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Magnetic resonance angiography for the primary diagnosis of pulmonary embolism: A review from the international workshop for pulmonary functional imaging

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World Journal of Radiology 2018年第6期10卷 52-64页

作者： Nanae Tsuchiya Edwin JR van Beek Yoshiharu Ohno Hiroto Hatabu Hans-Ulrich Kauczor Andrew Swift jens vogel-claussen Jürgen Biederer James Wild Mark O Wielpütz Mark L Schiebler Department of Radiology Graduate School of Medical Science University of the Ryukyus Department of Radiology University of Wisconsin-Madison Edinburgh Imaging Queen’s Medical Research Institute University of Edinburgh Division of Functional and Diagnostic Imaging Research Department of Radiology Kobe University Graduate School of Medicine Department of Radiology Brigham and Women’s Hospital Department of Diagnostic and Interventional Radiology University Hospital of Heidelberg Department of Radiology Royal Hallamshire Hospital University of Sheffield Department of Radiology Carl-Neuberg Strasse 1 Radiology Darmstadt Gross-Gerau County Hospital Department of Infection Immunity and Cardiovascular Disease University of Sheffield

Pulmonary contrast enhanced magnetic resonance angiography(CE-MRA) is useful for the primary diagnosis of pulmonary embolism(PE). Many sites have chosen not to use CE-MRA as a first line of diagnostic tool for PE because of the speed and higher efficacy of computerized tomographic angiography(CTA). In this review, we discuss the strengths and weaknesses of CEMRA and the appropriate imaging scenarios for the primary diagnosis of PE derived from our unique multiinstitutional experience in this area. The optimal patient for this test has a low to intermediate suspicion for PE based on clinical decision rules. Patients in extremis are not candidates for this test. Younger women(< 35 years of age) and patients with iodinated contrast allergies are best served by using this modality We discuss the history of the use of this test, recent technical innovations, artifacts, direct and indirect findings for PE, ancillary findings, and the effectiveness(patient outcomes) of CE-MRA for the exclusion of PE. Current outcomes data shows that CE-MRA and NM V/Q scans are effective alternative tests to CTA for the primary diagnosis of PE.

关键词： Female Lung Neoplasms Hypersensitivity Pulmonary embolism Magnetic resonance angiography Radiation induced Outcome assessment(health care) Artifacts Computerized tomography angiography

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Impact of the spindle number on the material transport and mixing during planetary roller melt granulation Author links open overlay panel

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Particuology 2024年第8期91卷 260-267页

作者： Tom Lang jens Bartsch Laboratory of Solids Process Engineering Department of Biochemical and Chemical EngineeringTU Dortmund University44227DortmundGermany

In comparison to the established twin-screw machines,the application of a planetary roller granulator for continuous operation of melt granulation is a promising alternative based on the unique process *** initial study focused on the material transport during processing as a key driver for the overall ***,the impact of direct process parameters on the residence time distribution was the main *** investigations are complemented in this study by considering the free processing volume,which is defined by the number of planetary spindles applied within a *** impact on the processing conditions is evaluated with respect to the process setting in terms of feed rate and rotation *** results highlight the potential of altering the underlying transport function in planetary roller melt granulation(PRMG)via the investigated direct process and equipment *** impact of the feed rate is lower in comparison,while a higher rotation speed as well as a higher free processing volume promote material ***,a normalization of the determined residence time distribution(RTD)model data was feasible with respect to the process settings and the number of applied planetary spindles in the processing *** demonstrates the key role of the free processing volume in the fundamental mechanisms of material transport and mixing during PRMG.

关键词： Continuous manufacturing Melt granulation Planetaryroller granulator Quality-by-Design Residence time Material mixing

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Proposition of atomic and close-to-atomic scale manufacturing

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Advances in Manufacturing 2024年第1期12卷 1-5页

作者： Ju‑Fan Zhang jens Ducree School of Mechanical and Materials Engineering University College DublinDublin 4Ireland School of Physical Sciences Dublin City UniversityDublinIreland

Atomic and close-to-atomic scale manufacturing(ACSM)is the core competence of Manufacturing *** other conceptions or terminologies that only focus on the atomic level precision,ACSM defnes a new realm of manufacturing where quantum mechanics plays the dominant role in the atom/molecule addition,migration and removal,considering the uncertainty principle and the discrete nature of *** ACSM is still in its infant stage,only little has been systematically elaborated at the core proposition of ACSM by now,hence there is a need to understand its concept and *** article elucidates the development of ACSM and clarifes its proposition,which aims to achieve a clearer understanding on ACSM and direct more efective eforts toward this promising area.

