检索结果-南通市图书馆

The.se.ually dimorphic e.pre.sion of glutamate.transporte.s and the.r implication in pain afte. spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Ne.ral Re.e.e.ation Re.e.rch 2025年第11期20卷 3317-3329页

作者： jennifer M.Colón-Me.cado Aranza I.Torrado-Tapias Iris K.Salgado Jose.M.Santiago Samue. e.Ocasio Rive.a Dina P.Bracho-Rincon Luis H.Pagan Rive.a Jorge.D.Miranda De.artme.t of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institute. of He.lth National Human Genome Research InstituteBethesdaMDUSA Unive.sidad Ce.tral de. Caribe School of MedicineBayamónPRUSA Unive.sity of Pue.to Rico Carolina CampusCarolinaPRUSA Institute.of Ne.robiology San JuanPRUSA

In addition to the.loss of motor function,~60% of patie.ts de.e.op pain afte. spinal cord *** ce.lular-mole.ular me.hanisms are.not we.l unde.stood,but the.data sugge.ts that plasticity within the.rostral,e.ice.te.,and caudal pe.umbra of the.injury site.initiate. a ce.lularmole.ular inte.play that acts as a re.iring me.hanism le.ding to ce.tral ne.ropathic *** can le.d to the.formation of ne. conne.tions trigge.ing abnormal se.sory *** e.citatory glutamate.transporte.s are.re.ponsible.for the.re.ptake.of e.trace.lular glutamate.which make. the. a critical targe. to pre.e.t ne.ronal hype.e.citability and *** pre.ious studie. showe. a se.ually dimorphic the.ape.tic window for spinal cord injury afte. tre.tme.t with the.se.e.tive.e.troge. re.e.tor modulator *** this study,we.inve.tigate. the.anti-allodynic e.fe.ts of tamoxife. in male.and fe.ale.rats with spinal cord *** hypothe.ize. that tamoxife. e.e.ts anti-allodynic e.fe.ts by incre.sing the.e.pre.sion of glutamate.transporte.s,le.ding to re.uce. hype.e.citability of the.se.ondary ne.ron or by de.re.sing abe.rant *** and fe.ale.rats re.e.ve. a mode.ate.contusion to the.thoracic spinal cord followe. by subcutane.us slow-re.e.se.tre.tme.t of tamoxife. or matrix pe.le.s as a control(place.o).We.use. von Fre. monofilame.ts and the.up-down me.hod”to e.aluate.me.hanical *** tre.tme.t de.re.se. allodynia only in fe.ale.rats with spinal cord injury re.e.ling a se.de.e.de.t *** e.pre.sion profile.of glutamate.gic transporte.s(e.citatory amino acid transporte. 1/glutamate.aspartate.transporte. and e.citatory amino acid transporte. 2/glutamate.transporte.-1)re.e.le. a se.ual dimorphism in the.rostral,e.ice.te.,and caudal are.s of the.spinal cord with a patte.n of e.pre.sion primarily on *** rode.ts showe. a significantly highe. le.e. of e.citatory amino acid transporte.-1 e.pre.sion while.male.rode.ts showe. incre.se.

关键词： allodynia ce.tral ne.ropathic pain e.AT-1/GLAST e.AT-2/GLT-1 glutamate.transporte.s se.e.tive.e.troge. re.e.tor modulator se.ual dimorphism spinal cord injury trauma

Progre.s towards using community conte.t with clinical data in primary care

在线全文

学校读者我要写书评

暂无评论

Family Me.icine.and Community He.lth 2019年第1期7卷 15-19页

作者： He.the. Angie. e.izabe.h A Jacobs Nathalie.Hugue. Sonja Likumahuwa-Ackman Ste.hanie.Robe.t jennifer e.devoe Ore.on He.lth&Scie.ce.Unive.sity PortlandOregonUSA Unive.sity of Te.as at Austin Dell Medical SchoolAustinTexasUSA Unive.sity of Wisconsin-Madison MadisonWisconsinUSA

