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A rat mode. of multicompartme.tal traumatic injury and he.orrhagic shock induce. bone.marrow dysfunction and profound ane.ia

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Animal Mode.s and e.pe.ime.tal Me.icine 2024年第3期7卷 367-376页

作者： Laure. S.Ke.ly jennifer A.Munle. e.ick e.Pons Kole.kode.B.Kannan e.izabe.h M.Whitle. Le.itia e.Bible.Philip A.e.ron Alicia M.Mohr De.artme.t of Surge.y and Se.sis and Critical Illne.s Re.e.rch Ce.te. University of Florida College of MedicineGainesvilleFloridaUSA Pathoge.e.is LLCGainesvilleFloridaUSA

Background:Se.e.e.trauma is associate. with syste.ic inflammation and organ *** rode.t trauma mode.s are.the.mainstay of postinjury re.e.rch but have.be.n criticize. for not fully re.licating se.e.e.human *** aim of this study was to cre.te.a rat mode. of multicompartme.tal injury which re.re.te. profound traumatic ***:Male.Sprague.Dawle. rats we.e.subje.te. to unilate.al lung contusion and he.orrhagic shock(LCHS),multicompartme.tal polytrauma(PT)(unilate.al lung contusion,he.orrhagic shock,ce.e.tomy,bife.oral pse.dofracture.,or na?ve.***,plasma toll-l ike.re.e.tor 4(TLR4),he.oglobin,sple.n to body we.ght ratio,bone.marrow(BM)e.ythroid proge.itor(CFU-Ge.M,BFU-e.and CFU-e.growth,plasma granulocyte.colony-stimulating factor(G-CSF)and right lung histologic injury we.e.asse.se. on day 7,with significance.de.ine. as p value.e.ults:Polytrauma re.ulte. in marke.ly more.profound inhibition of we.ght gain compare. to LCHS(p=0.0002)along with e.e.ate. plasma TLR4(pe. he.oglobin(pe.large. sple.n to body we.ght ratios(p=0.004).Both LCHS and PT de.onstrate. suppre.sion of CFU-e.and BFU-e.growth compare. to naive.pe.e.ate. in PT compare. to both na?ve.and LCHS(pe.onstrate. significant histologic right lung injury with poor alve.lar wall inte.rity and inte.stitial ***:Multicompartme.tal injury as de.cribe. he.e.e.tablishe. a re.roducible.mode. of multicompartme.tal injury with worse.e. ane.ia,sple.ic tissue.e.large.e.t,we.ght loss,and incre.se. inflammatory activity compare. to a le.s se.e.e.*** may se.ve.as a more.e.fe.tive.mode. to re.re.te.profound traumatic injury to re.licate.the.human inflammatory re.ponse.postinjury.

关键词： ane.ia i nflammation polytrauma pse.dofracture shock

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Diagnostic accuracy of e.OS score.in pre.icting DNR labe.ing afte. ICU admission:A prospe.tive.obse.vational study(e.OS-DNR)

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Journal of Inte.sive.Me.icine 2024年第2期4卷 216-221页

作者： Omar e.Ramadan Ahme. F.Mady Mohamme. A.Al-Odat Ahme. N.Balshi Ahme. W.Ale.re.y Taisy J.Ste.he. She.na R.Diolaso jennifer Q.Gano Wale.d Th.Ale.re.y De.artme.t of Critical Care King Saud Medical CityRiyadhSaudi Arabia Ane.the.ia De.artme.t Faculty of MedicineAin Shams UniversityCairoEgypt Ane.the.ia De.artme.t Faculty of MedicineTanta UniversityTantaEgypt Faculty of Me.icine Alexandria UniversityAlexandriaEgypt Nursing De.artme.t King Saud Medical CityRiyadhSaudi Arabia

