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首尔双子星

现代装饰 2024年第3期 184-187页

作者： Ben van berkel(设计) Gerard Loozekoot with Harlen Miller(设计) Crystal Tang and Ines Verna(设计) 不详

近期,UNStudio与奥雅纳和当地的Heerim建筑事务所联手,为新的和平公园摩天轮设计了一个愿景方案,这是首尔市政府为首尔上岩世界杯公园发起的一个地标项目。UNStudio的设计在初赛中脱颖而出,被选定与首尔住房社区公司合作,向首尔市提交... 详细信息

近期,UNStudio与奥雅纳和当地的Heerim建筑事务所联手,为新的和平公园摩天轮设计了一个愿景方案,这是首尔市政府为首尔上岩世界杯公园发起的一个地标项目。UNStudio的设计在初赛中脱颖而出,被选定与首尔住房社区公司合作,向首尔市提交设计方案。首尔市政府最近公布了UNStudio的设计方案,并暂时将其命名为“首尔双子星”。该项目是首尔市长提出的“汉江千般日落”愿景的一部分,旨在打造汉江沿岸的一千个景点,作为首尔市民的公共空间。

关键词：建筑事务所公共空间双子星摩天轮首尔市世界杯设计方案

Effects of pyrethroid and organophosphate insecticides on reared black soldier fly larvae(Hermetia illucens)

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Insect Science 2024年第3期31卷 817-834页

作者： Nathan Meijer Lisa Zoet Theo de Rijk Paul Zomer Deborah Rjkers H.J.van der Fels-Klerx Joop J.A.van Loon Wageningen Food Safety Research(WFSR) Part of Wageningen University and ResearchWageningenThe Netherlands Bestico B.V. Industrieweg 6Berkel en RodenrjsThe Netherlands Plant Sciences Group Laboratory of EntomologyWageningen UniversityWageningenTheNetherlands

Black soldier fly larvae(Hermetia illucens)receive growing interest as a potential alternative animal feed *** insects may be exposed to insecticide residues in the rearing *** study aimed to investigate the effects of six different pyrethroid and organophosphate insecticides on this insect species'*** toxicity of two"model"substances for each of these classes(cypermethrin;pirimiphosmethyl)was quantified,with and without the synergist piperonyl butoxide(PBO).Critical effect doses corresponding to 10%yield(CED10)for cypermethrin(0.4 mg/kg)and pirimiphos-methyl(4.8 mg/kg)were *** addition of PBO to cypermethrin enhanced its relative potency with a factor *** data were compared against the relative toxicity of two analogue substances in each class(permethrin,deltamethrin;chlorpyrifosmethyl,malathion).Results suggest that exposure to concentrations complying with legal limits can cause significant reductions in *** to multiple substances at lower concentrations resulted in negative additive and synergistic *** the tested substances,deltamethrin was most toxic,causing 94%yield at 0.5 mg/*** results suggested that transfer of tested substances to the larval biomass was substance-and concentration-specific,but appeared to be correlated to reduced yields and the presence of *** of organophosphates was overall low(<2%),but ranged from 8%to 75%for *** to very low limits in insect biomass(~0.01 mg/kg),high transfer may result in *** is recommended that rearing companies implement lower contractual thresholds,and that policymakers consider adjusting legally allowed maximum residue levels in insect feed.

关键词： feed insects pesticides rearing substrate

Scavenger receptor BI: A multi-purpose player in cholesterol and steroid metabolism

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World Journal of Gastroenterology 2010年第47期16卷 591-5924页

作者： Menno Hoekstra Theo JC van berkel Miranda van Eck Division of Biopharmaceutics Leiden/Amsterdam Center for Drug Research Gorlaeus Laboratories

Scavenger receptor class B type Ⅰ (SR-BI) is an important member of the scavenger receptor family of integral membrane glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of SR-BI in cholesterol and steroid metabolism. SR-BI in hepatocytes is the sole molecule involved in selective uptake of cholesteryl esters from high-density lipoprotein (HDL). SR-BI plays a physiological role in binding and uptake of native apolipoprotein B (apoB)-containing lipoproteins by hepatocytes, which identif ies SR-BI as a multipurpose player in lipid uptake from the blood circulation into hepatocytes in mice. In adrenocortical cells, SR-BI mediates the selective uptake of HDL-cholesteryl esters, which is eff iciently coupled to the synthesis of glucocorticoids (i.e. corticosterone). SR-BI knockout mice suffer from adrenal glucocorticoid insuff iciency, which suggests that functional SR-BI protein is necessary for optimal adrenal steroidogenesis in mice. SR-BI in macrophages plays a dual role in cholesterol metabolism as it is able to take up cholesterol associated with HDL and apoBcontaining lipoproteins and can possibly facilitate cholesterol efflux to HDL. Absence of SR-BI is associated with thrombocytopenia and altered thrombosis susceptibility, which suggests a novel role for SR-BI in regulating platelet number and function in mice. Transgenic expression of cholesteryl ester transfer protein in humanized SR-BI knockout mice normalizes hepatic delivery of HDL-cholesteryl esters. However, other pathologies associated with SR-BI def iciency, i.e. increased atherosclerosis susceptibility, adrenal glucocorticoid insuffi ciency, and impaired platelet function are not normalized, which suggests an important role for SR-BI in cholesterol and steroid metabolism in man. In conclusion, generation of SR-BI knockout mice has signif icantly contributed to our knowledge of the physiological role of SR-BI. Studies using these mice have identif ied SR-BI as a

关键词： Scavenger receptor class B type Ⅰ Highdensity lipoprotein Cholesterol Lipoprotein metabolism Liver Macrophages Adrenal gland Platelets Steroido- genesis

Analysis and Successful Factors for P2P Lending Platforms in the European Market

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Analysis and Successful Factors for P2P Lending Platforms in...