Community-le.e. factors have.significant impacts on *** is re.e.e. e.thusiasm for inte.rating the.e.data with e.e.tronic he.lth re.ord(e.R)data for use.in primary care.to improve.he.lth e.uity in the.***,it is valuable.to re.le.t on what has be.n publishe. to ***,we.comme.t on:(1)re.omme.dations about combining community-le.e. factors in e.Rs for use.in primary care.(2)e.ample. of how the.e.data have.be.n combine. and use.;and(3)the.impact of using combine. data on he.lthcare.patie.t he.lth and he.lth *** found publications discussing the.pote.tial of combine. data to inform clinical care.targe. inte.ve.tions,track population he.lth and spark community partne.ships with the.goal of re.ucing he.lth disparitie. and improving he.lth *** the.e.is gre.t e.thusiasm and pote.tial for using the.e.data to inform primary care.the.e.is little.e.ide.ce.of improve. he.lthcare.patie.t he.lth or he.lth e.uity.

关键词： clinical inte.rating e.uity

Ne. hype.te.sion and diabe.e. diagnose. following the.Affordable.Care.Act Me.icaid e.pansion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Family Me.icine.and Community He.lth 2020年第4期8卷 84-89页

作者： He.the. Angie. Nathalie.Hugue. David e.e.ie.-He.re.a Migue. Marino Te.e.a Schmidt Be.e.ly B Gre.n jennifer e.devoe Family Me.icine Oregon Health&Science UniversityPortlandOregonUSA Biostatistics Group Oregon Health&Science University-Portland State University School of Public HealthPortlandOregonUSA Re.e.rch OCHINPortlandOregonUSA Kaise. Pe.mane.te.Washington He.lth Re.e.rch Institute SeattleWashingtonUSA

Obje.tive.To asse.s the.Affordable.Care.Act(ACA)Me.icaid e.pansion’s impact on ne. hype.te.sion and diabe.e. diagnose. in community he.lth ce.tre.(CHCs).De.ign Rate. of ne. hype.te.sion and diabe.e. diagnose. we.e.compute. using ge.e.alise. e.timating e.uation Poisson mode.s and we.te.te. the.diffe.e.ce.in diffe.e.ce.DID)pre.ACA ve.sus post-ACA in state. that e.pande. Me.icaid compare. with those.that did *** We.use. e.e.tronic he.lth re.ord data(pre.ACA:1 January 2012-31 De.e.be. 2013-post-ACA:1 January 2014-31 De.e.be. 2016)from the.Acce.e.ating Data Value.Across a National Community He.lth Ce.te. Ne.work clinical data *** include. clinics with≥50 patie.ts contributing to pe.son-time.at risk in e.ch study *** Patie.ts age. 19-64 with≥1 ambulatory visit in the.study pe.iod we.e.*** the. e.clude. patie.ts who we.e.pre.nant during the.study pe.iod(N=127530).For the.hype.te.sion outcome.we.e.clude. individuals with a diagnosis of hype.te.sion prior to the.start of the.study pe.iod,those.who had a hype.te.sion diagnosis on the.r first visit to a clinic or the.r first visit afte. 3 ye.rs without a visit,and those.who had a diagnosis more.than 3 ye.rs afte. the.r last visit(pre.ACA non-e.pansion N=130973;e.pansion N=193198;post-ACA non-e.pansion N=186341;e.pansion N=251015).For the.diabe.e. analysis,we.e.clude. patie.ts with a diabe.e. diagnosis prior to study start,on the.r first visit or first visit afte. inactive.patie.t status,and diagnosis while.not an active.patie.t(pre.ACA non-e.pansion N=145435;e.pansion N=198558;post-ACA non-e.pansion N=215039;e.pansion N=264644).Re.ults In non-e.pansion state.,adjuste. hype.te.sion diagnosis rate. saw a re.ative.de.re.se.of 6%,while.in e.pansion state.,the.adjuste. rate. saw a re.ative.incre.se.of 7%(DID 1.14,95%CI 1.11 to 1.18).For diabe.e. diagnosis,adjuste. rate. in non-e.pansion state. e.pe.ie.ce. a significant re.ative.incre.se.of 28%and in e.pansion state. the.re.ative.incre.se.was 25%

关键词： diagnosis hype.te.sion e.pansion

He.lo, goodbye. and e.e.ything in be.we.n

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hello, goodbye, and everything in between

Cdc42 re.ulate. the.ce.lular localization of Cdc42e.1 in controlling ne.ral cre.t ce.l migration

作者： Smith jennifer e.

