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Regenerative Biomaterials 2020年第4期7卷 413-425页

作者： Hamad Alsaykhan jennifer Z.Paxton Anatomy@Edinburgh Edinburgh Medical School:Biomedical SciencesThe University of EdinburghTeviot PlaceEdinburgh EH89AGUK Department of Basic Medical Sciences College of Medicine and Health SciencesQassim UniversityPO Box 99151911 Unaizah CampusAl-Qassim 51911Saudi Arabia

Musculoskeletal tissue interfaces are a common site of injury in the young,active *** particular,the interface between the musculoskeletal tissues of tendon and bone is often injured and to date,no single treatment has been able to restore the form and function of damaged tissue at the bone-tendon *** engineering and regeneration hold great promise for the manufacture of bespoke in vitro models or implants to be used to advance repair and so this study investigated the material,orientation and culture choices for manufacturing a reproducible 3D model of a musculoskeletal interface between tendon and bone cell *** models are essential for future studies focussing on the regeneration of musculoskeletal interfaces in ***-encapsulated fibrin hydrogels,arranged in a horizontal orientation though a simple moulding procedure,were shown to best support cellular growth and migration of cells to form an in vitro tendon-bone *** study highlights the importance of acknowledging the material and technical challenges in establishing co-cultures and suggests a reproducible methodology to form 3D co-cultures between tendon and bone,or other musculoskeletal cell types,in vitro.

关键词： tendon bone 3D co-culture hydrogels musculoskeletal interface

Fueling the engine and releasing the break: combinational therapy of cancer vaccines and immune checkpoint inhibitors

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Cancer Biology & Medicine 2015年第3期12卷 201-208页

作者： jennifer Kleponis Richard Skelton Lei Zheng Department of Oncology Department of Surgery The Sidney Kimmel Comprehensive Cancer The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care Johns Hopkins University School of Medicine Masters of Health Science Program in Molecular Microbiology and Immunology Johns Hopkins University Bloomberg School of Public Health

Immune checkpoint inhibitors are increasingly drawing much attention in the therapeutic development for cancer treatment. However, many cancer patients do not respond to treatments with immune checkpoint inhibitors, partly because of the lack of tumor-infiltrating effector T cells. Cancer vaccines may prime patients for treatments with immune checkpoint inhibitors by inducing effector T-ceU infiltration into the tumors and immune checkpoint signals. The combination of cancer vaccine and an immune checkpoint inhibitor may function synergistically to induce more effective antitumor immune responses, and clinical trials to test the combination are currently ongoing.

关键词： Cancer vaccine immune checkpoint immunotherapy cytotoxic T-lymphocyte antigen-4 (CTLA-4) programmed death-1(PD- 1) programmed cell death ligand- I (PD -L 1 )

Short, Medium, and Long-Term Stroke Mortality in Libreville and Associated Factors

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Neuroscience & Medicine 2024年第1期15卷 39-50页

作者： Grass Aurelle Mambila Matsalou jennifer Nyangui Mapaga Pupchen M. Gnigone Minka’a Pagbe Michael Chermine Mboumba Mboumba Christian Allognon Mahutondji Aissata Ibrahima Camara Annick A. Nsounda Nelly Diouf Mbourou Michel-Arnaud Saphou-Damon Elsa Ayo Bivigou Philomene Kouna Ndouongo Neurology Department University Hospital of Libreville Libreville Gabon Cardiology Department University Hospitalof Libreville Libreville Gabon

Strokes are common around the world and especially in sub-Saharan Africa. They are responsible for severe sequelae and the majority of deaths. In Gabon, no study on stroke mortality has been conducted. Objective: To determine short, medium, long-term mortality and factors associated with long-term stroke mortality. Method: Our study took place in the Neurology Department of the University Hospital Center of Libreville (UHCL). It was a historical cohort study with descriptive and analytical purposes covering the period from June 1 to August 31, 2018 and taking into account hospitalized patients from January 1, 2013 to December 31, 2017. We conducted a comprehensive systematic recruitment of patients with stroke, 18 years old and more, and had been agreed to give information. We included all patients meeting the inclusion criteria. The data was gathered using Epi-Info 7 software. The CHI-2 test was used for the comparison of frequencies and the Student’s test, for comparison of means. Multivariate analysis with logistic regression allowed us to look for factors associated with long-term mortality. A result was statistically significant for a p 0.05 value. Results: At 3 months, 28 patients (18.1%) died, at 6 months thirty-one patients or 20.1% died. At 5 years old, fifty-three patients or 34.4% had died. The factors associated with long-term mortality, if the lost of sight were all alive were tobacco (p = 0.01) and stroke (p = 0.008). If all those who were lost to sight had died, no factor was associated with 5-year mortality. Conclusion: Stroke mortality must not be taken for granted, it can be underestimated because of the large number of lost sight. Measures must be put in place to strengthen post-stroke monitoring. .

