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A Randomized Controlled Trial of Mindfulness in Recovery from Colorectal Cancer

Chinese Journal of Integrative Medicine 2023年第7期29卷 590-599页

作者： Andrew McCombie jennifer jordan Roger Mulder Kishion Dee Ee Lin Ong Fernanda Fernandez Zimmermann Chris Frampton Frank Frizelle Te Whatu Ora(Health New Zealand)Waitaha Canterbury Christchurch 8011New Zealand University of Otago Christchurch 8140New Zealand The Psychology Hub Christchurch 8011New Zealand Oxford Mindfulness Centre University of OxfordOxfordOX12JDUnited Kingdom Nature and Nurture Sparks Christchurch 8013New Zealand University of Otago Dunedin(9016)New Zealand

Objective:This study examined whether a 4-week group-based mindfulness intervention would be superior in reducing psychological distress in colorectal cancer(CRC)patients compared to a psychoeducation and cognitive behavioural skills learning support active control ***:Patients with CRC were randomized via Computerised Permuted Block Randomisation to mindfulness or active control groups(2-h weekly sessions over 4 weeks).Outcomes were measured pre-intervention,and 8 weeks and 6 months *** primary outcome was psychological distress measured by the Hospital Anxiety and Depression *** outcomes were generic quality of life(QoL),disease specific QoL,mindfulness,and intervention credibility and ***:Sixty-eight participants were randomized to mindfulness(n=35)or active control group(n=33).Uptake of potentially eligible patients consenting was low(28.0%)and the dropout rate was 33.8%.Depression scores were reduced in both groups at week 8(P=0.020).Control participants had greater improvement in generic mental QoL scores at week 8 than mindfulness(P=0.023).In disease specific QoL,there was reduction in impotence symptom in the mindfulness group(P=0.022)and reduction in faecal incontinence in the control group(P=0.019).The embarrassment symptom had a significantly lower increase in the mindfulness group at week 8 compared to the control group(P=0.009).Both groups rated the treatments as credible and ***:Mindfulness was not superior to the active control group in terms of alleviating psychological distress but both treatments were associated with some improvements in *** was low uptake of both interventions.(Trial registration number:ACTRN12616001033437)

关键词： anxiety colorectal cancer depression distress mindfulness psychoeducation psychology psychological distress randomized controlled trial quality of life

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给海滩留一片乐土

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疯狂英语（口语版） 2013年第10期 28-28页

作者： jennifer jordan

炎炎烈日，亲们很多都会选择去游泳来避暑，美丽的海滩是很多人的首选之地。火辣辣的阳光，一头扎进碧蓝的海水，真有一种“透心凉”的惬意。可是，沙滩上吵闹的孩子、各种“手机粉”在电话里的喋喋不体，会瞬间扫了我们“清凉一夏”的... 详细信息

炎炎烈日，亲们很多都会选择去游泳来避暑，美丽的海滩是很多人的首选之地。火辣辣的阳光，一头扎进碧蓝的海水，真有一种“透心凉”的惬意。可是，沙滩上吵闹的孩子、各种“手机粉”在电话里的喋喋不体，会瞬间扫了我们“清凉一夏”的兴致。怎么办，怎么办？还想听着周杰伦的“阳光宅男”去和海滩玩游戏呢。别怕，jenniferjordan有办法帮我们解决。

关键词：海滩周杰伦阳光海水沙滩

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家长式领导的六种迹象

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商业评论 2024年第11期 122页

作者：詹妮弗·乔丹徐广彤瑞士IMD商学院

为了筹备与一家全球化学品公司即将开展的合作项目,我对该公司的高层管理人员及其下属进行了系列访谈.我听到了一种熟悉的抱怨:高层管理人员觉得下面的员工缺乏应有的主动性.因此,管理者觉得有义务、有责任去告诉直接下属该做什么,以及...

为了筹备与一家全球化学品公司即将开展的合作项目,我对该公司的高层管理人员及其下属进行了系列访谈.我听到了一种熟悉的抱怨:高层管理人员觉得下面的员工缺乏应有的主动性.因此,管理者觉得有义务、有责任去告诉直接下属该做什么,以及如何做.正如一位经理所说:"他们还没有准备好承担这样的责任,也不具备我们这样的全局视野和理解力."

