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Is it possible to use the HCR-20 V2 to assess the risk of violent recidivism of French offenders?

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Forensic Sciences Research 2022年第3期7卷 402-411页

作者： Ingrid Bertsch Robert Courtois Elodie Gallard christian Réveillère Thierry H.Pham Department of Psychology EE 1901 Qualipsy(Qualitéde vie et santépsychologique)University of ToursToursFrance Centre Ressource pour les Intervenants auprès des Auteurs de Violences Sexuelles Centre Val-de-Loire CHRU de ToursToursFrance Centre de Recherche en Défense Sociale CRDSTournaiBelgium Detention Center of Mauzac Mauzac-et-Grand-CastangFrance Department of Forensic Psychology University of Mons-HainautMonsBelgium

The Historical-Clinical-Risk Management Scale 20(HCR-20)is a structured tool to assess the risk of violence and assist in its *** professionals are reluctant to use it because only a few studies have shown its psychometric qualities with French *** objective of this study is to test the psychometric qualities of the HCR-20 with samples of violent detainees in *** HCR-20 and Level of Service/Case Management Inventory(LS/CMI)were administered to 128 violent offenders with an average age of(44.16±12.30)*** evaluated the reliability,internal consistency and validity of the HCR-20 and conducted an exploratory factor *** results show that the HCR-20 has good psychometric qualities with a sample of French *** the Risk domain presents weak results due to the data collection locations and the participants’*** were observed between certain *** exploratory factor analysis shows four factors explaining 44%of the *** continuation of this work will enable French professionals to use sound tools to assess the risk of recidivism.

关键词： HCR-20 assessment recidivism risk violence

Genetic vaccination with Flt3-L and GM-CSF as adjuvants: enhancement of cellular and humoral mmune responses that results in protective immunity in a murine model of hepatitis C virus infection

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World Journal of Gastroenterology 2006年第44期12卷 7118-7125页

作者： jens encke Jomo Bernardin Jasmin Geib Gocha Barbakadze Raymond Bujdoso Wolfgang Stremmel Department of InternalMedicine IV University of Heidelberg Im Neuenheimer Feld410 69120 Heidelberg Germany Department of Immunology University of Heidelberg Im Neuenheimer Feld 305 69120 Heidelberg Germany Department of InternalMedicine IV University of Heidelberg Im Neuenheimer Feld410 69120 Heidelberg Germany Department of Clinical Veterinary Medicine University of Cambridge Madingley Road Cambridge CB3 OES United Kingdom

AIM： To investigate whether transfection of plasmid DNA encoding these cytokines enhances both humoral and cellular immune responses to hepatitis C virus （HCV） in a murine model. METHODS： We established a tumor model of HCV infection using syngenic mouse myeloma cells stably transfected with NS5. Co-vaccination of DNA encoding granulocyte macrophage colony-stimulating factor （GM- CSF） and Flt-3 ligand together with a plasmid encoding for the HCV NS5 protein was carried out. Mice were sacrificed 14 d after the last immunization event with collection of spleen cells and serum to determine humoral and cellular immune responses. RESULTS： Co-vaccination of DNA encoding GM-CSF and Fit-3 ligand together with a plasmid encoding for the HCV NS5 protein induced increased antibody responses and CD4＋ T cell proliferation to this protein, Vaccination with DNA encoding GM-CSF and FIt-3L promoted protection against tumor formation and/or reduction in mice co- immunized with cytokine-encoding DNA constructs, This suggests this strategy is capable of generating cytotoxic T lymphocyte activity in vivo, Following inoculation with plasmid DNA encoding Flt-3L, no increase in spleen size or in dendritic cell （DC） and natural killer cell numbers was observed. This was in contrast to a dramatic increase of both cell types after administration of recombinant Flt3-L in vivo. This suggests that vaccination with plasmid DNA encoding cytokines that regulate DC generation and mobilization may not promote unwanted side effects, such as autoimmunity, splenic fibrosis or hematopoietic malignancies that may occur with administration of recombinant forms of these proteins. CONCLUSION： Our data support the view that plasmid DNA vaccination is a promising approach for HCV immunization, and may provide a general adjuvant vaccination strategy against malignancies and other pathogens.

