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Exposure of juvenile Chinook salmon to effluent from a large urban wastewater treatment *** *** responses

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Aquaculture and Fisheries 2024年第3期9卷 355-366页

作者： Suzanne C.Ball James P.Meador C.Andrew James jenifer k.mc.ntyre Washington State University School of the EnvironmentPuyallup Research and Extension Center2606 W Pioneer AvePuyallupWA98371USA Dept.of Environmental and Occupational Health Sciences School of Public Health4225 Roosevelt Way NESuite 100SeattleWA98105-6099USA University of Washington Tacoma Center for Urban Waters326 East D StreetTacomaWA98421-1801USA

Wastewater treatment plants release complex mixtures of chemicals into the aquatic environment as wastewater effluent(WWE);however,the effects of these mixtures are still poorly *** salmon(Oncorhynchus tshawytscha)are a culturally important species in the Pacific Northwest and are a vital food resource for southern resident killer whales(Orcinus orca)that are listed as‘critically endangered’under the *** Species Act(ESA).Chinook populations have declined drastically in this region and have failed to show significant recovery despite regional-to-federal efforts,resulting in many populations being listed as threatened under the *** source of stress to juvenile Chinook is chemical pollution from WWE during their outmigration along river corridors and residency in *** this study,we investigated effects of WWE on juvenile Chinook health in a ten-day exposure to dilutions of WWE from 0.1%to 20%.At the end of the exposure,we measured endpoints associated with endocrine disruption,brain function,osmoregulation,stress,and *** to WWE significantly(α=0.1 for all analyses)induced vitellogenesis,indicating endocrine system *** saw significant reductions in plasma glucose,an indication of stress,and brain Na+/k+-ATPase(NkA)activity,an enzyme essential for neuronal ***,metabolism was affected as evidenced by altered total protein,cholesterol,and albumin in plasma,a drastic decrease in whole body lipid content,and a significant increase in visible liver *** compared contaminant concentrations in exposure water with effects concentrations from the literature for chemicals known to induce vitellogenin or inhibit brain *** most contaminants,concentrations in exposure waters were several orders of magnitude below effects concentrations in the *** exception was estrogenic hormones,which were detected at similar concentrations in this study compared to concentrations in other studies tha

关键词： Wastewater effluent Chinook salmon Toxicity Sodium potassium ATPase Vitellogenin Physiology Metabolism Glucose

Information Centric Networking Based Cooperative Caching Framework for 5G Communication Systems

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Computers, Materials & Continua 2024年第9期80卷 3945-3966页

作者： R.Mahaveerakannan Thanarajan Tamilvizhi Sonia jenifer Rayen Osamah Ibrahim khalaf Habib Hamam Department of Computer Science and Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai602105India Department of Computer Science and Engineering Panimalar Engineering CollegeChennai600123India Department of Computer Science and Engineering Sathyabama Institute of Science and TechnologyChennai600119India Department of Solar Energy Al-Nahrain Research Center for Renewable EnergyAl-Nahrain UniversityJadriyaBaghdad64074Iraq Faculty of Engineering Universitéde MonctonNew BrunswickE1A3E9Canada Hodmas University College Mogadishu521376Somalia Bridges for Academic Excellence Tunis1002Tunisia School of Electrical Engineering University of JohannesburgAuckland ParkJohannesburg2006South Africa

The demands on conventional communication networks are increasing rapidly because of the exponential expansion of connected multimedia *** light of the data-centric aspect of contemporary communication,the information-centric network(ICN)paradigm offers hope for a solution by emphasizing content retrieval by name instead of *** 5G networks are to meet the expected data demand surge from expanded connectivity and Internet of Things(IoT)devices,then effective caching solutions will be required tomaximize network throughput andminimize the use of ***,an ICN-based Cooperative Caching(ICN-CoC)technique has been used to select a cache by considering cache position,content attractiveness,and rate *** findings show that utilizing our suggested approach improves caching regarding the Cache Hit Ratio(CHR)of 84.3%,Average Hop Minimization Ratio(AHMR)of 89.5%,and Mean Access Latency(MAL)of 0.4 *** a framework,it suggests improved caching strategies to handle the difficulty of effectively controlling data consumption in 5G *** improvements aim to make the network run more smoothly by enhancing content delivery,decreasing latency,and relieving *** improving 5G communication systems’capacity tomanage the demands faced by modern data-centric applications,the research ultimately aids in advancement.