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Immunotherapy in hepatocellular carcinoma: Combination strategies

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World Journal of Meta-Analysis 2020年第3期8卷 190-209页

作者： Alexander Claudius jordan jennifer Wu Department of Internal Medicine New York University School of MedicineNew YorkNY 10016United States Division of Hematology and Oncology Perlmutter Cancer CenterNew York University Langone Medical CenterNew YorkNY 10016United States

Liver cancer is one of the most common causes of cancer death globally,and its incidence in the United States is *** with advanced hepatocellular carcinoma(HCC)who are not candidates for surgical resection,liver transplant,or locoregional therapies can be treated with systemic *** agents,including sorafenib,lenvatinib,and regorafenib are approved for use as either first-or second-line therapy in this patient population,but all have relatively modest survival *** is potentially susceptible to therapy with checkpoint inhibitors,including agents such as nivolumab and pembrolizumab,which are both approved by the Food and Drug Administration for patients previously treated with sorafenib but have not demonstrated superior overall survival in phase III *** is clear that more effective approaches are needed to potentiate the effects of checkpoint inhibitors in patients with *** review will outline and appraise the current literature on the use of checkpoint inhibitors in HCC as part of a combination treatment involving an additional mode of *** list of agents that can be paired with checkpoint inhibitors includes an additional checkpoint inhibitor,vascular endothelial growth factor or vascular endothelial growth factor receptor inhibitors,tyrosine kinase inhibitors,OX-40 agonists,and PT-112 *** main non-pharmacologic therapies currently being studied for inclusion in a combination strategy include radiation therapy,trans-arterial chemoembolization,and ablation.

关键词： Hepatocellular carcinoma Liver neoplasms Antineoplastic agents Immunological Protein kinase inhibitors Angiogenesis inhibitors

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Arsenic speciation in freshwater fish:challenges and research needs

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Food Quality and Safety 2023年第3期7卷 383-407页

作者： Karen S.Hoy Tetiana Davydiuk Xiaojian Chen Chester Lau jordan R.M.Schofield Xiufen Lu jennifer A.Graydon Ruth Mitchell Megan Reichert X.Chris Le Department of Chemistry University of AlbertaEdmontonAlbertaCanada Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAlbertaCanada Alberta Health Health Protection BranchEdmontonAlbertaCanada

Food and water are the main sources of human exposure to *** is important to determine arsenic species in food because the toxicities of arsenic vary greatly with its chemical *** research has focused on high concentrations of arsenic species in marine *** concentrations of arsenic species in freshwater fish are much lower,and their determination presents analytical *** this review,we summarize the current state of knowledge on arsenic speciation in freshwater fish and discuss challenges and research *** samples are typically homogenized,and arsenic species are extracted using water/methanol with the assistance of sonication and enzyme *** species in the extracts are commonly separated using high-performance liquid chromatography(HPLC)and detected using inductively coupled plasma mass spectrometry(ICPMS).Electrospray ionization tandem mass spectrometry,used in combination with HPLC and ICPMS,provides complementary information for the identification and characterization of arsenic *** methods and perspectives discussed in this review,covering sample preparation,chromatography separation,and mass spectrometry detection,are directed to arsenic speciation in freshwater fish and applicable to studies of other food *** progress made in arsenic speciation analysis,a large fraction of the total arsenic in freshwater fish remains *** is challenging to identify and quantify arsenic species present in complex sample matrices at very low *** research is needed to improve the extraction efficiency,chromatographic resolution,detection sensitivity,and characterization capability.

关键词： Arsenic species environment food consumption freshwater fish human exposure identification of unknowns liquid chromatography mass spectrometry

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Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative

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World Journal of Gastrointestinal Oncology 2020年第7期12卷 756-767页

作者： jennifer L Leiting jordan M Cloyd Ahmed Ahmed Keith Fournier Andrew J Lee Sophie Dessureault Seth Felder Jula Veerapong Joel M Baumgartner Callisia Clarke Harveshp Mogal Charles A Staley Mohammad Y Zaidi Sameer H Patel Syed A Ahmad Ryan J Hendrix Laura Lambert Daniel E Abbott Courtney Pokrzywa Mustafa Raoof Christopher J LaRocca Fabian M Johnston Jonathan Greer Travis E Grotz Division of Hepatobiliary and Pancreas Surgery Mayo ClinicRochesterMN 55901United States Division of Surgical Oncology Department of SurgeryThe Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Surgical Oncology University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Gastrointestinal Oncology Moffitt Cancer CenterDepartment of Oncologic SciencesMorsani College of MedicineTampaFL 33612United States Division of Surgical Oncology Department of SurgeryUniversity of CaliforniaSan DiegoCA 92093United States Division of Surgical Oncology Department of SurgeryMedical College of WisconsinMilwaukeeWI 53226United States Division of Surgical Oncology Winship Cancer InstituteEmory UniversityAtlantaGA 30322United States Department of Surgery University of Cincinnati College of MedicineCincinnatiOH 45267United States Division of Surgical Oncology Department of SurgeryUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States Peritoneal Surface Malignancy Program Section of Surgical Oncology Huntsman Cancer InstituteUniversity of UtahSalt Lake CityUT 84112United States Division of Surgical Oncology Department of SurgeryUniversity of WisconsinMadisonWI 53792United States Christopher La Rocca Division of Surgical OncologyDepartment of SurgeryCity of Hope National Medical CenterDuarteCA 91010United States Department of Surgery Johns Hopkins UniversityBaltimoreMD 21287United States