关键词： DNA-vaccination Dendritic cells Flt3-L granulocyte macrophage colony-stimulating factor Hepatitis C virus

Comparative mitogenome phylogeography of two anteater genera (Tamandua and Myrmecophaga;Myrmecophagidae, Xenarthra): Evidence of discrepant evolutionary traits

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Zoological Research 2021年第5期42卷 525-547页

作者： Manuel Ruiz-García Daniel Pinilla-Beltrán Oscar E.Murillo-García christian Miguel Pinto Jorge Brito Joseph Mark Shostell Laboratorio de Genética de Poblaciones Molecular-Biología Evolutiva Departamento de BiologíaFacultad de CienciasPontificia Universidad JaverianaBogotáDC 110231Colombia Grupo de Investigación en Ecología Animal Departamento de BiologíaFacultad de Ciencias Naturales y ExactasUniversidad del ValleApartado AéreoCali 25360Colombia Instituto de Ciencias Biológicas Escuela Politécnica NacionalQuito 17012759Ecuador Instituto Nacional de Biodiversidad(INABIO) Quito 170135Ecuador Math Science and Technology DepartmentUniversity of Minnesota CrookstonCrookstonMN 56716USA

The species within Xenarthra(sloths,anteaters,and armadillos)are quintessential South American *** the three groups,Vermilingua(anteaters)contains the fewest extant and paleontological ***,we sampled and sequenced the entire mitochondrial genomes(mitogenomes)of two Tamandua species(Tamandua tetradactyla and ***)(n=74)from Central and South America,as well as Myrmecophaga tridactyla(n=41)from South *** Tamandua,we detected three different *** oldest(THI)contained many specimens with the *** morphotype(but also several with the *** morphotype)and originated in southeastern South America(currently Uruguay)before moving towards northern South America,where the THII haplogroup *** primarily contained specimens with the *** morphotype(but also several with the *** morphotype)and was distributed in Central America,Colombia,and *** and THII yielded a genetic distance of 4%.THII originated in either northern South America or“in situ”in Central America with haplogroup THIII,which consisted of~50%*** and 50%*** *** was mostly located in the same areas as THII,i.e.,Central America,Ecuador,and Colombia,though mainly in the *** three haplogroups overlapped in Colombia and ***,*** and *** were not reciprocally *** this reason,we considered that a unique species of Tamandua likely exists,i.e.,*** contrast to Tamandua,*** did not show different morphotypes throughout its geographical range in the ***,two very divergent genetic haplogroups(MHI and MHII),with a genetic distance of~10%,were *** basal haplogroup,MHI,originated in northwestern South America,whereas the more geographically derived haplogroup,MHII,overlapped with MHI,but also expanded into central and southern South ***,Tamandua migrated from south to north whereas Myrmecophaga migrated from

关键词： Anteaters Genetic diversity Mitogenomes Myrmecophaga Neotropics Phylogeography Spatial structure Tamandua

节能性与结构耐久性俱佳的新型暖边系统—Kodispace 4SG

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建设科技 2018年第17期 52-55,82页

作者： christian Scherer Ernst Semar Harald Becker Wolfgang Wittwer jens Wolthaus Thomas Scherer 李晶科梅林化工集团

本文介绍了一项创新性反应型丁基隔条技术。这项技术使采用结构装配的建筑外立面中的中空玻璃单元具备国际先进的暖边性能与优越的气密性。在极端的环境条件下,中空玻璃单元中的二道密封胶能够承受由于风荷载和极端温度而产生的高应力... 详细信息

