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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

The link between olfactory ensheathing cell survival and spinal cord injury repair: a commentary on common limitations of contemporary research

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Neural Regeneration Research 2020年第10期15卷 1848-1849页

作者： Ronak Reshamwala Megha shah James St.John jenny Ekberg Griffith Institute for Drug Discovery Griffith UniversityBrisbaneQLDAustralia Menzies Health Institute Queensland Griffith UniversitySouthportQLDAustraliaClem Jones Centre for Neurobiology and Stem Cell ResearchGriffith UniversityBrisbaneQLDAustralia

Olfactory ensheathing cells(OECs)are crucial players in the continuous regeneration of the olfactory nervous system that occurs through out life and are thought to have unique growth-promoting *** this reason,OEC transplantation has been thoroughly explored for the potential to promote neural repair after both central and peripheral nervous system *** studies have shown that OEC transplantation is safe and can promote recovery after spinal cord injury(SCI),both in animal models and in human clinical *** date,a variety of injury types and time-points after injury,as well as different delivery methods,have been *** have been encouraging(in rodent models including,for example,restoration of locomotion,breathing and climbing ability along with induction of axonal sprouting and some axonal regeneration)but highly variable(Barnett and Riddell,2007;Gomez et al.,2018).

关键词： injuries injury limitations

Reliable cell purification and determination of cell purity:crucial aspects of olfactory ensheathing cell transplantation for spinal cord repair

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Neural Regeneration Research 2020年第11期15卷 2016-2026页

作者： Ronak Reshamwala Megha shah Lucy Belt jenny A.K.Ekberg James A.St John Griffith Institute for Drug Discovery Griffith UniversityBrisbaneQLDAustralia Menzies Health Institute Queensland Griffith UniversitySouthportQLDAustralia Clem Jones Centre for Neurobiology and Stem Cell Research Griffith UniversityBrisbaneQLDAustralia

Transplantation of olfactory ensheathing cells,the glia of the primary olfactory nervous system,has been trialed for spinal cord injury repair with promising but variable outcomes in animals and *** ensheathing cells can be harvested either from the lamina propria beneath the neuroepithelium in the nasal cavity,or from the olfactory bulb in the *** these areas contain several other cell types,isolating and purifying olfactory ensheathing cells is a critical part of the *** is largely unknown how contaminating cells such as fibroblasts,other glial cell types and supporting cells affect olfactory ensheathing cell function post-transplantation;these cells may also cause unwanted *** is also,however,possible that the presence of some of the contaminant cells can improve ***,we reviewed the last decade of olfactory ensheathing cell transplantation studies in rodents,with a focus on olfactory ensheathing cell *** analyzed how purification methods and resultant cell purity differed between olfactory mucosa-and olfactory bulb-derived cell *** analyzed how the studies reported on olfactory ensheathing cell purity and which criteria were used to define cells as olfactory ensheathing ***,we analyzed the correlation between cell purity and transplantation *** found that olfactory bulb-derived olfactory ensheathing cell preparations are typically purer than mucosa-derived *** concluded that there is an association between high olfactory ensheathing cell purity and favourable outcomes,but the lack of olfactory ensheathing cell-specific markers severely hampers the field.

关键词： antibody astrocyte fibroblast glia glial cell injury nerve neuron trauma surgery

Calciomics:prediction and analysis of EF-hand calcium binding proteins by protein engineering

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Science China Chemistry 2010年第1期53卷 52-60页

作者： YANG jenny Jie Department of Chemistry Georgia State University

Ca2+ plays a pivotal role in the physiology and biochemistry of prokaryotic and mammalian *** also utilize the universal Ca2+ signal to create a specific cellular environment to achieve coexistence with the host,and to *** this paper we first describe our development of a grafting approach to understand site-specific Ca2+ binding properties of EF-hand proteins with a helix-loop-helix Ca2+ binding motif,then summarize our prediction and identification of EF-hand Ca2+ binding sites on a genome-wide scale in bacteria and virus,and next report the application of the grafting approach to probe the metal binding capability of predicted EF-hand motifs within the streptococcal hemoprotein receptor(Shr) of Streptococcus pyrogenes and the nonstructural protein 1(nsP1) of Sindbis *** methods such as the grafting approach are developed in conjunction with prediction algorithms we are better able to probe continuous Ca2+-binding sites that have been previously underrepresented due to the limitation of conventional methodology.

