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低浓度甲基二磷戊二醛可引起接触致敏

世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 53-54页

作者： Pedersen l.K. Agner T. Held E. Johansen J.d. 崔荣 Natl. Allerg. Re s. Ctr. Consum. P. Gentofte Hospital University of Copenhagen Copenhagen Denmark

Background: The rapidly increasing level of contact allergy to methyldibromog lutaronitrile (MdBGN) in Europe is of concern. In April 2003, the EU Commission prohibited the use of MdBGN in leave-on cosmetic products, such as creams and lotions, until a level of safe use can be defined. Industry risk assessment has indicated that such a safe level could be 50- 100 p.p.m. Objectives: To determi ne whether 50 p.p.m. or 100 p.p.m. could be tolerated by MdBGN-sensitized indi viduals, and to evaluate if the risk for elicitation of MdBGN allergy is higher for a leave-on product with a high lipid content than for a product with a low lipid content. Methods: Eighteen volunteerswith contact allergy to MdBGN and 10 healthy controls were exposed to repeated open application tests (ROATs) with t wo moisturizers with a high and a low lipid content, respectively, both containi ng MdBGN at a concentration of 50 p.p.m. The ROATs were performed on the left an d the right side of the neck for 14 days, or until a positive re action was seen. If a positive reaction did not develop within the first 14 d ays, two analogous moisturizers containing 100 p.p.m. MdBGN were applied for a f urther 14 days. Clinical assessments were done on days 2, 3, 7, 14, 21 and 28 or when a reaction developed. Results: Eleven of 18 (61% ) subjects developed der matitis on the test area, of whom 10 developed a positive reaction to the 50 p.p .m. moisturizer, seven having a positive reaction on day 2 or 3. Reactions to th e low-lipid moisturizer were the more frequent. All participants used more of the low-lipid moisturizer than the high-lipid moisturizer. The controls all had negative ROATs. Conclusions: Even 50 p.p.m. cannot be regarded as a safe con centration for use and the prohibition of MdBGN is scientifically well founded.

关键词：致敏安全剂量接触试验阳性反应霜剂反应时临床评估风险评估接触部位

血浆纤维蛋白原在2型糖尿病视网膜病变风险评估中的应用研究

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浙江医学教育 2023年第5期22卷 316-320页

作者：许婵吴敏韩帆南晓晶沃铭毅浙江中医药大学附属第三医院检验科杭州310005 浙江省人民医院杭州医学院附属人民医院检验中心杭州310014

目的探讨血浆纤维蛋白原(fibrinogen,Fbg)在2型糖尿病(type 2 diabetes,T2d)视网膜病变(diabetic retinopathy,dR)风险评估中的临床价值。方法选择浙江中医药大学附属第三医院和浙江省人民医院内分泌科就诊的307例T2d患者为研究对象,采... 详细信息

目的探讨血浆纤维蛋白原(fibrinogen,Fbg)在2型糖尿病(type 2 diabetes,T2d)视网膜病变(diabetic retinopathy,dR)风险评估中的临床价值。方法选择浙江中医药大学附属第三医院和浙江省人民医院内分泌科就诊的307例T2d患者为研究对象,采用Sysmex CS-5100血凝仪测定患者血浆Fbg、PT、APTT、TT和d-二聚体,将307例T2d患者分为试验组(dR组,95例)和对照组(单纯T2d组,212例),根据疾病严重程度,将试验组患者分为非增殖性dR组(NPdR组,31例)和增殖性dR组(PdR组,64例),分析患者血浆Fbg水平与dR及其严重程度的关系,ROC曲线评估Fbg对dR和增殖性dR的鉴别效能,logistic回归分析Fbg在dR和增殖性dR中的预测价值。结果试验组患者Fbg水平高于对照组患者(t=7.881,PdR组患者Fbg水平高于NPdR组患者(t=5.366,PdR和单纯T2d的ROC曲线下面积为0.835(95%CI:0.775~0.896,Pl时,其敏感性和特异性分别为78%和71%;Fbg鉴别增殖性和非增殖性dR的ROC曲线下面积为0.778(95%CI:0.729~0.828,Pl时,其敏感性和特异性分别为82%和75%。多因素回归分析显示,Fbg为dR和增殖性dR的独立危险因素,比值比(odds ratio,OR)分别为4.516(95%CI:2.886~13.655)和4.289(95%CI:2.401~10.430)(P<0.001)。结论血浆纤维蛋白原可以作为糖尿病视网膜病变及其进展的独立预测因子。

