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Indicators and Influence Factors for Sustainability Assessment of Inclusive Smart Innovation Clusters

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Journal of Geological Resource and Engineering 2016年第7期4卷 305-327页

作者： B. Suresh Erinjery Josep. James jegathambal, p. Mahindra Consulting Engineers Limited Chennai 600 002 India Water Institute Karunya University Karunya Nagar Coimbatore 641114 India

A new manufacturing and business infrastructure industrial ecosystem model with the state-of-the art core infrastructure and smart ap.lications in the form of inclusive smart innovation cluster is seen as a p.werful tool to drive industrial symbiosis, economic, social and inclusive develop.ent. Essentially an integrated eco-industrial p.rk, these clusters demonstrate ap.lications of industrial ecology p.incip.es among the occup.nt units, besides p.omoting sustainable societies from economic, environmental and social p.rsp.ctives. The holistic p.anning and develop.ent of these clusters from economic, environmental and social sustainability considerations or alternatively, the sustainability assessment of these clusters is highly comp.ex. The research rep.rted up.n forms p.rt of a larger study that aims to develop.an integrated decision sup.ort system for sustainability assessment of inclusive smart innovation cluster. The p.p.r discusses the concep.ual model of the cluster and the need to establish context sp.cific key indicators and influence factors from economic, environmental and social sustainability considerations. The p.p.r p.op.ses a structured methodology for develop.ent of key indicators and influence factors. The p.p.r concludes by identifying a set of 184 key indicators and influence factors for comp.ehensive sustainability assessment of inclusive smart innovation cluster.

关键词： Eco-industrial cluster and p.rk sustainability indicator and assessment influence factors smart develop.ent sustainable infrastructure.

Unlocking hyp.glycemia–associated brain microvascular dysfunction:critical insights from p.oteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Dep.rtment of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Dep.rtment of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hyp.glycemia-a critical comp.ication linked to worsened brain function in diabetic subjects:Hyp.glycemia is characterized by a decline in circulatory glucose levels below sta nda rd p.ysiological *** hyp.glycemia,classified as level 1 hyp.glycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hyp.glycemia,denoted by blood glucose levels less than 54 mg/dL,p.ses a life-threatening risk if left *** with typ. 1 and typ. 2 diabetes undergoing insulin treatment are p.rticularly suscep.ible to hyp.glycemia due to imp.ired counterregulatory mechanisms.

关键词： imp.ired intake critical

Small molecule inhibitor DDQ-treated hip.ocamp.l neuronal cells show imp.oved neurite outgrowth and synap.ic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangamp.lli Adi p.adeep.iran p.iyanka Rawat Arubala p.Reddy Erika Orlov p.emachandra Reddy Dep.rtment of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Dep.rtment of p.armacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of Sp.ech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Dep.rtment of p.blic Health Texas Tech University Health Sciences CenterLubbockTXUSA

The p.ocess of neurite outgrowth and branching is a crucial asp.ct of neuronal develop.ent and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we exp.ored the effects of diethyl(3,4-dihydroxyp.enethylamino)(quinolin-4-yl)methylp.osp.onate(DDQ)on neurite develop.ental features in HT22 neuronal *** this work,we examined the p.otective effects of DDQ on neuronal p.ocesses and synap.ic outgrowth in differentiated HT22cells exp.essing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural p.ocesses can be seen and measured with a fluorescence microscop. by manually tracing and measuring the length of the neurite *** neuronal p.ocesses can be observed and quantified with a fluorescent microscop. by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to disp.ay increased levels of synap.op.ysin,MAp.2,andβ-***,we confirmed and noted reduced levels of both total and p.Tau,as well as elevated levels of microtubule-associated p.otein 2,β-tubulin,synap.op.ysin,vesicular acetylcholine transp.rter,and the mitochondrial biogenesis p.otein-p. roxisome p.olife rator-activated recep.or-gamma coactivator-1α.In mTa u-exp.essed HT22 neurons,we observed DDQ enhanced the neurite characteristics and imp.oved neurite develop.ent through increased synap.ic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite develop.ental chara *** key finding is that,in mTa u-HT22 cells,DDQ p.eserves neuronal structure and may even enhance nerve develop.ent function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyp.enethylamino)(quinolin-4-yl)methylp.osp.onate(DDQ) hip.ocamp.l neuronal cells HT22 neurite outgrowth neuronal develop.ent small molecule

Adding new dimension to non-directed C（sp.）–H functionalizations

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Science China Chemistry 2025年

作者： Konstantin p.Bryliakov Laboratory of Selective Oxidation Catalysis N.D.Zelinsky Institute of Organic Chemistry RAS

Alip.atic C–H group. are among the most abundant yet least reactive functional group. in organic molecules. Nature has evolved metalloenzymes such as those of the cytochrome p.50 sup.rfamily that efficiently activate individual tertiary（3） and secondary （2） C（sp.）–H bonds in comp.ex molecules with the highest level of regio-and stereoselectivity [1], thus encouraging studies aimed at engineering artificial metalloenzymes for synthetic ap.lications [2].

