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evaluation of clinical outcomes in an interdisciplinary abdominal pain clinic: A retrospective, exploratory review

World Journal of Gastroenterology 2019年第24期25卷 3079-3090页

作者： Amanda D Deacy Craig A Friesen Vincent S Staggs jennifer V Schurman Division of Gastroenterology Children’s Mercy Kansas CityUMKC School of MedicineKansas CityMO 64108United States Division of Developmental and Behavioral Sciences Children’s Mercy Kansas CityUMKC School of MedicineKansas CityMO 64108United States Biostatistics and epidemiology Health Services and Outcomes ResearchChildren’s Mercy Kansas CityUMKC School of MedicineKansas CityMO 64108United States

BACKGROUND Pediatric functional gastrointestinal disorders(FGIDs)are common and wellaccepted to be etiologically complex in terms of the contribution of biological,psychological,and social factors to symptom ***,despite its documented benefits,interdisciplinary treatment,designed to address all of these factors,for pediatric FGIDs remains *** current study hypothesized that the majority of pediatric patients seen in an interdisciplinary abdominal pain clinic(APC)would demonstrate clinical resolution of symptoms during the study period and that specific psychosocial variables would be significantly predictive of GI symptom *** To evaluate outcomes with interdisciplinary treatment in pediatric patients with pain-related FGIDs and identify patient characteristics that predicted clinical *** Participants were 392 children,ages 8-18[M=13.8;standard deviation(SD)=2.7],seen between August 1,2013 and June 15,2016 in an interdisciplinary APC housed within the Division of Gastroenterology in a medium-sized Midwestern children's *** be eligible,patients had to be 8 years of age or older and have had abdominal pain for≥8 wk at the time of initial *** and psychosocial data collected as part of standard of care were retrospectively reviewed and analyzed in the context of the observational *** regression was used to model odds of reporting vs never reporting improvement,as well as to differentiate rapid from slower *** Nearly 70%of patients followed during the study period achieved resolution on at least one of the employed outcome *** those who achieved resolution during follow up,43%to 49%did so by the first follow up(i.e.,within roughly 2 mo after initial evaluation and initiation of interdisciplinary treatment).Patient age,sleep,ease of relaxation,and depression all significantly predicted the likelihood of *** specifically,the odds of clinical resolution w

关键词： Pediatric functional gastrointestinal disorders Integrated care Behavioral health consultation Treatment outcomes Abdominal pain clinic

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Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases

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World Journal of Gastroenterology 2013年第1期19卷 115-121页

作者： Ana Paula Oppenheimer Christopher Koh Mary McLaughlin John C Williamson Thomas D Norton jennifer Laudadio Theo Heller David e Kleiner Kevin P High Caryn G Morse Section of Infectious Diseases Department of MedicineWake Forest School of MedicineWinston-SalemNC 27109-7205United States Liver Diseases Branch National Institute of DiabetesDigestive and Kidney DiseasesNational Institutes of Health Clinical CenterBethesdaMD 20892-1403United States Laboratory of Immunoregulation National Institute of Allergy and Infectious DiseasesNational Institutes of Health Clinical CenterBethesdaMD 20892-1403United States Division of Infectious Diseases and Immunology Department of MedicineNew York University School of MedicineNew YorkNY 10016United States Laboratory of Pathology Wake Forest School of MedicineWinston-SalemNC 27109-7205United States Laboratory of Pathology National Cancer InstituteNational Institutes of Health Clinical CenterBethesdaMD 20892-1403United States Department of Critical Care Medicine National Institutes of Health Clinical CenterBethesdaMD 20892-1403United States

Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to *** in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not *** date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected *** report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated *** includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis *** HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral *** was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other *** HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes.

关键词： Human immunodeficiency virus Antiretroviral therapy Vanishing bile duct syndrome Ductopenia Liver biopsy

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A Malvaceae mystery: A mallow maelstrom of genome multiplications and maybe misleading methods?

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Journal of Integrative Plant Biology 2019年第1期61卷 12-31页

作者： Justin L.Conover Nisa Karimi Noah Stenz Cecile Ane Corrinne e.Grover Cynthia Skema jennifer A.Tate Kirsten Wolff Samuel A.Logan Jonathan F.Wendel David A.Baum Department of ecology Evolutionand Organismal BiologyIowa State University Department of Botany University of Wisconsin Madison Department of Statistics University of Wisconsin Madison Morris Arboretum of the University of Pennsylvania Institute of Fundamental Sciences Massey University School of Natural and environmental Sciences Newcastle University Wisconsin Institute for Discovery

