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Development of NK cell-based cancer immunotherapies through receptor engineering

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Cellular & Molecular Immunology 2024年第4期21卷 315-331页

作者： Audrey Page Nicolas Chuvin jenny Valladeau-Guilemond Stéphane Depil Centre de Recherche en Cancérologie de Lyon UMR INSERM U1052 CNRS 5286Centre Léon BérardLyonFrance ErVimmune LyonFrance Centre Léon Bérard LyonFrance UniversitéClaude Bernard Lyon 1 LyonFrance

Natural killer(NK)cell-based immunotherapies are attracting increasing interest in the field of cancer *** clinical trials have shown promising outcomes,alongside satisfactory product efficacy and *** developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic *** review focuses on surface receptor engineering in NK cell therapy and discusses its impact,challenges,and future *** approaches are based on engineering with chimeric antigen receptors to allow NK cells to target specific tumor antigens independent of human leukocyte antigen *** approach has increased the precision and potency of NK-mediated recognition and elimination of cancer *** addition,engineering NK cells with T-cell receptors also mediates the recognition of intracellular epitopes,which broadens the range of target *** tumor peptide recognition by NK cells has also been improved by optimizing immunoglobulin constant fragment receptor expression and ***,engineered NK cells have an improved ability to recognize and destroy target cells coated with specific antibodies,thereby increasing their antibodydependent cellular *** ability of NK cell receptor engineering to promote the expansion,persistence,and infiltration of transferred cells in the tumor microenvironment has also been ***-based strategies for sustained NK cell functionality within the tumor environment have also been discussed,and these strategies providing perspectives to counteract tumor-induced ***,receptor engineering has led to significant advances in NK cell-based cancer *** technical challenges are addressed,these innovative treatments will likely reshape cancer immunotherapy.

关键词： NK cells Cell therapy Receptor engineering CAR

Molecular regulation of calcium-sensing receptor(CaSR)-mediated signaling

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Chronic Diseases and Translational Medicine 2024年第3期10卷 167-194页

作者： Li Tian Corey Andrews Qiuyun Yan jenny J.Yang Department of Chemistry Center for Diagnostics and TherapeuticsAdvanced Translational Imaging FacilityGeorgia State UniversityAtlantaGeorgiaUSA

Calcium-sensing receptor(CaSR),a family C G-protein-coupled receptor,plays a crucial role in regulating calcium homeostasis by sensing small concentration changes of extracellular Ca^(2+),Mg^(2+),amino acids(e.g.,L-Trp and L-Phe),small peptides,anions(e.g.,HCO_(3)^(-)and PO_(4)^(3-)),and ***-mediated intracellular Ca^(2+)signaling regulates a diverse set of cellular processes including gene transcription,cell proliferation,differentiation,apoptosis,muscle contraction,and neuronal *** of CaSR with mutations results in diseases such as autosomal dominant hypocalcemia,familial hypocalciuric hypercalcemia,and neonatal severe *** also influences calciotropic disorders,such as osteoporosis,and noncalciotropic disorders,such as cancer,Alzheimer's disease,and pulmonary arterial *** study first reviews recent advances in biochemical and structural determination of the framework of CaSR and its interaction sites with natural ligands,as well as exogenous positive allosteric modulators and negative allosteric *** establishment of the first CaSR protein-protein interactome network revealed 94 novel players involved in protein processing in endoplasmic reticulum,trafficking,cell surface expression,endocytosis,degradation,and signaling *** roles of these proteins in Ca^(2+)-dependent cellular physiological processes and in CaSR-dependent cellular signaling provide new insights into the molecular basis of diseases caused by CaSR mutations and dysregulated CaSR activity caused by its protein interactors and facilitate the design of therapeutic agents that target CaSR and other family C G-protein-coupled receptors.

关键词： calcium signaling calcium-sensing receptor G-protein-coupled receptors structure trafficking

Impact of inorganic and organic pollutants from a Belgian wastewater treatment plant on adjacent surface and groundwaters

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 75-90页

作者： Mingyue Luo Yiqi Su Delphine jenny Vandeputte Yuwei Jia Guanlei Li Willy Baeyens Marijke Huysmans Marc Elskens Yue Gao Analytical Environmental and Geo-Chemistry Department(AMGC)Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium Hydrology and Hydraulic Engineering(HYDR) Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium

Under the pressure of global droughts and water shortage,it is essential to evolve toward a sustainable and robust water *** possible avenue is the maximum reuse of treated wastewater,but the quality of which determines its ***,inorganic(Cd,Pb,Cr,Ni,Cu,and As)and organic(xenoestrogens and polycyclic aromatic contaminants,PACs)contaminants were monthly monitored in an effluent of the wastewater treatment plant(WWTP),the surrounding surface waters and the local groundwater in *** and particulate concentrations of inorganic contaminants in these water bodies were *** addition,Diffusive Gradients in Thin-films(DGT)was used in situ to obtain bioavailable metal *** the WWTP effluent and surface waters,only Ni exceeds the Annual Average-Environmental Quality Standard(AA-EQS),while in the groundwater,dissolved As was the predominant ***,in the surface and effluent waters the highest lability degrees were observed for Cd and *** concentrations of these metal species in the effluent water were lower than in the other water ***-organic pollutants,xenoestrogens and PACs were analyzed by dual Estrogen and Aryl hydrocarbon Receptor-Chemical Activated LUciferase gene eXpression(ER&AhR-CALUX)*** the annual averaged(AA)bioequivalent concentration of E2(0.18 ng/L)is below the AA-EQS standard(0.4 ng/L),and the bioequivalent concentration of benzo[a]pyrene never exceeded the maximum admissible concentration(MAC),the reclamation and reuse of treated wastewater for groundwater replenishment and agricultural irrigation should pose no environmental problems,at least in a short-term.