Background Re.uscitation can some.ime. be.futile.and making a do-not-re.uscitate.DNR)de.ision is in the.be.t inte.e.t of the.*** e.e.tronic poor outcome.scre.ning(e.OS)score.was de.e.ope. to pre.ict 6-month poor outcome. of critically ill *** e.plore. the.diagnostic accuracy of the.e.OS score.in pre.icting DNR de.isions in the.inte.sive.care.unit(ICU).Me.hods This study was conducte. at the.ICU of a te.tiary re.e.ral hospital in Saudi Arabia be.we.n March and May ***,we.calculate. e.OS score. for all e.igible.conse.utive.admissions afte. 48 h in the.ICU and re.orde. the.DNR *** ability of the.score.to pre.ict DNR was e.plore. using logistic ***'s ide.l cut-off value.was calculate. using the.De.ong me.hod,and diffe.e.t diagnostic accuracy me.sure. we.e.ge.e.ate. with corre.ponding 95%confide.ce.inte.vals(CIs).Re.ults We.e.rolle. 857 patie.ts,125 re.e.ve. a DNR orde. and 732 did *** ave.age.e.OS score.of DNR and non-DNR patie.ts was 28.2±10.7 and 15.2±9.7,*** score.as a pre.ictor of DNR orde.,had an are. unde. re.e.ve. ope.ator characte.istic(AUROC)curve.of 81.8%(95%CI:79.0 to 84.3,Pe.'s ide.l cut-off value.17 was associate. with a se.sitivity of 87.2(95%CI:80.0 to 92.5,Pe.ificity of 63.9(95%CI:60.3 to 67.4,Pe.pre.ictive.value.of 29.2(95%CI:24.6 to 33.8,Pe.ative.pre.ictive.value.of 96.7(95%CI:95.1 to 98.3,Pe.e.OS score.pe.forme. we.l as a diagnostic te.t for patie.ts who will be.labe.e. as DNR during the.r ICU stay.A cut-off score.17 may he.p guide.clinical de.isions to withhold or comme.ce.re.uscitative.me.sure..

关键词： Do-not-re.uscitate.DNR) Re.uscitation Inte.sive.care.unit(ICU) Diagnostic accuracy Se.sitivity Spe.ificity

Gate.controlle. supe.curre.t e.fe.t in dry-e.che. Daye. bridge. of non-ce.trosymme.ric niobium rhe.ium

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Nano Re.e.rch 2024年第7期17卷 6575-6581页

作者： jennifer Koch Carla Cirillo Se.astiano Battisti Le.n Ruf Zahra Makhdoumi Kakhaki Ale.sandro Paghi Arme. Gulian Se.afim Te.nowijoyo Giorgio De.Simoni France.co Giazotto Carmine.Attanasio e.ke.Sche.r Ange.o Di Be.nardo De.artme.t of Physics University of KonstanzUniversitätsstraße 1078464 KonstanzGermany CNR-Spin c/o Universitàdegli Studi di Salernovia Giovanni Paolo II 13284084 Fisciano(SA)Italy Ne.T Istituto Nanoscienze-CNR and Scuola Normale SuperiorePiazza San Silvestro 1256127 PisaItaly Dipartime.to di Fisica“e.R.Caianie.lo” Universitàdegli Studi di SalernoVia Giovanni Paolo II 13284084 Fisciano(SA)Italy Advance. Physics Laboratory Institute for Quantum StudiesChapman UniversityBurtonsvilleMD 20866USA

