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Dracunculiasis eradication-Finishing the job before surprises arise

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Asian Pacific Journal of Tropical Medicine 2012年第7期5卷 505-510页

作者： Benjamin jelle Visser Academic Medical Centre University of AmsterdamMeibergdreef 91105AZAmsterdamThe Netherlands

Dracunculiasis(Guinea worm disease) is a preventable waterborne parasitic disease that affects the poorest people living in remote rural areas in sub-Saharan African countries,who do not have access to safe drinking *** Guinea Worm Eradication Program,a 25-year old campaign to rid the world of Guinea Worm disease has now reached its final stage accelerating to zero cases in all endemic *** the 19th and 20th centuries,dracunculiasis was common in much of Southern Asia and the African *** overall number of cases has been reduced tremendously by≥99%,from the 3.32 million cases estimated to have occurred in 1986 in Africa to only I 797 cases reported in 2010 reported in only five countries(Sudan,Mali,Ethiopia,Chad and Ghana) and Asia free of the *** achievement is unique in its kind - the only previously eradicated disease is smallpox,a viral infection for which vaccination was possible - and it has been achieved through primary community-based prevention and health education *** efforts need to be taken in two countries,South Sudan(comprising 94%or I 698 out of 1 797 of the cases reported world-wide in 2010) and Mali because of frequent movements of nomads in a vast area inside and outside Mali’s *** factors favourable to dracunculiasis eradication are available including adequate financial resources,community and political support and high levels of *** there is no reason that this disabling parasitic disease cannot be eradicated soon before surprises arise such as new civil conflicts in currently endemic countries.

关键词： Dracunculiasis Guinea worm disease Eradication

Landscape spatial configuration is a key driver of wild bee demographics

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Insect Science 2018年第1期25卷 172-182页

作者： Lazaros Neokosmidis Thomas Tscheulin jelle Devalez Theodora Petanidou Laboratory of Biogeography and Ecology Department of Geography University of the Aegean University Hill Mytflene Greece

The majority of studies investigating the effects of landscape composition and configuration on bee populations have been conducted in regions of intensive agricultural production, ignoring regions which are dominated by seminatural habitats, such as the islands of the Aegean Archipelago. In addition, research so far has focused on the landscape impacts on bees sampled in cropped fields while the landscape effects on bees inhabiting seminatural habitats are understudied. Here, we investigate the impact of the landscape on wild bee assemblages in 66 phryganic （low scrubland） communities on 8 Aegean islands. We computed landscape metrics （total area and total perimete^area ratio） in 4 concentric circles （250, 500, 750, and 1000 m） around the center of each bee sampling site including 3 habitat groups （namely phrygana, cultivated land, and natural forests）. We further measured the local flower cover in 25 quadrats distributed randomly at the center of each sampling site. We found that the landscape scale is more important than the local scale in shaping abundance and species richness of bees. Furthermore, habitat configuration was more important than the total area of habitats, probably because it affects bees＇ movement across the landscape. Phrygana and natural forests had a positive effect on bee demographics, while cultivated land had a negative effect. This demonstrates that phryganic specialists drive bee assemblages in these seminatural landscapes. This finding, together with the shown importance of landscape scale, should be considered for the management of wild bees with special emphasis placed on the spatial configuration of seminatural habitats.

关键词： Aegean Archipelago landscape analysis landscape ecology olive groves phryganic vegetation

科学严谨的患者信息登记是高质量胃癌外科研究的基石——荷兰上消化道癌症审计数据库11年经验分享

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中华胃肠外科杂志 2023年第2期26卷 148-153页

作者：王敬普 Eline M de Groot Maurits R Visser Misha D.P Luyer jelle P Ruurda Richard van Hillegersberg 荷兰乌特勒支大学医学中心外科部荷兰乌特勒支3584CX 荷兰临床审计研究所科学局荷兰莱顿2333AA 凯瑟琳那医院外科部荷兰埃因霍温5623EJ

随着过去数十年微创技术、围手术期康复干预和集中化医疗制度的逐步应用,胃癌术后30 d病死率和并发症发生率有了显著改善。然而,当前阶段的胃癌术后短期预后依然不容乐观,可能对胃癌手术治疗的疗效产生严重的负面影响,仍有很大的改善空... 详细信息

