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Safety Impact of Average Speed Control in the UK

Journal of Transportation Technologies 2016年第5期6卷 312-326页

作者： Harry Lahrmann Bo Brassøe Jonas Wibert Johansen jens christia. overgaard ma.sen Traffic Research Group Department of Civil Engineering Aalborg University Aalborg Denmark Ramboll Aarhus Denmark

There is considerable safety potential in ensuring that motorists respect the speed limits. High speeds increase the number and severity of accidents. Technological development over the last 20 years has enabled the development of systems that allow automatic speed control. The first generation of automatic speed control was point-based, but in recent years a potentially more effective alternative automatic speed control method has been introduced. This method is based upon records of drivers’ average travel speed over selected sections of the road and is normally called average speed control or section control. This article discusses the different methods for automatic speed control and presents an evaluation of the safety effects of average speed control, documented through changes in speed levels and accidents before and after the implementation of average speed control at selected sites in the UK. The study demonstrates that the introduction of average speed control results in statistically significant and substantial reductions both in speed and in number of accidents. The evaluation indicates that average speed control has a higher safety effect than point-based automatic speed control.

关键词： Average Speed Control Fixed Speed Cameras Automatic Speed Control Safety Effect UK

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A proteomic analysis of the effect of radiation therapy on wound healing in women reconstructed with the TRAM flap

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Advances in Bioscience and Biotechnology 2013年第11期4卷 1007-1012页

作者： Bekka O. Christensen jens overgaard Henrik Vorum Bent Honore Tine E. Damsgaard 1Department of Plastic Surgery Aarhus University Hospital Aarhus Denmark Department of Experimental Clinical Oncology Aarhus University Hos-pital Aarhus Denmark Department of Medical Biochemistry University of Aarhus Aarhus Denmark Department of Ophthalmology Aalborg University Hospital Aalborg Denmark Department of Plastic Surgery Aarhus University Hospital Aarhus Denmark 2Department of Experimental Clinical Oncology Aarhus University Hos-pital Aarhus Denmark

The incidence of breast cancer is still increasing, and with improved cancer treatment, more women live longer with the side effects of their treatment. The response of normal tissue to radiation continues for years after the treatment is completed. The influence of radiotherapy on the outcome of breast reconstructtive surgery remains unpredictable. The combination of two surgical sites of which one is previously irradiated, is rarely encountered in humans and thus compiles a unique opportunity to study the implications of irradiation followed by surgery. The aim of this study was to examine the long-term effect of radiation therapy on the proteins expressed in the wound tissue after a breast reconstruction. Ten patients were included in the study, all treated with radiotherapy after a mastectomy and breast reconstruction with a contralateral pedicled TRAM flap. Expanded poly-tetrafluoretylene polymer tubes were implanted for 10 days, subcutaneously, below the inframammary fold and below the donor site. The protein from the newly synthesized granulation tissue in the tubes was extracted and analyzed for differences in protein expression with 2D gel electrophoresis and mass spectrometry. A total of 676 proteins were detected;of these, 4 proteins changed significantly and were successfully identified. TPM4 and APOA4 from the radiation treated tissue were shown to be significantly decreased, whereas IGKC and VDAC1 were found to be significantly increased. The proteomic technique combined with the ePTFE tube wound model can elucidate some of the molecular alterations in the wound healing induced by radiation therapy. The protein modifications of TPM4, APOA4, IGKC and VDAC1 may influence the cell proliferation, apoptosis and the inflammation of the tissue repair process.

关键词： TRAM Flap Radiation Therapy Reconstructive Surgery Human Proteomics TPM VDAC APOA4

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放射、高温和MISO联合应用的交互作用

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中华放射肿瘤学杂志 1988年第4期 36-40页

作者：毛慧生,jens overgaard 天津肿瘤研究所丹麦肿瘤研究所

肿瘤组织内乏氧细胞的存在已被视为造成某些肿瘤放射治疗失败的主要原因。克服这些问题的途径包括使用乏氧细胞放射增敏剂及高温。而近年来,在动物实验中,人们更感兴趣的是将放射、加温和MISO三者合并使用(1～4,9)。但迄今,三者联合治... 详细信息

肿瘤组织内乏氧细胞的存在已被视为造成某些肿瘤放射治疗失败的主要原因。克服这些问题的途径包括使用乏氧细胞放射增敏剂及高温。而近年来,在动物实验中,人们更感兴趣的是将放射、加温和MISO三者合并使用(1～4,9)。但迄今,三者联合治疗的相互作用尚欠详尽的研究,尤其对于不引起正常组织明显损伤的治疗温度(41.5℃)及临床易于采用的治疗间隔(照射后30分钟

关键词：肿瘤组织联合应用放射增敏照射剂量治疗温度乏氧细胞 MISO 交互作用

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