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Simultaneous bilateral floating knee:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10172-10179页

作者： Chi-Ming Wu Hung-En Liao Shou-jen Lan Department of Orthopaedic Jen-Ai HospitalTaichung 42481Taiwan Department of Orthopaedic National Defense Medical CenterTaipei 11490Taiwan Department of Healthcare Administration Asia UniversityTaichung 41354Taiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402Taiwan School of Medical Science Putian UniversityPutian 351100Fujian ProvinceChina

BACKGROUND The phrase “floating knee is a flail knee joint,” referring to ipsilateral femoral and tibial fractures,was first used by Blake and Mc Bryde in *** condition is often caused by a high-energy trauma with often extensive injury to the soft tissues,and is accompanied by life-threatening systemic complications,including head,chest or abdominal injuries and a high incidence of fat *** knee is a severe and uncommon injury *** SUMMARY A 27-year-old man sustained multiple injuries when the electric motorcycle he was riding was hit by a *** injuries included traumatic hypovolemic shock,comminuted and open type II fractures of the left femoral shaft,fracture of the right femoral shaft,comminuted fracture of the bilateral tibial and fibular shaft,and multiple lacerations and abrasions on his forehead,lower lip,neck and *** diagnosis was simultaneous bilateral floating knee complicated with soft tissue *** emergency treatment and the exclusion of life-threating complications,open reduction and internal fixation were successfully performed using plates and screws in the bilateral femoral and tibial *** Simultaneous bilateral floating knee is a rare and severe injury *** treatment is challenging,and *** present a case report of a young adult who suffered from bilateral floating knees during road traffic *** also offer our treatment experience of this complex injury and review past literature.

关键词： Floating knee Femoral and tibial fractures High-energy trauma Life-threatening complications Fat embolism syndrome Case report

CO_2 sequestration utilizing basic-oxygen furnace slag:Controlling factors,reaction mechanisms and V–Cr concerns

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Journal of Environmental Sciences 2016年第3期28卷 99-111页

作者： Tung-Hsin Su Huai-jen Yang Yen-Hong Shau Eiichi Takazawa Yu-Chen Lee Department of Earth Sciences National Cheng-Kung UniversityTainan 70101Taiwan Department of Marine Biotechnology and Resources National Sun Yat-Sen UniversityKaohsiung 80424Taiwan Department of Geology Niigata University8050Ikarashi 2-no-choNishi-kuNiigata 950-2182Japan China Steel Corporation 1Chung-Kang Rd.Kaohsiung 81233Taiwan

Basic-oxygen furnace slag（BOF-slag） contains 〉35%CaO,a potential component for CO_*** this study,slag-water-CO_2 reaction experiments were conducted with the longest reaction duration extending to 96 hr under high CO_2 pressures of 100-300 kg/cm2 to optimize BOF-slag carbonation conditions,to address carbonation mechanisms,and to evaluate the extents of V and Cr release from slag *** slag carbonation degree generally reached the maximum values after 24 hr slag-water-CO_2 reaction and was controlled by slag particle size and reaction *** maximum carbonation degree of 71%was produced from the experiment using fine slag of〈0.5 mm under 100℃and a CO_2 pressure of 250 kg/cm^2 with a water/slag ratio of *** release from the slag to water was significantly enhanced（generally 〉2 orders） by slag *** contrast,slag carbonation did not promote chromium release until the reaction duration exceeded 24 ***,the water chromium content was generally at least an order lower than the vanadium concentration,which decreased when the reaction duration exceeded 24 ***,long reaction durations of 48-96 hr are proposed to reduce environmental impacts while keeping high carbonation *** textures and water compositions indicated that Mg-wustite,in addition to CaO-containing minerals,can also be ***,the conventional expression that only considered carbonation of the CaO-containing minerals undervalued the CO_2 sequestration capability of the BOF-slag by^20%.Therefore,the BOF-slag is a better CO_2 storage medium than that previously recognized.

