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Friction 2021年第1期9卷 191-200页

作者： Gabriele RIVA Francesco VARRIALE jens WAHLSTRÖM Brembo S.p.A. Stezzano(BG)Stezzano(BG)24040Italy KTH Royal Institute of Technology Stockholm 11428Sweden Department of Mechanical Engineering Lund UniversityLund 22100Sweden

The coefficient of friction(COF)is one of the most important parameters to evaluate the performance of a brake *** design proper brake systems,it is important to know the COF when estimating the brake force and resulting *** is challenging to simulate the COF since friction in disc brakes is a complex phenomenon that depends on several parameters such as sliding velocity,contact pressure,materials,and temperatures,*** is a lack of studies found in the literature focusing on simulation of the COF for a full brake system based on tribometer material *** aim of this work is therefore to investigate the possibility to use a finite element analysis(FEA)approach combined with a COF pv-map to compute the global COF of a disc brake *** local COF is determined from a pv-map for each local sliding velocity and contact pressure determined by the *** the local COF,the braking force of the entire brake system and the global COF can be *** obtained by the simulation are compared with dyno bench test of the same brake system to investigate the validity of the simulation *** show that the simulation is perfectly in line with the experimental measurements in terms of in-stop COF development,but slightly higher with a positive offset for every braking.

关键词： disc brakes friction coefficient simulation brake performance pin-on-disc

Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4151-4153页

作者： Andreas krämer Stefan Knapp Institute of Pharmaceutical Chemistry Goethe University FrankfurtMax-von-Laue-Str.960438Frankfurt am MainGermany Structural Genomics Consortium Buchmann Institute for Molecular Life SciencesGoethe-University FrankfurtMax-von-Laue-Str.1560438Frankfurt am MainGermany german Cancer Consortium(DKTK) German Cancer Research Center(DKFZ)DTKT Site Frankfurt-Mainz69120HeidelbergGermany

A recent study published in Nature by Radko-Juettner and colleagues reports an unexpected mutant-specific synthetic lethality in which the E3 protein ubiquitin ligase DCAF5 specifically degrades mutant but not wild-type SWI/SNF chromatin remodeling complexes.1 DCAF5 contains a likely druggable WDR domain,providing a new avenue for the development of novel therapeutics for aggressive cancers with SMARCB1 loss of function mutations.

关键词： tumour likely complexes

Model Experiments on Melting of Alloys with Low Melting Temperature in a Medium with High Melting Temperature

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Journal of Iron and Steel Research International 1999年第2期6卷 1-9页

作者： Becker jens-Ulrik Oeters Franz Thyssen-krupp Stahl GmbH Technical University Berlin

Experiments of alloy melting were carried out in water/HCl H 2O eutectic model system. The eutectic has a solid liquid equilibrium temperature of -74 ℃. 5 cm diameter spheres of the eutectic in which three thermocouples in the core, on the edge and in the middle between them had been positioned were cooled to -196 ℃ in liquid nitrogen. After cooling the spheres were immersed into water of 10 ℃, and the changes of temperatures with time in the three thermocouples were measured. In some experiments the temperature on the outer side of the spheres where an ice shell grew up was also measured. In these experiments, the growing rate of the shell was additionally determined. The results for the first minute of the melting process, where the system can be considered as one dimensional, were described by an exact solution of Fouriers equation. The density of liquid ferromanganese at 1 500 ℃ was measured.

关键词： alloy melting model experiment

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An Effective Feature Generation and Selection Approach for Lymph Disease Recognition

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Computer Modeling in Engineering & Sciences 2021年第11期129卷 567-594页

作者： Sunil kr.Jha Zulfiqar Ahmad School of Computer and Software Nanjing University of Information Science and TechnologyNanjing210044China Institute of Hydrobiology Chinese Academy of SciencesWuhan430072China

