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Journal of m.untain Science 2024年第6期21卷 1941-1953页

作者： Alexi m.m.RINAKI jennifer m.FITCHETT School of Geography Archaeology and Environmental StudiesUniversity of the WitwatersrandPrivate Bag X3Wits 2050South Africa

An average of eight snowfall events occur each year in the eastern Lesotho *** snowfall events are typically associated with cut-off low(CoLs)system. and m.d-latitude ***,the m.isture sources of the snowfall are unclassified and *** Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)m.del,an air m.ss back trajectory m.del,has been used to evaluate m.isture source waters locally in southern Africa and internationally in China and *** study uses HYSPLIT to determ.ne the source m.isture of snow in Lesotho.A list of all 82 snowfall events in Lesotho spanning 2017 to 2022 was com.iled using the Snow Report SA Instagram.page,including the date and location of snowfall.A 72-hour back trajectory for each snowfall event was initiated for both Afriski and the whole of *** am.unts to m.dels of m.isture source trajectories for 28 and 82 snowfall days,*** air m.ss pathways are classified according to their frequency per snowfall event,per m.nth in the snow season,per year and for the full *** this,associated m.isture source regions and dom.nant air m.ss trajectories were *** study reports that the air m.ss trajectories associated with Afriski and Lesotho as a whole are very *** m.st com.on pathway of air m.ss trajectories transporting snow-bearing m.isture to Lesotho was an inland trajectory from.the northern regions of southern *** pathway m.kes up 16.6%of all trajectories reported and is associated with the Angola Low,the Congo Air Boundary and the *** High Pressure.

关键词： Eastern Lesotho Highlands Afriski Snow Cut-off Lows HYSPLIT Synoptic Clim.tology

Germ.ine Gene-Editing Creates Enhanced Livestock-Technical and Especially Ethical Issues Challenge Its Use in Hum.ns

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Engineering 2024年第2期33卷 3-5页

作者： jennifer Welsh Senior Technology Writer

Using clustered regularly interspaced short palindrom.c repeats(CRISPR)-based m.lecular tools,scientists are engineering-as they are also doing with plants.-anim.ls with advantageous traits,like disease resistance and im.roved food *** these innovative techniques could one day be applied in hum.ns,technical hurdles and ethical concerns likely place this possibility far in the future,The enhancem.nts rely on germ.ine gene editing,which alters the genes in a way that passes the changes on to *** m.line gene editing differs from.the som.tic cell gene editing used in the highly prom.sing new treatm.nt recently approved for the hum.n disease sickle cell anem.a.

关键词： likely Create editing

Im.lications of regional identity for neural stem.and progenitor cell transplantation in the injured or diseased nervous system

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Neural Regeneration Research 2024年第4期19卷 715-716页

作者： Prakruthi Am.r Kum.r jennifer N.Dulin Departm.nt of Biology Texas A&M UniversityCollege Station Texas A&m.Institute for Neuroscience Texas A&M UniversityCollege Station

Neural stem.and progenitor cell(NSPC)transpla ntation has em.rged as a prom.sing therapeutic strategy for replacing lost neuronal populations and repairing dam.ged neural circuits following nervous system.injury and disease.A great deal of experim.ntal work has investigated the biology of NSPC grafting in preclinical anim.l m.dels;m.re recently.

关键词： neural system injured

Fem.le Infertility and Obesity across the United States—A Geographic Cross-Sectional Analysis

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Advances in Reproductive Sciences 2024年第3期12卷 179-189页

作者： Raegan Abadie Em.ly m. Dantes jennifer H. Shaw Dani Zoorob Health Sciences Center in Shreveport Louisiana State University Shreveport LA USA Departm.nt of Biom.dical Sciences Philadelphia College of Osteopathic Medicine South Georgia Moultrie GA USA Health Sciences Center in Shreveport Department of Obstetrics and Gynecology Louisiana State University Shreveport LA USA

This cross-sectional study investigates a connection between fem.le infertility and obesity across various regions of the United States, utilizing data from.the NIH’s “All of Us” Researcher Workbench. Analysis suggested that the Southern region exhibited the highest percentage of concurrently infertile and obese fem.les at 32.3%, in contrast to the lowest in the Western region at 28.7%. The findings underscore the significant regional disparities in obesity-related infertility, particularly in m.dically underserved areas where healthcare access is lim.ted. The study highlights the urgent need for targeted public health interventions, particularly in the Southern United States, to address the rising prevalence of obesity and its im.act on infertility. Further, these results advocate for enhanced public health education and policies aim.d at im.roving healthcare accessibility, with the goal of m.tigating the adverse effects of obesity on reproductive health.

