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中国建筑装饰装修 2015年第10期 52-59页

作者： Chloe Kessler jelena Stajic la belle equipe Spray建筑设计事务所

Remy和Julien是两个好朋友,同时也是两位泰拳冠军,他们共同经营着这家泰拳馆.Remy和Julien希望设计师设计一间与众不同的泰拳馆,这里的氛围应该是友好而舒适的,而“交流”则是这个项目的核心所在.

关键词：交流 La 设计师

Effects of Indole-3-Carbinol and Flavonoids Administered Separately and in Combination on Nitric Oxide Production and iNOS Expression in Rats

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Chinese Medicine 2010年第1期1卷 5-17页

作者： Evita Rostoka Larisa Baumane Sergejs Isajevs Aija Line Karina Silina Maija Dzintare Darja Svirina jelena Sharipova Ivars Kalvinsh Nikolajs Sjakste 不详

Beneficial effects of natural compounds are often attributed to modulation of NO production;however effects produced by plant extracts do not correlate with effects of purified components. The goal of our work was to study ability of flavonoids and indole-3-carbinol, as well as their combinations to modify NO production, iNOS gene and protein expression in rat tissues. Baicalein and luteolin decreased NO concentration in both intact and LPS-treated animals. Baicalein decreased iNOS gene expression. Luteolin decreased NO production in the liver and heart and number of iNOS-positive cells in the liver of LPS-treated animals. Combination of the two substances did not decrease the NO synthesis triggered by LPS, although it decreased iNOS gene expression. Quercetin decreased NO production in the heart, kidneys and blood of intact rats, but enhanced the LPS effect in testes, spleen and blood on NO production and iNOS protein expression in the liver. Indole-3-carbinol decreased NO concentration in the cerebellum, blood, lungs and skeletal muscles. The drug enhanced the LPS-triggered increase of NO production in all rat organs. It increased iNOS protein expression in intact liver;however it decreased the LPS-triggered outburst of the enzyme biosynthesis. Combination of indole3-carbinol with quercetin decreased NO production in LPS-treated animals however it slightly increased iNOS gene expression. Taken together our results suggest that modifications of NO level in tissues by a natural compound cannot be predicted from data about its effects on NOS expression or activity. Combination of substances can produce an effect differing from that of individual substances. This stresses importance of direct measurements of NO in the tissues.

关键词： Nitric Oxide Baicalein Luteolin Indole-3-Carbinol Quercetin Inducible Nitric Oxide Synthase

High dose chemotherapy with stem cell support in the treatment of testicular cancer

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World Journal of Stem Cells 2015年第11期7卷 1222-1232页

作者： Lazar Popovic Gorana Matovina-Brko Milica Popovic Dragana Petrovic Ana Cvetanovic jelena Vukojevic Darjana Jovanovic Medical School University of Novi Sad Department for Medical Oncology Oncology Institute of Vojvodina Department for Internal Medicine Clinical Center of Vojvodina Department for Oncology Clinical Center Nis

Testicular germ cell cancer(TGCC) is rare form of malignant disease that occurs mostly in young man between age 15 and 40. The worldwide incidence of TGCC is 1.5 per 100000 man with the highest rates in North Europe. After discovery of cisplatin cure rates of TGCC are very favorable between 90%-95% and unlike most solid tumors, cure rate for metastatic TGCC is around 80%. Metastatic TGCC is usually treated with 3-4 cycles of bleomycin, etoposide, cisplatinum chemotherapy with or without retroperitoneal surgery and cure rates with this approach are between 41% in poor risk group and 92% in good risk group of patients. Cure rates are lower in relapsed and refractory patients and many of them will die from the disease if not cured with first line chemotherapy. High dose chemotherapy(HDCT) approach was used for the first time during the 1980 s. Progress in hematology allowed the possibility to keep autologous haematopoietic stem cells alive ex-vivo at very low temperatures and use them to repopulate the bone marrow after sub-lethal dose of intesive myeloablative chemotherapy. Despite the fact that there is no positive randomized study to prove HDCT concept, cure rates in relapsed TGCC are higher after high dose therapy then in historical controls in studies with conventional treatment. Here we review clinical studies in HDCT for TGCC, possibilities of mobilising sufficient number of stem cells and future directions in the treatment of this disease.