关键词： Information-centric networking caching schemes 5G communication non-negative matrix factorization(NMF) weighted clustering algorithm

Predictors of the placebo response in a nutraceutical randomized controlled trial for depression

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Journal of Integrative Medicine 2024年第1期22卷 46-53页

作者： Rosemary Arnold jenifer Murphy-Smith Chee H.Ng David Mischoulon Gerard J.Byrne Chad A.Bousman Con Stough Michael Berk Jerome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression Clinical and Research Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psychiatry the University of MelbourneMelbourne 3052Australia Centre for Human Psychopharmacology Swinburne UniversityMelbourne 3122Australia The Institute for Mental and Physical Health and Clinical Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The Centre of Excellence in Youth Mental Health the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental Health the University of MelbourneParkville 3052Australia NICM Health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objective The placebo response in depression studies is the change in symptoms amongst those who receive an inactive *** well-designed randomized controlled trials(RCTs)of depression have a high proportion of placebo responders,with little understanding as to *** present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of placebo *** This is a secondary analysis of a nutraceutical depression RCT which identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant characteristics such as socio-demographics,clinical features,and recruitment methods,and their association with the placebo *** genetic polymorphisms were also *** response was measured based on change in Montgomery-Asberg Depression Rating Scale *** association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects *** Greater levels of education,particularly pursuing post-high school education,better self-reported general health,marriage/de facto,greater improvement in the first trial week,and more failed antidepressant therapies in the current depressive episode were associated with greater placebo *** increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant *** nucleotide polymorphisms from the tryptophan hydroxylase 1(TPH1)gene(A779C and A218C)were weakly associated with greater placebo response,although the evidence was attenuated after accounting for multiple *** This is,to our knowledge,the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo *** variables appeared to predict the placebo *** findings may encourage future trial design

关键词： Randomized controlled trial Placebo Depression Nutraceutical Psychiatry

Protective effect of long-chain polyunsaturated fatty acids on hepatorenal syndrome in rats

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World Journal of Nephrology 2024年第3期13卷 49-61页

作者： João Bruno Beretta Duailibe Cassiana Macagnan Viau jenifer Saffi Sabrina Alves Fernandes Marilene Porawski Department of Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil Department of Basic Health Sciences Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil Department of Hepatology and Basic Health Sciences Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil

BACkGROUND Hepatorenal syndrome(HRS)is the most prevalent form of acute kidney injury in cirrhotic *** is characterized by reduced renal blood flow and represents the most severe complication in cirrhotic patients with advanced *** research has indicated that antioxidants can delay the onset of a hyperdynamic circulatory state in cirrhosis and improve renal function in HRS *** omega-3 supplementation has significantly reduced the risk of liver *** supplementation could represent an additional therapy for individuals with *** To evaluated the antioxidant effect of omega-3 polyunsaturated fatty acid supplementation on the kidneys of cirrhotic *** Secondary biliary cirrhosis was induced in rats by biliary duct ligation(BDL)for 28 *** used 24 male Wistar rats divided into the following groups:I(control);II(treated with omega-3,1 g/kg of body weight);III(BDL treated with omega-3,1 g/kg of body weight);and IV(BDL without treatment).The animals were killed by overdose of anesthetic;the kidneys were dissected,removed,frozen in liquid nitrogen,and stored in a freezer at-80℃for later *** evaluated oxidative stress,nitric oxide(NO)metabolites,DNA damage by the comet assay,cell viability test,and apoptosis in the *** were analyzed by one-way analysis of variance,and means were compared using the Tukey test,with P≤*** Omega-3 significantly decreased the production of reactive oxygen species(Pkidneys of cirrhotic rats treated with omega-3(P<0.001).The activity of the antioxidant enzymes superoxide dismutase and catalase increased in the BDL+omega-3 group compared to the BDL group(P<0.01).NO production,DNA damage,and caspase-9 cleavage decreased significantly in the omega-3-treated BDL *** was an increase in mitochondrial electrochemical potential(P<0.001)in BDL treated with omega-3 compared to *** changes in the cell survival index in HRS with omega-3 c