Health care data mining is noteworthy in disease diagnosis and recognition *** exist several potentials to further improve the performance of machine learning based-classification methods in healthcare data *** selection of a substantial subset of features is one of the feasible approaches to achieve improved recognition results of classification methods in disease diagnosis *** the present study,a novel combined approach of feature generation using latent semantic analysis(LSA)and selection using ranker search(RAS)has been proposed to improve the performance of classification methods in lymph disease diagnosis *** performance of the proposed combined approach(LSA-RAS)for feature generation and selection is validated using three function-based and two tree-based classification *** performance of the LSA-RAS selected features is compared with the original attributes and other subsets of attributes and features chosen by nine different attributes and features selection approaches in the analysis of a most widely used benchmark and open access lymph disease *** LSA-RAS selected features improve the recognition accuracy of the classification methods significantly in the diagnosis prediction of the lymph *** tree-based classification methods have better recognition accuracy than the function-based classification *** best performance(recognition accuracy of 93.91%)is achieved for the logistic model tree(LMT)classification method using the feature subset generated by the proposed combined approach(LSA-RAS).

关键词： Disease data mining feature selection classification lymph diagnosis

Proposition of atomic and close-to-atomic scale manufacturing

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Advances in Manufacturing 2024年第1期12卷 1-5页

作者： Ju‑Fan Zhang jens Ducree School of Mechanical and Materials Engineering University College DublinDublin 4Ireland School of Physical Sciences Dublin City UniversityDublinIreland

Atomic and close-to-atomic scale manufacturing(ACSM)is the core competence of Manufacturing *** other conceptions or terminologies that only focus on the atomic level precision,ACSM defnes a new realm of manufacturing where quantum mechanics plays the dominant role in the atom/molecule addition,migration and removal,considering the uncertainty principle and the discrete nature of *** ACSM is still in its infant stage,only little has been systematically elaborated at the core proposition of ACSM by now,hence there is a need to understand its concept and *** article elucidates the development of ACSM and clarifes its proposition,which aims to achieve a clearer understanding on ACSM and direct more efective eforts toward this promising area.

关键词： Atomic and close-to-atomic scale manufacturing(ACSM) Atomic Precision Manufacturing Paradigm Manufacturing III

Soil Microbial Dynamics Modeling in Fluctuating Ecological Situations by Using Subtractive Clustering and Fuzzy Rule-Based Inference Systems

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Computer Modeling in Engineering & Sciences 2017年第4期113卷 443-459页

作者： Sunil kr.Jha Zulfiqar Ahmad School of Computer and Software Nanjing University of Information Science and TechnologyNanjing 210044China Department of Environmental Sciences University of CaliforniaRiversideCA 92521USA

Microbial population and enzyme activities are the significant indicators of soil *** microbial dynamics characterize microbial population and enzyme *** present study explores the development of efficient predictive modeling systems for the estimation of specific soil microbial dynamics,like rock phosphate solubilization,bacterial population,and ACC-deaminase *** specifically,optimized subtractive clustering(SC)and Wang and Mendel's(WM)fuzzy inference systems(FIS)have been implemented with the objective to achieve the best estimation accuracy of microbial *** measurements were performed using controlled pot experiment using minimal salt media with rock phosphate as sole carbon source inoculated with phosphate solubilizing microorganism in order to estimate rock phosphate solubilization potential of selected *** experimental parameters,including temperature,pH,and incubation period have been used as inputs SC-FIS and *** better performance of the SC-FIS has been observed as compared to the WM-FIS in the estimation of phosphate solubilization and bacterial population with the maximum value of the coefficient of determination(0.9988)2 R=in the estimation of previous microbial dynamics.

关键词： Phosphate solubilizing bacteria bacterial population ACC-deaminase activity subtractive clustering fuzzy rule-based prediction system

南非克留格尔国家公园马羚的种群下降:一个备择假说(英文)

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动物学报 2006年第2期52卷 406-409页

作者： R. krger K. H. ROgerS School of Ani mal Plant and Environmental Science University of the Witwatersrand JohannesburgSouth Africa

本研究报道了1979年以来南非克留格尔国家公园暂时性沼泽边界对马羚( Hippotragus equinus equinus)种群下降的影响。干旱和由此导致的生境退化以及随之产生的食草动物之间的采食竞争是解释马羚种群数量下降的可能假说。我们认为,确定... 详细信息