关键词： Atomic and close-to-atomic scale manufacturing(ACSM) Atomic Precision Manufacturing Paradigm Manufacturing III

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Feeding the vasculature with cruciferous vegetables:a secret for organ protection

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Signal Transduction and Targeted Therapy 2024年第3期9卷 828-830页

作者： Priya Veluswamy jens Wippermann Max Wacker Heart Surgery Research Department of Cardiothoracic SurgeryOtto-von-Guericke University HospitalMagdeburgGermany

Two very recent back-to-back papers published in Nature1,2 decipher the holistic role of the aryl hydrocarbon receptor(AHR)/dietary-ligand axis,in enteric and pulmonary vasculature to emphasize tolerance induction and vessel integrity during homeostasis,sterile inflammation and *** studies spectacularly highlight the significance of endothelium in orchestrating tissue tolerance by demonstrating the multifaceted activities of endothelial-expressed AHR that protects the vasculature to maintain organ homeostasis.

关键词： maintain sterile homeostasis

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Developing fertility control for rodents: a framework for researchers and practitioners

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Integrative Zoology 2024年第1期19卷 87-107页

作者： Giovanna MASSEI jens JACOB Lyn A.HINDS Botstiber Institute for Wildlife Fertility Control Department of Environment and GeographyUniversity of YorkHeslingtonYorkUK Rodent Research Institute for Epidemiology and Pathogen DiagnosticsJulius Kühn–Institute(JKI)Federal Research Institute for Cultivated PlantsMünsterGermany CSIRO Health and Biosecurity CanberraACTAustralia

Fertility control is often heralded as a humane and effective technique for management of overabundant wildlife,including *** intention is to reduce the use of lethal and inhumane methods,increase farm productivity and food security as well as reduce disease transmission,particularly of *** developed a framework to guide researchers and stakeholders planning to assess the effectiveness of a potential contraceptive agent for a particular *** guidelines describe the overarching research questions which must be sequentially addressed to ensure adequate data are collected so that a contraceptive can be registered for use in broad-scale rodent *** framework indicates that studies should be undertaken iteratively and,at times,in parallel,with initial research being conducted on(1)laboratory-based captive assessments of contraceptive effects in individuals;(2)simulation of contraceptive delivery using bait markers and/or surgical sterilization of different proportions of afield-based or enclosure population to determine how population dynamics are affected;(3)development of mathematical models which predict the outcomes of different fertility control scenarios;and(4)implementation of large-scale,replicated trials to validate contraceptive efficacy under various management-scalefield *** some circumstances,fertility control may be most effective when integrated with other methods(*** culling).Assessment of non-target effects,direct and indirect,and the environmental fate of the contraceptive must also be *** fertility control for a species is a resource-intensive commitment but will likely be less costly than the ongoing environmental and economic impacts by rodents and rodenticides in many contexts.

关键词： captive studies field applications modeling oral contraceptive delivery population management rodents

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Pin-on-disc tribological characterization of single ingredients used in a brake pad friction material

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Friction 2024年第11期12卷 2576-2593页

作者： Davide CARLEVARIS Francesco VARRIALE jens WAHLSTRÖM Cinzia MENAPACE Department of Industrial Engineering University of TrentoTrento 38123Italy Brembo S.p.A StezzanoBergamo 24040Italy Department of Mechanical Engineering Sciences Lund UniversityLund 22100Sweden

Researchers have long been studying the effects of the modification of friction material compositions on their tribological *** models have also been developed,but they are of limited use in the design of new ***,this research aims to investigate the tribological behaviour of single ingredients in friction materials to develop a tribological *** dataset could then be used as a foundation for a cellular automaton(CA)predictive model,intended to be a tool for designing friction *** samples were almost entirely composed of four distinct friction material ingredients,and one sample composed of their mixture was successfully ***-on-disc(PoD)tribometer testing and scanning electron microscopy/energy-dispersive X-ray spectroscopy(SEM/EDXS)analysis were used for the tribological *** material showed distinct tribological properties and evolution of the contact surface features,and the synergistic effect of their mutual interaction was also demonstrated by their mixture.

