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The N-terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism

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Animal Models and Experimental Medicine 2025年第1期8卷 114-125页

作者： Xue wang Chunyou Ning Xingyi Cheng Zhengzhong Wu Dongbo Wu Xuemei Ding Cunxiang Ju Zhihang Zhou Lingfeng wan Wei Zhao Peiliang Shi GemPharmatech Chengdu Co. Ltd.ChengduChina Center of Infectious Diseases West China HospitalSichuan UniversityChengduChina Gempharmatech Shanghai Co. Ltd.ShanghaiChina Department of Gastroenterology the Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Fatty Liver Disease Center of Integrated Chinese and Western Medicine Affiliated Hospital of Nanjing University of Chinese MedicineNanjingChina School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College ChengduChina Department of Clinical Biochemistry School of Laboratory MedicineChengdu Medical CollegeChengduChina GemPharmatech Co. Ltd.GuangdongChina

Background:The emerging incidence of pathogenic liver conditions is turning into a major concern for global *** of pyroptosis in hepatocytes instigates cel-lular disintegration,which in turn liberates substantial quantities of pro-inflammatory intracellular substances,thereby accelerating the advancement of liver ***,directing therapeutic efforts towards inhibiting pyroptosis could po-tentially serve as an innovative approach in managing inflammation related chronic hepatic ***:GSDMD-NT^(ki/wt)mice and Alb-cre^(ki/wt)mice were generated using CRISPR/Cas9 *** crossing the two strains together,we induced conditional cell death by doxycycline to construct a mouse model of liver *** analyzed differ-entially expressed genes by RNA sequencing and explored their biological *** efficacy of obeticholic acid(OCA)in the treatment of liver fibrosis was ***:Doxycycline-treated GSDMD-NT^(ki/wt)×Alb-cre^(ki/wt)mice showed severe liver damage,vacuolation of hepatocytes,increased collagen fibers,and accumulation of lipid *** expression of liver fibrosis related genes was greatly increased in the doxycycline-treated mouse liver compared with untreated mouse ***-sequencing showed that upregulated differentially expressed genes were involved in inflammatory responses,cell activation,and metabolic *** with OCA alleviated the liver fibrosis,with reduced ALT and AST levels seen in the GSDMD-NT^(ki/wt)×Alb-cre^(ki/wt)***:We successfully constructed a novel mouse model for liver *** GSDMD-NT-induced fibrosis may be mediated by abnormal lipid *** re-sults demonstrated that we successfully constructed a mouse model of liver fibrosis,and GSDMD-NT induced fibrosis by mediating lipid metabolism.

关键词： GSDMD-NT lipid metabolism liver fibrosis NASH pyroptosis

A Case Study on Garbage Code Redistribution Methods for Heart Failure at City Level by Two Approaches

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Biomedical and Environmental Sciences 2025年第1期38卷 119-125页

作者： Liqun Liu Zemin Cai Xuewei wang Chunping wang Xiangyun Ma Xianfeng Meng Bofu Ning Ning Li Xia wan Institute of Basic Medical Sciences Chinese Academy of Medical Sciences(CAMS)and School of Basic MedicinePeking Union Medical College(PUMC)Beijing 100005China State Key Laboratory of Respiratory Health and Multimorbidity Beijing 100005China School of Public Health Weifang Medical UniversityWeifang 261042ShandongChina Xuanwei Center for Disease Control and Prevention Xuanwei 655400YunnanChina Weifang Center for Disease Control and Prevention Weifang 261061ShandongChina

Cause of death surveillance data is most important for developing effective health policies,whose quality is crucially affected by the accuracy of the underlying cause of death(UCOD)provided in death *** World Health Organization(WHO)has clearly defined a UCOD as“the disease or injury which initiated the train of morbid events leading directly to death,or the circumstance of the accident or violence which produced the fatal injuries”[1].