The.application of a gate.voltage.to control the.supe.conducting curre.t flowing through a nanoscale.supe.conducting constriction,name. as gate.controlle. supe.curre.t(GCS),has raise. gre.t inte.e.t for fundame.tal and te.hnological *** gain a de.pe. unde.standing of this e.fe.t and de.e.op supe.conducting te.hnologie. base. on it,the.mate.ial and physical parame.e.s crucial for the.GCS e.fe.t must be.***-down fabrication protocols should also be.optimize. to incre.se.de.ice.scalability,although studie. sugge.t that top-down fabricate. de.ice. are.more.re.ilie.t to show a ***,we.inve.tigate.gate. supe.conducting nanobridge. made.with a top-down fabrication proce.s from thin films of the.nonce.trosymme.ric supe.conductor niobium rhe.ium with varying ratios of the.constitue.ts(NbRe..Unlike.othe. de.ice. pre.iously re.orte. and made.with a top-down approach,our NbRe.de.ice. syste.atically e.hibit a GCS e.fe.t whe. the. we.e.fabricate. from NbRe.thin films with small grain size.and e.che. in spe.ific *** obse.vations pave.the.way for the.re.lization of top-down-made.GCS de.ice. with high *** re.ults also imply that physical parame.e.s like.structural disorde. and surface.physical prope.tie. of the.nanobridge.,which can be.in turn modifie. by the.fabrication proce.s,are.crucial for a GCS obse.vation,providing the.e.ore.also important insights into the.physics unde.lying the.GCS e.fe.t.

关键词： supe.conductivity non-ce.trosymme.ric supe.conductors supe.conducting de.ice. gate. de.ice. gate.controlle. supe.curre.t top-down fabrication

e.ucidating re.ulatory proce.se. of inte.se.physical activity by multi-omics analysis

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Military Me.ical Re.e.rch 2024年第4期 479-499页

作者： e.ne.to S.Nakayasu Marina A.Gritse.ko Young-Mo Kim jennifer e.Kyle.Ke.ly G.Stratton Carrie.D.Nicora Nathalie.Munoz Kathle.n M. Navarro Danie. Claborne.Yuqian Gao Karl K.We.tz Vane.sa L. Paurus Ke.t J. Bloodsworth Ke.se. A. Alle. Lisa M. Brame. Fe.nando Monte. Kathle.n A. Clark Grant Tie.je.Justin Te.guarde. Kristin e.Burnum-Johnson Biological Scie.ce. Division Pacific Northwest National Laboratory e.vironme.tal and Mole.ular Scie.ce. Division Pacific Northwest National Laboratory Ce.te.s for Dise.se.Control and Pre.e.tion National Institute for Occupational Safety and Health Western States Division Computational Analytics Division Pacific Northwest National Laboratory National Se.urity Dire.torate Pacific Northwest National Laboratory Los Ange.e. County Fire.De.artme.t Ce.te.s for Dise.se.Control and Pre.e.tion National Institute for Occupational Safety and Health Respiratory Health Division e.vironme.tal and Mole.ular Toxicology Oregon State University

Background: Physiological and bioche.ical proce.se. across tissue. of the.body are.re.ulate. in re.ponse.to the.high de.ands of inte.se.physical activity in se.e.al occupations, such as fire.ighting, law e.force.e.t, military, and sports. A be.te. unde.standing of such proce.se. can ultimate.y he.p improve.human pe.formance.and pre.e.t illne.se. in the.work ***: To study re.ulatory proce.se. in inte.se.physical activity simulating re.l-life.conditions, we.pe.forme. a multi-omics analysis of 3 biofluids(blood plasma, urine. and saliva) colle.te. from 11 wildland fire.ighte.s be.ore.and afte. a 45 min, inte.se.e.e.cise.re.ime.. Omics profile. post-vs. pre.e.e.cise.we.e.compare. by Stude.t's t-te.t followe. by pathway analysis and comparison be.we.n the.diffe.e.t omics ***: Our multi-omics analysis ide.tifie. and quantifie. 3835 prote.ns, 730 lipids and 182 me.abolite. combining the.3 diffe.e.t type. of sample.. The.blood plasma analysis re.e.le. signature. of tissue.damage.and acute.re.air re.ponse.accompanie. by e.hance. carbon me.abolism to me.t e.e.gy de.ands. The.urine.analysis showe. a strong, concomitant re.ulation of 6 out of 8 ide.tifie. prote.ns from the.re.in-angiote.sin syste. supporting incre.se. e.cre.ion of catabolite., re.bsorption of nutrie.ts and mainte.ance.of fluid balance. In saliva, we.obse.ve. a de.re.se.in 3 pro-inflammatory cytokine. and an incre.se.in 8 antimicrobial pe.tide.. A syste.atic lite.ature.re.ie. ide.tifie. 6 pape.s that support an alte.e. susce.tibility to re.piratory ***: This study shows simultane.us re.ulatory signature. in biofluids indicative.of home.static mainte.ance.during inte.se.physical activity with possible.e.fe.ts on incre.se. infe.tion susce.tibility, sugge.ting that caution against re.piratory dise.se. could be.e.it worke.s on highly physical de.anding jobs.

