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Atypical Atm-p53 genetic interaction in osteogenesis is mediated by Smad1 signaling

分子细胞生物学报:英文版 2012年第2期4卷 118-120页

作者： Gang Ma Lili Li Yuanyu Hu jenny fung ling chau Bi Jin Au Deyong Jia Huijuan Liu James Yeh Lin He Aijun Hao Baojie Li The Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China Key Laboratory of the Ministry of Education for Experimental Teratology Shandong University School of MedicineJinan 250012China The Institute of Molecular and Cell Biology Agency for ScienceTechnologyand ResearchSingapore 138632Singapore

Dear Editor,Tumor suppressor p53 is activated in re-sponse to genotoxic stress by Atm and other PI3K-like kinases,which phosphoryl-ate p53 and stabilize p53(Barlow et al.,1997),leading to cell cycle arrest,senes-cence... 详细信息

关键词： Smad1 PI3K damage p53

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Important role of cardiac spect imaging in patients undergoing percutaneous transluminal coronary angioplasty

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Chinese Medical Journal 1999年第3期 64-67页

作者： Babington Chun kuen Yung, Wai Kwong Chan, Chiu Sun Yue, Wai chau Fan, Kwok Fai Leung Amy Siu ling fung and James Chi sang Chan Department of Radiology and Organ Imaging (Yung CK, Fan WC, Chan CS) & Department of Medicine and Geriatrics (

Objective To examine the utilization and contribution of cardiac perfusion scans to patients undergoing percutaneous transluminal coronary angioplasty. Methods From July 1996 to January 1998, 34 patients underwent percutaneous transluminal coronary angioplasty and cardiac SPECT imaging was studied. Twenty five patients had pre procedure SPECT scans. The agreement between angioplasty strategies and SPECT findings of ischemia and hypokinesia was *** When radionuclide imaging was performed before revascularization procedures, 84% of the patients had intervention strategies guided by scan findings. Perfusion scan findings including extent and severity of ischemia, degree of hypokinesia directed the selection of target vessel for angioplasty in the patient subgroup with multi vessel disease. Post angioplasty radionuclide cardiac scans were performed only on symptomatic patients, demonstrating ischemia and hypokinesia in most of them, conceivably reflected the selection *** We recommend routine pre and post angioplasty radionuclide imaging with multigated scans for wall motion assessment for all patients receiving coronary intervention.

关键词： multigated SPECT angioplasty ischemia hypokinesia

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