作者： Julian van berkel 上海交通大学

学位级别：硕士

The banking crisis highlights the problems in the current traditional lending models,and a lot of borrowers’ needs to stay ***,the modern digital age comes with numerous innovations within the financial *** of these innovations is alternative lending,and this thesis’ main research objective is the phenomenon of P2 P lending platforms.P2 P lending is an emerging online application that acts as an intermediary where people can directly borrow money from each *** alternative lending market that originates from this offers benefits to both borrowers and *** boundaries for this thesis are detailing the best practices for a list of success factors for a startup P2 P lending platform within the European market to become a market *** thesis is divided into three main parts,namely the external analysis of P2 P lending,the competitive advantages analysis,and the strategic *** main theoretical contribution lies in obtaining a comprehensive success theory on the P2 P lending market and *** a brief introduction of this occurrence,different kinds of P2 P lending are discussed,and the main methods in shaping a strategic blueprint are *** first part,the external analysis,is divided into a macro view of the industry,which is described through the viewpoint of a PESTLE ***,the market analysis compares different industries *** competitive advantages analysis consists of a business overview,a value chain analysis,a business resource view and a business capacity *** points of view are condensed into the main strategic plan,which is the success factor strategy for startup P2 P lending platforms to become leading in the European Market by adding the results of a questionnaire on P2 P *** these analyses,active and passive leading models are presented that would fit P2 P platforms in ***,some conclusions and future thoughts are penned *** contain l

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Emerging roles of the intestine in control of cholesterol metabolism

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World Journal of Gastroenterology 2006年第40期12卷 6429-6439页

作者： Janine K Kruit Albert K Groen Theo J van berkel Folkert Kuipers Department of Pediatrics Center for Liver Digestive and Metabolic Diseases University Medical Center Groningen Groningen The Netherlands Department of Experimental Hepatology Academic Medical Center Amsterdam The Netherlands Division of Biopharmaceutics Leiden/Amsterdam Center for Drug Research Leiden University Leiden The Netherlands

The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels.

关键词： Cholesterol metabolism Intestine High density lipoprotein Cholesterol absorption Reverse cholesterol transport

Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study

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World Journal of Gastrointestinal Oncology 2017年第12期9卷 466-474页

作者： René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM berkel Joost M Klaase Paul J van Diest Department of Surgery Medisch Spectrum Twente Laboratory for Pathology East-Netherlands Netherlands Comprehensive Cancer Organization Location Enschede Department of Pathology University Medical Center Utrecht

AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal *** TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards *** Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases.

关键词： Rectal cancer Adenocarcinoma Prognosis Recurrence Pathology Tumor-stroma ratio

COVID-19 and low-dose radiation therapy

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Radiation Medicine and Protection 2021年第4期2卷 139-145页

作者： Neal E.Dunlap Victor van berkel Lu Cai Department of Radiation Oncology University of Louisville School of MedicineLouisvilleKY40202USA Department of Cardiovascular and Thoracic Surgery University of Louisville School of MedicineLouisvilleKY40202USA Pediatric Research Institute Departments of PediatricsPharmacology and ToxicologyUniversity of Louisville School of MedicineLouisvilleKY40202USA

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative pathogen of the coronavirus disease 2019(COVID-19),has caused more than 179 million infections and 3.8 million deaths *** health authorities working on the COVID-19 outbreak continue to explore methods to reduce the rate of its transmission to healthy *** protocols thus far have focused on social distancing and masking,treatment with antivirals early in infection,and steroids to reduce the inflammatory *** alternative approach is therapy with low dose radiation(LDR),which has several advantages compared to the current drugs and *** date more than 10 case reports and pilot clinical trial preliminary outcome are available from different *** reports cover a wide range of patient conditions and LDR treatment *** one report showed the failure to observe the improvement of COVID-19 patients after LDR therapy,the majority showed some clinical improvement,and demonstrated the safety of LDR for COVID-19 patients,particularly with 0.5 *** review aims to summarize the potential rationales and mechanisms of LDR therapy for COVID-19 patients,and its current clinical status and potential use.

关键词： Low dose radiation Radiation hormesis Radiotherapy COVID-19 SARS-CoV-2

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韩国天安格兰亚商城

中国建筑装饰装修 2011年第7期 62-71页

作者： Ben van berkel

精选理由正如建筑师Ben van berkel所说：“关于Galleria Cheonan的效果最有趣的地方是：由于外观上对中庭和叠纹的处理,造成了一种假象,让人觉得建筑的规模似乎可以改变,也导致了双重图像的产生。这栋建筑没有一幅永久不变的图像。”

关键词：商城韩国建筑师 van 图像中庭

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清洁生产观点1:生产与工业发展

生态毒理学报 2002年第1期24卷 28-32页

作者： René van berkel CSBP Professor of Cleaner Production and Director Center of Excellence in Cleaner ProductionCurtin University of Technology GPO Box U 1987 Perth WA 6845Australia

对清洁生产的定义仍然合适吗?促进清洁生产的潜在的关键性假设在今天的工业世界依然行得通吗?如何改变清洁生产计划以提高其效率并在未来十年在对它的理解方面产生飞跃?这篇文章就谈论了这类问题.并在改进目前的清洁生产实践方面提出了... 详细信息

对清洁生产的定义仍然合适吗?促进清洁生产的潜在的关键性假设在今天的工业世界依然行得通吗?如何改变清洁生产计划以提高其效率并在未来十年在对它的理解方面产生飞跃?这篇文章就谈论了这类问题.并在改进目前的清洁生产实践方面提出了建议.

关键词：清洁生产生产观关键性假设未来十年生产计划效率实践工业