本文介绍了一项创新性反应型丁基隔条技术。这项技术使采用结构装配的建筑外立面中的中空玻璃单元具备国际先进的暖边性能与优越的气密性。在极端的环境条件下,中空玻璃单元中的二道密封胶能够承受由于风荷载和极端温度而产生的高应力。为了适应上述应力,科技人员设计了一套反应型丁基系统,该系统融合了隔条、干燥剂与丁基密封胶的各项功能。相比于刚性隔条,这套隔条系统利用中空玻璃单元的整个内部空间来吸收由于环境应力引起的形变。该隔条与玻璃和第二道硅酮密封胶的化学粘合保证了封边条卓越的耐久性。由于在产品应用中采用电脑控制,再加上隔条的极低的渗透性,在正常大规模生产条件下,中空玻璃单元也能达到en 1279-3(气密性)标准的要求。这就使三玻两腔的中空玻璃的制作变得尤为简单,更易于制作高精度的大板结构中空玻璃,造型设计也更加自由。创新的反应型隔条系统已成为中空玻璃单元技术领域的里程碑,为建筑外立面带来了卓越的耐久性和节能效果,使建筑外立面的能源可持续性迈出了辉煌的一步。

关键词：暖边系统丁基隔条

Efficient Video Copy Detection： Sequence Matching in the H.264 Compressed Domain

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通讯和计算机（中英文版） 2011年第12期8卷 1047-1070页

作者： christian Kas Henri Nicolas Laboratoire Bordelais de Recherche en Informatique （LaBRI） University of Bordeaux 1 33405 Talence France

Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 235-243页

作者： Francisco M. Ojeda christian Miiller Daniela Bornigen David-Alexandre Tregouet Arne Schillert Matthias Heinig Tanja Zeller Renate B. Schnabel Department of General and Interventional Cardiology University Heart Center Hamburg-Eppendorf 20246 Hamburg Germany German Center for Cardiovascular Research (DZHK) Hamburg |Kiel| Luebeck Germany Sorbonne Universites University Pierre et Marie Curie Paris 06 Institut National pour la Sante et la Recherche Medicale (INSERM) Unite Mixte de Recherche en Sante (UMR_S) 1166 F-75013 Paris France Institute for Cardiometaholism and Nutrition (ICAN) F-75013 Paris France Institut fur Medizinische Biometrie und Statistik Universitat zu Lubeck Universitatsklinikum Schleswig-Holstein Campus Lubeck 23562 Lubeck Germany Institute of Computational Biology German Research Center for Environmental Health Helmholtz Zentrum Munchen 85764 Neuherberg Germany

Prognostic models based on survival data frequently make use of the Cox proportional hazards model. Developing reliable Cox models with few events relative to the number of predictors can be challenging, even in low-dimensional datasets, with a much larger number of observations than variables. In such a setting we examined the performance of methods used to estimate a Cox model, including （i） full model using all available predictors and estimated by standard techniques, （ii） backward elimination （BE）, （iii） ridge regression, （iv） least absolute shrinkage and selection operator （lasso）, and （v） elastic net. Based on a prospective cohort of patients with manifest coronary artery disease （CAD）, we performed a simulation study to compare the predictive accuracy, calibration, and discrimination of these approaches, Candidate predictors for incident cardiovascular events we used included clinical variables, biomarkers, and a selection of genetic variants associated with CAD. The penalized methods, i.e., ridge, lasso, and elastic net, showed a comparable performance, in terms of predictive accuracy, calibration, and discrimination, and outperformed BE and the full model. Excessive shrinkage was observed in some cases for the penalized methods, mostly on the simulation scenarios having the lowest ratio of a number of events to the number of variables. We conclude that in similar settings, these three penalized methods can be used interchangeably. The full model and backward elimination are not recommended in rare event scenarios.

关键词： Proportional hazards regression Penalized regression Events per variable Coronary artery disease

Machine-learned interatomic potentials by active learning:amorphous and liquid hafnium dioxide

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npj Computational Materials 2020年第1期6卷 803-810页

作者： Ganesh Sivaraman Anand Narayanan Krishnamoorthy Matthias Baur christian Holm Marius Stan Gábor Csányi Chris Benmore Álvaro Vázquez-Mayagoitia Leadership Computing Facility Argonne National LaboratoryArgonneIL 60439USA Institute for Computational Physics Universität StuttgartAllmandring 3Stuttgart 70569Germany Helmholtz-Institute Münster:Ionics in energy Storage(IEK-12) Forschungszentrum Jülich GmbHCorrensstrasse 46Münster 48149Germany Applied Materials Division Argonne National LaboratoryArgonneIL 60439USA Department of engineering University of CambridgeTrumpington StreetCambridge CB21PZUK X-ray Science Division Argonne National LaboratoryArgonneIL 60439USA Computational Science Division Argonne National LaboratoryArgonneIL 60439USA