关键词： Metal contaminants DGT Labile metal fractions ERE/AhR-CALUX BEQ Xenoestrogens and polycyclic aromatic contaminants

Which Cities are More Attractive for Business Investment?

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China's Foreign Trade 2024年第1期 61-63页

作者： jenny Hu 不详

A good business environment is the soft power and core competitiveness for urban economic development,and is a key element to attract business in***,the“Top 50 Cities with Business Investment Attraction”(hereinafter referred to as the Survey)released by the Big Data Research Institute of Qi Chacha shows that the siphonic effect of the first-tier cities is significant,and in the past five years,enterprises in Shanghai,Beijing and Shenzhen have been invested in the most frequently.

关键词： invested enterprises traction

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An Unforgettable Trip Into an Intangible Cultural Heritage at Quanzhou

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China's Foreign Trade 2024年第2期 60-63页

作者： jenny Hu 不详

Quanzhou,as the only starting point of the Maritime Silk Road recognized by the United Nations,was praised as"the most prosperous city in the world"by Marco *** July 25th,2021,China's"Quanzhou:Emporium of the World in Song-Yuan China"was added to the UNESCO World Heritage List as a cultural site,bringing the total number of the country's UNESCO World Heritage sites to *** twentytwo world heritage sites in Quanzhou.

关键词： UNESCO forget bringing

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音-义连接经验对自然拼读教学法效果的影响

心理发展与教育 2024年 368-376页

作者：姜莹盖笑松 jenny Thomson 东北师范大学心理学院吉林省普通高等学校人文社会科学重点研究基地东北师范大学心理健康教育研究中心谢菲尔德大学人类语言交际科学学院

非英语母语国家的英语语音教学中，越来越多引入了英语母语国家的自然拼读教学法。然而，缺乏先前音-义连接经验的非英语母语者能否从这种形-音对应训练中同等获益呢?为了检验非英语母语者中音-义连接经验对拼读教学法效果的影响，以12... 详细信息

非英语母语国家的英语语音教学中，越来越多引入了英语母语国家的自然拼读教学法。然而，缺乏先前音-义连接经验的非英语母语者能否从这种形-音对应训练中同等获益呢?为了检验非英语母语者中音-义连接经验对拼读教学法效果的影响，以120名四年级小学生为被试，采用单因素三水平(前置音-义连接训练组作为实验组，前置首音辨别训练组作为积极对照组，无前置训练组作为消极对照组)被试间实验设计，考查了拼读法训练效果。结果发现，在前置训练中建立起单词音-义连接的儿童从随后的拼读法训练中受益更多，表现出更强的单词拼读能力，并且在新词材料中表现出了近迁移效应。该结果提示在汉语母语者中引进自然拼读教学法的局限性以及解决思路。

关键词：拼读教学法语音意识音-义连接单词拼读外语教学

From EBIT to SEBIT(Sustainable EBIT):Sustainable Performance Accounting(SPA)Using the Example of CO_(2) Accounting

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Journal of Modern Accounting and Auditing 2024年第2期20卷 49-71页

作者： Knut Henkel jenny Lay-Kumar Christian Hiß University of Applied Sciences Emden/Leer EmdenGermany Regionalwert Research gGmbH LeipzigGermany Agriculture Food&Beverages sector writing teamLeipzigGermany Regionalwert Leistungen GmbH Freiburg Br.Germany

Corporate sustainability reporting has become increasingly important in recent ***,conventional approaches reach their limits when it comes to quantifying and measuring the actual sustainability performance of a *** article presents a new approach:Sustainable Performance Accounting(SPA),which is based on an extension of bookkeeping by including ESG *** enables companies to systematically measure and manage their sustainability *** article provides an overview of the basics of SPA methodology and uses a comprehensive example showing how SPA can be implemented in *** article is aimed at interested readers from science and practice as well as decision-makers who are interested in future-oriented sustainability reporting.

关键词： CO_(2)accounting CO_(2)emissions CSRD ESG(Environmental Social Governance) ESG bookkeeping ESG provision ESG asset ESRS integrated financial reporting internalisation of external effects connectivity monetisation of ESG issues sustainability sustainability indicators negative emissions sequestration performance Sustainable Performance Accounting(SPA)

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

巴黎对在塞纳河举办奥运游泳比赛“充满信心”

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商业周刊（中文版） 2024年第6期 38-39页

作者： jenny Che Alexandre Rajbhandari 逸思(译) 不详

一位巴黎市官员表示,该市已准备好今夏在塞纳河举办奥运会游泳比赛,除非出现严重的恶劣天气导致水质下降。上周发布的一份报告发现,作为主要城市水道的塞纳河中细菌含量偏高。负责体育事务的巴黎副市长皮埃尔·拉巴丹(Pierre Rabadan)说... 详细信息

一位巴黎市官员表示,该市已准备好今夏在塞纳河举办奥运会游泳比赛,除非出现严重的恶劣天气导致水质下降。上周发布的一份报告发现,作为主要城市水道的塞纳河中细菌含量偏高。负责体育事务的巴黎副市长皮埃尔·拉巴丹(Pierre Rabadan)说,天气寒冷的月份水质通常会变差,那也正是为该报告服务的非营利组织采样的时间。

关键词：游泳比赛细菌含量奥运会巴黎市非营利组织恶劣天气塞纳河体育事务