本研究报道了1979年以来南非克留格尔国家公园暂时性沼泽边界对马羚( Hippotragus equinus equinus)种群下降的影响。干旱和由此导致的生境退化以及随之产生的食草动物之间的采食竞争是解释马羚种群数量下降的可能假说。我们认为,确定马羚的生境斑块选择并测定影响暂时性沼泽边界变化与马羚种群下降的关联性因子,可解释马羚种群下降的备择假说。在北部平原区,边界呈斑块状分布的沼泽是马羚的高矿质采食源。实施狩猎管理工程期间,人工做成的大多数水道分布于沼泽边界及其附近,造成马羚与其它食草动物的采食竞争和天敌捕食压力的增高。旱季降雨的缺乏,加上沼泽边界区域采食竞争以及天敌捕食压力,是引发马羚在北部平原生境普遍退化之前其种群提前下降的因素[动物学报52 (2) : 406 -409 , 2006]。

关键词：马羚沼泽边界生境退化

Artificial sweetener sucralose: a possible modulator of autoimmune diseases

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5123-5125页

作者： Nicolle kränkel Ursula Rauch-kroehnert Deutsches Herzzentrum der Charité Klinik für KardiologieAngiologie und IntensivmedizinCampus Benjamin-Franklin(CBF)12203BerlinGermany DZHK(german Centre for Cardiovascular Research) Partner site BerlinBerlinGermany Friede Springer—Centre of Cardiovascular Prevention@Charité Charité—University Medicine BerlinBerlinGermany

In their research article in Nature in March 2023,Fabio Zani and colleagues reported that high concentrations of the zero-calorie artificial sweetener sucralose affected the proliferation and differentiation of T cells toward interferon-γ-producing subsets,with no effect observed for B cells and myeloid cells.1 The publication has raised high hopes in the lay press on a widely available cure for patients suffering from autoimmune diseases.

关键词： autoimmune interferon diseases

Liver cirrhosis and arterial hypertension

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World Journal of Gastroenterology 2006年第5期12卷 678-685页

作者： jens H Henriksen Soren Moller Department of Clinical Physiology 239University of CopenhagenH:S Hvidovre HospitalCopenhagenDenmark

Characteristic findings in patients with cirrhosis are vasodilatation with low overall systemic vascular resistance, high arterial compliance, increased cardiac output, secondary activation of counter-regulatory systems （renin-angiotensin-aldosterone system, sympathetic nervous system, release of vasopressin）, and resistance to vasopressors. The vasodilatory state is mediated through adrenomedullin, calcitonin generelated peptide, nitric oxide, and other vasodilators, and is most pronounced in the splanchnic area. This constitutes an effective （although relative） counterbalance to increased arterial blood pressure. This review considers the alterations in systemic hemodynamics in patients with cirrhosis in relation to essential hypertension and arterial hypertension of the renal origin. Subjects with arterial hypertension （essential, secondary） may become normotensive during the development of cirrhosis, and arterial hypertension is rarely manifested in patients with cirrhosis, even in cases with renovascular disease and high circulating renin activity. There is much dispute as to the understanding of homoeostatic regulation in cirrhotic patients with manifest arterial hypertension. This most likely includes the combination of vasodilatation and vasoconstriction in parallel.

关键词： Arterial compliance Central vascular filling Chyperdynamic circulation Kidney function, Nitric oxide Blood pressure regulation Renin-angiotensin-aldosterone system Sympathetic nervous system Vasodilatation Vasoconstriction

Resolvent Estimates and Quantification of Nonlinear Stability

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Acta Mathematica Sinica,English Series 2000年第1期16卷 1-20页

作者： Heinz-Otto kreiss jens Lorenz Department of Mathematics UCLALos AngelesCA 90095USA Department of Mathematics and Statistics UNMAlbuquerqueNM 87131USA

The aim of this paper is to clarify the role played by resolvent estimates for nonlinear *** will give examples showing that a large resolvent may lead to a small domain of nonlinear *** other examples the resolvent is large,but the domain of nonlinear stability is completely *** case prevails depends on the details of the problem. We will also show that the size of the resolvent depends in an essential way on the norms that are used.

关键词： Resolvent estimates Nonlinear stability Pseudospectrum Convection-dominated flow