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Clinical trials for treating recurrent head and neck cancer with boron neutron capture therapy using the Tsing-Hua Open Pool Reactor

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Cancer Communications 2018年第1期38卷 393-399页

作者： Ling-wei Wang Yen-Wan Hsueh Liu Fong-In chou Shiang-Huei Jiang Department of Oncology Taipei Veterans General HospitalNo.201Section 2Shih-Pai RoadTaipei 11217TaiwanChina School of Medicine National Yang Ming UniversityTaipei 11217TaiwanChina Institute of Nuclear Engineering and Science National Tsing Hua UniversityHsin-ChuTaiwanChina Nuclear Science and Technology Development Center National Tsing Hua UniversityHsin-ChuTaiwanChina

Head and neck(HN)cancer is an endemic disease in Taiwan,*** recurrent HN cancer after full-dose irradia-tion poses a therapeutic challenge,and boron neutron capture therapy(BNCT)may be a solution that could provide durable local control with tolerable *** Tsing-Hua Open Pool Reactor(THOR)at National Tsing-Hua University in Hsin-Chu,provides a high-quality epithermal neutron source for basic and clinical BNCT *** first clinical trial,entitled“A phase I/II trial of boron neutron capture therapy for recurrent head and neck cancer at THOR”,was carried out between 2010 and 2013.A total of 17 patients with 23 recurrent HN tumors who had received high-dose photon irradiation were enrolled in the *** fructose complex of l-boronophenylalanine was used as a boron carrier,and a two-fraction BNCT treatment regimen at 28-day intervals was used for each *** was acceptable,and although the response rate was high(12/17),re-recurrence within or near the radiation site was *** obtain better local control,another clinical trial entitled“A phase I/II trial of boron neutron capture therapy combined with image-guided intensity-modulated radiotherapy(IG-IMRT)for locally recurrent HN cancer”was initiated in *** first administration of BNCT was performed according to our previous protocol,and IG-IMRT was initiated 28 days after *** of May 2017,seven patients have been treated with this *** treatment-related toxicity was similar to that previously observed with two BNCT *** patients had a complete response,but locoregional recurrence was the major cause of failure despite initially good *** clinical trials combining BNCT with other local or systemic treatments will be carried out for recurrent HN cancer patients at THOR.

关键词： Head and neck cancer Boron neutron capture therapy Tsing-Hua Open Pool Reactor Boronophenylalanine

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The status evaluation of the permafrost environment along the Chaida'er-Muli Railway in southern Qilian Mountains in northern Qinghai Province,China

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Journal of Mountain Science 2016年第12期13卷 2124-2134页

作者： CAO wei SHENG Yu chou Ya-ling WU Ji-chun LI Jing WANG Sheng-ting State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences Key Laboratory of Disaster Prevention and Mitigation in Civil Engineering of Gansu Province Lanzhou University of Technology

Engineering construction has major influence on the permafrost *** paper analyzes the interaction between engineering construction and permafrost environment along the Chaidaer-Muli Railway(simply,CMR) based on the press-state-response(PSR) *** permafrost environmental system is divided into three subsystems,consisting of permafrost thermal stability,proneness to the freeze-thawing erosion and permafrost ecological *** subsystem considers its most important influencing *** Progression Method(CPM) is applied to calculate the current environment condition along the *** result indicates that:(1) as far as the thermal stability is concerned,most sections along the CMR are mainly concentrated in rank Ⅲ(fair situation),and a few in Ⅱ(good situation) and Ⅳ(bad situation),respectively;(2) for the proneness tothe freeze-thawing erosion,the entire railway route falls largely in rank Ⅱ(good situation);(3) along the CMR,the ecological fragility of the permafrost environment is in rank Ⅱ(good situation),or slightly fragile;(4) overall,the permafrost environments along the CMR are in rank Ⅲ(fair situation) or Ⅱcondition(good situation).In general,the permafrost environment along the CMR is *** is mainly because a series of active measures of protecting permafrost were taken for stabilizing the CMR foundation *** the one hand,we should try our best to minimize the influences that engineering activities have exerted on ecology and environment,on the other hand,the positive measures have made improvements to prevent the permafrost environment from deterioration.

关键词： Permafrost environment Press-stateresponse framework Catastrophe theory Chaida'erMu Railway Environmental impact

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Adaptive peer-to-peer streaming with MutualCast

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 737-748页

作者： chou Philip A Microsoft Research One Microsoft Way Redmond WA 98052 USA

Application Layer Multicast (ALM) can greatly reduce the load of a server by leveraging the outgoing bandwidth of the participating nodes. However, most proposed ALM schemes become quite complicated and lose bandwidth efficiency if they try to deal with networks that are significantly heterogeneous or time-varying. In earlier work, we proposed MutualCast, an ALM scheme with fully connected mesh that quickly adapts to the time-varying networks, while achieving provably optimal throughput performance. In this paper, we study how MutualCast can be paired with adaptive rate control for streaming media. Specifically, we combine Optimal Rate Control (ORC), our earlier control-theoretical framework for quality adaptation, with the MutualCast delivery scheme. Using multiple bit rate video content, we show that the proposed system can gracefully adjust the common quality received at all the nodes while maintaining a continuous streaming experience at each, even when the network undergoes severe, uncorrelated bandwidth fluctuations at different peer nodes.

