y=K_(w)^(1)_(1) K^(w)_(2)^(2);w_(1)=t_(0)t_(1) and w_(2)=t_(0)t_(2);and ii)The generated signature consists of a set of 3 components(e,S_(1),S_(2)).We use the technique of hiding the signer’s public key Y,which is the coefficientλgenerated by the group nanager,in the process of forming the group signature and representative collective signature to enhance the privacy of all members of the signing collective.

关键词： computing roots finding roots modulo collective signature signing collective signing group

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new collective Signatures Based on the Elliptic curve Discrete Logarithm Problem

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computers, Materials & continua 2022年第10期73卷 595-610页

There have been many digital signature schemes were developed based on the discrete logarithm problem on a finite *** this study,we use the elliptic curve discrete logarithm problem to build new collective signature *** cryptosystem on elliptic curve allows to generate digital signatures with the same level of security as other cryptosystems but with smaller *** extend practical applicability and enhance the security level of the group signature protocols,we propose two new types of collective digital signature schemes based on the discrete logarithm problem on the elliptic curve:i)the collective digital signature scheme shared by several signing groups and ii)the collective digital signature scheme shared by several signing groups and several individual *** two new types of collective signatures have combined the advantages of group digital signatures and collective digital *** signatures have a fixed size and do not depend on the number of members participating in the creation of the final collective *** of the advantages of the proposed collective signature protocols is that they can be deployed on top of the available public key infrastructures.

关键词： Elliptic curve signing group individual signer collective signature group signature

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Polygonal Finite Element for Two-Dimensional Lid-Driven cavity Flow

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computers, Materials & continua 2022年第3期70卷 4217-4239页

作者： T.Vu-huu c.Le-Thanh h.nguyen-Xuan M.Abdel-Wahab Faculty of civil Engineering Vietnam Maritime University484 Lach Tray Str.Hai PhongVietnam Faculty of civil Engineering and Electricity Ho Chi Minh City Open UniversityVietnam cIRTech Institute Ho ChiMinh City University of Technology(HUTECH)Ho Chi Minh CityVietnam Department of Architectural Engineering Sejong University209 NeungdongroGwangjinguSeoul05006Republic of Korea Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde903B-9052ZwijnaardeBelgium

This paper investigates a polygonal finite element(PFE)to solve a two-dimensional(2D)incompressible steady fluid problem in a cavity *** is a well-known standard benchmark(i.e.,lid-driven cavity flow)-to evaluate the numerical methods in solving fluid problems controlled by the navier-Stokes(n-S)equation *** approximation solutions provided in this research are based on our developed equal-order mixed PFE,called *** is an exciting development based on constructing the mixed scheme method of two equal-order discretisation spaces for both fluid pressure and velocity fields of flows and our proposed stabilisation *** this research,to handle the nonlinear problem of n-S,the Picard iteration scheme is *** proposed method’s performance and convergence are validated by several simulations coded by commercial software,i.e.,*** this research,the benchmark is executed with variousReynolds numbers up to the maximum Re=*** results then numerously compared to available sources in the literature.

关键词： Lid-driven cavity incompressible steady navier-Stokes equations polygonal finite element method

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Interactive effect of dietary vitamin E and inorganic mercury on growth performance and bioaccumulation of mercury in juvenile olive flounder, Paralichthys olivaceus treated with mercuric chloride

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Animal nutrition 2017年第3期3卷 276-283页

作者： Mohammad Moniruzzaman Jun-ho Lee Jin-hyeok Lee Seonghun Won Jim h.Damusaru Sungchul c.Bai Department of Marine Bio-materials and Aquaculture Feeds & Foods Nutrition Research CenterPukyong National University

A 6-week feeding trial was carried out to evaluate the effects of dietary vitamin E(DL-a-tocopheryl acetate, TA) on growth and mercury(hg) accumulation in juvenile olive flounder(Paralichthys olivaceus)treated with mercuric chloride(hgcl_2). Vitamin E and hgcl_2 were added to the semi-purified basal *** semi-purified diets in a 2 × 3 factorial design were formulated to contain 2 levels of hg(0 or 20 mg hgcl_2/kg diet) and 3 levels of vitamin E(0, 100, or 200 mg TA/kg diet). Experimental fish(n = 360,9.99 ± 0.15 g) were randomly allocated into 30-L tanks at a density of 20 fish per tank with 3 replicates in each treatment and were fed twice a day. At the end of the feeding trial, dietary hg depressed the growth performances in terms of weight gain(WG), specific growth rate(SGR), feed efficiency(FE) and protein efficiency ratio(PER) in fish, while fish fed the diets supplemented with vitamin E showed significant growth improvement in both presence and absence of hgcl_2 in the diets(P not affected in fish fed the experimental diets. Whole body compositions of fish such as lipid and moisture contents were influenced by dietary vitamin E supplementation. Total hg contents of muscle, liver and kidney tissues were significantly reduced in fish fed diets supplemented with vitamin E(Phile the two-way AnOVA showed that increasing hg concentration has resulted in a reduction in vitamin *** body fatty acids of fish like eicosapentaenoic acid(EPA) and docosahexaenoic acid(DhA) contents were decreased by dietary hg. however, supplementation of dietary vitamin E improved the a-linolenic acid(ALA) and EPA contents in fish. Our results suggest that dietary supplementation of vitamin E has potential effects on growth improvement and ameliorating inorganic hg bioaccumulation in juvenile olive flounder.

关键词： Vitamin E Mercury Growth Bioaccumulation Olive flounder

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