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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.w.So Konstantin Feinberg Marina Manoraj Jenny cheung jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

co/co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang chen Yongyue Zhuang Yanxin Qiao Yu Zhang Aihua Yuan hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NcS)decorated with dual-phase co/co_(7)Fe_(3)heterojunctions(coFe@NcS).The phase composition of materials has been adjusted by controlling the alloying *** optimal coFe_(0.08)@NcS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active co_(7)Fe_(3)alloy and metallic co *** the coFe_(0.08)@NcS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mw·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/c+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng Song Ihar Razanau Juanxiu Xiao wei Xiao Di hu Guoxiong wang college of chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South china Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（c1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert c–H bond, low selectivity, and problematic side reactions, including cO2emissions and coke deposition. Electrochemical conversion of methane（EcM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of EcM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance EcM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the EcM process, including insights into EcM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of cH4conversion rates, and minimization of cO2emission.

关键词： Methane Electrochemical conversion Reaction mechanism catalyst design Electrode Electrocatalysis

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. we then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Energetics and conserved quantity of an axially moving string undergoing three-dimensional nonlinear vibration

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Acta Mechanica Sinica 2008年第2期24卷 215-221页

作者： Liqun chen c. w. Lim hu Ding Department of Mechanics Shanghai University Shanghai 200444 China Department of construction and Building City University of Hong Kong Hong Kong China Shanghai Institute of Applied Mathematics and Mechanics Shanghai 200072 China

Nonlinear three-dimensional vibration of axially moving strings is investigated in the view of energetics. The governing equation is derived from the Eulerian equation of motion of a continuum for axially accelerating strings. The time-rate of the total mechanical energy associated with the vibration is calculated for the string with its ends moving in a prescribed way. For a string moving in a constant axial speed and constrained by two fixed ends, a conserved quantity is proved to remain unchanged during three-dimensional vibration, while the string energy is not conserved. An approximate conserved quantity is derived from the conserved quantity in the neighborhood of the straight equilibrium configuration. The approximate conserved quantity is applied to verify the Lyapunov stability of the straight equilibrium configuration. Numerical simulations are performed for a rubber string and a steel string. The results demonstrate the variation of the total mechanical energy and the invariance of the conserved quantity.

关键词： Nonlinear free vibration Axial movingstring Energetics conserved quantity Stability

ELEcTROcHEMIcAL INVESTIGATION ON cARBON NANOTUBE FILM wITH DIFFERENT PRETREATMENTS

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Acta Metallurgica Sinica(English Letters) 2003年第4期16卷 295-301页

作者： c.G.hu w.L.wang w.Zhu DepartmentofAppliedPhysics ChongqingUniversityChongaing400044China KeyLaboftheEducationMinistryforPhotoelectricTechnologyandSystem ChongqingUniversityChongqing400044China Departmentofchemistry ChongqingUniversityChongqing400044ChinaManuscriptreceived25November2002

wide potential windows were found at carbon nanotube film electrodes in neutral solutions after being treated with nitric acid and mixed acid. Electrochemical reversibility was investigated at carbon nanotube films with different pretreatments for ferri/ferrocyanide and quinone /hydroquinone. carbon nanotube film electrodes presented quasi-reversible electrochemical behavior for both electrolytes. In the range of scan rate, carbon nanotube film electrodes treated with acids showed heterogeneous electron-transfer properties, which was mainly controlled by its electron state density on the surface of the film. On the whole, the carbon nanotube electrode with nitric acid treatment presented the best electrochemical behaviors, so we chose it as an analytical electrode to determine the trace compound in dilute solution. The results demonstrated that this new electrode material exhibits superior performance characteristics for the detection of azide anion.

关键词： carbon nanotubes cyclic voltammetry treatment azide anion

construction of 3D porous cu_(1.81)S/nitrogen-doped carbon frameworks for ultrafast and long-cycle life sodium-ion storage

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 191-200页

作者： chen chen Hongyu Xue Qilin hu Mengfan wang Pan Shang Ziyan Liu Tao Peng Deyang Zhang Yongsong Luo Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific ***,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs ***,the three-dimensional porous cu_(1.81)S/nitrogen-doped carbon frameworks(cu_(1.81)S/Nc)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for ***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/c cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 *** work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.

关键词： copper sulfide nanoparticles porous carbon framework fast charging long-cycle performance sodium-ion full batteries

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社交媒体健康信息用户信任形成机理研究

现代情报 2025年第1期45卷 97-111页

作者：初彦伯王萍胡姝姝吉林大学商学与管理学院吉林长春130012

[目的/意义]在公共卫生事件频发的背景下,国民对健康信息需求急剧增长。社交媒体作为用户信息获取的重要途径之一,在高效传播健康信息的同时,也为虚假健康信息的产生和传播提供便利条件。随着社交媒体渗透力和影响力不断扩大,用户对健... 详细信息

[目的/意义]在公共卫生事件频发的背景下,国民对健康信息需求急剧增长。社交媒体作为用户信息获取的重要途径之一,在高效传播健康信息的同时,也为虚假健康信息的产生和传播提供便利条件。随着社交媒体渗透力和影响力不断扩大,用户对健康信息的不确定感愈发强烈。鉴于此,本文对社交媒体健康信息用户的信任形成机理进行探索,以期为后续相关研究提供参考和借鉴。[方法/过程]解构社交媒体健康信息用户信任形成的要素,建构面向用户感知过程的信任综合框架,从用户、信息和环境3个方面提出社交媒体健康信息用户信任理论假设模型,并对结构模型进行修正。[结果/结论]研究从理论层面明晰社交媒体健康信息用户感知信任过程以及用户心理变化的进程。研究还发现热评情感极性、涉入度、信源可信度、冲突解决对信任存在显著的正向影响。信任对采纳意愿存在显著的正向影响。参照群体规范对采纳意愿存在显著的正向影响。此外,信任分别在热评情感极性、涉入度、信源可信度和冲突解决与信息采纳意愿之间起到完全中介作用。

关键词：社交媒体健康信息信任感知可信度

Increasing polymer scission rate by tying an overhand knot

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Science china chemistry 2024年第11期67卷 3498-3499页

作者： Yuheng hu jennifer T.Ou Jim Yhuang Yuanning Feng Department of chemistry and Biochemistry The University of OklahomaNormanOK 73019USA

Similar to the phenomenon of knotted ropes in life, knotted climbing ropes will reduce their strength due to knots. Although computer simulations [1], theoretical speculation[2,3], and intuition [3] suggest that similar processes may occur at the nanoscale, this hypothesis has not been experimentally proven before. with the increasing maturity of molecular recognition and self-assembly, a research communication by Leigh et al. [4] published in Nature chemistry introduced a molecular overhand knot into a polymer to study its effect on the scission rate of the polymer chain under tension.

关键词： polymer hypothesis hough