Previous research suggests that Gossypium has undergone a 5-to 6-fold multiplication following its divergence from Theobroma. However, the number of events, or where they occurred in the Malvaceae phylogeny remains unknown. We analyzed transcriptomic and genomic data from representatives of eight of the nine Malvaceae subfamilies. Phylogenetic analysis of nuclear data placed Dombeya(Dombeyoideae) as sister to the rest of Malvadendrina clade, but the plastid DNA tree strongly supported Durio(Helicteroideae) in this position. Intraspecific Ks plots indicated that all sampled taxa, except Theobroma(Byttnerioideae), Corchorus(Grewioideae), and Dombeya(Dombeyoideae), have experienced whole genome multiplications(WGMs). Quartet analysis suggested WGMs were shared by Malvoideae-Bombacoideae and Sterculioideae-Tilioideae, but did not resolve whether these are shared with each other or Helicteroideae(Durio).Gene tree reconciliation and Bayesian concordance analysis suggested a complex history. Alternative hypotheses are suggested, each involving two independent autotetraploid and one allopolyploid event. They differ in that one entails an allopolyploid origin for the Durio lineage,whereas the other invokes an allopolyploid origin for Malvoideae-Bombacoideae. We highlight the need for more genomic information in the Malvaceae and improved methods to resolve complex evolutionary histories that may include allopolyploidy, incomplete lineage sorting, and variable rates of gene and genome evolution.

关键词： research data

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Phase 3 trial of first generation protease inhibitor therapy for hepatitis C virus/human immunodeficiency virus coinfection

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World Journal of Hepatology 2017年第4期9卷 217-223页

作者： Kenneth e Sherman Minhee Kang Richard Sterling Triin Umbleja Kristen Marks jennifer J Kiser Beverly Alston-Smith Wayne Greaves Adeel A Butt 无 Division of Digestive Diseases University of Cincinnati College of Medicine harvard T.h. Chan School of Public health Department of Gastroenterology Virginia Commonwealth University Division of Infectious Disease Weill Cornell Medical School University of Colorado School of Pharmacy NIAID-Division of AIDS Merck and Co Inc. University of Pittsburgh School of Medicine hamad healthcare Quality Institute the ACTG 5294 BIRTH Study Team

AIMTo evaluate efficacy/safety of hepatitis C virus (HCV) protease inhibitor boceprevir with pegylated interferon (PeG-IFN) alfa and weight-based ribavirin (RBV) in a phase 3 trial. MeTHODSA prospective, multicenter, phase 3, open-label, single-arm study of PeG-IFN alfa, weight-based RBV, and boceprevir, with a PeG-IFN/RBV lead-in phase was performed. The HCV/human immunodeficiency virus coinfected study population included treatment naïve (TN) and treatment experienced (Te) patients. Treatment duration ranged from 28 to 48 wk dependent upon response-guided criteria. All patients had HCV Genotype 1 with a viral load > 10000 IU/mL. Compensated cirrhosis was allowed. Sample size was determined to establish superiority to historical (PeG-IFN plus RBV) rates in sustained viral response (SVR). ReSULTSA total of 257 enrolled participants were analyzed (135 TN and 122 Te). In the TN group, 81.5% were male and 54.1% were black. In the Te group, 76.2% were male and 47.5% were white. Overall SVR12 rates (HCV RNA P = 0.002). Among the TN, SVR12 was 42.1% among whites and 27.4% among blacks (P = 0.09). CONCLUSIONThe trial met its hypothesis of improved SVR compared to historical controls but overall SVR rates were low. All-oral HCV treatments will mitigate these difficulties.

关键词： Human immunodeficiency virus Hepatitis C virus Boceprevir Pegylated interferon alfa Ribavirin

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extracellular matrix-derived materials for tissue engineering and regenerative medicine:A journey from isolation to characterization and application

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Bioactive Materials 2024年第4期34卷 494-519页

作者： Helena Vilaça-Faria jennifer Noro Rui L.Reis Rogério P.Pirraco 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkParque de Ciência e TecnologiaZona Industrial da Gandra4805-017BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory BragaGuimarãesPortugal

Biomaterial choice is an essential step during the development tissue engineering and regenerative medicine(TeRM)*** selected biomaterial must present properties allowing the physiological-like recapitulation of several processes that lead to the reestablishment of homeostatic tissue or organ *** derived from the extracellular matrix(eCM)present many such properties and their use in the field has been steadily *** this growing importance,it becomes imperative to provide a comprehensive overview of eCM biomaterials,encompassing their sourcing,processing,and integration into TeRM *** review compiles the main strategies used to isolate and process eCM-derived biomaterials as well as different techniques used for its characterization,namely biochemical and chemical,physical,morphological,and ***,some of their applications in the TeRM field are explored and discussed.