关键词： injuries initiated distribution

Phonon-mediated superconductivity in orthorhombic XS(X=Nb,Ta or W)

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Chinese Physics B 2025年第2期34卷 419-423页

作者： Guo-Hua Liu Kai-Yue Jiang Yi wan Shu-Xiang Qiao Jin-Han Tan Na Jiao Ping Zhang Hong-Yan Lu School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China Institute of Applied Physics and Computational Mathematics Beijing 100088China

The unique three-dimensional orthorhombic NbS(o-NbS)compound synthesized in 1969 has recently been experimentally confirmed to be a superconductor[***.B 108174517(2023)].However,there is currently no theoretical research on its superconducting *** this work,we investigate the superconducting properties of o-Nb S from first-principles *** on the Eliashberg equation,it is found that the superconductivity mainly originates from the coupling between the electrons of Nb-4d orbitals and the vibrations of Nb atoms in the low-frequency region and those of S atoms in the high-frequency region.A superconducting transition temperature(T_c)of 10.7 K is obtained,which is close to the experimental value and higher than most transition metal chalcogenides(TMCs).The calculated thermodynamic properties in the superconducting state,such as specific heat,energy gap,isotope coefficient,etc.,also indicate that o-NbS is a conventional phonon-mediated *** results are consistent with recent experimental reports and provide a good understanding of the superconducting mechanism of o-Nb ***,the TMCs of o-TaS and o-WS are also investigated;these belong to the same and neighboring groups of Nb,and we find that o-TaS and o-WS are also phonon-mediated superconductors with T_c of 8.9 K and 7.2 K,respectively.

关键词： first-principles calculations phonon-mediated superconductivity orthorhombic transition metal chalcogenides

Engineering N3C vacancies in hierarchical porous carbon nitride nanosheets for room temperature ultradeep photocatalytic aerobic oxidative desulfurization

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Science China Chemistry 2025年

作者： Yina Nie Weijie Yang Xin wang Xiang Li Lele Wei Xiaolin Bai Lin Liu Feng Fu Jun wan College of Chemistry & Chemical Engineering Research Institute of Comprehensive Energy Industrial Technology Shaanxi Key Laboratory of Chemical Reaction Engineering Yan'an University Anhui Engineering Research Center of Carbon Neutrality College of Chemistry and Materials Science Anhui Normal University

The production of ultra-low sulfur clean fuels holds global significance for improving energy efficiency and reducing environmental pollution. Photocatalytic aerobic oxidative desulfurization（PODS） offers an attractive approach to efficiently remove refractory heterocyclic aromatic sulfur compounds under mild conditions. However, the sluggish charge dynamics,insufficient molecule activation, and slow mass transfer within photocatalysts restrict the overall desulfurization efficiency,hindering the widespread application of this technology. Herein, we developed a defective g-C3N4（M1U3CN） photocatalyst with bridged N3Cvacancies and hierarchical porous structures to address these limitations. This catalyst not only demonstrates outstanding dibenzothiophene（DBT） removal efficiency of 99.6% for model oil with high conversion and selectivity but also achieves complete sulfur removal from gasoline as well as 96.7% sulfur removal for distilled diesel at room temperature,successfully achieving ultradeep aerobic oxidative desulfurization. The introduction of rich N3Cvacancies and abundant micromeso-macroporous distribution in M1U3CN enhances kinetic efficiencies by promoting charge carrier separation, mass transfer,and molecular activation simultaneously; resulting in exceptional PODS performance. This work provides a collaborative strategy to overcome kinetic challenges in aerobic oxidative desulfurization via defect and structural engineering of the catalyst.

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Multi-instrumental observations of nighttime X-pattern of equatorial ionization anomaly during magnetically quiet time: case study

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Earth and Planetary Physics 2025年第02期 410-423页

作者： XinYi Rang Chao Xiong YuHao Zheng Jing Liu Yu Jiao ShunZu Gao YuYang Huang Xin wan Fan Yin Department of Space Physics Electronic Information School Wuhan University School of Space Science and Physics Shandong Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space Sciences Shandong University Planetary Environmental and Astrobiological Research Laboratory (PEARL) School of Atmospheric Sciences Sun Yatsen University

