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Use of intravascular imaging in managing coronary artery disease

World Journal of Cardiology 2014年第6期6卷 393-404页

作者： sanda jegere Inga Narbute Andrejs Erglis Latvian Centre of Cardiology Pauls Stradins Clinical University Hospital Institute of Cardiology University of Latvia

For many years,coronary angiography has been considered "the gold standard" for evaluating patients with coronary artery disease. However,angiography only provides a planar two-dimensional silhouette of the lumen and is unsuitable for the precise assessment of atherosclerosis. With the introduction of intravascular imaging,direct visualization of the arterial wall is now feasible. Intravascular imaging modalities extend diagnostic information,thereby enabling more precise evaluation of plaque burden and vessel remodeling. Of all technologies,intravascular ultrasound(IVUS) is the most mature and widely used intravascular imaging technique. Optical coherence tomography(OCT) is an evolving technology that has the highest spatial resolution of existing imaging methods,and it is becoming increasingly widespread. These methods are useful tools for planning interventional strategies and optimizing stent deployment,particularly when stenting complex lesions. We strongly support the mandatory use of IVUS for left main percutaneous coronary intervention(PCI). In addition,it can be used to evaluate vascularresponses,including neointimal growth and strut apposition,during follow-ups. Adequately powered randomized trials are needed to support IVUS or OCT use in routine clinical practice and to answer whether OCT is superior to IVUS in reducing adverse events when used to guide PCI. The current perception and adoption of innovative interventional devices,such as bioabsorbable scaffolds,will increase the need for intravascular imaging in the future.

关键词： Imaging Ultrasonics Optical coherence tomography Stent Restenosis Thrombosis

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Bone Marrow Mononuclear Cell Extraction. Does the Operator Performance Affect Processing Efficacy？

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Journal of Pharmacy and Pharmacology 2016年第5期4卷 192-198页

作者： Jakobsons Eriks Cakstina Inese Erglis Kristaps Erglis Martins Pirtniece Liene Elina Krumina NarbuteInga Briede Ieva jegere sanda Smolova Rita Muiznieks Indrikis Erglis Andrejs Latvian Centre of Cardiology Pauls Stradins Clinical University Hospital Riga L V-1002 Latvia Cell Transplantation Centre Pauls Stradins Clinical University Hospita l Riga LV-1002 Latvia Research Institute of Cardiology University of Latvia Riga LV-1586 Latvia Department of Biology Division of Microbiology and Bioteehnology University of Latvia Riga LV-1586 Latvia

Different cell populations from bone marrow are used in various clinical trials for cardiac diseases during last decade. Four clinical studies are on going in our institution and enrol patients with cardiac diseases, coronary disease and type 2 diabetes, patients with osteoarthritis. Density gradient is used to separate bone marrow mononuclear cells. Cell processing looses are significant. To find out critical control points we analysed processing process and differences in cell yields between operators performing cell extraction. Bone marrow mononuclear cells were isolated using Ficoll density gradient centrifugation. Cells were counted using flow cytometry for mononuclear cell total counts, CD34＋ population count and viability analysis. The patients who underwent bone marrow aspiration followed by cell isolation received cell suspension for transplantation. Two cells processing for separate patients were performed at once. Same standard operation procedures were applied. Processing looses between operators performing cell extraction were analysed. Bone marrow samples from eight patients were processed. Mononuclear cells were extracted. Operator performances were compared. Operator A average bone marrow mononuclear cell yield in starting material was 9,97 ± 9,98 %, CD34＋ population yield 75,46±79,67%. Operator B average bone marrow mononuclear cell yield in starting material was 24,68 ± 14,8 %, CD34＋ population yield 70,42 ±44.84%. Operator A average cell viability in starting material was 45,24 ± 9,55%, after cell processing 42,96 ± 23,66 %. Operator B average cell viability in starting material was 49,85 ± 5,48%, after cell processing 69,52 ± 6,65 %.

关键词： Bone marrow mononuclear cells cell yield cell extraction cell count

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