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The Ortholog of LYVE-1 Is Required for Thoracic Duct Formation in Zebrafish

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CellBio 2013年第4期2卷 228-247页

作者： Wen-Han Chen Wen-Fang Tseng Gen-Hwa Lin Andrew Schreiner Hsiao-Rong Chen mark m. Voigt Chiou-Hwa Yuh jen-Leih Wu Shuan Shian Huang Jung San Huang Auxagen Inc. St. Louis USA Department of Biochemistry and molecular Biology Saint Louis University School of Medicine Doisy Research Center St. Louis USA Department of Pharmacology and Physiological Science Saint Louis University School of Medicine St. Louis USA Division of molecular and Genomic medicine National Health Research Institutes Chunan Chinese Taipei Institute of Cellular and Organismic Biology Academia Sinica Taipei Chinese Taipei Institute of Systems Biology and Bioinformatics National Central University Jhongli Chinese Taipei

LYVE-1 (also termed CRSBP-1), a 120-kDa disulfide-linked dimeric type I membrane glycoprotein, is a specific marker for lymphatic endothelial cells (LECs) and exhibits multiple ligand (hyaluronic acid and growth factors/cytokines) binding activity in mammals. Recent studies indicate that LYVE-1/CRSBP-1 ligands (VEGF-A165, PDGF-BB, oligopeptides containing the cell-surface retention sequence (CRS) motifs of VEGF-A165 and PDGF-BB) induce opening of lymphatic intercellular junctions in vitro and in vivo. To determine the function of the ortholog of mammalian LYVE-1 in zebrafish, we cloned it (zLyve-1). The cloned cDNA (zLyve1) encodes a 328-amino-acid type I membrane glycoprotein. The protein and genomic structure evidence supports the notion that the cloned zLyve-1 is the ortholog of LYVE-1 in zebrafish. zLyve-1 expressed in cultured cells by transfection exhibits hyaluronic acid binding activity but lacks the growth factor binding activity seen in mammalian homologs. Knockdown of zLyve-1 levels by embryo microinjection with a specific antisense morpholino oligonucleotide (mO2) in wild-type and Tg(fli1:EGFP)-transgenic zebrafish causes defects in thoracic duct (TD) formation. Such zebrafish injected with mO2 also exhibit impaired TD flow (as determined by intramuscular injection of FITC-dextran). The phenotypes in these zebrafish injected with mO2 are reversed by co-injection with zLyve1cDNA. In situ hybridization reveals that zLyve-1 is expressed in the posterior cardinal vein (PCV). Expression of zLyve-1 at the highest level in the PCV occurs at 3 dpf which coincides with the time for TD formation in zebrafish development. These results suggest that zLyve-1 is required for TD formation. They also suggest that zLyve-1 is distinct from mammalian LYVE-1 in its role in lymphatic function.

关键词： zLyve-1 morpholino Knockdown Thoracic Duct Posterior Cardinal Vein Endothelial Cells

SOmE RESULTS ON THE STRUCTURE OF FEEDFORWARD INVERSES

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Science in China,Ser.A 1984年第2期 157-162页

作者：陶仁骥 Institute of Computing Technology Academia Sinica Beijing

Let m’=@（ma,f） be a semi-input-memory finite automaton with input alphabet Y andoutput alphabet X. In this paper, the following results are given: （i） If #X = #Y, then m’is a feedforward inverse with delay free if and only if there exists a cycle C of the statediagram of ma such that #f (y0,…, yc-1, Y, λ（P）) = #X for any state p in C and y0, …,yc-1 in Y. （ii） If X = Y = {0, 1}, then m’ is a feedforward inverse with delay 1 if and onlyif there exists a cycle C of state diagram of ma such that f（y0, …,yc,λa（p）） can be expressedin the form of f’(y0,…,yc-1,λa（p）) ?yc for any state p in C and y0,…,yc in Y, or of f'(y0,…,yc-2,λa（p）)?yc-1 for any state p in C and y0,…,yc in Y.