BACKGROUND Cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPEC)for peritoneal carcinomatosis can be performed in two ways:Open or closed abdominal *** To evaluate the impact of HIPEC method on post-operative and long-term survival *** Patients undergoing CRS with HIPEC from 2000-2017 were identified in the United States HIPEC collaborative ***-operative,recurrence,and overall survival outcomes were compared between those who received open vs closed *** Of the 1812 patients undergoing curative-intent CRS and HIPEC,372(21%)patients underwent open HIPEC and 1440(79%)underwent closed *** was no difference in re-operation or severe complications between the two *** HIPEC had higher rates of 90-d readmission while open HIPEC had a higher rate of 90-d *** multi-variable analysis,closed HIPEC technique was not a significant predictor for overall survival(hazards ratio:0.75,95%confidence interval:0.51-1.10,P=0.14)or recurrence-free survival(hazards ratio:1.39,95%confidence interval:1.00-1.93,P=0.05)in the entire *** findings remained consistent in the appendiceal and the colorectal *** In this multi-institutional analysis,the HIPEC method was not independently associated with relevant post-operative or long-term *** technique may be left to the discretion of the operating surgeon.

关键词： Mucinous appendiceal carcinoma Cytoreductive surgery Multi-institutional

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CXCR5^(+)PD-1^(++)CD4^(+)T cells colonize infant intestines early in life and promote B cell maturation

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Cellular & Molecular Immunology 2023年第2期20卷 201-213页

作者： Ana jordan-Paiz Glòria Martrus Fenja L.Steinert Max Kaufmann Adrian F.Sagebiel Renée R.C.E.Schreurs Anne Rechtien Martin E.Baumdick Johannes M.Jung Kimberly J.Möller Lucy Wegner Cordula Grüttner Laura Richert Roland Thünauer jennifer Schroeder-Schwarz Johannes Bvan Goudoever Teunis B.H.Geijtenbeek Marcus Altfeld Steven T.Pals Daniel Perez Paul L.Klarenbeek Christian Tomuschat Guido Sauter Ingo Königs Udo Schumacher Manuel A.Friese Nathaniel Melling Konrad Reinshagen Madeleine J.Bunders Department of Virus Immunology Leibniz Institute of VirologyHamburg20251Germany University Medical Center Hamburg-Eppendorf Hamburg20246Germany Institute of Neuroimmunology and Multiple Sclerosis Center for Molecular Neurobiology HamburgUniversity Medical Center Hamburg-EppendorfHamburg20251Germany Department of General Visceral and Thoracic SurgeryUniversity Medical Center Hamburg-EppendorfHamburg20246Germany Department of Experimental Immunology Amsterdam Infection&Immunity InstituteAmsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterUniversity of Amsterdam and Vrije Universiteit AmsterdamAmsterdam1105 AZThe Netherlands I.Department of Medicine University Medical Center Hamburg-EppendorfHamburg20246Germany Partner Site Hamburg-Lübeck-Borstel-Riems German Center for Infection Research(DZIF)Hamburg20246Germany University of Bordeaux Institut National de la Santéet de la Recherche MédicaleBordeaux Population Health Research Center UMR1219 and INRIA SISTM TeamBordeaux33000France Institute of Anatomy and Experimental Morphology University Medical Center Hamburg-EppendorfHamburg20246Germany Department of Pathology Amsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Rheumatology and Clinical Immunology and Department of Experimental Immunology Amsterdam Infection&Immunity InstituteAmsterdam University Medical CenterUniversity of AmsterdamAmsterdam1007 MBThe Netherlands Amsterdam Rheumatology&Immunology Center Amsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Pediatric Surgery University Medical Center Hamburg-EppendorfHamburg20246Germany Institute of Pathology University Medical Center Hamburg-EppendorfHamburg20246Germany Department of Pediatric Surgery Altona Children’s HospitalHamburg22763Germany III.Department of Medicine University M

Gastrointestinal infections are a major cause for serious clinical complications in *** induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++CD4+T cells(TFH cells).We investigated the ontogeny of CXCR5+PD-1++CD4+T cells in human *** CXCR5+PD-1++CD4+T cells were absent in fetal intestines,CXCR5+PD-1++CD4+T cells increased after birth and were abundant in infant intestines,resulting in significant higher numbers compared to *** findings were supported by scRNAseq analyses,showing increased frequencies of CD4+T cells with a TFH gene signature in infant intestines compared to ***-cultures of autologous infant intestinal CXCR5+PD-1+/−CD4+T cells with B cells further demonstrated that infant intestinal TFH cells were able to effectively promote class switching and antibody production by B *** together,we demonstrate that functional TFH cells are numerous in infant intestines,making them a promising target for oral pediatric vaccine strategies.