关键词： Stroke Mortality Associated Factors Libreville

Classification of different sustainable flood retention basin types

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Journal of Environmental Sciences 2010年第6期22卷 898-903页

作者： Michelle Robinson Miklas Scholz Nicolas Bastien jennifer Carfrae Scottish Agricultural College Peter Wilson Building Institute for Infrastructure and Environment School of EngineeringThe University of EdinburghWilliam Rankine Building School of Built Environment Heriot-Watt University

Using a revised version of a previously published expert classification system, a database of potential Sustainable Flood Retention Basins has been developed for Scotland. The research shows that the majority of small and former （often old） drinking water reservoirs are kept full and their spillways are continuously in operation. Utilising some of the available capacity to contribute to flood control could significantly reduce the costs of complying with the European Union Flood Directive. Furthermore, the application of a previously developed classification model for Baden in Germany for the Scottish data set showed a lower diversity for basins in Scotland due to less developed infrastructure. The classification system appears to be robust and has the potential, with minor modifications, to be applied across Europe. The principle value of this approach is a clear and unambiguous categorisation, based on standard variables, which can help to promote communication and understanding between stakeholders.

关键词： classification system diffuse pollution control principal component analysis runoff control sustainable flood retention basin

Effect of successive sprays on liquid distribution in fluidized beds

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Particuology 2021年第1期19卷 17-24页

作者： Cedric Briens Liliana Pardo Reyes Franco Berruti jennifer McMillan Institute for Chemicals and Fuels from Alternative Resources Western University22312 Wonderland Rd.IldertonONN0M 2A0Canada Edmonton Research Centre Syncrude Canada Ltd942117th AveEdmontonABT6N 1H4 Canada

In processes such as Fluid Coking^(™),agglomerate formation should be minimized since it reduces the yield of valuable products,and degrades operability because of the fouling of *** experimental model,consisting of an aqueous solution of gum arabic with a dye,has been successfully developed to simulate the formation of agglomerates in the Fluid Coking^(™)process,where bitumen is sprayed into a fluidized bed of coke particles The particles wetted by a spray could be predicted by assuming that all the particles in the wake of bubbles formed from the tip of the spray jet have been wetted by the injected *** transfer of liquid from particles wetted with the spray to dry bed particles was relatively ineffective,as the number of wet particles increased by only 50%.With successive liquid injections,the proportion of the liquid trapped in agglomerates increases in latter injections:large agglomerates from earlier injections accumulate above the grid and are carried by gas bubbles into the spray jet cavity,where they seed fresh agglomerates.

关键词： Fluidized bed Liquid injection Agglomerate formation Fluid Coker

Optimising repetitive transcranial magnetic stimulation for neural circuit repair following traumatic brain injury

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Neural Regeneration Research 2015年第3期10卷 357-359页

作者： jennifer Rodger Rachel M.Sherrard Experimental and Regenerative Neuroscience School of Animal Biologythe University of Western Australia Sorbonne Universités UPMC Univ Paris 06 & CNRSInstitut de Biologie Paris Seine-B2AUMR 8256 Biological Adaptation and AgeingParis France

While it is well-known that neuronal activity promotes plasticity and connectivity, the success of activity-based neural rehabilitation programs remains extremely limited in human clinical experience because they cannot adequately control neuronal excitability and activity within the injured brain in order to induce repair. However, it is possible to non-invasively modulate brain plasticity using brain stimu- lation techniques such as repetitive transcranial （rTMS） and transcranial direct current stimulation （tDCS） techniques, which show promise for repairing injured neural circuits （Henrich-Noack et al., 2013; Lefaucher et al., 2014）. Yet we are far from having full control of these techniques to repair the brain following neurotrauma and need more fundamen- tal research （Ellaway et al., 2014; Lefaucher et al., 2014）. In this perspective we discuss the mechanisms by which rTMS may facilitate neurorehabilitation and propose experimental techniques with which magnetic stimulation may be investi- gated in order to optimise its treatment potential.

关键词： TMS Optimising repetitive transcranial magnetic stimulation for neural circuit repair following traumatic brain injury

Direct impacts of climatic warming on heat stress in endothermic species: seabirds as bioindicators of changing thermoregulatory constraints

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Integrative Zoology 2012年第2期7卷 121-136页

作者： Stephen A.OSWALD jennifer M.ARNOLD Division of Science Pennsylvania State UniversityBerks CampusReadingPennsylvaniaUSA

There is now abundant evidence that contemporary climatic change has indirectly affected a wide-range of species by changing trophic interactions,competition,epidemiology and ***,direct physiological impacts of changing climates are rarely reported for endothermic species,despite being commonly reported for ec*** review the evidence for changing physiological constraints on endothermic vertebrates at high temperatures,integrating theoretical and empirical perspectives on the morphology,physiology and behavior of marine *** for increasing heat stress exposure depends on changes in multiple environmental variables,not just air temperature,as well as organism-specific morphology,physiology and *** breeding at high latitudes are vulnerable to the forecast,extensive temperature changes because of the adaptations they possess to minimize heat ***-latitude species will also be challenged as they currently live close to their thermal limits and will likely suffer future water ***,highly-active species,particularly aerial foragers,are acutely vulnerable as they are least able to dissipate heat at high ***,direct physiological impacts of climatic change appear underrepresented in the published literature,but available data suggest they have much potential to shape behavior,morphology and distribution of endothermic spe*** between future heat stress events and other energetic constraints on endotherms remains largely unexplored but will be key in determining the physiological impacts of climatic ***-scale,biophysical modeling,informed by experiments that quantify thermoregulatory responses of endotherms to heat stress,is an essential precursor to urgently-needed analyses at the population or species level.

