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Pathogen-associated T follicular helper cell plasticity is critical in anti-viral immunity

Science China(Life Sciences) 2022年第6期65卷 1075-1090页

作者： Han Feng Xiaohong Zhao jenny xie Xue Bai Weiwei Fu Hairong Chen Hong Tang Xiaohu Wang Chen Dong Institute for Immunology Tsinghua UniversityBeijing 100084China Discovery Immunology Bristol Myers SquibbPrinceton NJ 08543USA Department of Gastroenterology Peking University Third HospitalBeijing 100191China CAS Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of ScienceBeijing 100101China CAS Key Laboratory of Molecular Virology and Immunology Institute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200025China Pasteurien College Suzhou UniversitySuzhou 215123China Shanghai Immune Therapy Institute Shanghai Jiao Tong University School of Medicine Affiliated Renji HospitalShanghai 200127China

T follicular helper(Tfh)cells are critical in providing help for B cells in the germinal center reaction.Tfh cell plasticity,especially with regard to their expression of effector Th cytokines,has been described,but lacks in-depth analysis with genetic approaches.In this study,we systemically compared transcriptomic profiles of Tfh cells derived from various types of immune responses and found gene clusters corresponding to effector Th cells were differentially induced in response to pathogens or immune responses.Of special interest,a subset of Tfh cells producing IFN-γwas generated in an influenza virus infection,partially dependent on the innate cytokine IL-12.Lineage-tracing mouse model revealed unique developmental regulation of IFN-γ~+Tfh cells,while selective ablation of these cells impaired the induction of Ig G2c~+germinal center B cells and the control of influenza infection.These results indicate that pathogen-associated Tfh cell plasticity is necessary for host immunity,which has implications in vaccine design.

关键词： T follicular helper(Tfh)cell plasticity influenza infection IFN-γ IgG2

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The Establishment of Mathematical Models for the Composition Analysis and Identification of Ancient Glass Products

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Open Journal of Applied Sciences 2023年第11期13卷 2149-2171页

作者： jenny Zhang Ding Li Yu xie Junfeng Xiang School of Energy and Power Engineering Jiangsu University Zhenjiang China

Glass is the precious material evidence of the trade of the early Silk Road. The ancient glass was easily affected by the environmental impact and weathering, and the change of composition ratios affected the correct judgment of its category. In this paper, mathematical models and methods such as Chi-square test, weighted average method, principal component analysis, cluster analysis, binary classification model and grey correlation analysis were used comprehensively to analyze the data of sample glass products combined with their categories. The results showed that the weathered high-potassium glass could be divided into 12, 9, 10 and 27, 7, 22 and so on.

关键词： Principal Component Analysis System Clustering Sensitivity Analysis Binary Classification Model Logistic Regression Analysis Grey Correlation Analysis

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海南文昌海草床沉积物硫氧化细菌的多样性

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海南大学学报（自然科学版） 2022年第4期40卷 333-343页

作者：林珍妮覃意龄章翔谢珍玉海南大学南海海洋资源利用国家重点实验室海南海口570228 海南大学海洋学院海南海口570228

以热带海草床沉积物土著硫氧化微生物资源的开发为目的,首先选择培养基并对海南文昌海草床沉积物中可培养硫氧化细菌进行了富集培养和分离纯化,进而利用16S rRNA测序方法获得了硫氧化细菌的分类信息并建立了系统发育树,最后对其硫氧化... 详细信息

以热带海草床沉积物土著硫氧化微生物资源的开发为目的,首先选择培养基并对海南文昌海草床沉积物中可培养硫氧化细菌进行了富集培养和分离纯化,进而利用16S rRNA测序方法获得了硫氧化细菌的分类信息并建立了系统发育树,最后对其硫氧化性质进行检测,共分离鉴定出38株具有硫氧化功能的菌株,它们均来源于变形菌门(Proteobacteria)中的γ-变形菌纲(Gamma-Proteobacteria)和厚壁菌门(Firmicutes).其中弧菌属(Vibrio)、芽孢杆菌属(Bacillus)和产微球茎菌属(Microbulbifer)为优势属,同时获得了嗜盐单胞菌属(Halomonas)、海杆菌属(Marinobacter)和深海海旋菌属(Thalassospira)中常见的硫化物氧化细菌.测序分析结果表明,海南文昌海草床环境样品中硫氧化细菌的多样性丰富,且不同站位之间受沉积物间隙水硫化物浓度的影响也存在差异.本研究获得了海南文昌海草床不同类型的硫氧化细菌菌株,丰富了海南海草床土著硫氧化细菌的菌种资源,为海草床沉积物硫化物微生物治理技术的开发奠定了基础.