随着过去数十年微创技术、围手术期康复干预和集中化医疗制度的逐步应用,胃癌术后30 d病死率和并发症发生率有了显著改善。然而,当前阶段的胃癌术后短期预后依然不容乐观,可能对胃癌手术治疗的疗效产生严重的负面影响,仍有很大的改善空间。高质量的临床研究是分析治疗结果和评估新治疗策略的重要工具。因此,严谨的胃癌患者信息登记作为高质量外科研究的基础应受到足够重视。在过去的11年里,荷兰上消化道癌症审计(DUCA)数据库在上消化道肿瘤患者的数据登记和维护方面拥有丰富的经验,它在数据登记、数据质量控制、数据申请和使用以及数据安全等方面采取的有效措施,使得该数据库中患者数据的质量保持在较高水平。这些数据已被广泛用于医疗质量监测和科学研究,对改善上消化道癌症患者的术后短期预后产生了非常积极的影响。DUCA的工作可能对建立基于人群的临床数据库具有一定的参考价值。

关键词：胃肿瘤并发症荷兰上消化道癌症审计,数据库

Postoperative complications and weight loss following jejunostomy tube feeding after total gastrectomy for advanced adenocarcinomas

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Chinese Journal of Cancer Research 2017年第4期29卷 333-340页

作者： hylke j.f.brenkman stéphanie v.s.roelen elles steenhagen jelle p.ruurda richard van hillegersberg cancer center department of surgeryuniversity medical center utrechtPO Box 855003508 GAUtrechtthe Netherlands internal medicine and dermatology department of dieteticsuniversity medical center utrechtPO Box 855003508 GAUtrechtthe Netherlands

Objective： Patients undergoing total gastrectomy for cancer are at risk of malnourishment. The aim of this self- controlled study was to examine the effect of jejunostomy tube feeding （JTF） and other factors on postoperative weight and the incidence of jejunostomy-related complications in patients undergoing total gastrectomy for cancer. Methods： All consecutive patients who underwent total gastrectomy for gastric cancer with jejunostomy plaeement were included from a prospective single-center database （2003-2014）. Jejunostomy-related complications and postoperative weight changes were evaluated up to 12 months after surgery. Multivariable linear regression analysis was performed to identify factors associated with weight loss 12 months after gastreetomy. Results： Of 113 patients operated in the study period, 65 received JTF after total gastrectomy for a median duration of 18 d [interquartile range （IQR）, 10-55 d]. Jejunostomy-related complieations occurred in 11 （17%） patients, including skin leakage （n=3） and peritoneal leakage （n=2）, luxation （n=3）, occlusion （n=2）, infection （n=l） and torsion （n=l）. In 2 （3%） patients, a reoperation was needed due to jejtmostomy-related complications. The mean preoperative weight of patients was 71.8 kg （100%）, and remained stable during JTF （73.9 kg, 103%, P=0.331）. After JTF was stopped, the mean weight of patients decreased to 64.9 kg （90%） at 12 months after surgery （P〈0.001）. A high preoperative body mass index （BMI）（〉_25 kg/m2） was associated with high postoperative weight loss compared to patients with a low BMI （〈25 kg/m2）（16.3% vs. 8.6%, P=0.016）. Conclusions： JTF can prevent weight loss in the early postoperative phase. However, this is at the prize of possible complications. As weight loss in the long term is not prevented, routine JTF should be re-evaluated and balanced against the selected use in preoperatively malnourished patients. Special attention should be paid to patients with a high preoperative BMI, who ar

关键词： Gastric cancer total gastrectomy jejunostomy tube feeding weight

Self-assembled formation of long, thin, and uncoalesced GaN nanowires on crystalline TiN films

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Nano Research 2018年第1期11卷 565-576页

作者： David van Treeck Gabriele Calabrese jelle J. W. Goertz Vladimir M. Kaganer Oliver Brandt Sergio Fernandez-Garrido, Lutz Geelhaar PauI-Drude-lnstitut f~r Festk6rperelektronik Leibniz-lnstitut im Forschungsverbund Berlin e.V. Hausvogteiplatz 5-7 I 0117 Berlin Germany