关键词： climatic change direct effects of climate physiology seabirds thermoregulation

Perspectives:Gene expression in fisheries management

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Current Zoology 2010年第1期56卷 157-174页

作者： jennifer L.NIELSEN Scott A.PAVEY US Geological Survey Alaska Science Center Department of Biological Sciences Simon Frasier University National Park Service

Functional genes and gene expression have been connected to physiological traits linked to effective production and broodstock selection in aquaculture, selective implications of commercial fish harvest, and adaptive changes reflected in non-commercial fish populations subject to human disturbance and climate change. Gene mapping using single nucleotide polymorphisms （SNPs） to identify functional genes, gene expression （analogue microarrays and real-time PCR）, and digital sequencing technologies looking at RNA transcripts present new concepts and opportunities in support of effective and sustainable fisheries. Genomic tools have been rapidly growing in aquaculture research addressing aspects of fish health, toxicology, and early development. Genomic technologies linking effects in functional genes involved in growth, maturation and life history development have been tied to selection resulting from harvest practices. Incorporating new and ever-increasing knowledge of fish gehomes is opening a different perspective on local adaptation that will prove invaluable in wild fish conservation and management. Conservation of fish stocks is rapidly incorporating research on critical adaptive responses directed at the effects of human dis- turbance and climate change through gene expression studies. Genomic studies of fish populations can be generally grouped into three broad categories： l） evolutionary genomics and biodiversity; 2） adaptive physiological responses to a changing environment; and 3） adaptive behavioral genomics and life history diversity. We review current genomic research in fisheries focusing on those that use microarrays to explore differences in gene expression among phenotypes and within or across populations, information that is critically important to the conservation of fish and their relationship to humans [Current Zoology 56 （1）： 157-174, 2010].

关键词： Fish genome Fisheries management Conservation Gene expression

A Socialist Satire： Manhua Magazine and Political Cartoon Production in the PRC, 1950-1960

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Frontiers of History in China 2013年第1期8卷 78-103页

作者： jennifer Altehenger Department of History and Lau China Institute King's College London Strand WC2R 2LS UK

In June 1950, Manhua magazine published its first issue in Shanghai. Until its closure in 1960, it remained the only national publication dedicated solely to the popularization and discussion of political cartoons. Terse cartoons were needed to promote the numerous mass campaigns initiated by the new government, remind readers of the continuing battle against enemies of the new Communist state, and rally the people in support of a new military conflict developing on the Korean peninsula. This article discusses key moments in the institutional history of Manhua and its artists. The magazine, I argue, played a crucial but often overlooked role in the contest over the form and content of popular cartooning in the first decade of CCP rule. In such, it was the satirical counterpart to the ever more popular lianhuanhua （serial comics）. Cartoonists believed their art might contribute to establishing socialism through well-intentioned and constructive criticism. This, however, did not harmonize with the increasingly fervent control mechanisms of the party-state＇s cultural bureaucracy. The history of Manhua magazine is therefore an example of the expanding political supervision of the popular arts throughout the 1950s. At the same time it is a study of an art that, though popular and political, never won the same political acclaim as its counterpart, lianhuanhua.

关键词： Manhua magazine political cartoons New China cultural production socialism

Transforming Sylvia Plath through Contemporary Chinese Women＇s Poetry

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2017年第1期11卷 38-72页

作者： jennifer Feeley Independent Scholar

The introduction and translation of Sylvia Plath＇s （1932-63） poetry into Chinese in the 198os had a significant impact on women＇s poetry in contemporary China, particularly the work of Zhai Yongming （b. 1955） and Lu Yimin （b. 1962）. Expanding on Lawrence Venuti＇s theory of translation and intertextuality, this article explores the relationship between Chinese translations of Plath and the poetry of Zhai and Lu. It examines four sets of Plath translations and the accompanying paratextual commentaries, demonstrating how Plath＇s Chinese translators inscribe their individual interpretations onto their translations. It shows how these texts are integral in shaping the early poetic output of Zhai and Lu, who further recontextualize Plath through their own poetry, revealing how Plath has been understood, evaluated, and transformed in contemporary China. Ultimately, this process results in a bold new gendered poetics that marks a turning point in Chinese women＇s writing.

关键词： Zhai Yongming Lu Yimin Sylvia Plath translation women's poetry