关键词： Mineral CO_2 sequestration BOF-slag Carbonation

Chest pain in a heart transplant recipient:A case report

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World Journal of Clinical Cases 2021年第16期9卷 3966-3970页

作者： Yu-jen Chen Chien-Sung Tsai Tsai-Wang Huang Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Cardiovascular Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan

BACKGROUND Heart transplantation is recommended for the treatment of patients with refractory heart *** pain after heart transplantation is usually considered noncardiac owing to the denervated ***,data from case reports on tacrolimus-induced achalasia after heart transplantation are *** aimed to present a case of tacrolimus-induced achalasia that developed after heart tran-splantation,which was successfully relieved by laparoscopic Heller *** SUMMARY A 67-year-old man with a history of Type 2 diabetes mellitus,hyperlipidemia,and dilated cardiomyopathy had congestive heart failure following orthotopic heart transplantation with tacrolimus treatment 12 years *** the 10-year follow-up after the heart transplantation,the patient presented with persistent cough,dysphagia,heartburn,and retrosternal chest pain lasting for 2 *** endoscopy revealed no specific *** years later,the patient experienced the same symptoms,including chest pain lasting for 4 *** and manometry confirmed the presence of *** reports showed that discontinuing calcineurin inhibitor(CNI)treatment and endoscopic botulinum toxin injection could treat CNI-induced *** to the risk of rejection of the transplanted heart and considering the temporary benefits of botulinum toxin injection in achalasia,the patient underwent laparoscopic Heller *** was relieved without *** months later,he had no signs of recurrence of the *** In transplant patients with chest pain and gastrointestinal symptoms, CNIinducedachalasia may be one of the differential diagnoses. Esophagogram/manometry is useful for diagnosis.

关键词： Heart transplantation Refractory heart failure Chest pain Achalasia Esophagogram Case report

Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese

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World Journal of Gastroenterology 2005年第6期11卷 797-802页

作者： May-jen Huang Sien-Sing Yang Min-Shung Lin Ching-Shan Huang Department of Laboratory Medicine Department of Liver Unit Department of Family Medicine School of Medicine and Health Sciences

AIM: Single nucleotide polymorphisms (SNPs) of uridinediphosphoglucuro -nosyltransferase 1A7 (UGT1A7) gene are associated with the development of orolaryngeal cancer, hepatocellular carcinoma, and colorectal cancer. We performed this research to establish the techniques for determining UGT1A7 gene and basic data of this gene for Taiwan Chinese. METHODS: We collected blood samples from 112 healthy adults and 505 subjects carrying different genotypes of UGT1A1, and determined the promoter area and the entire sequence of UGT1A7 exon 1 by polymerase chain reaction. We designed appropriate primers and restriction enzymes to detect variant UGT1A7 genotypes found in the study subjects. RESULTS: Six SNPs at nucleotides 33, 387, 391, 392, 622, and 756 within the coding region of UGT1A7 exon 1 were found. The incidence of UGT1A7*l/*2 (N129R131W208/ K129K131W208) was predominant (35.7%) while that of UGT1A7 *3/*3 (K129K131R208/K129K131R208) was the least (2.7%). The allele frequency of UGT1A7*3, which exists in a considerable proportion of Caucasians (0.361) and Japanese (0.255), was identified only to be 0.152 in our study subjects. A novel variation at nucleotide -57 in the upstream was found, which was associated with SNPs at nucleotides 33, 387, 391, 392, and 622 in one of the variant haplotypes. The nucleotide changes at positions 387, 391, 392 and 756 were in linkage in another variant haplotype. The allele frequency of UGT1A7*3 was 0.018, 0.158, 0.242, 0.433, and 0.920 in subjects carrying wild, A(TA)6TAA/A(TA)7TAA, A(TA)7TAA/A(TA)7TAA, 211G/211A, and 211A/211A variants of UGT1A1 gene, respectively. By using natural or mutagenesis primers, we successfully detected the variations at nucleotides -57, 33, 387, and 622 with the restriction enzymes HpyCH4 Ⅳ, TaqⅠ, AflⅡ, and Rsa Ⅰ, respectively. CONCLUSION: The results indicate that the allele frequencies of UGT1A7 gene in Taiwan Chinese are different from those in Caucasians and Japanese. Carriage of the nucleotide 211- vari