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Journal of Mole.ular Ce.l Biology 2018年第5期10卷 376-387页

作者： Shlomi Cohe. Danie. T. Kovari We.bin We. Re.e.ca Ke.te.jennifer e. Curtis Shuyi Nie School of Biological Scie.ce. Georgia institute of Technology Atlanta GA 30332 USA School of Physics Georgia Institute of Technology Atlanta GA 30332 USA Pe.it Institute.for Bioe.gine.ring and Bioscie.ce Georgia Institute of Technology Atlanta GA 30332 USA De.artme.t of Physics Emory University Atlanta GA 30322 USA Wallace.H. Coulte. De.artme.t of Biome.ical e.gine.ring Georgia institute of Technology Atlanta GA 30332 USA

The.me.be. of Rho family of small GTPase. Cdc42 plays important and conse.ve. role. in ce.l polarity and motility. The.Cdc42e. family prote.ns have.be.n ide.tifie. to bind to Cdc42, ye. how the. inte.act with Cdc42 to re.ulate.ce.l migration re.ains to be.e.ucidate.. In this study, we.focus on Cdc42e.l, which is e.pre.se. pre.ominantly in the.highly migratory ne.ral cre.t ce.ls in frog e.bryos. Through morpholino-me.iate. knockdown, we.show that Cdc42e.l is re.uire. for the.migration of cranial ne.ral cre.t ce.ls. Loss of Cdc42e.l le.ds to rounde. ce.l shape. and the.formation of me.brane.ble.s, consiste.t with the.obse.ve. disruption in actin organization and focal adhe.ion alignme.t. As a re.ult, Cdc42e.1 is critical for ne.ral cre.t ce.ls to apply traction force. at the.corre.t place.to migrate.e.ficie.tly. We.furthe. show that Cdc42e.1 is localize. to two are.s in ne.ral cre.t ce.ts： in me.brane.protrusions toge.he. with Cdc42 and in pe.inucie.r patche. whe.e.Cdc42 is abse.t. Cdc42 dire.tly inte.acts with Cdc42e.l （through the.CRIB domain） and change. in Cdc42 le.e. shift the.distribution of Cdc42e.l be.we.n the.e.two subce.lular locations, controlling the.formation of me.brane.protrusions and dire.tionality of migration as a conse.ue.ce. The.e.re.ults sugge.t that Cdc42e.1 e.aborate. Cdc42 activity in ne.ral cre.t ce.ls to promote.the.r e.ficie.t migration.

关键词： actin cytoske.e.on ne.ral cre.t Rho GTPase. Cdc42 e.fe.tor prote.n 1 ce.l migration

Advance.e.ts and challe.ge. in tre.ting advance. gastric cance. in the.We.t

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointe.tinal Oncology 2019年第9期11卷 652-664页

作者： jennifer L Le.ting Travis e.Grotz Division of He.atobiliary and Pancre.s Surge.y Mayo Clinic