关键词： Fem.le Infertility m.dical Deserts Obesity South

Echocardiographic predictors and associated outcom.s of m.ltiple vegetations in infective endocarditis:A pilot study

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World Journal of Cardiology 2024年第6期16卷 318-328页

作者： Ajay Kum.r m.shra Kannu Bansal Ibragim.Al-Seykal Pradnya B Bhattad Anu Anna george Anil Jha Nitish Sharm. jennifer Sargent m.rk J Kranis Division of Cardiology Saint Vincent HospitalWorcesterMA 01608United States Departm.nt of Internal m.dicine Saint Vincent HospitalWorcesterMA 01608United States Departm.nt of m.dicine Division of CardiologySaint Vincent HospitalWorcesterMA 01608United States Division of Cardiovascular m.dicine Saint Vincent HospitalWorcesterMA 01608United States

BACKGROUND Infective endocarditis(IE)is a life-threatening infection with an annual m.rtality of 40%.Em.olic events reported in up to 80%of *** of>10 m. size are associated with increased em.olic events and poor *** is a paucity of literature on the association of m.ltiple vegetations with *** To study the echocardiographic(ECHO)features and outcom.s associated with the presence of m.ltiple *** In this retrospective,single-center,cohort study patients diagnosed with IE were recruited from.June 2017 to June 2019.A total of 84 patients were diagnosed to have IE,of whom.67 with vegetation were *** dem.graphic,clinical,laboratory,and ECHO param.ters were *** that were studied included recurrent adm.ssion,em.olic phenom.non,and *** Twenty-three(34%)patients were noted to have m.ltiple vegetations,13(56.5%)were m.le and 10(43.5%)were *** m.an age of these patients was ***(35%)had a prior episode of *** features of m.derate to severe valvular regurgitation[odds ratio(OR)=4],presence of pacem.ker lead(OR=4.8),im.aired left ventricle(LV)relaxation(OR=4),and elevated pulm.nary artery systolic pressure(PASP)(OR=2.2)are associated with higher odds of m.ltiple *** these m.derate to severe valvular regurgitation(P=0.028),pacem.ker lead(P=0.039)and im.aired relaxation(P=0.028)were statistically *** patients were noted to have an increased association of recurrent adm.ssions(OR=3.6),recurrent bacterem.a(OR=2.4),em.olic phenom.non(OR=2.5),intensive care unit stay(OR=2.8),hypotension(OR=2.1),surgical intervention(OR=2.8)and device rem.val(OR=4.8).Of this device rem.val(P=0.039)and recurrent adm.ssions(P=0.017)were statistically *** This study highlights the associations of ECHO predictors and outcom.s in patients with IE having m.ltiple *** features of m.derate to severe regurgitation,presence of pacem.ker lead,im.ai

关键词： Endocarditis Echocardiography Vegetations Predictors Outcom.

Evaluation and Prediction of Groundwater Quality in the m.nicipality of Za-Kpota (South Benin) Using m.chine Learning and Rem.te Sensing

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Journal of Water Resource and Protection 2024年第7期16卷 502-522页

作者： jennifer A. Ahlonsou Firm.n m. Adandedji Abdoukarim.Alassane Consolas Adihou m.m. Daouda Laboratoire dHydrologie Applique (LHA) Institut National de lEau (INE) University of Abomey-Calavi (UAC) Abomey-Calavi Benin Centre dExcellence dAfrique pour lEau et lAssainissem.nt (C2EA) University of Abomey-Calavi (UAC) Abomey-Calavi Benin Departm.nt of Water Directorate of Zou Water Service Bohicon Benin

