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Accuracy of triage strategies for human papillomavirus DNA-positive women in low-resource settings:A cross-sectional study in China

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Chinese Journal of Cancer Research 2017年第6期29卷 496-509页

作者： Margaret Wang Shangying Hu Shuang zha o Wenhua zha.g Qinjing Pan Xun zha.g FengChen Jinxiu Han Junfei Ma jennifer S.Smith Youlin Qiao Caihong Zhou Fanghui zhao Department of Cancer Epidemiology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Pritzker School of Medicine University of ChicagoChicagoIL 60637-5415USA UJMT Fogarty Consortium NIH Fogarty International CenterBethesdaMD 20892-2220USA Department of gynecological Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Cytology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Wuxiang Maternal and Child Health Care and Family Planning Service Center Changzhi 046300China Xiangyuan Maternal and Child Health Care and Family Planning Service Center Changzhi 046200China Department of Epidemiology University of North CarolinaChapel HillNC 27599-7435USA Department of Education National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective： CareHPV is a human papillomavirus （HPV） DNA test for low-resource settings （LRS）. This study assesses optimum triage strategies for careHPV-positive women in LRS. Methods： A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid （VIA）, liquid-based cytology and HPV testing by physician- and self-collected careHPV, and physician-collected Hybrid Capture 2 （HC2）. Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary. HPV-positivity was defined as _〉1.0 relative light units/cutoff （RLU/CO） for both careHPV and HC2. Primary physician-HC2, physician-careHPV and self-careHPV and in sequential screening with cytology, VIA, or increased HPV test-positivity performance, stratified by age, were assessed for cervical intraepithelial neoplasia （CIN） grade 2/3 or worse （CIN2/3＋） detection. Results： The sensitivities and specificities of primary HPV testing for CIN2＋ were： 83.8%, 88.1% for physician- careHPV; 72. 1%, 88.2% for self-careHPV; and 97.1%, 86.0% for HC2. Physician-careHPV test-positive women with VIA triage had a sensitivity of 30.9% for CIN2＋ versus 80.9% with cytology triage. Self-careHPV test- positive women with VIA triage was 26.5% versus 66.2 % with cytology triage. The sensitivity of HC2 test-positive women with VIA triage was 38.2 % versus 92.6% with cytology triage. The sensitivity of physician-careHPV testing for CIN2＋ decreased from 83.8% at _〉1.0 RLU/CO to 72.1% at _〉10.00 RLU/CO, while the sensitivity of self- careHPV testing decreased from 72.1% at _〉1.0 RLU/CO to 32.4% at _〉10.00 RLU/CO; similar trends were seen with age-stratification. Conclusions： VIA and cytology triage improved specificity for CIN2/3 than no triage. Sensitivity with VIA triage was unsuitable for a mass-screening program. VIA provider training might improve this strategy. Cytology triage could be feasible where a high-quality cytology program exists. Triage of HPV t

关键词： Cervical cancer human papillomavirus careHPV testing screening triage

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*** STRIKES Sowing the seeds for the C-pop movement

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城市漫步（上海版、英文） 2014年第11期 47-47页

作者： ZOEY zha 不详

With a resume that includes collaborations with global pop stars like jennifer Lopez and girls generation,Los Angeles based production team *** have developed a formula for outrageously catchy hit *** other Asian nations like South Korea and Japan have gone through culture-shaking pop revolutions,the duo of Adam Nierow and Peter Habib have set their sights on China,and have already proven to have a golden touch based on their record breaking partnership with The Voice of China season one runner-up Momo Wu.

关键词： shaking breaking resume

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