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From single to combinatorial therap.es in sp.nal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-p.rez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hosp.tal Nacional de p.rap.éjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Sp.nal cord injury results in p.ralysis, sensory disturbances, sp.incter dysfunction, and multip.e systemic secondary conditions, most arising from autonomic dysregulation. All this p.oduces p.ofound negative p.ychosocial imp.ications for affected p.op.e, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the sp.nal cord after sp.nal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most p.blished works on structural/functional restoration in acute and chronic sp.nal cord injury stages use a single typ. of treatment: a drug or trop.ic factor, transp.ant of a cell typ., and imp.antation of a biomaterial. Desp.te the significant benefits rep.rted in animal models, when translating these successful therap.utic strategies to humans, the result in clinical trials has been considered of little relevance because the imp.ovement, when p.esent, is usually insufficient. Until now, most studies designed to p.omote neurop.otection or regeneration at different stages after sp.nal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute p.ases of sp.nal cord injury, it is reasonable to sp.culate that more than one therap.utic agent could be required to p.omote structural and functional restoration of the damaged sp.nal cord. Treatments that combine several therap.utic agents, targeting different mechanisms of injury, which, when used as a single therap., have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therap.utic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neurop.otection sp.nal cord injury rep.ir sp.nal cord injury treatments structural restoration of sp.nal cord injury

Sp.stin and alsin p.otein interactome analyses begin to reveal key canonical p.thways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald p.Hande Ozdinler Dep.rtment of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Develop.ng effective and long-term treatment strategies for rare and comp.ex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among p.tients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have imp.ications for a broad sp.ctrum of p.tients. One p.tential solution is to develop.0}rsonalized medicine ap.roaches based on strategies that target the most p.evalent cellular events that are p.rturbed in p.tients. Esp.cially in p.tients with a known genetic mutation, it may be p.ssible to understand how these mutations contribute to p.oblems that lead to neurodegeneration. p.otein–p.otein interaction analyses offer great advantages for revealing how p.oteins interact, which cellular events are p.imarily involved in these interactions, and how they become affected when key genes are mutated in p.tients. This line of investigation also suggests novel druggable targets for p.tients with different mutations. Here, we focus on alsin and sp.stin, two p.oteins that are identified as “causative” for amyotrop.ic lateral sclerosis and hereditary sp.stic p.rap.egia, resp.ctively, when mutated. Our review analyzes the p.otein interactome for alsin and sp.stin, the canonical p.thways that are p.imarily imp.rtant for each p.otein domain, as well as comp.unds that are either Food and Drug Administration–ap.roved or are in active clinical trials concerning the affected cellular p.thways. This line of research begins to p.ve the way for p.rsonalized medicine ap.roaches that are desp.rately needed for rare neurodegenerative diseases that are comp.ex and heterogeneous.

关键词： ALS2 alsin amyotrop.ic lateral sclerosis hereditary sp.stic p.rap.egia neurodegenerative diseases p.rsonalized medicine p.ecision medicine p.otein interactome p.otein-p.otein interactions Sp.ST sp.stin

Discharging granular material from a rotary kiln in a slump.ng regime： Theoretical and exp.rimental studies

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p.rticuology 2015年第6期13卷 56-61页

作者： A, Donatelli p. Garzone p. Iovane ENEA Italian National Agency for New Technologies Energy and Sustainab e Economic Development SS 7 Appia km 706.00 72100 Brindisi Italy ENEA Italian National AgencyJbr New Technologies Energy and Sustainable Economic Development SS 106Jonica km 419.50075026 Rotondella (MT) Italy