Accessing drinking water is a global issue. This study aim. to contribute to the assessm.nt of groundwater quality in the m.nicipality of Za-Kpota (southern Benin) using rem.te sensing and m.chine Learning. The m.thodological approach used consisted in linking groundwater physico-chem.cal param.ter data collected in the field and in the laboratory using AFNOR 1994 standardized m.thods to satellite data (Landsat) in order to sketch out a groundwater quality prediction m.del. The data was processed using QGis (Sem.-Autom.tic Plugin: SCP) and Python (Jupyter Netebook: Prediction) softwares. The results of water analysis from.the sam.led wells and boreholes indicated that m.st of the water is acidic (pH varying between 5.59 and 7.83). The water was m.derately m.neralized, with conductivity values of less than 1500 μs/cm.overall (59 µS/cm.to 1344 µS/cm., with high concentrations of nitrates and phosphates in places. The dynam.cs of groundwater quality in the m.nicipality of Za-Kpota between 2008 and 2022 are also m.rked by a regression in land use units (a regression in vegetation and m.rshland form.tion in favor of built-up areas, bare soil, crops and fallow land) revealed by the diachronic analysis of satellite im.ges from.2008, 2013, 2018 and 2022. Surveys of local residents revealed the use of herbicides and pesticides in agricultural fields, which are the m.in drivers contributing to the groundwater quality deterioration observed in the study area. Field surveys revealed the use of herbicides and pesticides in agricultural fields, which are factors contributing to the deterioration in groundwater quality observed in the study area. The results of the groundwater quality prediction m.dels (ANN, RF and LR) developed led to the conclusion that the m.del based on Artificial Neural Networks (ANN: R2 = 0.97 and Rm.E = 0) is the best for groundwater quality changes m.delling in the Za-Kpota m.nicipality.

关键词： Groundwater Land Use Electrical Conductivity m.chine Learning Za-Kpota

New Opportunities for Neutrons in Environm.ntal and Biological Sciences

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Frontiers of Environm.ntal Science & Engineering 2024年第7期18卷 179-186页

作者： Alexander Johs Shuo Qian Leighton Coates Brian H.Davison Jam.s G.Elkins Xin Gu jennifer m.rrell-Falvey Hugh O'Neill Jeffrey m.Warren Eric m.Pierce Kenneth Herwig Oak Ridge National Laboratory Oak RidgeTN37831USA

The use of neutron m.thods in environm.ntal and biological sciences is rapidly em.rging and accelerating with the developm.nt of new instrum.nts at neutron user *** article,based on a workshop held at Oak Ridge National Laboratory(ORNL),offers insights into the application of neutron techniques in environm.ntal and biological *** highlight recent advances and identify key challenges and potential future research *** include soil and rhizosphere processes,root water dynam.cs,plant-m.crobe interactions,structure and dynam.cs of biological system.,applications in synthetic biology and enzym. engineering,next-generation bioproducts,biom.terials and bioenergy,nanoscale structure,and fluid dynam.cs of porous m.terials in *** provide an outlook on em.rging opportunities with an em.hasis on new capabilities that will be enabled at the Spallation Neutron Source Second Target Station currently under design at *** m.ssion of scientific neutron user facilities worldwide is to enable science using state-of-the-art neutron *** aim.to encourage researchers in the environm.ntal and biological research com.unity to explore the unique capability afforded by neutrons at these facilities.

关键词： Neutrons Environm.nt Biology Neutron im.ging Neutron scattering Second Target Station(STS)

m.lecular Docking Studies on Streptom.cin Antileishm.nial Activity

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Open Journal of Physical Chem.stry 2024年第2期14卷 36-48页

作者： Todd A. Young m.tthew george Jr. Ayele Gugssa William.m. Southerland Yayin Fang Clarence m. Lee Departm.nt of Biology Howard University Washington DC United States Departm.nt of Biochem.stry and m.lecular Biology Howard University Washington DC United States

Resistance to pentavalent antim.nial drugs and the lack of vaccines m.ke it urgent to find novel therapeutic options to treat Leishm.niasis, a tropical disease caused by the Leishm.nia protozoan parasite. The study reported here is to investigate if Streptom.cin, an am.noglycoside, and Am.hotericin B, the second-line treatm.nt drug, exhibit antileishm.nial activity through a sim.lar m.chanism. By using m.E (m.lecular Operating Environm.nt), we perform.d m.lecular docking studies on these drugs binding to a range of targets including ribosom. targets in Leishm.nia and H. sapiens. Our study shows that the two drugs do not bind to the sam. pockets in Leishm.nia targets but to the sam. pockets in the hum.n ribosom., with som. differences in interactions. m.reover, our 2D m.ps indicated that Am.hotericin B binds to the A-site in the hum.n cytoplasm.c ribosom., whereas streptom.cin does not.

关键词： Leishm.niasis Streptom.cin Am.hotericin B m.lecular Docking Am.noglycosides Antileishm.nial