关键词： SOmE RESULTS ON THE STRUCTURE OF FEEDFORWARD INVERSES 一夕

Surface Improvement and Status Simulation of Alloy Tool Steel by Electrochemical Polishing

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Surface Improvement and Status Simulation of Alloy Tool Stee...

Some Observations of the Spherulites of Nylon-6 by Solvent Etching and by Iodine Treatment

第十六届国际电加工会议

作者： Jung-Chou Hung Shu-Jhuan Liu Kuan-Chih Chiu Tzu-Hung Wen Shuo-jen Lee Technical Development and Test Service Section Regional R&D Services DepartmentMetal Industries Research and Development CentreTai-Chung 407Taiwan Department of mechanical Engineering Yuan Ze UniversityChung-Li 320Taiwan

This study improves the surface of an alloy tool steel and simulates status of one-pulse electrochemical *** COmSOL multiphysicssoftware is utilized to simulate and predict the status of one-pulse electrochemical *** content includes current conduction model and moving boundary *** simulated corner variation is compared with experimental ***-pulse electrochemical polishing parameter effects on the surface are *** tool steel with a good surface roughness was obtained using one-pulse electrochemical polishing parameter as voltage of 15 V,machining time of 0.1 sec,electrolyte concentration of 30%and inlet electrolyte pressure of 7 Kgf/*** results show that surface roughness is improved from 0.25μm Ra to 0.095μm Ra.

关键词： One-pulse electrochemical polishing Simulation Surface roughness Alloy tool steel

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Science in China,Ser.A 1963年第6期 910-912页

作者：钱人元陈寿羲

Although the etching technique is a stand-ard practice in metallographic studies of thetexture of block metals,similar method for theobservation of spherulite formation of crystal-line polymers has not been widely used untilrecently either for electron-optical or *** of large differencesin the ease of dissolution of the crystalline andamorphous regions of a polymer block bysuitable solvents,the morphology of crystallineaggregates present at the surface of the blockwill stand out in relief under reflected lightafter solvent *** have observed somespherulite structures in Nylon-6 as shown inPlate *** a technique similar to that des-cribed by ***-6 samples in blockwere sliced,washed with acetone and heatedto melting(m.p.215°)in a 230℃ bath whileheld between two microscope *** thebath temperature was lowered to 204°*** 6—10 hr the sampleswere quenched into acetone at 0。.Specimens

关键词： Some Observations of the Spherulites of Nylon-6 by Solvent Etching and by Iodine Treatment

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线形天线阵辐射图形中旁瓣的减小

物理学报 1961年第12期 592-599页

作者：任朗卢明儒

为了减小线形天线阵辐射图形中的旁瓣,本文前一作者提出了与辐射图形中零点相对应的复量多项式的根在复数面中单位圆上的一个分布函数。这个分布函数是 φk=2βl/（1-n）{1+ξk1-lnε/ln（n-2）},它包含了谢昆诺夫的均匀分布（ξ=1）;因... 详细信息

为了减小线形天线阵辐射图形中的旁瓣,本文前一作者提出了与辐射图形中零点相对应的复量多项式的根在复数面中单位圆上的一个分布函数。这个分布函数是 φk=2βl/（1-n）{1+ξk1-lnε/ln（n-2）},它包含了谢昆诺夫的均匀分布（ξ=1）;因此,谢昆诺夫的分布可以看成是我们的分布的一个特例。计算结果证明,应用我们的分布函数,对于不均匀线形天线阵的辐射图形将有较好的控制,尤其对于减小主瓣附近的旁瓣有利。这样作会使远离主瓣的旁瓣变大一些,但后一清况可以用本文前一作者所提出的移动最末一个零点的位置加以改善。

关键词：旁瓣主瓣形天零点点(数学) 辐射图形天线阵

直接接触式膜蒸馏用于处理含盐溶液的实验研究

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化工学报 2018年第A2期69卷 246-251页

作者：刘羊九韩吉田王云山任天健山东大学能源与动力工程学院山东济南250061 约翰内斯堡大学机械工程学系

采用聚偏氟乙烯(PVDF)中空纤维膜作为膜材料,利用直接接触式膜蒸馏法处理质量分数分别为5%、15%和25%的NaCl溶液;使用正交实验方法对操作条件进行优化设计,研究表明当料液侧入口温度T1为80℃,渗透液侧入口温度T3为20℃,流量100 L/h时膜... 详细信息