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Association be.we.n high de.uctible.he.lth plan cove.age.and age.at pe.iatric umbilical he.nia re.air

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World Journal of Pe.iatric Surge.y 2023年第2期6卷 70-76页

作者： Morgan e.Doty Lindsay A Gil jennifer N Coope. The.Ohio State.Unive.sity Colle.e.of Me.icine ColumbusOhioUSA De.artme.t of Surge.y Nationwide Children's HospitalThe Ohio State UniversityColumbusOhioUSA De.artme.t of Pe.iatrics Nationwide Children's HospitalThe Ohio State UniversityColumbusOhioUSA

Background High de.uctible.he.lth plans(HDHPs)are.associate. with the.avoidance.of both ne.e.sary and unne.e.sary *** he.nia re.air(UHR)is a proce.ure.that is fre.ue.tly unne.e.sarily pe.forme. in young childre.,contrary to be.t practice.*** hypothe.ize. that childre. with HDHPs,as compare. with othe. type. of comme.cial he.lth plans,are.le.s like.y to unde.go UHR be.ore.4 ye.rs of age.but are.also more.like.y to have.UHR de.aye. be.ond 5 ye.rs of *** Childre. age. 0-18 ye.rs old re.iding in me.ropolitan statistical are.s(MSAs)who unde.we.t UHR in 2012-2019 we.e.ide.tifie. in the.IBM Marke.scan Comme.cial Claims and e.counte.s Database.A quasi-e.pe.ime.tal study de.ign using MSA/ye.r-le.e. HDHP pre.ale.ce.among childre. as an instrume.tal variable.was e.ploye. to account for se.e.tion bias in HDHP ***-stage.le.st square. re.re.sion mode.ing was use. to e.aluate.the.association be.we.n HDHP cove.age.and age.at *** A total of 8601 childre. we.e.include.(me.ian age.5 ye.rs,IQR 3-7).Univariable.analysis re.e.le. no diffe.e.ce. be.we.n the.HDHP and non-HDHP groups in the.like.ihood of UHR be.ng pe.forme. be.ore.4 ye.rs of age.27.7%vs 28.7%,p=0.37)or afte. 5 ye.rs of age.39.8%vs 38.9%,p=0.52).Ge.graphical re.ion,me.ropolitan are. size.and ye.r we.e.associate. with HDHP *** variable.analysis de.onstrate. no association be.we.n HDHP cove.age.and unde.going UHR ate.rs of age.p=0.76)or>5 ye.rs of age.p=0.87).Conclusions HDHP cove.age.is not associate. with age.at pe.iatric *** studie. should inve.tigate.othe. me.ns by which UHRs in young childre. can be.avoide..

关键词： pe.iatric he.nia like.y

Carbon Se.ue.tration through CO2 Foam-e.hance. Oil Re.ove.y： A Gre.n Che.istry Pe.spe.tive

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e.gine.ring 2018年第3期4卷 336-342页

作者： jennifer A. Clark e.ik e. Santiso De.artme.t of Che.ical and Biomole.ular e.gine.ring North Carolina State University Raleigh NC 27695 USA

通过二氧化碳(CO_2)驱油来提高石油采收率(e.R),这作为一种经济上可行的碳封存方法受到了相当大的关注,并且最近许多研究都集中在开发增强的CO_2发泡添加剂上。然而,人们对这些添加剂在泄漏事件中潜在的长期环境影响知之甚少,并且应考... 详细信息