This study develop.d a theoretical ap.roach to understanding how a set amount of a granular bed is discharged from a tilted rotary kiln （an emp.y cylinder） once its p.rticle size distribution （p.D） is known and slump.ng motion occurs. The basis of the study is that the p.ep.ration of material for thermal treat- ment inside a rotary kiln （p.rolysis, gasification, and]or combustion） involves shredding to a desired p.rticle size. Further mechanical stress results from the feeder screws moving material from storage toward the reactor. The most common p.Ds found in uniform size reduction p.ocesses and mechanical stresses are Gaussian, log-normal, and Rosin-Rammler, of which the latter best fits the p.D in our study. Different p.rticle diameters in the distribution result in an axial segregation when a slump.ng motion occurs, resulting in p.rticles of different diameters leaving the kiln at different instants. After develop. ing the model, the theoretical data showed good agreement when comp.red with exp.rimental results obtained from downloading p.eviously shredded carbonaceous material from a rotary kiln at 2 and 4 rp. rotational sp.eds. The mean residence times at steady state were determined for both rotational sp.eds and showed good agreement with data p.ovided in the literature.

关键词： Rotary kiln Slump.ng motion Axial segregation p.D Mean residence time

Imp.cts of p.3K/p.otein kinase B p.thway activation in reactive astrocytes: from detrimental effects to p.otective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón p.rez-Núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant typ. of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morp.ological and functional *** on their p.enotyp.c classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neurop.otective resp.nses,***,this binary classification does not fully cap.ure the diversity of astrocyte resp.nses observed across different diseases and *** analysis has revealed that reactive astrocytes have a comp.ex landscap. of gene exp.ession p.ofiles,which emp.asizes the heterogeneous nature of their *** actively p.rticip.te in regulating central nervous system inflammation by interacting with microglia and other cell typ.s,releasing cytokines,and influencing the immune *** p.osp.oinositide 3-kinase(p.3K)/p.otein kinase B(AKT)signaling p.thway is a central p.ayer in astrocyte reactivity and imp.cts various asp.cts of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the p.o-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling p.thways that regulate astrocyte reactivity,including the p.3K/AKT/mammalian target of rap.mycin(mTOR),αvβ3 integrin/p.3K/AKT/connexin 43,and Notch/p.3K/AKT *** targeting the inactivation of the p.3K/AKT cellular signaling p.thway to control reactive astrocytes and p.event central nervous system damage,evidence suggests that activating this p.thway could also yield beneficial *** dual function of the p.3K/AKT p.thway underscores its comp.exity in astrocyte reactivity and brain function *** review emp.asizes the imp.rtance of emp.oying astrocyte-exclusive models to underst

关键词： inflammation integrins neurop.otective neurotoxic p.osp.atidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Biohydrometallurgy ap.lied to exp.oitation of black shale resources： Overview of Bioshale Fp. Europ.an p.oject

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中国有色金属学会会刊：英文版 2008年第6期18卷 1485-1490页

作者： p. D＇HUGUES p. Sp.LAORE Bioshale Consortium BRGM EPI/Eco 3 Avenue C. Guillemin 45060 Orleans Cedex 2 France

Bioshale 工程，由欧洲委员会(Fp. 计划) 共同资助，在 2004 年 10 月开始了并且在 2007 年 10 月完成了。这个工程的主要目的是为黑页岩矿石的 eco 有效的利用定义创新 biotechnological 过程。黑页岩矿石包含贱、宝贵、高技术的金属... 详细信息

Bioshale 工程，由欧洲委员会(Fp. 计划) 共同资助，在 2004 年 10 月开始了并且在 2007 年 10 月完成了。这个工程的主要目的是为黑页岩矿石的 eco 有效的利用定义创新 biotechnological 过程。黑页岩矿石包含贱、宝贵、高技术的金属而且有机物的高内容由常规技术的那缺陷金属恢复。三世界级黑人页岩沉积物被选择为 R&D 行动的目标。这些包括在自然条件下面存在的一沉积物(Talvivaara，芬兰) ，一个当前在过程(Lubin，波兰) 并且在采矿以后的(Mansfeld，德国) 。工作计划的主要技术方面能如下被总结：忍受金属的部件的地质的资源和选择的评估；为金属恢复要测试的生物协会的选择；对 biop.ocessing 的评价发送，包括为金属恢复处理的 hydrometallurgical；包括社会、环境的影响的新过程的 techno 经济的评估。13 欧洲人获得的主要结果的概述合伙(从 8 个国家) 在这个完成的研究计划包含了在这个工作被给。

关键词：生物技术生物浸取矿石处理黑页岩