关键词： UGT1A7 gene Single nudeotide polymorphisms Genotype Taiwan Chinese

Application of Proteomics in the Study of Tumor Metastasis

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Genomics, Proteomics & Bioinformatics 2004年第3期2卷 152-166页

作者： Zhen Cai jen-Fu Chiu Qing-Yu He Department of Surgery The University of Hong KongHong KongChina Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis The University of Hong KongHong KongChina Institute of Molecular Biology The University of Hong KongHong KongChina Department of Chemistry The University of Hong KongHong KongChina

Tumor metastasis is the dominant cause of death in cancer patients. However, the molecular and cellular mechanisms underlying tumor metastasis are still elusive. The identi?cation of protein molecules with their expressions correlated to the metastatic process would help to understand the metastatic mechanisms and thus facilitate the development of strategies for the therapeutic interventions and clini- cal management of cancer. Proteomics is a systematic research approach aiming to provide the global characterization of protein expression and function under given conditions. Proteomic technology has been widely used in biomarker discovery and pathogenetic studies including tumor metastasis. This article provides a brief review of the application of proteomics in identifying molecular factors in tumor metastasis process. The combination of proteomics with other experimental ap- proaches in biochemistry, cell biology, molecular genetics and chemistry, together with the development of new technologies and improvements in existing method- ologies will continue to extend its application in studying cancer metastasis.

关键词： proteomics metastasis tumor mechanism protein identification MALDI-TOF SELDI-ProteinChip

Performance of supersonic model combustors with staged injections of supercritical aviation kerosene

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Acta Mechanica Sinica 2010年第5期26卷 661-668页

作者： Feng-Quan Zhong Xue-Jun Fan Gong Yu Jian-Guo Li Chih-jen Sung LHD Institute of Mechanics Chinese Academy of Sciences100190 Beijing China University of Connecticut Storrs CT 06269 USA

Supersonic model combustors using two-stage injections of supercritical kerosene were experimentally investigated in both Mach 2.5 and 3.0 model combustors with stagnation temperatures of approximately 1,750 K. Supercritical kerosene of approximately 760 K was prepared and injected in the overall equivalence ratio range of 0.5-1.46. Two pairs of integrated injector/flameholder cavity modules in tandem were used to facilitate fuel-air mixing and stable combustion. For single-stage fuel injection at an upstream location, it was found that the boundary layer separation could propagate into the isolator with increasing fuel equivalence ratio due to excessive local heat release, which in turns changed the entry airflow conditions. Moving the fuel injection to a further downstream location could alleviate the problem, while it would result in a decrease in combustion efficiency due to shorter fuel residence time. With two-stage fuel injections the overall combustor performance was shown to be improved and kerosene injections at fuel rich conditions could be reached without the upstream propagation of the boundary layer separation into the isolator. Furthermore, effects of the entry Mach number and pilot hydrogen on combustion performance were also studied.

关键词： Supersonic combustion Staged injection Combustion efficiency Supercritical kerosene

Human Detection for Video Surveillance in Hospital

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Journal of Electronic Science and Technology 2017年第2期15卷 147-152页

作者： Cheng-Hung Chuang Zhen-You Lian Po-Ren Teng Miao-jen Lin Department of Computer Science and Information Engineering Asia UniversityTaichung 41354 the Psychiatry Department Chang Bing Show Chwan Memofial Hospital Changhua 50544

This paper presents a human detection system in a vision-based hospital surveillance environment. The system is composed of three subsystems, i.e. background segmentation subsystem （BSS）, human feature extraction subsystem （HFES）, and human recognition subsystem （HRS）. The codebook background model is applied in the BSS, the histogram of oriented gradients （HOG） features are used in the HFES, and the support vector machine （SVM） classification is employed in the HRS. By means of the integration of these subsystems, the human detection in a vision-based hospital surveillance environment is performed. Experimental results show that the proposed system can effectively detect most of the people in hospital surveillance video sequences.

