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Ice Cores as a Source for Antimicrobials:From Bioprospecting to Biodesign

Biodesign Research 2023年第1期5卷 155-157页

作者： Ying-Chiang jeffrey Lee Bahar Javdan department of Molecular Biology Princeton UniversityPrincetonNJ 08544USA. Rutgers Robert Wood Johnson Medical School New BrunswickNJ 08901USA.

The golden age has passed for antibiotic discovery,and while some antibiotics are currently in various phases of clinical trials in the United States,many pharmaceutical companies have abandoned antibiotic *** the need for antibiotics,we should expand our horizon for therapeutic mining and can look toward understudied sources such as ice *** cores contain microorganisms and genetic material that have been frozen in time for thousands of *** antibiotics used by these organisms are encoded in their genomes,which can be unlocked,identified,and characterized with modern advances in molecular biology,genetic sequencing,various computational approaches,and established natural product discovery *** synthetic biology can be used in natural product discovery approaches,synthetic biology and bioengineering efforts can also be leveraged in the selection and biodesign of increased compound yields,potency,and ***,we provide the perspective that ice cores can be a source of novel antibiotic compounds and that the tools of synthetic biology can be used to design better antimicrobials.

关键词： stability prospecting companies

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David Foster Wallace's balancing books

David Foster Wallace's balancing books

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作者： jeffrey Severs.

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The Essential Cosmic Perspective jeffrey Bennett...[et al.]. 2nd ed.

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2003年

作者： jeffrey Bennett...[et al.].

Edition of: The cosmic perspective, designed for one-term courses in introductory astronomy.

ISBN: (纸本)0805385843

Edition of: The cosmic perspective, designed for one-term courses in introductory astronomy.

关键词： Astronomy.

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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作者： jeffrey Ford.

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Surviving genocide

Surviving genocide

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作者： jeffrey Ostler.

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The therapeutic implications of immunosuppressive tumor aerobic glycolysis

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Cellular & Molecular Immunology 2022年第1期19卷 46-58页

作者： Bradley I.Reinfeld WKimryn Rathmell Tae Kon Kim jeffrey C.Rathmell department of Medicine Division of Hematology and OncologyVanderbilt University Medical CenterNashvilleTNUSA

In 2011,Hanahan and Weinberg added“deregulating Cellular Energetics”and“Avoiding Immune destruction”to the six previous hallmarks of *** this seminal paper,there has been a growing consensus that these new hallmarks are not mutually exclusive but rather *** following review summarizes how founding genetic events for tumorigenesis ultimately increase tumor cell glycolysis,which not only supports the metabolic demands of malignancy but also provides an immunoprotective niche,promoting malignant cell proliferation,maintenance and *** mechanisms by which altered metabolism contributes to immune impairment are multifactorial:(1)the metabolic demands of proliferating tumor cells and activated immune cells are similar,thus creating a situation where immune cells may be in competition for key nutrients;(2)the metabolic byproducts of aerobic glycolysis directly inhibit antitumor immunity while promoting a regulatory immune phenotype;and(3)the gene programs associated with the upregulation of glycolysis also result in the generation of immunosuppressive cytokines and *** this perspective,we shed light on important considerations for the development of new classes of agents targeting cancer *** types of therapies can impair tumor growth but also pose a significant risk of stifling antitumor immunity.

关键词： cancer metabolism immuno logy glycolysis

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Panorama of boron nitride nanostructures via lamp ablation

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Nano Research 2019年第3期12卷 557-562页

作者： Sehrina Eshon Weike Zhang Martin Saunders Yujun Zhang Hui Tong Chua jeffrey M. Gordon department of Chemical Engineering The University of Western Australia Perth WA 6009 Australia Centre for Microscopy Characterisation and Analysis The University of Western Australia Perth WA 6009 Australia School of Environmental Science and Engineering Taiyuan University of Technology Taiyuan 030024 China department of Material Science and Engineering Shandong University Jinan 250061 China department of Solar Energy and Environmental Physics Blaustein Institutes far Desert Research Bert-Gurion University of the Negev Sede Boqer Campus 8499000 Israel

A diverse range of remarkable boron n itride (BN) nano structures subsumi ng nano-homs, nano-rods, nano-platelets, and clusters of hollow nano spheres (nano-onions, arguably of greatest applied and fun damental in terest) have bee n produced exclusively from crystalline BN precursor powder via lamp ablation. The procedure is safe, devoid of toxic reagents, simple, rapid and scalable—generating some genres of nan oparticles that had previously proved elusive. Product structure and composition were unambiguously assessed by high-resoluti on transmission electron microscopy, energy-dispersive X-ray spectroscopy and electron energy loss spectroscopy.