关键词： Long-chain polyunsaturated fatty acids Antioxidant effect Hepatorenal syndrome Liver cirrhosis Reactive oxygen species Apoptosis

No consistent legacy effects of invasion by giant goldenrod(Solidago gigantea)via soil biota on native plant growth

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Journal of Plant Ecology 2016年第3期9卷 320-327页

作者： jenifer könig Mark van kleunen Wayne Dawson Department of Biology University of KonstanzUniversitaetsstrasse 10Konstanz D78457Germany

Aims Changes in soil microbial communities after occupation by invasive alien plants can represent legacy effects of invasion that may limit recolonization and establishment of native plant species in soils previously occupied by the *** this study,for three sites in southern Germany,we investigated whether invasion by giant goldenrod(Solidago gigantea)leads to changes in soil biota that result in reduced growth of native plants compared with neighbouring uninvaded *** We grew four native plant species as a community and treated those plants with soil solutions from invaded or uninvaded soils that were sterilized,or live,with live solutions containing different fractions of the soil biota using a decreasing sieve mesh-size *** measured aboveground biomass of the plants in the communities after a 10-week growth *** FindingsAcross all three sites and regardless of invasion,communities treated with20μm are more pathogenic to the native plants than smaller organisms in these *** all three sites,there was only a non-significant tendency for the native community biomass to differ among soil solution types,depending on whether or not the soil was *** one site showed significant differences in community biomass among soil solution types,depending on whether or not the soil was invaded;community biomass was significantly lower when treated with the complete soil biota solution than with soil biotakely to be hindered by changes in soil microbial community composition as a result of previous invasion.

关键词： exotic plants invasive plant impacts plant-soil feedback soil microbes

A COMPARATIVE STUDY OF THE INVENTORY SYSTEM WITH SERVICE FACILITY AND POSTPONED DEMANDS

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Journal of Systems Science and Systems Engineering 2014年第2期23卷 176-195页

作者： J.Sebastian Arockia jenifer B.Sivakumar School of Mathematics Madurai Kamaraj University

In this article, we present a continuous review （s,S） inventory system with a service facility consisting of finite buffer （capacity N ） and a single server. The customers arrive according to a Poisson process. The individual customer＇s unit demand is satisfied after a random time of service, which is assumed to be exponential. When the inventory level drops to s＇an order for Q（= S-s） items is placed. The lead time of reorder is assumed to be exponential distribution. An arriving customer, who finds the buffer is full, enters into the pool of infinite size or leaves the system according to a Bernolli trial. At the time of service completion, if the buffer size drops to a preassigned level L （1 〈 L 〈 N） or below and the inventory level is above s, we select the customers from the pool according to two different policy ： in first policy, with probability p （0 〈 p 〈 1） we select the customer from the head of the pool and we place the customer at the end of the buffer; in the second policy, with p （0 〈 p 〈 1） the customer from the pool is transferred to the buffer for immediate service and after completion of his service we provide service to the customer who is in the buffer with probability one. If at a service completion epoch the buffer turns out to be empty, there is at least one customer in the pool and the inventory level is positive, then the one ahead of all waiting in the pool gets transferred to the buffer, and his service starts immediately. The joint probability distribution of the number of customers in the pool, number of customers in the buffer and the inventory level is obtained in the steady-state case. Various stationary system performance measures are computed and total expected cost rate is calculated. A comparative result of two models is illustrate numerically.