In this study, we provide a detailed case study of the X-pattern of equatorial ionization anomaly(EIA) observed on the night of September 12, 2021 by the Global-scale Observations of the Limb and Disk(GOLD) mission. Unlike most previous studies about the X-pattern observed under the severely disturbed background ionosphere, this event is observed under geomagnetically quiet and low solar activity conditions. GOLD's continuous observations reveal that the X-pattern intensity evolves with local time, while its center's longitude remains constant. The total electron content(TEC) data derived from the ground-based Global Navigation Satellite System(GNSS) network aligns well with GOLD observations in capturing the formation of the X-pattern, extending coverage to areas beyond GOLD's observational reach. Additionally, the ESA's Swarm mission show that both sides of the X-pattern can coincide with the occurrence of small-scale equatorial plasma bubbles(EPBs). To further analyze the possible drivers of the X-pattern, observations from the Ionospheric Connection Explorer(ICON) satellite were used. It shows that the latitudinal expansion(or width) between the EIA crests in two hemispheres is proportional(or inversely proportional) to the upward(or downward) plasma drift velocity, which suggests that the zonal electric field should have a notable influence on the formation of EIA X-pattern. Further simulations using the SAMI2 model support this mechanism, as the X-pattern of EIA is successfully reproduced by setting the vertical plasma drift to different values at different longitudes.

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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen wan Fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

Scaled non-passive environmental interaction force tracking for telerobotic manufacturing system with variable time delay

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Science China Technological Sciences 2025年第3期68卷 171-182页

作者： Yukui ZHANG Fangyu PENG Yiming wan Chen CHEN Zhitao GAO Haoyan LIU Yu wanG Rong YAN Xiaowei TANG School of Mechanical Science and Engineering Huazhong University of Science and Technology School of Artificial Intelligence and Automation Huazhong University of Science and Technology Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering Wuhan University of Science and Technology

Robot teleoperation plays an important role in industrial manufacturing in unknown and dangerous environments beyond human reach. In telerobotic manufacturing tasks, environmental interaction forces may vary significantly from task to ***, it is crucial to provide operators with the specific proportional feedback of environmental interaction forces to enhance their environmental awareness and manipulation capabilities. However, variable time delays and various scales of environmental interaction force feedback seriously affect the system stability, which should be rigorously addressed when designing control parameters. To cope with these difficulties, a position and scaled force tracking control framework is proposed and the LyapunovKrasovskii theory is used to obtain a simple algebraic stability criterion with the scaling factor of the environmental interaction force feedback. In addition, a low-pass filter-based radial basis function neural network is designed to avoid the effect of the measurement noise and the sudden change of the non-passive environmental interaction force on the system stability. Compared with different controllers in various telerobotic manufacturing tasks such as heavy lifting, cutting, and polishing, our proposed method achieves better position and scaled force tracking performance.

关键词： non-passive interaction force position tracking scaled force tracking stability analysis telerobotic manufacturing system variable time delay

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Monitoring of urinary iodine concentration in naval pilots:should iodine be supplemented or limited at coastal stations?

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Military Medical Research 2025年第1期12卷 154-156页

作者： Jia Zeng Qi Li Xiang Lu Dan-Dan Liu Rong-Guan Jiao Yan-Qing Jiang Yan-Bing Liu wan-Qing Xu Jun Ma Guo-Li Gu Department of Aeronautical Diseases Naval Medical CenterNaval Medical University of Chinese PLAShanghai 200052China No.92853 Station Troops Hospital of Chinese PLA Huludao 125000LiaoningChina Department of Intensive Care Unit Naval Medical CenterNaval Medical University of Chinese PLAShanghai 200052China Department III of Internal Medicine Naval Medical CenterNaval Medical University of Chinese PLAShanghai 200052China Department of General Surgery Air Force Medical CenterAir Force Medical University of Chinese PLABeijing 100142China

Dear Editor,In recent years,there has been a significant upward trend in the detection rate of thyroid diseases among military flight personnel[1].Thyroid diseases not only pose a serious threat to the health of flight personnel but also have negative impacts on the aviation safety and combat effectiveness of *** has been confirmed that the occurrence and progression of thyroid diseases are closely linked to dietary iodine *** have manifested that long-term excessive or insufficient iodine intake can lead to thyroid diseases[2,3].

关键词： Naval pilot Thyroid Urinary iodine