Gastric cance. is a le.ding cause.of cance. incide.ce.and de.th *** with advance. gastric cance. be.e.it from a multi-modality tre.tme.t *** oncologic re.e.tion with ne.ative.margins and comple.e.lymphade.e.tomy plays a crucial role.in long-te.m survival for patie.ts with re.e.table.*** utilization of minimally invasive.te.hnique. for gastric cance. has be.n slowly incre.sing and is proving to be.both te.hnically and oncologically *** che.othe.apy is the.curre.t standard of care.for advance. gastric cance..A varie.y of che.othe.apy re.ime.s have.be.n use. with the.combination of doce.axe.,oxaliplatin,5-fluorouracil,and le.covorin be.ng the.curre.t re.omme.dation give. its supe.ior ability to induce.a comple.e.pathologic re.ponse.and prolong *** use.of radiation has be.n more.controve.sial with its optimal place.in the.tre.tme.t se.ue.ce.be.ng *** are.curre.t ongoing studie. asse.sing the.impact of radiation as an adjunct or in place.of *** tre.tme.ts(e.g.,trastuzumab for human e.ide.mal growth factor re.e.tor 2 positive.tumors and pe.brolizumab for programme. de.th-ligand 1 positive.tumors)are.showing promise.and are.part of a continue. e.phasis on individualize. *** che.othe.apy may also play a role.in pre.e.ting pe.itone.l re.urre.ce. for patie.ts with high risk *** tre.tme.t of patie.ts with advance. gastric cance. in the.We.t continue. to advance.and improve.with a be.te. unde.standing of optimal tre.tme.t se.ue.ce. and the.utilization of pe.sonalize. tre.tme.t re.ime.s.

关键词： Gastric cance. D2 lymphade.e.tomy Minimally invasive surge.y Ne.adjuvant che.othe.apy Che.oradiation Targe.e. tre.tme.ts

Solve.t-fre. microwave.assiste. synthe.is of te.orite.nanoparticle.de.orate. multi-walle. carbon nanotube.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mate.ials Scie.ce.& Te.hnology 2019年第6期35卷 1121-1127页

作者： jennifer A. Rudd Cathre. e. Gowe.lock Virginia Gome. e.a Kazimie.ska Abdullah M. Al-e.izi e.rico Andre.li Andre. R. Barron e.e.gy Safe.y Re.e.rch Institute Swansea University Bay Campus Swansea SA1 8EN UK Che.istry De.artme.t College of Sciences KingSaud University Riyadh Saudi Arabia De.artme.t of Che.istry Rice University Houston Texas 77005 USA De.artme.t of Mate.ials Scie.ce.and Nanoe.gine.ring Rice University Houston Texas 77005 USA

Coppe.-de.orate. carbon nanotube.(CNTs) have.important applications as pre.ursors for ultraconductive.coppe. wire.. Te.orite.de.orate. CNTs(CuO-CNTs) are.ide.l candidate. and are.curre.tly de.e.ope. using laborious proce.se.. For this re.son, we.have.de.e.ope. a facile.and scalable.me.hod for the.synthe.is of CuO-CNTs from coppe. ace.ate. It was found that the.optimal loading of coppe. ace.ate.onto the.CNTs was 23.1 wt% and that thre. 1-minute.microwave.tre.tme.ts we.e.sufficie.t for the.de.omposition of coppe. ace.ate.to coppe. oxide. The.loading of coppe. oxide.onto the.nanotube. was confirme. using X-ray photoe.e.tron spe.troscopy, e.e.gy-dispe.sive.X-ray spe.troscopy and the.mogravime.ric analysis. The.mate.ials we.e.characte.ise. using X-ray diffraction and scanning e.e.tron microscopy.

关键词： Microwave.assiste. synthe.is Multi-walle. carbon nanotube. Te.orite Nanoparticle

Optimizing outcome. for patie.ts with gastric cance. pe.itone.l carcinomatosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointe.tinal Oncology 2018年第10期10卷 282-289页

作者： jennifer L Le.ting Travis e.Grotz Division of He.atobiliary and Pancre.s Surge.y Mayo Clinic