We propose an active learning scheme for automatically sampling a minimum number of uncorrelated configurations for fitting the Gaussian Approximation Potential(GAP).Our active learning scheme consists of an unsupervised machine learning(ML)scheme coupled with a Bayesian optimization technique that evaluates the GAP *** apply this scheme to a Hafnium dioxide(HfO2)dataset generated from a“melt-quench”ab initio molecular dynamics(AIMD)*** results show that the active learning scheme,with no prior knowledge of the dataset,is able to extract a configuration that reaches the required energy fit ***,molecular dynamics(MD)simulations performed using this active learned GAP model on 6144 atom systems of amorphous and liquid state elucidate the structural properties of HfO2 with near ab initio precision and quench rates(i.e.,1.0 K/ps)not accessible via *** melt and amorphous X-ray structural factors generated from our simulation are in good agreement with *** addition,the calculated diffusion constants are in good agreement with previous ab initio studies.

关键词： amorphous dioxide scheme

Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system

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Neural Regeneration Research 2017年第8期12卷 1231-1240页

作者： Julia J.Segura-Uribe Rodolfo Pinto-Almazán Angélica Coyoy-Salgado Claudia E.Fuentes-Venado christian Guerra-Araiza Unidad de Investigacion Modica en enfermedades Neurologicas Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Mexico City Mexico Seccion de Estudios de Posgrado e Investigacion Escuela Superior de Medicina Instituto Politecnico Nacional Mexico City Mexico Unidad de Investigacion Hospital Regional de Alta Especialidad Ixtapaluca Ixtapaluca Mexico Institute for the Developing Mind Children's Hospital Los Angeles Los Angeles CA USA Department of Pediatrics Keck School of Medicine University of Southern California Los Angeles CA USA Consejo Nacional de Ciencia y Tecnologia Mexico City Mexico Clinica de Trastornos del Sueno Universidad Autonoma Metropolitana-Iztapalapa Mexico City Mexico Servicio de Medicina Fisica y Rehabilitacion Hospital General de Zona No. 197 Texcoco Mexico Unidad de Investigacion Modica en Farmacologla Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Mexico City Mexico

Estrogen receptor modulators are compounds of interest because of their estrogenic agonistic/antagonistic effects and tissue specificity. These compounds have many clinical applications, particularly for breast cancer treatment and osteoporosis in postmenopausal women, as well as for the treatment of climacteric symptoms. Similar to estrogens, neuroprotective effects of estrogen receptor modulators have been described in different models. However, the mechanisms of action of these compounds in the central nervous system have not been fully described. We conducted a systematic search to investigate the effects of estrogen receptor modulators in the central nervous system, focusing on the modulation of cytoskeletal proteins. We found that raloxifene, tamoxifen, and tibolone modulate some cytoskeletal proteins such as tau, microtuble-associated protein 1（MAP1）, MAP2, neurofilament 38（NF38） by different mechanisms of action and at different levels： neuronal microfilaments, intermediate filaments, and microtubule-associated proteins. Finally, we emphasize the importance of the study of these compounds in the treatment of neurodegenerative diseases since they present the benefits of estrogens without their side effects.

关键词： estrogen receptor modulators selective estrogen receptor modulators microtubules neurofilaments tibolone tamoxifen raloxifene

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Eclats de vert

中国与非洲（法文版） 2024年第6期16卷 32-33页

作者： DR christian SEKOMO BIRAME directeur général de l'Agence nationale de recherche et de développement industriels au Rwanda

Au fil des années,le continent africain a importédes véhicules d'occasionàessence et au diesel,souventâgés de plus de 10 *** véhiculesémettent du dioxyde de carbone,un gazàeffet de serre(GES)majeur responsable du changement *** Rwanda,le transport routier represente 13% desémissions de GES du pays,selon I'Autoritéde gestion environnementale du *** tant que continent en développement,I'Afrique continue de polluer l'air,en partie à cause de l'importation de voitures d'occasion en provenance des pays développés.

关键词： des continent les