关键词： extracted eCM extraction methods Characterization eCM-derived applications

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Diet quality in patients with stroke

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Stroke & Vascular Neurology 2019年第3期4卷 154-157页

作者： jennifer L Dearborn Tehmina Khera Meghan Peterson Zartashia Shahab Walter N Kernan Department of Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology Yale UniversityNew HavenConnecticutUSA Department of Internal Medicine Yale University School of MedicineNew HavenConnecticutUSA

Objective A healthy diet is associated with reduced risk for stroke,myocardial infarction,cancer and *** examined the prevalence of a healthy diet in patients with a recent stroke or transient ischaemic attack(TIA).Methods We recruited a convenience sample of 95 patients with a recent ischaemic stroke or *** information from a 125-item Food Frequency Questionnaire,we calculated dietary quality and the percentage of patients meeting recommended daily intake(RDI)for common macronutrients and *** The mean age of patients was 66 years(SD:16)and 46%were women.39 patients(41%)were classified as having a healthy diet(35%of men and 48%of women).The majority of patients were within the RDI for carbohydrates(56.8%),total fat(61.1%),long-chain n-3 fats(68.4%),polyunsaturated fats(79.0%)and protein(96.8%).Very few patients consumed the recommended intake for sodium(25.3%),and even fewer consumed the RDI for potassium(4.2%),with the majority of patients consuming too much sodium and too little *** We found that most patients with recent stroke or TIA were not following a healthy diet before their stroke *** most patients,sodium intake was much above and potassium intake was much below RDI.

关键词： patients intake potassium

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Pasture-finishing of bison improves animal metabolic health and potential health-promoting compounds in meat

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1759-1776页

作者： Stephan van Vliet Amanda D.Blair Lydia M.Hite jennifer Cloward Robert e.Ward Carter Kruse Herman A.van Wietmarchsen Nick van eekeren Scott L.Kronberg Frederick D.Provenza Center for Human Nutrition Studies Department of NutritionDieteticsand Food SciencesCollege of Agriculture and Applied SciencesUtah State UniversityLoganUT 84322USA Department of Wildland Resources Utah State UniversityLoganUT 84332USA Department of Animal Science South Dakota State UniversityBrookingsSD 57707USA Turner Institute of ecoagriculture BozemanMT 59718USA Louis Bolk Institute Bunnik 3981AJthe Netherlands Northern Great Plains Research Laboratory USDA-Agricultural Research ServiceMandanND 58554USA

Background With rising concerns regarding the effects of red meat on human and environmental health,a growing number of livestock producers are exploring ways to improve production systems.A promising avenue includes agro-ecological practices such as rotational grazing of locally adapted ***,growing consumer interest in pasture-finished meat(i.e.,grass-fed)has raised questions about its nutritional ***,the goal of this study was to determine the impact of two common finishing systems in North American bison—pasture-finished or pen-finished on concentrates for 146 d—on metabolomic,lipidomic,and fatty acid profiles of striploins(*** lumborum).Results Six hundred and seventy-one(671)out of 1570 profiled compounds(43%)differed between pasture-and penfinished conditions(n=20 animals per group)(all,Pelative to pasture-finished animals,the muscle of pen-finished animals displayed elevated glucose metabolites(~1.6-fold),triglycerides(~2-fold),markers of oxidative stress(~1.5-fold),and proteolysis(~1.2-fold).In contrast,pasture-finished animals displayed improved mitochondrial(~1.3-fold higher levels of various Krebs cycle metabolites)and carnitine metabolism(~3-fold higher levels of long-chain acyl carnitines)(all Pe-finishing also concentrated higher levels of phenolics(~2.3-fold),alpha-tocopherol(~5.8-fold),carotene(~2.0-fold),and very long-chain fatty acids(~1.3-fold)in their meat,while having lower levels of a common advanced lipoxidation(4-hydroxy-nonenal-glutathione;~2-fold)and glycation end-product(N6-carboxymethyllysine;~1.7-fold)(all Peta-tocopherol,and three phenolics commonly found in alfalfa were~2.5-fold higher in pen-finished animals(all Pesting some concentrate feeding,or grazing plants rich in those compounds,may be *** Pasture-finishing(i.e.,grass-fed)broadly improves bison metabolic health and accumulates additional po

关键词： Bison Grass-fed Meat Nutrition Omega-3 fats Pasture-raised Phytochemicals

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Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5

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Bone Research 2023年第3期11卷 595-606页

作者： Cassandra R.Diegel Ina Kramer Charles Moes Gabrielle e.Foxa Mitchell J.McDonald Zachary B.Madaj Sabine Guth Jun Liu jennifer L.Harris Michaela Kneissel Bart O.Williams Department of Cell Biology Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Diseases of Aging and Regenerative Medicine Novartis Institutes for Biomedical ResearchCH-4002 BaselSwitzerland Bioinformatics and Biostatistics Core Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Oncology Novartis Institutes for Biomedical ResearchSan DiegoCA 92121USA