关键词： TFH cells B cells Antibodies Intestine Pediatrics

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Female Carriers of the Met Allele of the BDNF Val66Met Polymorphism Develop Weaker Fear Memories in a Fear-Potentiated Startle Paradigm

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Journal of Behavioral and Brain Science 2022年第5期12卷 211-235页

作者： Phillip R. Zoladz Mackenzie R. Riggenbach jordan N. Weiser jennifer J. Hipskind Leighton E. Wireman Kelsey L. Hess Tessa J. Duffy Julie K. Handel MacKenzie G. Kaschalk Kassidy E. Reneau Brianne E. Mosley Psychology Program The School of Health and Behavioral Sciences Ohio Northern University Ada USA

The val66met polymorphism of the bdnf gene, which is associated with compromised brain-derived neurotrophic factor (BDNF) signaling, impaired synaptic plasticity, and impaired learning, may increase one’s susceptibility to stress- and anxiety-related disorders. Indeed, previous work has reported greater anxiety-related behaviors and impairments of fear conditioning and extinction in individuals who carry the met allele that results from this polymorphism. Nevertheless, findings in this area of research have been equivocal. Thus, we examined the influence of the val66met polymorphism on fear conditioning, extinction, and extinction memory testing. One hundred and twenty healthy participants completed differential fear conditioning in a fear-potentiated startle paradigm, followed by extinction and extinction memory testing 24 and 48 hr later, respectively. Participants were genotyped for the val66met polymorphism and divided into met allele carriers and non-carriers. Results revealed that, although both met-carriers and non-carriers developed conditioned fear, met-carriers exhibited significantly weaker fear acquisition than non-carriers. This difference persisted throughout extinction and extinction memory testing and, during these last two days of testing, was primarily evident in females. These results are consistent with previous work demonstrating that this polymorphism is associated with impaired amygdala-dependent fear learning and extend such findings by demonstrating that females may be more sensitive to such effects.

关键词： Fear Conditioning Extinction Polymorphism BDNF Val66Met Startle

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色彩疗愈法:如何选择油漆颜色?

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建筑实践 2016年第9期 116-118页

作者： jennifer Kovacs Silvis 田晓

与宣威(Sherwin-Williams)色彩营销总监Jackie jordan的对话项目实施前,要亲自查看每一个空间,确保你所做的决定,与将来要使用这个空间的人达成最有效的匹配。无论是一个全新投产的朝阳项目,或是推陈翻新的夕阳产品,一个精心配制的调色... 详细信息

与宣威(Sherwin-Williams)色彩营销总监Jackie jordan的对话项目实施前,要亲自查看每一个空间,确保你所做的决定,与将来要使用这个空间的人达成最有效的匹配。无论是一个全新投产的朝阳项目,或是推陈翻新的夕阳产品,一个精心配制的调色方案即可使医疗保健机构发生奇迹般的改进。但首先要确定的是,这个需要改进的场所最适合什么颜色的油漆,我们不仅要充分考虑其内部设施的类型,也要考虑该其所

关键词：设计师

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Nat Genet:单基因突变导致过敏性皮炎的发生

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现代生物医学进展 2017年第27期17卷 I0004-I0004页

作者： Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg Laboratory of Allergic Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Department of Pharmacology and Molecular Therapeutics Uniformed Services University of the Health Sciences Bethesda Maryland USA Immunodeficiency Diagnosis and Treatment Program Department of Pediatrics National Jewish Health Denver Colorado USA Department of Translational Medicine University of Piemonte Orientale Novara Italy Department of Immunobiology Yale University School of Medicine New Haven Connecticut USA Immunology Service Department of Laboratory Medicine NIH Clinical Center National Institutes of Health Bethesda Maryland USA Human Immunological Disease Section National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Merck Research Laboratories Merck and Co. Inc. Boston Massachusetts USA Clinical Research Directorate/Clinical Monitoring Research Program Leidos Biomedical Research Inc. NCI Campus at Frederick Frederick Maryland USA Servicio de Immunología y Reumatología Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan Buenos Aires Argentina Division of Dermatology Department of Medicine Washington University School of Medicine St. Louis Missouri USA Department of Pediatrics Division of Rheumatology and Department of Pathology and Immunology Washington University School of Medicine St. Louis Missouri USA Department of Pediatrics Children’s Hospital of Philadelphia Philadelphia Pennsylvania USA.

最近，研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变：CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析，发现了这一导致疾病产生的基因、

关键词：过敏性皮炎基因突变 Nat 神经性皮炎血缘关系研究所传染病 NIH

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