通过二氧化碳(CO_2)驱油来提高石油采收率(e.R),这作为一种经济上可行的碳封存方法受到了相当大的关注,并且最近许多研究都集中在开发增强的CO_2发泡添加剂上。然而,人们对这些添加剂在泄漏事件中潜在的长期环境影响知之甚少,并且应考虑到在典型的CO_2 e.R操作中注入添加剂的量对环境的影响可能是深远的。本文概述了表面活性剂和表面活性剂/基于纳米颗粒的CO_2发泡系统的最新进展,重点介绍了CO_2泡沫泄漏可能对环境造成的影响。所研究的大多数表面活性剂在油藏条件下不可能降解,并且其释放可能对野生动物造成严重的负面影响。随着近来添加剂(如非离子表面活性剂、纳米颗粒和其他化学品)应用的进一步发展,可能不再允许使用严格的阴离子表面活性剂。本文讨论了生产泡沫系统的最新进展,并着重介绍了开发环境友好CO_2e.R方法的可能的策略。

关键词：表面活性剂纳米颗粒碳封存提高石油采收率

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The.be.e.its of be.ng dominant:he.lth corre.ate. of male.social rank and age.in a marmot

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Curre.t Zoology 2022年第1期68卷 19-26页

作者： Ke.ta UCHIDA Rache. NG Samue. A.VYDRO jennifer e.SMITH Danie. T.BLUMSTe.N De.artme.t of e.ology&e.olutionary Biology University of CaliforniaLos AngelesCA 90095-1606USA De.artme.t of Biology Mills CollegeOaklandCA 94613USA The.Rocky Mountain Biological Laboratory Crested ButteCO 81224USA

The.be.e.its of dominance.may not come.without costs,particularly for *** e.ample.the.immunocompe.e.ce.handicap hypothe.is”state. that male. with e.hance. mating succe.s allocate.re.ource. to e.hance.re.roductive.output at a cost to the.r curre.t he.lth,whe.e.s the.re.ource.quality hypothe.is”pre.icts that high-ranking male. may be.e.it from incre.se. re.roduction and good *** the.pre.ictions from e.ch have.be.n we.l te.te. in captive.animals and in a varie.y of highly social primate.,fe.e. studie. have.be.n carrie. out in fre.-living,facultative.y social *** adult male.ye.low-be.lie. marmots(Marmota flavive.te.),we.e.aluate. pre.ictions of the.e.hypothe.e. by e.amining the.re.ationship be.we.n social rank and 2 he.lth indicators—fe.al glucocorticoid me.abolite.FCM)le.e.s,and ne.trophil/lymphocyte.N/L)ratios—afte. accounting for variation e.plaine. by age.body mass,and *** found that highe.-ranking male. te.de. to have.a lowe. N/L ratio(re.le.ting good he.lth)than lowe.-ranking individuals,whe.e.s FCM le.e.s we.e.not significantly re.ate. to *** addition,he.vie. male.marmots had lowe. N/L ratios,whe.e.s body mass was not associate. with FCM *** also found that olde. adult male. had lowe. FCM le.e.s(re.le.ting le.s physiological stre.s)but highe. N/L ratios than younge. ***,we.found that FCM le.e.s de.re.se. as the.active.se.son progre.se. and FCM le.e.s we.e.associate. with the.time.of the.***,our re.ults sugge.t that socially-dominant male.marmots e.joye. be.te.,not worse.he.lth in te.ms of lowe. N/L ratios.

关键词： immunocompe.e.ce.handicap hypothe.is life.history trade.offs N/L ratio physiological stre.s re.ource.quality hypothe.is

Ultraviole. light e.posure.and its pe.e.rance.through the.e.e.in a porcine.mode.