We investigate in detail the self-assembled nucleation and growth of vertically oriented GaN nanowires by molecular beam epitaxy on crystalline TiN films. We demonstrate that this type of substrate allows for the growth of long and thin GaN nanowires that do not suffer from coalescence, a problem common to the growth on Si and other substrates. Only beyond a certain nanowire length that depends on the nanowire density and exceeds here 1.5 bun, coalescence takes place by bundling, i.e. the same process as on Si. By analyzing the nearest neighbor distance distribution, we identify the diffusion-induced repulsion of neighboring nanowires as the main mechanism limiting nanowire density during nucleation on TiN. Since on Si the final density is determined by shadowing of the impinging molecular beams by existing nanowires, it is the difference in adatom surface diffusion that enables the formation of nanowire ensembles with reduced density on TiN. These nanowire ensembles combine properties that make them a promising basis for the growth of core-shell heterostructures.

关键词： nanocolumn gallium nitride nucleation metal substrate coalescence core-shell

Survival trends of patients with non-metastatic gastric adenocarcinoma in the US and European countries:the impact of decreasing resection rates

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Cancer Communications 2022年第7期42卷 648-662页

作者： Lei Huang Lina Jansen Rob H.A.Verhoeven jelle P.Ruurda Liesbet Van Eycken Harlinde De Schutter Jan Johansson Mats Lindblad Tom B.Johannesen Vesna Zadnik Tina Zagar Sjoerd M.Lagarde Cornelis J.Hvan de Velde Petra Schrotz-King Hermann Brenner Division of Clinical Epidemiology and Aging Research German Cancer Research Center(DKFZ)Heidelberg 69120Germany Medical Faculty Heidelberg of Heidelberg University Heidelberg 69120Germany German Cancer Consortium German Cancer Research CenterHeidelberg 69120Germany Department of Research&Development Netherlands Comprehensive Cancer OrganizationUtrecht 3501 DBThe Netherlands Department of Medical Oncology Amsterdam University Medical CentersAmsterdam 1105 AZThe Netherlands Department of Surgery University Medical Center UtrechtUtrecht 3508 GAThe Netherlands Belgian Cancer Registry Brussels B-1210Belgium Department of Esophageal and Gastric Surgery Lund University HospitalLund 22185Sweden Department of Clinical Science Interventionand TechnologyDivision of SurgeryKarolinska University HospitalStockholm 17176Sweden Registry Department The Cancer Registry of NorwayOslo 0379Norway Epidemiology and Cancer Registry Institute of Oncology LjubljanaLjubljana 1000Slovenia Department of Surgery Erasmus Medical Centre-University Medical Centre RotterdamRotterdam 3015 CEThe Netherlands Department of Surgical Oncology Leiden University Medical CenterLeiden 2300 RCThe Netherlands Division of Preventive Oncology German Cancer Research Center and National Center for Tumor DiseasesHeidelberg 69120Germany

Background:We previously observed decreasing resection rates of nonmetastatic gastric adenocarcinoma(GaC)in the US and some European *** and to what extent these trends affect the trends in overall survival(OS)of patients with non-metastatic GaC at the population level remain *** large international population-based cohort study aimed to assess the impact of the previously observed decreasing resection rates on multivariable-adjusted trends in the long-term OS of patients with non-metastatic ***:Individual-level data of patients with non-metastatic GaC were obtained from the national cancer registries of the Netherlands,Belgium,Sweden,Norway,and Slovenia,and the US Surveillance,Epidemiology,and End Results *** analyzed data for each country *** between year of diagnosis and OS were assessed using Cox proportional hazards regression model with adjustment for multiple prognostic variables,with and without including resection and chemotherapy as potential explanatory ***:A total of 66,398 non-metastatic GaC patients diagnosed in 2003-2016 were analyzed,with an accumulated follow-up of 172,357 *** adjustment for resection,OS was improved only slightly in the US[hazard ratio(HR)_(per year)=0.99;HR_(≥vs.<2010)=0.96],and no improvement was observed in the investigated European countries,with OS even worsening in Sweden(HR_(per year)=1.03;HR_(≥vs.<2010)=1.17).After adjusting for resection,the increasing OS trend became stronger in the US(HR_(per year)=0.98;HR_(≥vs.<2010)=0.88),and the temporal trend became insignificant in *** Slovenia(HR_(per year)=0.99;HR_(≥vs.<2010)=0.92)and Norway(HR_(per year)=0.97;HR_(≥vs.<2010)=0.86),improved OS over time emerged after resection *** OS in patients undergoing resection was observed in the US,the Netherlands,and *** for chemotherapy did not alter the observed *** analyses by tumor location showedm