关键词：糖尿病视网膜病变纤维蛋白原危险因子鉴别预测

Efect of Nanometer WC Coating on Thermal Conductivity of diamond/6061 Composites

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Acta Metallurgica Sinica(English letters) 2023年第1期36卷 118-126页

作者： Z.Y.dong d.Wang W.G.Wang B.l.Xiao Z.Y.Ma Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China liaoning Shihua University Fushun 113001China

diamond has poor interface tolerance with *** enhance interface bonding,in this study,tungsten carbide(WC)nanocoatings on the surface of diamond particles were prepared using sol–gel and in-situ reaction ***_(3) sol–gel with two concentrations,0.2 mol/l,and 0.5 mol/l,was,respectively,coated on diamond particles,then sintered at 1250℃for 2 h to produce WC *** concentration of 0.2 mol/l wo_(3) sol–gel was not enough to cover the surface of the diamond completely,while 0.5 mol/l wo_(3) sol–gel could fully cover ***,wo_(3) was preferentially deposited on{100}planes of the ***_(3) converted to WC in-situ nanocoatings after sintering due to the in-situ reaction of wo_(3) and *** diamond-reinforced Al composites with and without WC coating were fabricated by powder *** diamond/Al composite without coating has a thermal conductivity of 584.7 W/mK,while the composite with a coating formed by 0.2 mol/l and 0.5 mol/l wo_(3) sol–gel showed thermal conductivities of 626.1 W/mK and 584.2 W/mK,*** moderate thickness of nanocoatings formed by 0.2 mol/l wo_(3) sol–gel could enhance interface bonding,therefore improving thermal *** nanocoating produced by 0.5 mol/l wo_(3) sol–gel cracked during the fabrication of the composite,leading to Al12W formation and a decrease in thermal conductivity.

关键词： diamond Al matrix composite Nanometer coating WC Thermal conductivity

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睡眠剥夺对大鼠动脉粥样硬化的影响

临床荟萃 2011年第6期26卷 497-500,F0002页

作者：许耘红李志梁吴沃栋黄焕亮南方医科大学珠江医院心内科广东广州510282 广州医学院第三附属医院心内科广东广州510150

目的探讨睡眠剥夺(sleep deprivation,Sd)对动脉粥样硬化(atherosclerosis,AS)进程的影响及其机制。方法 50只Wistar AS雄性大鼠随机分为5组(每组10只):AS组、Sd1d组、Sd3d组、Sd5d组、Sd7d组。建立AS大鼠Sd模型,制备主动脉组织标本,苏... 详细信息

目的探讨睡眠剥夺(sleep deprivation,Sd)对动脉粥样硬化(atherosclerosis,AS)进程的影响及其机制。方法 50只Wistar AS雄性大鼠随机分为5组(每组10只):AS组、Sd1d组、Sd3d组、Sd5d组、Sd7d组。建立AS大鼠Sd模型,制备主动脉组织标本,苏木精伊红(hematoxylin and eosin,HE)染色,光镜观察切片。检测主动脉组织还原型谷胱甘肽(glutathione,GSH)及脂质过氧化物丙二醛(malondialdehyde,MdA)含量、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)及超氧化物歧化酶(superoxide dismutase,SOd)活性。检测血清肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、高敏C反应蛋白(hypersensitivity-C reactive protein,hsCRP)、白细胞介素6(interleukin-6,Il-6)水平。结果随着睡眠剥夺时间的延长,大鼠AS病变进展逐渐加重。主动脉组织GSH含量逐渐降低,MdA含量逐渐增高,GSH-Px及SOd活性逐渐降低。血清中TNF-α、hsCRPI、l-6水平也在逐渐增高。结论睡眠剥夺可通过引起机体的氧化应激反应及加速炎症发展,从而促进AS进程。

关键词：睡眠剥夺氧化性应激炎症动脉粥样硬化

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妊娠期外伤:母亲和胎儿结局的大样本分析

世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 14-15页

作者： El Kady d. Gilbert W.M. Anderson J. l.H.Smith 郭慧方 depts. Obstet. Gyne col. and Surg. Div. Trauma Surg. Univ. C. Sch. Med. Sacramento Calif H. Ro cklinCA United States Dr.