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Inte.national Journal of Ophthalmology(e.glish e.ition) 2023年第2期16卷 172-177页

作者： Hide.i Fukuoka He.e.a e.Gali jennifer J.Bu Ruti Se.la Natalie.A.Afshari Shile. e.e.Institute Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCA 92093USA

AIM:To de.e.mine.the.amount of ultraviole.(UV)light irradiance.that various laye.s of the.e.e.re.e.ve.as sunlight passe. through the.e.e.and to inve.tigate.the.prote.tive.be.e.its of UV light-blocking contact ***:Twe.ty-four porcine.e.e. we.e.pre.are. in one.of thre. ways:isolate. corne.,corne. and le.s toge.he.,or whole.e.e.*** light irradiance.was me.sure. with a UV-A/B light me.e. be.ore.and afte. the.e.e.pre.arations we.e.place. ove. the.me.e. to me.sure.UV light pe.e.ration in e.ch e.e.*** the.whole.e.e.pre.aration,a hole.was place. in the.fove. to me.sure.light as it passe. through the.***,UVprote.tive.contact le.se. we.e.place. ove. the.structure.,and UV light pe.e.rance.was *** of UV light e.posure.we.e.take. outdoors at various locations and ***:Corne. absorbe. 63.56%of UV light that re.che. the.*** and le.s absorbe. 99.34%of UV *** e.e.absorbe. 99.77%of UV *** UV-prote.tive.contact le.se. we.e.place.,absorption was 98.90%,99.55%,and 99.87%,*** light e.posure.was de.e.de.t on dire.tionality and time.of day,and was gre.te.t in are.s of high albe.o that re.le.t significant amounts of light,such as a ***:Corne. absorbs the.majority of UV light that re.che. the.e.e.in this ***-prote.tive.contact le.se. re.uce.UV e.posure.to the.*** with high albe.o e.pose.the.e.e.to highe. le.e.s of UV light.

关键词： ultraviole. light pe.e.rance contact le.s corne. le.s

Local and range.wide.distribution of song type. sugge.t Ove.birds(Se.urus aurocapilla)have.song ne.ghborhoods but not macro-diale.ts

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Avian Re.e.rch 2023年第2期14卷 191-199页

作者： Patrick M.Jagie.ski jennifer R.Foote De.artme.t of Biology Algoma UniversitySault Ste.MarieONCanada

The.song syste.s of oscine.passe.ine.(songbirds)are.comple. and *** songs are.use. for both mate.attraction and te.ritory de.e.se.and are.the.e.ore.important signals for survival and re.roduction,compre.e.sive.knowle.ge.of within and among spe.ie. song structure.and distribution is informative.for unde.standing the.e.olution of song re.e.toire. and vocal *** this study,we.e.plore. variation in the.song structure.of the.Ove.bird(Se.urus aurocapilla),a wide.pre.d warble.(Family Parulidae.found in North Ame.ican *** analyze. re.ordings from the.2021 bre.ding se.son to asse.s song type.variation at a local(n=158 birds;Sault ***,ON)and bre.ding range.scale.n=512 birds;e.ird).We.characte.ize. the.local song type. and te.te. whe.he. Ove.birds share.song type. with the.r ne.ghbors more.ofte. than e.pe.te. by *** the. characte.ize. song type. of Ove.birds across the.bre.ding range.to de.e.mine.whe.he. any ge.graphic patte.n of song cluste.ing e.ists(i.e.,macro-diale.ts).We.found 10 distinct song type. and some.e.ide.ce.for song type.cluste.ing at the.local study site.i.e.,song ne.ghborhoods).We.found 7 of those.10 song type. throughout the.bre.ding range.and ide.tifie. an additional 24 type. that we.e.not re.orde. in our local *** found no e.ide.ce.for song diale.ts across the.Ove.bird bre.ding *** study contribute. to our unde.standing of Ove.bird song while.simultane.usly adding to our unde.standing of ge.graphic structuring of warble. *** work contribute. to de.ine.ting a more.compre.e.sive.unde.standing of factors affe.ting diale.t de.e.opme.t for this dive.se.group of songbirds.

关键词： Diale.ts e.ird Ge.graphic variation Ove.bird Parulidae Se.urus aurocapilla Song type

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