Proper regulation of Wnt signaling is critical for normal bone development and *** in several Wnt signaling components,which increase the activity of the pathway in the skeleton,cause high bone mass in human subjects and mouse *** bone mass is often accompanied by severe headaches from increased intracranial pressure,which can lead to fatality and loss of vision or hearing due to the entrapment of cranial *** addition,progressive forehead bossing and mandibular overgrowth occur in almost all *** that would provide symptomatic relief in these subjects are ***-mediated palmitoylation is necessary for Wnt secretion and binding to the frizzled *** inhibition of porcupine is a highly selective method of Wnt signaling *** treated three different mouse models of high bone mass caused by aberrant Wnt signaling,including homozygosity for loss-of-function in Sost,which models sclerosteosis,and two strains of mice carrying different point mutations in Lrp5(equivalent to human G171V and A214V),at 3 months of age with porcupine inhibitors for 5–6 *** significantly reduced both trabecular and cortical bone mass in all three *** demonstrates that porcupine inhibition is potentially therapeutic for symptomatic relief in subjects who suffer from these disorders and further establishes that the continued production of Wnts is necessary for sustaining high bone mass in these models.

关键词： homeostasis function mass

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Tooth loss patterns in older adults with special needs:a Minnesota cohort

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International Journal of Oral Science 2011年第1期3卷 27-33页

作者： jennifer J.Clark Department of Dental ecology University of North CarolinaChapel HillNC 27599USA

This study was conducted to detail tooth loss patterns in older adults with special needs. A total of 491 elderly subjects with special needs were retrospectively selected and followed during 10/1999-12/2006. Medical, dental, cognitive, and functional assessments were abstracted from dental records and used to predict risk of tooth loss. Tooth loss events were recorded for subjects during follow-up. Chi-squared tests were used to study the association between tooth loss and the selected risk factors. Logistic, poisson, and negative binomial regressions were developed to study tooth loss patterns. Overall, 27% of the subjects lost at least one tooth during follow-up. Fourteen subjects had tooth loss events per 100 person-years. Tooth loss pattern did not differ significantly among different special-needs subgroups （i.e. community-dwelling vs. long-term care, physically disabled vs. functionally independent）. Special-needs subjects with three or more active dental conditions at arrival had more than twice the risk of losing teeth than those without any existing conditions. After adjusting other factors, the number of carious teeth or retained roots at arrival was a significant predictor of tooth loss for older adults with special needs （P=0.001）. These findings indicate that appropriately managing active caries and associated conditions is important to prevent tooth loss for older adults with special needs.

关键词： tooth loss elderly special needs

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evaluating the sensitivity of SARS-CoV-2 infection rates on college campuses to wastewater surveillance

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Infectious Disease Modelling 2021年第1期6卷 1144-1158页

作者： Tony e.Wong George M.Thurston Nathaniel Barlow Nathan D.Cahill Lucia Carichino Kara Maki David Ross jennifer Schneider School of Mathematical Sciences Rochester Institute of TechnologyRochesterNY14623USA School of Physics and Astronomy Rochester Institute of TechnologyRochesterNY14623USA Applied Critical Thinking&Collaboratory for Resiliency&Recovery Rochester Institute of TechnologyRochesterNY14623USA Department of Civil engineering Technology Environmental Management&SafetyRochester Institute of TechnologyRochesterNY14623USA

As college campuses reopened in fall 2020,we saw a large-scale experiment unfold on the efficacy of various strategies to contain the SARS-CoV-2 *** individual surveillance testing via nasal swabs and/or saliva is among the measures that colleges are pursuing to reduce the spread of the virus on ***,some colleges are testing wastewater on their campuses for signs of infection,which can provide an early warning signal for campuses to locate COVID-positive ***,a representation of wastewater surveillance has not yet been incorporated into epidemiological models for college campuses,nor has the efficacy of wastewater screening been evaluated relative to traditional individual surveillance testing,within the structure of these ***,we implement a new model component for wastewater surveillance within an established epidemiological model for college *** use a hypothetical residential university to evaluate the efficacy of wastewater surveillance for maintaining low infection *** find that wastewater sampling with a 1-day lag to initiate individual screening tests,plus completing the subsequent tests within a 4-day period can keep overall infections within 5%of the infection rates seen with traditional individual surveillance *** results also indicate that wastewater surveillance can effectively reduce the number of false positive cases by identifying subpopulations for surveillance testing where infectious individuals are more likely to be *** a Monte Carlo risk analysis,we find that surveillance testing that relies solely on wastewater sampling can be fragile against scenarios with high viral reproductive numbers and high rates of infection of campus community members by outside *** results point to the practical importance of additional surveillance measures to limit the spread of the virus on campus and the necessity of a proactive response to the initial signs of outbreak.

关键词： Compartment model Sensitivity analysis Risk analysis COVID-19 Pandemic Wastewater

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