关键词： Continuous review inventory system postponed demands service facility finite waiting hall pool with infinite size

Inequality and the Urban-rural Divide in China:Effects of Regressive Taxation

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China & World Economy 2010年第6期18卷 36-55页

作者： jenifer Piesse Business School Bournemouth University

Using three comparable national representative household surveys for China in 1988, 1995 and 2002, the present paper reveals the regressivity and urban bias of China＇s direct tax and welfare system in this period It shows that a regressive taxation system and skewed allocation of subsidies increases the urban-rural income gap and enhances overall inequality. Modeling these relationships indicates that the relatively poorer rural population has a net tax liability, whereas those in the richer urban areas receive net subsidies. This pattern is common in China, although the extent of the bias varies. This skewed system of tax and welfare payments is a major cause of the persisting urban-rural income gap and contributes to the overall income inequality in China. The abolishment of the agriculture tax in 2006 has had a positive impact on rural people ＇s livelihoods.

关键词： China inequality subsidies taxation urban-rural divide

Deep Learning with Optimal Hierarchical Spiking Neural Network for Medical Image Classification

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Computer Systems Science & Engineering 2023年第2期44卷 1081-1097页

作者： P.Immaculate Rexi jenifer S.kannan Department of Computer Science and Engineering Anjalai Ammal Mahalingam Engineering CollegeKoilvenni614403Tamil NaduIndia Department of CSE E.G.S.Pillay Engineering CollegeNagapattinam611002Tamil NaduIndia

Medical image classification becomes a vital part of the design of computer aided diagnosis(CAD)*** conventional CAD models are majorly dependent upon the shapes,colors,and/or textures that are problem oriented and exhibited complementary in medical *** recently developed deep learning(DL)approaches pave an efficient method of constructing dedicated models for classification *** the maximum resolution of medical images and small datasets,DL models are facing the issues of increased computation *** this aspect,this paper presents a deep convolutional neural network with hierarchical spiking neural network(DCNN-HSNN)for medical image *** proposed DCNN-HSNN technique aims to detect and classify the existence of diseases using medical *** addition,region growing segmentation technique is involved to determine the infected regions in the medical ***,NADAM optimizer with DCNN based Capsule Network(CapsNet)approach is used for feature extraction and derived a collection of feature ***,the shark smell optimization algorithm(SSA)based HSNN approach is utilized for classification *** order to validate the better performance of the DCNN-HSNN technique,a wide range of simulations take place against HIS2828 and ISIC2017 *** experimental results highlighted the effectiveness of the DCNN-HSNN technique over the recent techniques interms of different *** type your abstract here.

关键词： Medical image classiﬁcation spiking neural networks computer aided diagnosis medical imaging parameter optimization deep learning

A New Hybrid Feature Selection Sequence for Predicting Breast Cancer Survivability Using Clinical Datasets

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Intelligent Automation & Soft Computing 2023年第7期37卷 343-367页

作者： E.jenifer Sweetlin S.Saudia Centre for Information Technology and Engineering Manonmaniam Sundaranar UniversityTirunelveliIndia

This paper proposes a hybrid feature selection sequence comple-mented with filter and wrapper concepts to improve the accuracy of Machine Learning(ML)based supervised classifiers for classifying the survivability of breast cancer patients into classes,living and deceased using METABRIC and Surveillance,Epidemiology and End Results(SEER)*** ML-based classifiers used in the analysis are:Multiple Logistic Regression,k-Nearest Neighbors,Decision Tree,Random Forest,Support Vector Machine and Multilayer *** workflow of the proposed ML algorithm sequence comprises the following stages:data cleaning,data balancing,feature selection via a filter and wrapper sequence,cross validation-based training,testing and performance *** results obtained are compared in terms of the following classification metrics:Accuracy,Precision,F1 score,True Positive Rate,True Negative Rate,False Positive Rate,False Negative Rate,Area under the Receiver Operating Characteristics curve,Area under the Precision-Recall curve and Mathews Correlation *** comparison shows that the proposed feature selection sequence produces better results from all supervised classifiers than all other feature selection sequences considered in the analysis.

关键词： Accuracy feature selection filter methods ML-based classifiers wrapper methods