关键词： Peer-to-peer streaming, Distribution capacity, Quality adaptation, MutualCast

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A New Optimizing Method for Planar Arrays Pattern 36

A New Optimizing Method for Planar Arrays Pattern

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第36届中国控制会议

作者： Yongbin chou Xianlin Huang Shuchun Zhang wei Jiang Center for Control Theory and Guidance Technology Harbin Institute of Technology

ISBN: (纸本)9781538629185

Traditional particle swarm optimization（PSO） will be failed because of falling into local optimum solutions and converging too slowly when being used to optimize planar array pattern. So a new method is presented to improve the traditional PSO convergence by means of efficient estimation of the optimum particle’s initial values. A desired pattern is first constructed, and then the corresponding aperture weights can be estimated by means of matrix operation. These weights then are assigned to a particle as initial values（this operation is equivalent to making an efficient estimation of the optimum particle’s initial values）, while the other particles are initialized randomly, then the traditional PSO algorithm is used to search for the global best solutions. The simulation results proved that this method could rapidly converge to satisfying global solutions and the desired aperture weights could be achieved. So this improved PSO method presented here is far better than the traditional PSO to solve the optimization problems of planar array pattern.

关键词： planar array sidelobes interference pattern optimization Particle Swarm Optimization(PSO)

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Measuring the orbital periods of low mass X-ray binaries in the X-ray band

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Research in Astronomy and Astrophysics 2014年第11期14卷 1367-1382页

作者： Yi chou Graduate Institute of Astronomy National Central University

A low mass X-ray binary （LMXB） contains either a neutron star or a black hole accreting materials from its low mass companion star. It is one of the primary astrophysical sources for studying stellar-mass compact objects and accreting phe- nomena. As with other binary systems, the most important parameter of an LMXB is the orbital period, which allows us to learn about the nature of the binary system and constrain the properties of the system＇s components, including the compact ob- ject. As a result, measuring the orbital periods of LMXBs is essential for investigating these systems even though fewer than half of them have known orbital periods. This article introduces the different methods for measuring the orbital periods in the X-ray band and reviews their application to various types of LMXBs, such as eclipsing and dipping sources, as well as pulsar LMXBs.

关键词： X-rays: binaries -- binaries: close -- methods: data analysis

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A new model for evaluating the electrical conductivity of nonferrous slag

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International Journal of Minerals,Metallurgy and Materials 2009年第5期16卷 500-504页

作者： Kuo-Chih chou School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

Electrical conductivity of molten slag is an important physicochemical property for designing the refming process in electric smelting furnaces. Though conductivities of many slag systems have been measured, the quantitative relationships of conductivity with slag composition and temperature are still very limited. In this article, the Arrhenius law was used to describe the experimental data of conductivities for CaO-MgO-Al2O3-SiO2, CaO-Al2O3-SiO2, CaO-MnO-AlEO3-SiO2, as well as CaO-MgO-MnO- Al2O3-SiO： systems, and it is found that activation energy can be expressed as a linear function of the content of components, where the optical basicity of slag must be within the range of 0.58 to 0.68.

关键词： electrical conductivity Arrhenius law activation energy optical basicity

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Combustion characteristics and kinetics of anthracite with added chlorine

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International Journal of Minerals,Metallurgy and Materials 2017年第7期24卷 745-755页

作者： Cui Wang Jian-liang Zhang Guang-wei Wang Ke-xin Jiao Zheng-jian Liu Kuo-chih chou School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Beijing 100083 China

The combustion process of Yangquan anthracite（YQ） with the addition of 0.045wt%, 0.211wt%, 1.026wt%, and 2.982wt% chlorine was investigated using a thermogravimetric method from an ambient temperature to 1173 K in an air atmosphere. Results show that the YQ combustion characteristics are not significantly affected by an increase in chlorine content. Data acquired for combustion conversion are then further processed for kinetic analysis. Average apparent activation energies determined using the model-free method（specifically the KAS method） are 103.025, 110.250, 99.906, and 110.641 k J/mol, respectively, and the optimal kinetic model for describing the combustion process of chlorine-containing YQ is the nucleation kinetic model, as determined by the z（α） master plot method. The mechanism function of the nucleation kinetic model is then employed to estimate the pre-exponential factor, by making use of the compensation effect. The kinetic models to describe chlorine-containing YQ combustion are thus obtained through advanced determination of the optimal mechanism function, average apparent activation energy, and the pre-exponential factor.