关键词： Ca2+ EF-hand calcium binding pockets protein grafting approach Streptococcus pyrogenes Sindbis virus

Laboratory assessment of Alaska aggregates using Micro-Deval test

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Frontiers of Structural and Civil Engineering 2017年第1期11卷 27-34页

作者： jenny LIU Sheng ZHAO Anthony MULLIN Department of Civil and Environmental Engineering University of Alaska Fairbanks Fairbanks AK 99775-5900 USA Center for Environmentally Sustainable Transportation in Cold Climates Institute of Northern Engineering University of AlaskaFairbanks Fairbanks AK 99775-5900 USA

Aggregates suitable for use in asphalt concrete （AC） pavement construction must meet durability criteria. Thus, it is critical to select appropriate tests to properly characterize aggregate durability. In Alaska, durability tests currently being used for aggregates in AC pavement include Los Angeles （LA） abrasion test, sulfate soundness test and Washington degradation test. However, there have long been concerns arising over Washington degradation test used as an acceptance tool, motivating pavement practitioners to seek more suitable alternatives. This paper presents a study to investigate the feasibility of using Micro-Deval test, commonly used in other states, to evaluate the durability of Alaskan aggregates in AC pavement as well as its potential to replace Washington degradation test. Micro-Deval test, Washington degradation test and other tests currently specified in Alaska were conducted on aggregates from 16 batches representing statewide sources. Based on the testing results, it is found that using Micro-Deval test for durability assessment of Alaska aggregates was feasible and reproducible, and a high potential was revealed to use Micro-Deval test to replace Washington degradation test in Alaska. It is recommended that Micro-Deval test be considered as an additional test for a certain period, but in the long run should be used along with current LA abrasion and sulfate soundness tests to provide a more desirable durability assessment of Alaska aggregates used in AC pavement.

关键词： aggregate durability Washington degradation test Micro-Deval test

Connecting Race to Ethics Related to Technology:A Call for Critical Tech Ethics

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Journal of Social Computing 2021年第4期2卷 357-364页

作者： jenny Ungbha Korn the Berkman Klein Center for Internet and Society Harvard UniversityCambridgeMA 02138USA

Critical tech ethics is my call for action to influencers,leaders,policymakers,and educators to help move our society towards centering race,deliberately and intentionally,to tech *** too long,when“ethics”is applied broadly across different kinds of technology,ethics does not address race explicitly,including how diverse forms of technologies have contributed to violence against and the marginalization of communities of *** several years of research,I have studied online behavior to evaluate gender and racial biases.I have concluded that a way to improve technologies,including the Internet,is to create a specific type of ethics termed“critical tech ethics”that connects race to ethics related to *** article covers guiding theories for discovering critical tech ethical challenges,contemporary examples for illustrating critical tech ethical challenges,and institutional changes across business,education,and civil society actors for teaching critical tech ethics and encouraging the integration of critical tech ethics with undergraduate computer *** tech ethics has been developed with the imperative to help improve society through connecting race to ethics related to technology,so that we may reduce the propagation of racial injustices currently occurring by educational institutions,technology corporations,and civil *** aim is to improve racial equity through the development of critical tech ethics as research,teaching,and practice in social norms,higher education,policy making,and civil society.