Pe.itone.l carcinomatosis (PC) from gastric cance. has traditionally be.n conside.e. a te.minal progre.sion of the.dise.se.and is associate. with poor survival out-come.. Positive.pe.itone.l cytology similarly worse.s the.survival of patie.ts with gastric cance. and tre.tme.t options for the.e.patie.ts have.be.n limite.. Re.e.t ad-vance. in multimodality tre.tme.t re.ime.s have.le. to innovative.ways to care.for and tre.t patie.ts with this dise.se.burde.. One.of the.e.advance. has be.n to use.ne.adjuvant the.apy to try and conve.t patie.ts with positive.ytologyorlow-volume.PC to ne.ative.cytolo-gy with no e.ide.ce.of active.pe.itone.l *** strate.ie. include.the.use.of ne.adjuvant syste.ic che.othe.apy alone.using ne.adjuvant laparoscopic he.te. intrape. itone.l che.othe.apy(NLHIPe.)afte. syste.ic che.othe.apy,or using ne.adjuvant intra-pe.itone.l and syste.ic che.othe. apy(NIPS)in a bi-dir e.tional manne.. For patie.ts with highe. volume.PC,cytore.uctive.surge.y (CRS) and hype.the.mic intrape.ritone.l che.othe.apy(HIPe.)have.be.n mainstays of tre.tme.t. Whe. use. toge.he., CRS and HIPe. can improve.ove.all outcome. in prope.ly se.e.te. patie.ts,but ove.all survival outcome. re.ain unacce.tably *** e.te.t of pe.itone.l dise.se. commonly me.sure. by the.pe.itone.l carcinomatosis inde. (PCI), and the.com-ple.e.e.s of cytor e.uction,has be.n shown to gre.tly impact outcome. in patie.ts unde.going CRS and *** use. of NLHIPe. and NLHIPe. plus NIPS have.both be.n shown to de.re.se.the.PCI and thus incre.se.the.opportunity for comple.e.cytore.uction. Ne.e. the.apie. like.pre.surize. intrape.itone.l ae.osol che.othe. apy and immunothe.apy, such as catumaxomab, along with improve. syste.ic che.othe.ape.tic re.ime.s, are.be.ng e.plore. with gre.t *** is e.citing progre.s be.ng made.in the.manage.e.t of PC from gastric can-ce. and its’ tre.tme.t is no longe. futile.

关键词： Pe.itone.l carcinomatosis inde. Pe.itone.l carcinomatosis Gastric cance. Cytore.uctive surge.y He.te. intrape.itone.l che.othe.apy Ne.adjuvant intrape.itone.l and syste.ic che.othe.apy

Carbon Se.ue.tration through CO2 Foam-e.hance. Oil Re.ove.y： A Gre.n Che.istry Pe.spe.tive

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

e.gine.ring 2018年第3期4卷 336-342页

作者： jennifer A. Clark e.ik e. Santiso De.artme.t of Che.ical and Biomole.ular e.gine.ring North Carolina State University Raleigh NC 27695 USA

e.hance. oil re.ove.y （e.R） via carbon dioxide.（CO2） flooding has re.e.ve. a conside.able.amount of atte.tion as an e.onomically fe.sible.me.hod for carbon se.ue.tration, with many re.e.t studie. focus- ing on de.e.oping e.hance. CO2 foaming additive., Howe.e., the.pote.tial long-te.m e.vironme.tal e.fe.ts of the.e.additive. in the.e.e.t of le.kage.are.poorly unde.stood and, give. the.amount of additive. inje.te. in a typical CO2 e.R ope.ation, could he.far-re.ching, This pape. pre.e.ts a summary of re.e.t de.e.opme.ts in surfactant and surfactant/nanoparticle.hase. CO2 foaming syste.s, with an e.phasis on the.possible.e.vironme.tal impacts of CO2 foam le.kage. Most of the.surfactants studie. are.unlike.y to de.rade.unde. re.e.voir conditions, and the.r re.e.se.can cause.major ne.ative.impacts on wildlife. With re.e.t advance. in the.use.of additive. （e.g,, nonionic surfactants, nanoparticle., and othe. che.icals） the.use.of harsh anionic surfactants may no longe. he.warrante., This pape. discusse. re.e.t advance. in producing foaming syste.s, and highlights possible.strate.ie. to de.e.op e.vironme.tally frie.dly CO2 e.R me.hods,

关键词： Surfactants Nanoparticle. Carbon se.ue.tration e.hance. oil re.ove.y