关键词： chlorine anthracite combustion characteristics kinetics

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Regulating the intrinsic electronic structure of carbon nanofibers with high-spin state Ni for sodium storage with high-power density

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Journal of Materials Science & Technology 2024年第4期171卷 16-23页

作者： Zhijia Zhang Gang Xie Yuefang Chen Yanhao wei Mengmeng Zhang Shulei chou Yunxiao Wang Yifang Zhang Yong Jiang School of Materials Science and Engineering Institute of Quantum Materials and DevicesState Key Laboratory of Separation Membrane and Membrane ProcessesTiangong UniversityTianjin 300387China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Institute for Superconducting and Electronic Materials University of WollongongWollongongNSW 2522Australia

Carbon nanofibers(CNFs)with high specific surface area show great potential for sodium storage as a hard carbon ***,CNFs anchored with Ni nanoparticles(CNFs/Ni)were prepared through chemical vapor deposition and impregnation reduction methods,in situ growing on the three-dimensional porous copper current collector(3DP-Cu).The coupling effect of high-spin state Ni nanopar-ticles leads to the increase of defect density and the expansion of lattice spacing of ***,the 3DP-Cu ensures a high loading capacity of CNFs and short ion/electron transport *** an integral binder-free anode,the 3DP-Cu/CNFs/Ni exhibits excellent electrochemical performance,which demon-strates a high specific capacity with 298.5 mAh g^(-1)at 1000 mA g^(-1)after 1500 cycles,and a high power density with 200 mAh g^(-1)over 1000 cycles at 5000 mA g^(-1).Density functional theory calculation re-sults show that the high-spin state Ni regulates the electronic structure of CNFs,which significantly reduces the adsorption energy for Na^(+)(-2.7 Ev)and thus enables high-rate *** regulation of the electronic structure of carbon materials by high-spin state metal provides a new strategy for developing high-power carbonaceous anode materials for sodium-ion batteries.

关键词： Carbon nanofibers Ni nanoparticles High-spin state Sodium-ion batteries Anode materials Density functional theory calculation

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Path planning for mobile robot using self-adaptive learning particle swarm optimization

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Science China(Information Sciences) 2018年第5期61卷 267-284页

作者： Guangsheng LI Wusheng chou School of Mechanical Engineering and Automation Beihang University State Key Laboratory of Virtual Reality Technology and Systems Beihang University

As a challenging optimization problem, path planning for mobile robot refers to searching an optimal or near-optimal path under different types of constrains in complex environments. In this paper, a self-adaptive learning particle swarm optimization(SLPSO) with different learning strategies is proposed to address this problem. First, we transform the path planning problem into a minimisation multi-objective optimization problem and formulate the objective function by considering three objectives: path length, collision risk degree and smoothness. Then, a novel self-adaptive learning mechanism is developed to adaptively select the most suitable search strategies at different stages of the optimization process, which can improve the search ability of particle swarm optimization(PSO). Moreover, in order to enhance the feasibility of the generated paths, we further apply the new bound violation handling schemes to restrict the velocity and position of each particle. Finally, experiments respectively with a simulated robot and a real robot are conducted and the results demonstrate the feasibility and effectiveness of SLPSO in solving mobile robot path planning problem.

关键词： path planning self-adaptive learning particle swarm optimization learning strategy learning mechanism boundary violations handling

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Study of Non-Ideal Effects for Extended Gate Field Effect Transistor Chlorine Ion Sensing Device

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稀有金属材料与工程 2006年第A03期35卷 242-243页

作者： Jung-Chuan chou Pei-Lan chou Graduate School of Electronic Engineering National Yunlin University of Science and TechnologyDouliouTaiwan 640China Graduate School of Optoelectronics National Yunlin University of Science and TechnologyDouliouTaiwan 640China

We use the extended gate field effect transistor (EGFET)as the structure of the chlorine ion sensor,and the chlorine ion ionophores (ETH9033 and TDDMAC1)are incorporated into solvent polymeric membrane (PVC/DOS),then the chlorine ion selective membrane is formed on the sensing window,and the fabrication of the EGFET chlorine ion sensing device is *** surface potential on the sensing membrane of the EGFET chlorine ion sensing device will be changed in the different chlorine ion concentration solutions,then changes further gate voltage and drain current to detect chlorine ion *** will study non-ideal effects such as temperature,hysteresis and drift effects for the EGFET chlorine ion sensing device in this paper,these researches will help us to improve the sensing characteristics of the EGFET chlorine ion sensing device.

关键词： extended gate field effect transistor chlorine ion ionophore chlorine ion sensing device temperature effect hysteresis effect drift effect

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