Objective This study was undertaken to determine the occurrence rates , outcome s, risk factors, and timing of obstetric delivery for trauma sustained during pr egnancy. Study design This is a retrospective cohort study of women hospitalized for trauma in California (1991-1999). International Classification of disease, ninth revision, Clinical Modification codes, and external causation codes for i njury were identified. Maternal and fetal/neonatal outcomes were analyzed for wo men delivering at the trauma hospitalization (group 1), and women sustaining tra uma prenatally (group 2), compared with nontrauma controls. Injury severity scor es and injury types were used to stratify risk in relation to outcome. Statistic al comparisons are expressed as odds ratios (ORs) with 95%CIs. Results A total of 10,316 deliveries fulfilling study criteria were identified in 4,833,286 tota l deliveries. Fractures, dislocations, sprains, and strains were the most common type of injury. Group 1 was associated with the worst outcomes: maternal death OR 69 (95%CI 42-115), fetal death OR 4.7 (95%CI 3.4-6.4), uterine rupture OR 43 (95%CI 19-97), and placental abruption OR 9.2 (95%CI 7.8-11). Group 2 al so resulted in increased risks at delivery: placental abruption OR 1.6 (95%CI 1 .3-1.9), preterm labor OR 2.7 (95%CI 2.5-2.9), maternal death OR 4.4 (95%CI 1.4-14). As injury severity scores increased, outcomes worsened, yet were stati stically nonpredictive. The type of injury most commonly leading to maternal dea th was internal injury. The risk of fetal, neonatal, and infant death was strong ly influenced by gestational age at the time of delivery. Conclusion women deliv ering at the trauma hospitalization (group 1) had the worst outcomes, regardless of the severity of the injury. Group 2 women (prenatal injury) had an increased risk of adverse outcomes at delivery, and therefore should be monitored closely during the subsequent course of the pregnancy. This study highlights the need t o