关键词： High dose chemotherapy Germ-cell cancer Stem cell transplantation Plerixafor

Photometric and Spectroscopic Study of Two Low Mass Ratio Contact Binary Systems:CRTS J225828.7-121122 and CRTSJ030053.5+230139

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Research in Astronomy and Astrophysics 2023年第11期23卷 1-6页

作者： Surjit S.Wadhwa jelena Petrović Nick F.H.Tothill Ain Y.De Horta Miroslav D.Filipović Gojko Djurašević School of Science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia Astronomical Observatory Volgina 711060 BelgradeSerbia

The study reports photometric and spectroscopic observations of two recently recognized contact binary *** systems show total eclipses and analysis of the light curves indicates both have very low mass ratios of less than *** derive absolute parameters from color and distance based calibrations and show that,although both have low mass ratios,they are likely to be in a stable orbit and unlikely to *** other respects,both systems have characteristics similar to other contact binaries with the secondary larger and brighter than their main sequence counterparts and we also find that the secondary is considerably denser than the primary in both systems.

关键词： (stars:)binaries:eclipsing stars:mass-loss techniques:photometric

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拨云见日

Optical frequency synthesizer with an integrated erbium tunable laser

作者： (美)依莲娜·佛高(jelena Fedurko)

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Light(Science & Applications) 2019年第1期8卷 22-29页

作者： Ming Xin Nanxi Li Neetesh Singh Alfonso Ruocco Zhan Su Emir Salih Magden jelena Notaros Diedrik Vermeulen Erich P.Ippen Michael R.Watts Franz X.Kartner Research Laboratory of Electronics Massachusetts Institute of TechnologyCambridgeMA 02139USA John A.Paulson School of Engineering and Applied Science Harvard UniversityCambridgeMA 02138USA Center for Free-Electron Laser Science DESY and Hamburg UniversityNotkestraße 8522607 HamburgGermany Institute of Microelectronics Agency for ScienceTechnology and Research(A*STAR)138634 SingaporeSingapore Analog Photonics 1 Marina Park DriveBostonMA 02210USA Department of Electrical and Electronics Engineering Koc UniversitySarıyerIstanbul 34450Turkey

Optical frequency synthesizers have widespread applications in optical spectroscopy,frequency metrology,and many other ***,their applicability is currently limited by size,cost,and power *** photonics technology,which is compatible with complementary-metal-oxide-semiconductor fabrication processes,provides a low-cost,compact size,lightweight,and low-power-consumption *** this work,we demonstrate an optical frequency synthesizer using a fully integrated silicon-based tunable *** synthesizer can be self-calibrated by tuning the repetition rate of the internal mode-locked laser.A 20 nm tuning range from 1544 to 1564 nm is achieved with~10−13 frequency instability at 10 s averaging *** flexibility and fast reconfigurability are also demonstrated by fine tuning the synthesizer and generating arbitrary specified patterns over time-frequency *** work promotes the frequency stability of silicon-based integrated tunable lasers and paves the way toward chip-scale lowcost optical frequency synthesizers.

关键词： synthesizer tunable tuning

Modeling sustainability:population,inequality,consumption,and bidirectional coupling of the Earth and Human Systems

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National Science Review 2016年第4期3卷 470-494页

作者： Safa Motesharrei Jorge Rivas Eugenia Kalnay Ghassem R.Asrar Antonio J.Busalacchi Robert F.Cahalan Mark A.Cane Rita R.Colwell Kuishuang Feng Rachel S.Franklin Klaus Hubacek Fernando Miralles-Wilhelm Takemasa Miyoshi Matthias Ruth Roald Sagdeev Adel Shirmohammadi Jagadish Shukla jelena Srebric Victor M.Yakovenko Ning Zeng University of Maryland College Park Institute for Global Environment and Society 3. Joint Global Change Research Institute College Park 4. University Corporation for Atmospheric Research 5. Johns Hopkins University Applied Physics Laboratory NASA Goddard Space Flight Center Lamont–Doherty Earth Observatory of Columbia University 8. Spatial Structures in the Social Sciences/Population Studies and Training Center Brown University RIKEN Advanced Institute for Computational Science School of Public Policy and Urban Affairs and Department of Civil and Environmental EngineeringNortheastern University 11. Department of AtmosphericOceanicand Earth SciencesGeorge Mason University

Over the last two centuries,the impact of the Human System has grown dramatically,becoming strongly dominant within the Earth System in many diferent ***,inequality,and population have increased extremely fast,especially since about 1950,threatening to overwhelm the many critical functions and ecosystems of the Earth *** in the Earth System,in turn,have important feedback efects on the Human System,with costly and potentially serious ***,current models do not incorporate these critical *** argue that in order to understand the dynamics of either system,Earth System Models must be coupled with Human System Models through bidirectional couplings representing the positive,negative,and delayed feedbacks that exist in the real *** particular,key Human System variables,such as demographics,inequality,economic growth,and migration,are not coupled with the Earth System but are instead driven by exogenous estimates,such as United Nations population *** makes current models likely to miss important feedbacks in the real Earth–Human system,especially those that may result in unexpected or counterintuitive outcomes,and thus requiring diferent policy interventions from current *** importance and imminence of sustainability challenges,the dominant role of the Human System in the Earth System,and the essential roles the Earth System plays for the Human System,all call for collaboration of natural scientists,social scientists,and engineers in multidisciplinary research and modeling to develop coupled Earth–Human system models for devising efective science-based policies and measures to beneit current and future generations.