关键词： gastric adenocarcinoma resection rate adjusted overall survival temporal trend prognostic factors international population-based cohort study

Retromer Subunits VPS35A and VPS29 Mediate Prevacuolar Compartment （PVC） Function in Arabidopsis

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Molecular Plant 2013年第6期6卷 1849-1862页

作者： Tomasz Nodzynski Mugurel I. Ferarub Sibylle Hirsch Riet De Rycke Claudiu Niculaes Wout Boerjan jelle Van Leene Geert De Jaeger Steffen Vanneste Jiri Friml Mendel Centre for Plant Genomics and Proteomics Central European Institute of Technology (CEITEC) Masaryk University (MU) Kamenice 5 CZ-625 00Brno Czech Republic Department of Plant Systems Biology VIB and Department of Plant Biotechnology and Bioinformatics Ghent University 9052 Gent Belgium Institute of Science and Technology Austria (IST Austria) Am Campus 1 3400 Klosterneuburg Austria Present address: Department of Applied Genetics and Cell Biology University of Natural Resources and Life Sciences (BOKU) 1190 Vienna Austria Present address: Institute of Plant Biology University of Zurich 8008 ZCirich Switzerland

Intracellular protein routing is mediated by vesicular transport which is tightly regulated in eukaryotes. The protein and lipid homeostasis depends on coordinated delivery of de novo synthesized or recycled cargoes to the plasma membrane by exocytosis and their subsequent removal by rerouting them for recycling or degradation. Here, we report the characterization of protein affected trafficking 3 （pat3） mutant that we identified by an epifluorescence-based for- ward genetic screen for mutants defective in subcellular distribution of Arabidopsis auxin transporter PIN1-GFR While pat3 displays largely normal plant morphology and development in nutrient-rich conditions, it shows strong ectopic intracellular accumulations of different plasma membrane cargoes in structures that resemble prevacuolar compart- ments （PVC） with an aberrant morphology. Genetic mapping revealed that pat3 is defective in vacuolar protein sorting 35A （VPS35A）, a putative subunit of the retromer complex that mediates retrograde trafficking between the PVC and trans-Golgi network. Similarly, a mutant defective in another retromer subunit, vps29, shows comparable subcellular defects in PVC morphology and protein accumulation. Thus, our data provide evidence that the retromer components VPS35A and VPS29 are essential for normal PVC morphology and normal trafficking of plasma membrane proteins in plants. In addition, we show that, out of the three VPS35 retromer subunits present in Arabidopsis thaliana genome, the VPS35 homolog A plays a prevailing role in trafficking to the lyric vacuole, presenting another level of complexity in the retromer-dependent vacuolar sorting.

关键词： retromer VPS35 VPS29 prevacuolar compartment (PVC) vacuolar trafficking Arabidopsis thaliana.

Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity

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Cellular & Molecular Immunology 2023年第6期20卷 666-679页

作者： Elien Grajchen Melanie Loix Paulien Baeten Beatriz F.Côrte-Real Ibrahim Hamad Sam Vanherle Mansour Haidar Jonas Dehairs jelle Y.Broos James M.Ntambi Robert Zimmermann Rolf Breinbauer Piet Stinissen Niels Hellings Sanne G.S.Verberk Gijs Kooij Martin Giera Johannes V.Swinnen Bieke Broux Markus Kleinewietfeld Jerome J.A.Hendriks Jeroen F.J.Bogie Department of Immunology and Infection Biomedical Research InstituteHasselt UniversityDiepenbeekBelgium University MS Center Hasselt PeltBelgium Neuro-Immune Connections and Repair Lab Department of Immunology and InfectionBiomedical Research InstituteHasselt UniversityDiepenbeekBelgium VIB Laboratory of Translational Immunomodulation VIB Center for Inflammation ResearchHasselt UniversityDiepenbeekBelgium Department of Oncology Laboratory of Lipid Metabolism and CancerLKI–Leuven Cancer InstituteKU Leuven-University of LeuvenLeuvenBelgium Department of Molecular Cell Biology and Immunology Amsterdam University Medical CenterVrije Universiteit AmsterdamAmsterdam NeuroscienceMS Center AmsterdamAmsterdamThe Netherlands Center for Proteomics and Metabolomics Leiden University Medical CenterLeidenThe Netherlands Department of Biochemistry Department of Nutritional SciencesUniversity of Wisconsin-MadisonMadisonUSA Institute of Molecular Biosciences University of GrazGrazAustria BioTechMed-Graz GrazAustria Institute of Organic Chemistry Graz University of TechnologyGrazAustria Cardiovascular Research Institute Maastricht Department of Internal MedicineMaastricht UniversityMaastrichtThe Netherlands

