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Clinical significance of Helicobacter pylori cagA and iceA genotype status

World Journal of Gastroenterology 2010年第35期16卷 4443-4447页

作者： Nasser Amjad Hussain Ali Osman Najibah Abdul Razak Junaini Kassian jeffri din Nasuruddin bin Abdullah Department of Surgery International Islamic University Malaysia Department of Basic Medical Sciences International Islamic University MalaysiaKuantan 25710PahangMalaysia Department of Surgery Hospital Tengku Ampuan Afzan

AIM:To study the presence of Helicobacter pylori(***) virulence factors and clinical outcome in *** infected ***:A prospective analysis of ninety nine ***-positive patients who underwent endoscopy in our Endoscopy suite were included in this *** was isolated from antral biopsy samples and the presence of cagA,iceA,and iceA2 genotypes were determined by polymerase chain reaction and a reverse hybridization *** for *** infection was performed in all patients using the rapid urease test(CLO-Test).RESULTS:From a total of 326 patients who underwent endoscopy for upper gastrointestinal symptoms,99 patients were determined to be *** ulceration was seen in 33 patients(33%).The main virulence strain observed in this cohort was the cagA gene isolated in 43 *** was associated with peptic ulcer pathology in 39.5%(17/43) and in 28%(16/56) of non-ulcer ***1 was present in 29 patients(29%) and iceA2 in 15 patients(15%).Ulcer pathology was seen in 39%(11/29) of patients with iceA1,while 31%(22/70) had normal *** corresponding values for iceA2 were 33%(5/15) and 33%(28/84),***:Virulence factors were not common in our *** incidence of factors cagA,iceA1 and iceA2 were very low although variations were noted in different ethnic groups.

关键词： Ethnicity Helicobacter pylori Peptic ulcer disease Virulence factors

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