关键词： disc brakes sliding contact wear behaviour scanning electron microscopy(SEM) modelling

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Semi-analytical calculation model for friction of polymers on the example of POM|PE-UHMW and steel|PE-UHMW

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Friction 2024年第10期12卷 2355-2369页

作者： André BERGMANN jens SUMPF Niels DALLINGER Martin MONEKE Markus GOLDER Professorship of Conveying Engineering and Materials Handling Chemnitz University of TechnologySachsen 09126Germany Institute of Plastics Engineering Darmstadt University of Applied SciencesDarmstadt 64295Germany

In this paper,a semi-analytical calculation model for the coefficient of friction(COF)of single spherical protrusions is *** allows the prediction of the deformative friction part(μ_(def))and adhesive friction part(μ_(def))of the friction pairings steel|polyethylene with ultra-high molecular weight(PE-UHMW)and polyoxymethylene(POM)|*** experimental studies included unlubricated friction tests,which served to determine the total COF(μ_(def)),as well as tests being lubricated with silicone oil,from whichμ_(def)is *** on the verification tests,it could be shown that both states of lubrication result in the same deformation and that the relationship between the rear angle(w)andμ_(def)postulated in the calculation model is ***,friction tests with segmented spheres were carried out,which allow a specific variation of *** can be concluded that for both pairings theμ_(def)is generally of minor significance(approx.1/3μ_(tot))and the influence of theμ_(adh)predominates(approx.2/3μ_(tot))the friction *** themtot decreases with increasing contact pressure especially in the low pressure range and depends on the form of motion(continuous and discontinuous).

关键词： tribology friction polymers model contact polyoxymethylene(POM) polyethylene with ultra-high molecular weight(PE-UHMW)

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Wear dependent virtual flow rate sensor for progressing cavity pumps with deformable stator

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Petroleum Science 2024年第2期21卷 1346-1353页

作者： jens Müller Sebastian Leonow Johannes Schulz Christian Hansen Martin Monnigmann Ruhr-Universitat Bochum Universit atsstraûe 150Bochum44801Germany SEEPEX GmbH Scharnh olzstraûe 344Bottrop46240Germany

This contribution presents a novel wear dependent virtual flow rate sensor for single stage single lobe progressing cavity pumps. We study the wear-induced material loss of the pump components and the impact of this material loss on the volumetric efficiency. The results are combined with an established backflow model to implement a backflow calculation procedure that is adaptive to wear. We use a laboratory test setup with a highly abrasive fluid and operate a pump from new to worn condition to validate our approach. The obtained measurement data show that the presented virtual sensor is capable of calculating the flow rate of a pump being subject to wear during its regular operation.

关键词： Backflow Progressing cavity pump Virtual sensor Wear

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Advanced brain organoids for neuroinflammation disease modeling

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Neural Regeneration Research 2024年第1期19卷 154-155页

作者： Sonia Sabate-Soler Henry Kurniawan jens Christian Schwamborn Luxembourg Centre for Systems Biomedicine University of LuxembourgEsch-sur-AlzetteLuxembourg

Brain organoids mimic closely the embryonic human brain:Over the last decade,the development of human organoid systems has evolved *** tissues have been modeled with organoids,such as the gut,lung,liver,kidney retina and *** systems have a high cellular heterogeneity,with many cell types integrated into the same ***'cellular populations interact between and amongst each other in a cellular and molecular level,which represents an advantage with respects to monolayer 2D cell culture systems.

关键词： inflammation lung kidney

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Assistive techniques and their added value for tremor classification in multiple sclerosis

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Neural Regeneration Research 2024年第5期19卷 977-978页

作者： Nabin Koirala Abdulnasir Hossen Ioannis U.Isaias jens Volkmann Muthuraman Muthuraman Child Study Center School of MedicineYale UniversityNew HavenCTUSA Department of Electrical&Computer Engineering Sultan Qaboos UniversityAl-KhodMuscatOman Neural Engineering with Signal Analytics and Artificial Intelligence Department of NeurologyUniversity Hospital of WürzburgWürzburgGermany Centro Parkinson e Parkinsonism Azienda Socio Sanitaria Territoriale G.Pini-CTO20126 MilanItaly

Tremor occurs in about half of multiple sclerosis(MS)*** tremor has a broad frequency range of 2.5-7 Hz,with a higher prevalence of postural tremor(44%)compared to intentional tremor(6%)(Alusi et al.,2001).Tremor may affect the upper and lower extremities,head,and trunk,and may even affect the vocal cords in isolated cases of palatal *** tremor is classically attributed to lesions of the brain stem,cerebellum,or cerebellar peduncles,and tremor intensity has been shown to correlate with the number of lesions or their functional ***,recent work has demonstrated that inflammatory damage to the cerebello-thalamic and cortico-thalamic pathways might also play an important role in causing tremor,as it co-occurs with other signs and symptoms of MS such as dysarthria,dysmetria,dysdiadochokinesia,and dystonia(Alusi et al.,2001).

关键词： tremor sclerosis

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