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Protective effect of long-chain polyunsaturated fatty acids on hepatorenal syndrome in rats

World Journal of Nephrology 2024年第3期13卷 49-61页

作者： João Bruno Beretta Duailibe Cassiana Macagnan Viau jenifer saffi Sabrina Alves Fernandes Marilene Porawski Department of Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil Department of Basic Health Sciences Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil Department of Hepatology and Basic Health Sciences Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil

BACKGROUND Hepatorenal syndrome(HRS)is the most prevalent form of acute kidney injury in cirrhotic *** is characterized by reduced renal blood flow and represents the most severe complication in cirrhotic patients with advanced *** research has indicated that antioxidants can delay the onset of a hyperdynamic circulatory state in cirrhosis and improve renal function in HRS *** omega-3 supplementation has significantly reduced the risk of liver *** supplementation could represent an additional therapy for individuals with *** To evaluated the antioxidant effect of omega-3 polyunsaturated fatty acid supplementation on the kidneys of cirrhotic *** Secondary biliary cirrhosis was induced in rats by biliary duct ligation(BDL)for 28 *** used 24 male Wistar rats divided into the following groups:I(control);II(treated with omega-3,1 g/kg of body weight);III(BDL treated with omega-3,1 g/kg of body weight);and IV(BDL without treatment).The animals were killed by overdose of anesthetic;the kidneys were dissected,removed,frozen in liquid nitrogen,and stored in a freezer at-80℃for later *** evaluated oxidative stress,nitric oxide(NO)metabolites,DNA damage by the comet assay,cell viability test,and apoptosis in the *** were analyzed by one-way analysis of variance,and means were compared using the Tukey test,with P≤*** Omega-3 significantly decreased the production of reactive oxygen species(P<0.001)and lipoperoxidation in the kidneys of cirrhotic rats treated with omega-3(P<0.001).The activity of the antioxidant enzymes superoxide dismutase and catalase increased in the BDL+omega-3 group compared to the BDL group(P<0.01).NO production,DNA damage,and caspase-9 cleavage decreased significantly in the omega-3-treated BDL *** was an increase in mitochondrial electrochemical potential(P<0.001)in BDL treated with omega-3 compared to *** changes in the cell survival index in HRS with omega-3 c

关键词： Long-chain polyunsaturated fatty acids Antioxidant effect Hepatorenal syndrome Liver cirrhosis Reactive oxygen species Apoptosis

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