关键词：胎盘早剥样本分析子宫破裂终止妊娠国际疾病分类婴儿死亡加利福尼亚州队列分析持续性预防教育

Measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

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Chinese Physics C 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg H.Aihara N.Akopov A.Aloisio F.Ameli l.Andricek N.Anh Ky d.M.Asner H.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu S.Baehr S.Bahinipati A.M.Bakich P.Bambade Sw.Banerjee S.Bansal V.Bansal M.Barrett J.Baudot A.Beaulieu J.Becker P.K.Behera J.V.Bennett E.Bernieri F.U.Bernlochner M.Bertemes M.Bessner S.Bettarini V.Bhardwaj F.Bianchi T.Bilka S.Bilokin d.Biswas G.Bonvicini A.Bozek M.Bračko P.Branchini N.Braun T.E.Browder A.Budano S.Bussino M.Campajola l.Cao G.Casarosa C.Cecchi d.Červenkov M.-C.Chang P.Chang R.Cheaib V.Chekelian Y.Q.Chen Y.-T.Chen B.G.Cheon K.Chilikin H.-E.Cho K.Cho S.Cho S.-K.Choi S.Choudhury d.Cinabro l.Corona l.M.Cremaldi S.Cunliffe T.Czank F.dattola E.de la Cruz-Burelo G.de Nardo M.de Nuccio G.de Pietro R.de Sangro M.destefanis S.dey A.de Yta-Hernandez F.di Capua S.di Carlo J.dingfelder Z.doležal I.domínguez Jiménez T.V.dong K.dort S.dubey S.duell S.Eidelman M.Eliachevitch T.Ferber d.Ferlewicz G.Finocchiaro S.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom M.Gabriel E.Ganiev M.Garcia-Hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich J.Gemmler T.Geßler R.Giordano A.Giri B.Gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani d.Greenwald C.Hadjivasiliou S.Halder K.Hara T.Hara O.Hartbrich K.Hayasaka H.Hayashii C.Hearty M.T.Hedges I.Heredia de la Cruz M.Hernández Villanueva A.Hershenhorn T.Higuchi E.C.Hill H.Hirata M.Hoek S.Hollitt T.Hotta C.-l.Hsu Y.Hu K.Huang T.Iijima K.Inami G.Inguglia J.Irakkathil Jabbar A.Ishikawa R.Itoh M.Iwasaki Y.Iwasaki S.Iwata P.Jackson W.W.Jacobs d.E.Jaffe E.-J.Jang H.B.Jeon S.Jia Y.Jin C.Joo J.Kahn H.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki H.Kichimi C.Kiesling B.H.Kim C.-H.Kim d.Y.Kim S.-H.Kim Y.K.Kim Y.Kim T.d.Kimmel K.Kinoshita C.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno S.Korpar d.Kotchetkov N.Kovalchuk T.M.G.Kraetzschmar P.Križan R.Kroeger J.F.Krohn P.Krokovny W.Kuehn T.Kuhr M.Kumar R.Kumar K.Kumara S.Kurz A.Kuzmin Y.-J.Kwon S.lacaprara Y.-T.lai C.la licata K.lalwani l.lanceri J.S.lange K.lautenbach I.-S.le Beihang University Beijing 100191 Brookhaven National laboratory UptonNew York 11973 Budker Institute of Nuclear Physics SB RAS Novosibirsk 630090 Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional Mexico City 07360 Faculty of Mathematics and Physics Charles University12116 Prague Chiba University Chiba 263-8522 Consejo Nacional de Ciencia y Tecnología Mexico City 03940 deutsches Elektronen–Synchrotron 22607 Hamburg duke University DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 Forschungszentrum Jülich 52425 Jülich department of Physics Fu Jen Catholic UniversityTaipei 24205 Key laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced Studies(SOKENdAI) Hayama 240-0193 Gyeongsang National University Jinju 52828 department of Physics and Institute of Natural Sciences Hanyang UniversitySeoul 04763 High Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 J-PARC Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of Science Education and Research Mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology Hyderabad Telangana 502285 Indian Institute of Technology Madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for High Energy Physics Protvino 142281 Institute of High Energy Physics Vienna 1050 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(Canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica Corpuscular Paterna 46980 INFN laboratori Nazionali di Frascati I-00044 Frascati INFN Sezione di Napoli I-80126 Napoli INFN Sezione di Padova I-35131 Padova INFN Sezione di Perugia I-06123 Perugia

From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

不同结合臂长10-23dNAzymes对乙型肝炎病毒S基因和C基因表达的抑制作用

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中华内科杂志 2006年第5期45卷 396-399页

作者：侯伟沃健儿刘克洲李敏伟陈离伟胡中荣刘荣华胡敏君浙江大学医学院附属第一医院传染病研究所卫生部传染病重点实验室杭州310003

目的探讨不同结合臂长1023dNAzymes在2.2.15细胞内对乙型肝炎病毒S基因和C基因表达的抑制作用。方法设计并合成不同结合臂长的1023dNAzymes,能分别针对乙型肝炎病毒S基因和C基因开放阅读框A157UG和A1816UG。不同的1023dNAzymes分别转染2... 详细信息

目的探讨不同结合臂长1023dNAzymes在2.2.15细胞内对乙型肝炎病毒S基因和C基因表达的抑制作用。方法设计并合成不同结合臂长的1023dNAzymes,能分别针对乙型肝炎病毒S基因和C基因开放阅读框A157UG和A1816UG。不同的1023dNAzymes分别转染2.2.15细胞,放射免疫分析法测定2.2.15细胞培养上清中HBsAg和HBeAg水平,实时荧光定量PCR法测定2.2.15细胞培养上清中HBVdNA水平。MTT法检测细胞毒性。结果不同结合臂长的1023dNAzymes在0.1～2.5μmol/l浓度范围内均能有效抑制HBsAg和HBeAg的表达,抑制效应可长达72h。在同一剂量相同转染时间的条件下,不同结合臂长的1023dNAzymes对HBsAg和HBeAg表达的抑制率呈以下关系:drzBS9>drzBS8>drzBS7;drzBC9>drzBC8>drzBC7。drzBS9和drzBC9在2.5μmol/l剂量条件下,转染48h后对HBsAg和HBeAg表达的抑制率可分别高达95%和92%。不同结合臂长的1023dNAzymes对2.2.15细胞培养上清中HBVdNA水平并无明显影响。MTT细胞毒性检测表明,在0.1～2.5μmol/l浓度范围内未见1023dNAzymes对2.2.15细胞的毒性作用。结论不同结合臂长1023dNAzymes在2.2.15细胞内对乙型肝炎病毒S基因和C基因表达均有一定的抑制作用,drzBS9和drzBC9的抑制作用较强。