The imbalance between pathogenic and protective T cell subsets is a cardinal feature of autoimmune disorders such as multiple sclerosis(MS).Emerging evidence indicates that endogenous and dietary-induced changes in fatty acid metabolism have a major impact on both T cell fate and *** date,however,the molecular mechanisms that underlie the impact of fatty acid metabolism on T cell physiology and autoimmunity remain poorly ***,we report that stearoyl-CoA desaturase-1(SCD1),an enzyme essential for the desaturation of fatty acids and highly regulated by dietary factors,acts as an endogenous brake on regulatory T-cell(Treg)differentiation and augments autoimmunity in an animal model of MS in a T cell-dependent *** by RNA sequencing and lipidomics analysis,we found that the absence of Scd1 in T cells promotes the hydrolysis of triglycerides and phosphatidylcholine through adipose triglyceride lipase(ATGL).ATGL-dependent release of docosahexaenoic acid enhanced Treg differentiation by activating the nuclear receptor peroxisome proliferator-activated receptor *** findings identify fatty acid desaturation by SCD1 as an essential determinant of Treg differentiation and autoimmunity,with potentially broad implications for the development of novel therapeutic strategies and dietary interventions for autoimmune disorders such as MS.

关键词： Regulatory T cells Autoimmunity Fatty acid metabolism Stearoyl-CoA desaturase-1 Multiple sclerosis

Distribution,structure and biosynthetic gene families of(1,3;1,4)-β-glucan in Sorghum bicolor

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Journal of Integrative Plant Biology 2015年第4期57卷 429-445页

作者： Riksfardini A.Ermawar Helen M.Collins Caitlin S.Byrt Natalie S.Betts Marilyn Henderson Neil J.Shirley Julian Schwerdt jelle Lahnstein Geoffrey B.Fincher Rachel A.Burton Australian Research Council Centre of Excellence in Plant Cell Walls University of Adelaide

In cereals, the presence of soluble polysaccharides including（1,3;1,4）-b-glucan has downstream implications for human health, animal feed and biofuel applications. Sorghum bicolor（L.） Moench is a versatile crop, but there are limited reports regarding the content of such soluble ***, the amount of（1,3;1,4）-b-glucan present in sorghum tissues was measured using a Megazyme assay. Very low amounts were present in the grain, ranging from 0.16%–0.27%（w/w）, while there was a greater quantity in vegetative tissues at 0.12–1.71%（w/w）. The fine structure of（1,3;1,4）-b-glucan, as denoted by the ratio of cellotriosyl and cellotetraosyl residues,was assessed by high performance liquid chromatography（HPLC） and ranged from 2.6–3：1 in the grain, while ratios in vegetative tissues were lower at 2.1–2.6：1. The distribution of（1,3;1,4）-b-glucan was examined using a specific antibody and observed with fl uorescence and transmission electron microscopy. Micrographs showed a variable distribution of（1,3;1,4）-b-glucan in fl uenced by temporal and spatial factors. The sorghum orthologs of genes implicated in the synthesis of（1,3;1,4）-b-glucan in other cereals, such as the Cellulose synthase-like（Csl） F and H gene families were de *** pro filing of these genes across sorghum tissues was carried out using real-time quantitative polymerase chain reaction, indicating that, as in other cereals, Csl F6 transcripts dominated.

关键词： Cellulose synthase-like genes cell wall composition mixed-linkage glucan grain sorghum