关键词： Aboron nitride nanostructures nano-onions lamp ablation non-toxic

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Single-layer graphene as a highly selective barrier for vanadium crossover with high proton selectivity

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Journal of Energy Chemistry 2021年第8期30卷 419-430,I0009页

作者： Saheed Bukola Zhaodong Li Jason Zack Christopher Antunes Carol Korzeniewski Glenn Teeter jeffrey Blackburn Bryan Pivovar National Renewable Energy Laboratory(NREL) 80401 GoldenUnited States department of Chemistry Texas Tech University79409 LubbockUnited States*Corresponding author(email:Saheed.Bukola@nrel.gov

We report near-zero crossover for vanadium cross-permeation through single-layer graphene immobilized at the interface of two Nafion?polymer electrolyte *** ion diffusion and migration,including proton mobility through membrane composites,were studied with and without graphene under diffusion and migration ***-layer graphene was found to effectively inhibit vanadium ion diffusion and migration under specific *** single-layer graphene composites also enabled remarkable ion transmission selectivity improvements over pure Nafion membranes,with proton transport being four orders of magnitude faster than vanadium ion *** values of 0.02±0.005Ωcm^(2) for proton and 223±4Ωcm^(2) for vanadium ion through single atomic layer graphene are *** high selectivity may have significant impact on flow battery applications or for other electrochemical devices where proton conductivity is required,and transport of other species is *** results emphasize that crossover may be essentially completely eliminated in some cases,enabling for greatly improved operational viability.

关键词： Ion selectivity Polymer electrolyte membrane Redox flow battery Single-layer graphene Vanadium crossover 2D nanomaterial

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Mineralogical characteristics and photocatalytic properties of natural sphalerite from China

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Journal of Environmental Sciences 2020年第3期32卷 156-166页

作者： Can Shen Xiangping Gu Bin Yang dexian Zhang Zhilin Wang Zhengxiang Shu jeffrey Dick Anhuai Lu Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of Education Central South UniversityChangsha 410083China School of Geoscience and Info-physics Central South UniversityChangsha 410083China

Different natural sphalerites have a range of photocatalytic properties that can potentially be exploited for environmental remediation *** develop value in the exploitation of sphalerite,samples were collected from 19 ore deposits in China and characterized for their mineralogical and photocatalytic properties.X-ray diffraction(XRD) and electron probe micro analysis(EPMA) measurements indicated that all the natural sphalerites from various localities crystallized in cubic phases with various chemical *** substitution of Fe for Zn ranged from 0.235% to 14.826% by weight,Mn from 0.004% to4.868%,Cu from 0.009% to 5.529% and Cd from 0.133% to 1.576%.As Fe became more abundant,the color of natural sphalerite darkened,becoming almost black;and higher Fe content was associated with stronger visible light *** spectra showed emission mainly related to S-vacancies and progressively decreasing fluorescence intensity with increasing Fe *** of the photocatalytic degradation of methyl orange indicated that the sample with the highest Cd content but moderate Fe content had the highest photocatalytic ***,the degradation of Methyl Orange(30 mg/L)attained 82.11% efficiency under visible light irradiation for 4 hr of natural sphalerite with4.262% Fe and 1.576% ***,the Fe content in sphalerite was found to contribute to the visible light absorption ability and the recombination rate of photo-generated electrons and holes,while substitution by Cd was observed to have a greater effect on the photocatalytic *** findings provide a scientific basis for the profitable utilization of base metal resources like sphalerite.

关键词： Natural sphalerite Mineralogical properties Band gap Photodegradation of Methyl Orange

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PROTEIN CHARACTERIZATION USING DYNAMIC AND STATIC LIGHT SCATTERING

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China Particuology 2003年第5期1卷 219-222页

作者： jeffrey Yang Kevin Mattison SiberHegner China Ltd. 26/F West Tower Hanwei Plaza No.7 Guanghua Road Beijing 100004 P. R. ChinaMalvern Instruments Inc. 10 Southville Road Southborough MA01772 USA

IntroductionThe stability of a protein formulation to a variety of solution perturbations is critical to its success as a pharmaceutical product. Because of the sensitivity of the protein to solution changes, invasive characterization techniques can be problematic. Light scattering is a non-invasive technique that has received wide acceptance in the area of protein formulation and characterization.

关键词： is on of for PROTEIN CHARACTERIZATION USING DYNAMIC AND STATIC LIGHT SCATTERING SLS Nano in from with that

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