关键词： race gender ethics tech bias equity society policy

NUDGING OCCUPANT BEHAVIOR-CULTIVATING POSITIVE ASSOCIATIONS BETWEEN COMFORT,HEALTH,AND BUILDING EFFICIENCY ACTIONS WITH THE DENVER HOUSING AUTHORITY

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Journal of Green Building 2015年第1期10卷 68-84页

作者： jenny Carney YR and G Sustainability Consulting Education and Analysis United States

*** CTION Established in 1938,the Housing Authority of the City and County of Denver(DHA)is one of the nation’s most successful housing authorities,providing a variety of livable affordable housing options throughout Denver ***’s mission is to serve the residents of Denver by developing,owning,and operating safe,decent,and affordable housing in a manner that promotes thriving *** manages,owns,and operates a large portfolio of residential,warehouse,office and commercial properties through the City and County of Denver,*** of DHA’s strategic goals is to develop and operate sustainable energy efficiency properties through the Denver *** continues to develop and rehab buildings that meet the USGBC rating system and Green Enterprise Communities Standards,include the development of LEED Platinum *** addition to developing and maintaining energy efficient properties,DHA is also focused on engaging with residents to encourage responsible choices around energy *** believes there is significant opportunity for energy and water savings through focusing on the human dimension of energy ***&G has been working with DHA since 2010 supporting sustainable design initiatives for their new construction *** 2014,YR&G began working with DHA to design,implement,and perform measurement and verification for a resident education and engagement program focused on energy and water conservation *** intent is to produce a replicable program that can be implemented across DHA properties.

关键词： Multi-family residential energy efficiency water efficiency affordable housing occupant engagement behavior community-based social marketing(CBSM) health comfort

Study of methods for endpoint aware inspection in a next generation firewall

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Cybersecurity 2022年第4期5卷 56-70页

作者： jenny Heino Antti Hakkala Seppo Virtanen Department of Computing University of TurkuTurkuFinland Forcepoint LLC HelsinkiFinland

Given the global increase in remote work with the COVID-19 pandemic and deperimeterization due to cloud deployment of next generation frewalls,the concept of a next generation firewall is at a breaking *** is becoming more dificult to define the barrier between the good and the *** provide the best security for an endpoint with minimal false positives or false negatives it is often necessary to identify the communicating endpoint application.n this study,we present an analysis of key research and methods for providing endpoint aware protection in the context of a next generation frewall We examine both academic research as well as state-of-the-art of the existing next generation firewall *** divide endpoint application identification into passive and active *** passive endpoint application identification,we study several traffc fingerprinting methods for different *** active methods we consider active scanning,endpoint metadata analysis and content injection and reference existing *** conclude that there are several open areas for future research,and that none of the considered methods is a silver bullet solution for endpoint aware inspection in the context of a next generation *** our best knowledge,this is the first study to examine current research and existing implementations of endpoint aware inspection.

关键词： Network traffc Endpoint identification NGFW Endpoint aware inspection

Local Discontinuous-Galerkin Schemes for Model Problems in Phase Transition Theory

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Communications in Computational Physics 2008年第9期4卷 860-893页

作者： jenny Haink Christian Rohde Fachbereich Mathematik-IANS Universitat StuttgartPfaffenwaldring 57D-70569 StuttgartGermany.

Local Discontinuous Galerkin(LDG)schemes in the sense of[5]are a flexible numerical tool to approximate solutions of nonlinear convection problems with complicated dissipative *** terms frequently appear in evolution equations which describe the dynamics of phase changes in ***-vapour mixtures or in elastic *** report on results for one-dimensional model problems with dissipative terms including third-order and convolution *** entropy inequalities and L2-stability results are proved for those model *** is common in phase transition theory the solution structure sensitively depends on the coupling parameter between viscosity and *** avoid spurious solutions due to the counteracting effect of artificial dissipation by the numerical flux and the actual dissipation terms we introduce Tadmors’entropy conservative *** numerical experiments underline the reliability of our approach and also illustrate interesting and(partly)new phase transition phenomena.

关键词： Conservation laws discontinuous-Galerkin method dynamical phase boundaries Tadmor flux convolution operator.