关键词： Index Terms--Background segmentation codebook histogram of oriented gradients (HOG) human classification support vector machine (SVM) video surveillance.

Peanut consumption and reduced risk of colorectal cancer in women:A prospective study in Taiwan

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World Journal of Gastroenterology 2006年第2期12卷 222-227页

作者： Chih-Ching Yeh San-Lin You Chien-jen Chen Fung-Chang Sung Department of Risk Management China Medical University College of Public Health Taichung 404Taiwan China Institutes of Epidemiology National Taiwan University College of Public Health Taipei 100Taiwan China Institute of Environment Health China Medical University College of Public Health Taichung 404 Taiwan and Institute of Environment Health National Taiwan University College of Public Health Taipei 100 Taiwan China

AIM： To examine whether peanut consumption is associated with a reduced risk of colorectal cancer in a prospective cohort with a 10-year follow-up. METHODS： In 1990-1992, residents （12026 men and 11917 women aged 30 to 65 years） in 7 townships, Taiwan, were interviewed and recruited into a cancerscreening cohort and annually followed up. Colorectal cancer cases in this cohort were identified from cancer registry and death certificates. Incidence rates of this disease by the end of 2001 were calculated by gender for the primary study variable and covariates. The dietary intake was assessed by means of weekly food frequency measures, including frequently consumed food groups and folk dishes including sweet potato, bean products, peanut products, pickled foodstuffs, nitrated or smoked foodstuffs. RESULTS： During the study period, 107 new colorectal cancer cases （68 men and 39 women） were confirmed. The multivariate Cox＇s proportional hazard model showed that the relative risk （RR） of peanut consumption was 0.73 [95% confidence interval （CI） = 0.44-1.21] for men and 0.42 （95% CI = 0.21-0.84） for women. However, frequent intake of pickled foodstuffs was harmful for women （RR= 2.15, 95% CI=0.99-4.65）. The risk of colorectal cancer was also elevated among cigarette smokers but not significant （P〈 0.05）.CONCLUSION： This study suggests that frequent intake of peanut and its products may reduce colorectal cancer risk in women, demonstrating the anti-proliferating effect of peanut intake.

关键词： Peanuts Colorectal cancer Diet Gender difference Prospective study Taiwan

Single daily amikacin versus cefotaxime in the short-course treatment of spontaneous bacterial peritonitis in cirrhotics

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World Journal of Gastroenterology 2005年第43期11卷 6823-6827页

作者： Tai-An Chen Gin-Ho Lo Kwok-Hung Lai Whey-jen Lin Division of Gastroenterology

AIM: To compare the efficacy and safety of single daily amikacin vs. cefotaxime in the 5-d treatment of spontaneous bacterial peritonitis (SBP).METHODS: Thirty-seven cirrhotic patients with SBP,19 in group A and 18 in group B, were studied. Group A received 1 g of cefotaxime every 6 h, and group B received 500 mg of amikacin qd. Both antibiotics were administered up to 5 d and the responses were ***: Infection was cured in 15 of 19 patients (78.9%) treated with cefotaxime and in 11 of 18 (61.1%)treated with amikacin. Four patients of the Cefotaxime group (21.1%) and five patients of the Amikacin group (27.8%) died. Two in each group (10.5% vs 11.1%)had renal impairment during study period. One in each group (5.3% vs 5.6%) may be considered to suffer from nephrotoxicity due to increased urinary β2-microglobulin ***: In this study, single daily doses of amikacin in the treatment of SBP in cirrhotics were not associated with an increased incidence of renal impairment or nephrotoxicity. However, a 5-d regimen of amikacin is less effective than a 5-d regimen of cefotaxime in the SBP treatment.

关键词： Spontaneous bacterial peritonitis Amikacin Cefotaxime