采用聚偏氟乙烯(PVDF)中空纤维膜作为膜材料,利用直接接触式膜蒸馏法处理质量分数分别为5%、15%和25%的NaCl溶液;使用正交实验方法对操作条件进行优化设计,研究表明当料液侧入口温度T1为80℃,渗透液侧入口温度T3为20℃,流量100 L/h时膜通量最大,可达12.599 kg/(m2·h);当料液侧入口温度T1为80℃,渗透液侧入口温度T3为35℃,流量Q为40L/h时造水比最高,可达13.775,截留率均可达到99.9%以上;单因素实验结果表明膜通量随着T1和Q的增大而增加,随着T3的升高而降低;造水比随着T1、T3的升高而增加,随着Q的增加而降低。研究表明膜蒸馏技术处理含盐溶液具有很好的应用前景。

关键词：直接接触式膜蒸馏 PVDF中空纤维膜蒸馏脱盐设计

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XAD-4微孔介质半挥发性PAHs吸附机制特征的研究

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过程工程学报 2006年第Z2期6卷 150-154页

作者：李经民庄智仁云林科技大学环境与安全卫生工程系

以"吸附相"机制探讨温度效应(30,50,70℃)影响XAD-4七种半挥发性PAHs(AcPy,AcP,Flu,PA,Ant,Fl,Pyr)吸附滞留特征.实验结果显示,随温度30℃升至70℃,XAD-4微孔介质七种PAHs单位吸附滞留体积(Vg)由31.8～58.5m3降至19.5～24.6m3;高温环境(70℃)PAHs微孔介质吸附可能已由低温环境(30℃)孔径吸附转变为表面吸附.此外,讨论了七种气相PAHs化合物单位吸附滞留体积(Vg)与其过冷液蒸汽压(PL)相关性,结果显示两者呈负相关,PAHs已经不是气态型吸附式而是以纳米液态气胶进行微孔吸附行为.本研究结果显现微孔介质比表面积不是PAHs吸附效能唯一关键因子,温度效应与介质孔径效应都可能影响PAHs微孔吸附效能与介质吸附型式(表面吸附vs.孔径吸附).

关键词：半挥发性有机化合物温度效应孔径吸附纳米气胶

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VISCOSITY AND LIGHT SCATTERING STUDIES OF POLYmETHYLmETHACRYLATE IN mETHYL ACETATE- ETHANOL

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Science in China,Ser.A 1962年第12期 1649-1658页

作者：钱人元施良和 Institute of Chemistry Academia Sinica

A polymethylmethacrylate fraction of molecular weight 2.63×106 has been studied by viscosity and by light scattering in an iso-refractive solvent-non-solvent system, methylacetate-ethanol. The results show that d log [η]/d log （）1/2=3 as demanded by Flory-Fox’s theoretical interpretation of intrinsic viscosity. It is shown that the solution viscosity has reached the region of Newtonian flow at low shear rates under the conditions of ordinary viscometric determinations. The composition of θ-solvent of the system at 25.0° has been found to be γw（ethanol）=0.509. The molecular weight distribution of the sample was determined by the method of sedimentation velocity in ultracentrifuge at the vicinity of θ-temperature in acetone-ethanol. Thus a reliable polydispersity correction could be applied to the evaluation of Flory’s universal constant, which gave φ=1.61×1023, somewhat lower than generally accepted. From the integral distribution of sedimentation coefficients of the sample and the experimental values of m>w and [η]θ, it is possible to evaluate （） and （）θ in the relationss=（）sm1/2 and [η]θ=（）θm1/2for a hypothetical monodisperse system. The values found for polymethylmethacrylate in θ-solvent at 25.0°are （）s=3.02×10-15 and （）θ=4.59×10-2.

关键词： ETHANOL VISCOSITY AND LIGHT SCATTERING STUDIES OF POLYmETHYLmETHACRYLATE IN mETHYL ACETATE