关键词： Earth and Human System Models population migration inequality data assimilation bidirectional couplings and feedbacks sustainability

Nanoscale Particles Enhanced Gold Plating

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Nanoscale Particles Enhanced Gold Plating

Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cells in vitro

The 2011 International Conference on Key Engineering Materials and Computer Science(KEMCS 2011)

作者： Jian Song Christian Koch Liangliang Wang Srecko Stopic jelena Bogovic Bernd Friedrich Andreas M?bius Axel Fuhrmann OWL University of Applied Sciences Liebigstr.8732657 LemgoGermany RWTH Aachen Germany Enthone GmbH LangenfeldGermany

Using precious metals as plating materials is an effective measure to avoid failures of electrical contacts caused by frettingWhen using precious metals, such as gold, one of the limitations to their lifetime is the wear resistanceIn order to improve the wear resistance of gold plates, gold alloy is usually usedInstead of alloying elements, nanoscale particles of metal oxides were used for the modification of plates in our investigationSome of the nanoscale particles show considerable impact on the performance of plates for electrical contactsThis paper shows the first results and new challenges when using nanoscale particles for electroplating.

关键词： nanoparticle plating fretting wear electrical contacts

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World Journal of Clinical Oncology 2012年第6期3卷 82-91页

作者： Feray Kockar Hatice Yildrim Rahsan Ilikci Sagkan Carsten Hagemann Yasemin Soysal jelena Anacker Ahmed Ayad Hamza Dirk Vordermark Michael Flentje Harun M Said Department of Biology Faculty of Art and Science Balikesir University Department of Immunology and Allergy Diseases Gulhane Military Medical Academy Tumorbiology Laboratory Department of Neurosurgery University of Würzburg Faculty of Medicine Department of Medical Genetics Afyon Kocatepe University Department of Obstetrics and Gynaecology University of Würzburg School of Medicine Southern Illinois University Department of Radiation Oncology University-Halle-Wittenberg Department of Radiation Oncology University of Wuerzburg

AIM: To study the expression of carbonic anhydrase(CA) 9 in human hepatocellular carcinoma(HCC) ***: We studied CA9 protein, CA9 m RNA and hypoxia-inducible factor-1 alpha(HIF-1α) protein levels in Hep3 B cells exposed in different parallel approaches. In one of these approaches, HCC cells were exposed to extreme in vitro hypoxia(24 h 0.1% O2) without or with interleukin(IL)-1, IL-6, tumor necrosis factoralpha(TNF-α) and transforming growth factor-beta(TGF-β) stimulation for the same hypoxic exposure time or exposed to normoxic oxygenation conditions without or with cytokine ***: The tumour cell line analysed showed a strong hypoxic CA9 m RNA expression pattern in response to prolonged severe hypoxia with cell-line specific patterns and a marked induction of CA9 protein in response to severe hypoxia. These results were paralleled by the results for HIF-1α protein under identical oxygenation conditions with a similar expression tendency to that displayed during the CA9 protein expression experimental series. Continuous stimulation with the cytokines, IL-1, IL-6, TNF-α and TGF-β, under normoxic conditions significantly increased the carbonic anhydrase 9 expression level at both the protein and m RNA level, almost doubling the CA9 m RNA and CA9 and HIF-1α protein expression levels found under hypoxia. The findings from these experiments indicated that hypoxia is a positive regulator of CA9 expression in HCC, and the four signal transduction pathways, IL-1, IL-6, TNF-α and TGF-β, positively influence CA9 expression under both normoxic and hypoxic ***: These findings may potentially be considered in the design of anti- cancer therapeutic approaches involving hypoxia-induced or cytokine stimulatory effects on expression. In addition, they provideevidence of the stimulatory role of the examined cytokine families resulting in an increase in CA9 expression under different oxygenation conditions in human cancer, especially HCC, and

关键词： Angiogenesis Carbonic anhydrase 9 Hypoxia Hypoxia-inducible factor-1 alpha Oxygen Radiotherapy Transforming growth factor-beta Tumour microenviroment