关键词：海草床沉积物分离鉴定硫氧化物细菌

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Genome Editing of a Rice CDP-DAG Synthase Confers Multi-pathogen Resistance

Genome Editing of a Rice CDP-DAG Synthase Confers Multi-path...

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中国植物病理学会2023年学术年会

作者： SHA Gan SUN Peng KONG Xiaojing HAN Xinyu SUN Qiping LAETITIA Fouillen ZHAO Juan LI Yun YANG Lei WANG Yin GONG Qiuwen ZHOU Yarn ZHOU Wenqing JAIN Rashmi GAO Jie HUANG Renliang CHEN Xiaoyang ZHENG Lu ZHANG Wanying QIN Ziting ZHOU Qi ZENG Qingdong xie Kabin XU Jiandi TSAN-Yu Chiu GUO Liang jenny C.Mortimer YOHANN Boutté LI Qiang KANG Zhensheng PAMELA C.Ronald LI Guotian Department of Plant Pathology and the Genome Center University of CaliforniaDavis National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University BGI-Shenzhen State Key Laboratory of Crop Stress Biology for Arid Areas Northwest A&F University School of Agriculture Food and WineUniversity of Adelaide Innovative Genomics Institute University of CaliforniaBerkeley

The discovery and application of genome editing introduce a new era of plant breeding,giving researchers efficient tools for the precise engineering of crop genomes.Here, we demonstrate the power of genome editing for engineering broad-spectrum disease resistance in rice( Oryza sativa).We first isolated a lesion mimic mutant( LMM) from a mutagenized rice population, demonstrated that a29-bp deletion in a gene we named RESISTANCE TO BLAST1( RBL1) caused this phenotype and showed that this mutation caused a ca.20-fold reduction in yield.RBLl encodes a cytidine diphosphate diacylglycerol(CDP-DAG) synthase required for phospholipid biosynthesis.Mutation of RBL1 results in reduced levels of phosphatidylinositol(P1) and its derivative PI(4, 5) P.Rice PI(4, 5) P is enriched in cellular structures specifically associated with effector secretion and fungal infection, suggesting a role as a disease susceptibility factor.Using targeted genome editing, we obtained an allele of RBL1, named RBL1, which confers broad-spectrum resistance but does not decrease yield in a model rice variety as assessed in small-scale field trials.Our study has demonstrated the usefulness of editing of an LMM gene, a strategy relevant to diverse LMM genes and crops.

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亚洲临床试验纳入的HCV感染患者中,基线NS5A和NS5B NI耐药相关变异的流行率

亚洲临床试验纳入的HCV感染患者中,基线NS5A和NS5B NI耐药相关变...

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第九届全国疑难及重症肝病大会

作者： Wei Lai Masao Omata Young-Suk Lim Wan-Long Chuang Dao Long xie Qing Hou Jin Lin Jia Jidong Evguenia Svarovskaia Ross Martin Brian Doehle jenny Yang Shampa De-Oertel Benedetta Massetto Kathryn Kersey Diana M.Brainard Hongmei Mo Nguyen Kinh Jia-Horng Kao Kwang-Hyub Han Masashi Mizokami Duan Zhongping YamanashiPrefecturalHospitalOrganization KaohsiungMedicalUniversityHospital KaohsiungMedicalUniversity YonseiUniversityCollegeofMedicineSeoul ShanghaiJiaotonhUniversityRuijinHospital NationalHospitalOrganizationNagasakiMedicalCenter AsanMedicalCenter UniversityofUlsanCollegeofMedicine PekingUniversityPeople’sHospital NationalTaiwanUniversityCollegeofMedicineandHospital NationalHospitalofTropicalDiseases GileadScience Inc BeijingFriendshipHospitalAffiliatedtoCapitalMedicalUniversity BeijingYouanHospitalAffiliatedtoCapitalMedicalUniversity BachMaiHospital HanoiMedicalUniversityHospital NanfangHospitalofSouthernMedicalUniversity

背景:耐药相关变异(RAS)可以降低一些HCV的直接抗病毒(DAA)药物的疗效。尽管已经有关于欧洲和北美洲的NS5A和NS5B RAS的流行率的详尽描述,但是有关其在亚洲的流行率的资料相对较少。此研究在适用的情况下,对比美国和欧洲(EU),评估了NS5A...

背景:耐药相关变异(RAS)可以降低一些HCV的直接抗病毒(DAA)药物的疗效。尽管已经有关于欧洲和北美洲的NS5A和NS5B RAS的流行率的详尽描述,但是有关其在亚洲的流行率的资料相对较少。此研究在适用的情况下,对比美国和欧洲(EU),评估了NS5A和NS5B核苷类抑制剂(NI)RAS在中国大陆、中国台湾、日本、韩国和越南的基因1b、2、3和6型HCV感染患者中的流行率。

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