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Acta Pharmacologica Sinica 2000年第2期 17-29页

作者： jennifer ong,david ib kerr Department of Anaesthesia and Intensive Care The University of Adelaide Ade-laide South Australia 5005 Australia Department of Anaesthesia and Intensive Care The University of Adelaide Ade-laide South Australia 5005 Australia

Bicuculline-insensitive receptors for the inhibitory neurotransmitter γ-aminobutyric acid (GABA), GABAB receptors, are a distinct subclass of receptors that mediate depression of synaptic transmission and contribute to neu-ronal inhibition. When activated, these receptors reduce transmission at excitatory and inhibitory synapses, as a result of an increase in K+ conductance, or a decrease in voltage-dependent Ca2+ currents. They are also linked to G-proteins, or intracellular effector systems in a very complex manner. The recent development of highly specific and potent agonists and antagonists for these receptors has led to a much better understanding of their physiology and pharmacology, including their heterogeneity, as well as their molecular biology. Over the past year, expression and cloning studies have contributed to major advances in characterizing GABAB receptor structure, with the discovery of the amino acid sequences of GABABRla/R1b splice variants and GABABR2 receptors. These isoforms are

关键词： γ-氨基丁酸 GABA-B受体 GABABR2受体巴氯芬 GABA受体激动剂 GABA受体拮抗剂

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胸腹主动脉瘤：杂交修复术结果

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中国普通外科杂志 2015年第6期24卷 775-780页

作者： Gchad Hughes Nicholas D Andersen jennifer M Hanna Richard L McCann 老启芳美国北加利福尼亚杜伦杜克大学医学中心外科学系心胸外科学组美国北加利福尼亚杜伦杜克大学医学中心外科学系血管外科学组不详

目的:胸腹主动脉瘤(TAAA)的治疗依然是外科中最富挑战性的工作,特别是存在退行性变动脉瘤的老年患者同时患肺疾病更是如此。这篇更新后的单中心报道是关于我们对高危TAAA患者采用完全内脏动脉去分支化结合动脉瘤腔内隔绝的杂交修复术经... 详细信息

目的:胸腹主动脉瘤(TAAA)的治疗依然是外科中最富挑战性的工作,特别是存在退行性变动脉瘤的老年患者同时患肺疾病更是如此。这篇更新后的单中心报道是关于我们对高危TAAA患者采用完全内脏动脉去分支化结合动脉瘤腔内隔绝的杂交修复术经验。方法:从2005年3月—2012年6月间58名患者在单中心接受解剖外内脏血管去分支化及随后的动脉瘤腔内隔绝术。内脏旁路的中位数为4支,最初的33例采用同期手术方式,而最近的25例采用分期手术。结果:患者中位年龄为69.0岁,50%为女性,所有患者存在严重合并症而不适合传统开放修复术。平均主动脉直径(6.7±1.2)cm,30 d/住院病死率、脑卒中率、永久性轻瘫/截瘫率分别为9%、0%以及4%。最近25例分期手术患者的这三种并发症率分别为4%、0%以及0%。平均随访时间(26±21)个月,内脏人工血管通畅率95.3%,所有闭塞的内脏人工血管均为肾动脉,无1例引起永久性截瘫,2例患者需再干预,1例出现ib型内漏,1例出现III型内漏,5年免于再干预率为94%,Kaplan-Meier总体生存率为1年78%、5年62%,5年主动脉相关生存率为87%。结论:这些更新后的结果 ,继续支撑着这一观点:运用完全内脏动脉去分支联合动脉瘤腔内隔绝的杂交技术治疗高龄且不适合传统开放手术的高危TAAA患者是一种理想的选择,而采取分期手术的方式能取得更佳的结果。

关键词：主动脉,胸主动脉,腹动脉瘤修复,腔内预后

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Elastic and Rheological Property Measurements at High Pressure and Temperature Using Ultrasonic Data Transfer Function Method

Elastic and Rheological Property Measurements at High Pressu...

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18th International Conference on High Pressure Science and Technology

作者： Baosheng Li jennifer Kung Robert C.Liebermann Donald J.Weidner Mineral Physics Institute State University of New York at Stony Brook Stony Brook NY 11794 USA Mineral Physics Institute State University of New York at Stony Brook Stony Brook NY 11794 USA Mineral Physics Institute State University of New York at Stony Brook Stony Brook NY 11794 USA Mineral Physics Institute State University of New York at Stony Brook Stony Brook NY 11794 USA

＜正＞ Elastic and rheological properties of Earth minerals at high pressure and temperature are crucial for the understanding of the composition, structure and the dynamics of the Earth’s interior. Recently, we have developed the techniques to measure sound velocity to 8GPa and 1500K using ultrasonic interferemetry and in-situ synchrotron X-ray diffraction in a DIA-type, cubic anvil high pressure apparatus （SAM85） installed at beamline X17B at NSLS in Brookhaven National Laboratory. In these experiments, a piezoelectric transducer is mounted onto a non-stressed surface at the back of the WC anvil to transmit and receive acoustic signals from buffer rod and sample enclosed in Boron epoxy pressure medium. Conventional methods, such as pulse echo overlap and phase comparison, involve sending rf pulse as input signals and recording the in-phase and out-of-phase interference between the buffer rod and sample echoes for travel time measurements. In this case, data collection over a frequency range of 30 MHz takes several minutes which is not satisfactory for capturing the information related to the time dependent processes, such as strain relaxation at high pressure and temperature and phase transformations. In this study, we have implemented a new ultrasonic method for travel time measurements by recording the data transfer function in a a few seconds. Instead of rf pulse, a waveform of sine function （sin（x）/x） with a center frequency of the transducer resonance frequency is sent to excite the piezoelectric transducer. Figure la is an input sine signal with center frequency 50 MHz from 25 to 75 MHz. Its amplitude in the frequency domain is shown in Fig. ib. The amplitude of the signal sent to the buffer rod and sample will be modulated by the transducer response in the corresponding frequency range. The data transfer function, i.e., the response from the buffer rod and sample along the wave propagation path is then recorded. Figure 2 is the recorded data transfe

关键词： Elasticity Synchrotron High Pressrue

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