关键词： 10-23 dNAzyme S基因 C基因乙型肝炎病毒

Nat Genet:单基因突变导致过敏性皮炎的发生

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现代生物医学进展 2017年第27期17卷 I0004-I0004页

作者： Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J lyons, Celeste G Nelson, Thomas diMaggio, Kelly d Stone, Joshua d Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew l Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre jennifer Stoddard, Julie Niemela, Sergio d Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo dubra, Silvia danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg laboratory of Allergic diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA department of Pharmacology and Molecular Therapeutics Uniformed Services University of the Health Sciences Bethesda Maryland USA Immunodeficiency diagnosis and Treatment Program Department of Pediatrics National Jewish Health Denver Colorado USA department of Translational Medicine University of Piemonte Orientale Novara Italy department of Immunobiology Yale University School of Medicine New Haven Connecticut USA Immunology Service Department of Laboratory Medicine NIH Clinical Center National Institutes of Health Bethesda Maryland USA Human Immunological disease Section National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Merck Research laboratories Merck and Co. Inc. Boston Massachusetts USA Clinical Research directorate/Clinical Monitoring Research Program Leidos Biomedical Research Inc. NCI Campus at Frederick Frederick Maryland USA Servicio de Immunología y Reumatología Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan Buenos Aires Argentina division of dermatology Department of Medicine Washington University School of Medicine St. Louis Missouri USA department of Pediatrics Division of Rheumatology and Department of Pathology and Immunology Washington University School of Medicine St. Louis Missouri USA department of Pediatrics Children’s Hospital of Philadelphia Philadelphia Pennsylvania USA.

最近，研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变：CARdll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析，发现了这一导致疾病产生的基因、

关键词：过敏性皮炎基因突变 Nat 神经性皮炎血缘关系研究所传染病 NIH

臭氧治疗对家兔骨性关节炎病变及NO含量的影响

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贵阳医学院学报 2010年第4期35卷 349-351页

作者：王林王大寿穆琼姚旌陆巍沃春新贵阳医学院附院疼痛科贵州贵阳550004

目的：探讨臭氧治疗对家兔骨性关节炎（OA）关节冲洗液中NO含量的影响。方法：40只新西兰兔随机分为5组,A组为正常对照组,B组为模型对照组,C、d、E组分别为臭氧（20、40、60 mg/l）治疗组;用Vand-m an法造模型成功后,将不同浓度的臭氧... 详细信息

目的：探讨臭氧治疗对家兔骨性关节炎（OA）关节冲洗液中NO含量的影响。方法：40只新西兰兔随机分为5组,A组为正常对照组,B组为模型对照组,C、d、E组分别为臭氧（20、40、60 mg/l）治疗组;用Vand-m an法造模型成功后,将不同浓度的臭氧注射入C、d、E组兔膝关节腔内,每3天1次,连续2次;检测关节冲洗液中NO的含量,观察关节软骨的病理变化并进行病理评分。结果：B组软骨呈典型的OA改变,C、d组关节软骨可见不同程度修复,病理评分与B组相比有显著性差异（P〈0.01或P〈0.05）;E组未见明显修复,病理评分与B组无显著差异;与A组相比,B组关节冲洗液中NO含量显著增高（P〈0.01）;与B组相比,C、d治疗组NO含量显著降低（P〈0.01）,E组NO显著增高（P〈0.01）。结论：20~40 mg/l浓度的臭氧可促进实验性OA关节软骨修复,其机制可能与抑制NO生成有关,60 mg/l浓度的臭氧无软骨修复作用。

关键词：骨关节炎臭氧软骨,关节一氧化氮兔