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Placental accommodations for transport and metabolism during intra-uterine crowding in pigs

Journal of Animal science and Biotechnology 2015年第2期6卷 163-176页

作者： jeffrey L Vallet Anthony K Mc Neel Jeremy R Miles Bradley A Freking U.s. Department of Agriculture Agricultural Research Service U.S. Meat Animal Research CenterState Spur 18D Clay Center NE 68933 USA

Litter size and birth weights are limited by uterine capacity, defined as the ability of the uterus to maintain the appropriate development of some number of conceptuses. Uterine capacity is the result of the combined effects of uterine, placental and embryo/fetal function. The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight （and therefore reduced intrauterine space） in early gestation compared to late gestation. However, even in late gestation, mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. One such mechanism is likely to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. Fold depth, and therefore the maternal fetal interactive surface, increases as gestation advances and is greater in placenta from smal fetuses. On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. Glycosaminoglycans are polymers of forms of glucose （glucosamine, glucuronic acid, iduronic acid） suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus. Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is linked to regulation of trophoblast cell proliferation through regulation of mTOR. These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental m

关键词： Glycosaminoglycans Nutrient transport Placenta

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Remarks at the Banquet of Beijing Forum 2006

Remarks at the Banquet of Beijing Forum 2006

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文明的和谐与共同繁荣：对人类文明方式的思考——北京论坛（2006）

作者： jeffrey s.Lehman the Joint Center for China-U.s.Law & Policy studies

Good evening I am honored to have been invited to offer a few words of welcome to this extraordinarily distinguished community of participants in the 2006 Beijing *** in its third year,the Beijing Forum has emerged as one of the great international focal points for discussion of the important questions facing our world.I know that I speak for everyone here when I

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Menaquinone (Vitamin K2) Enhancement of <i>staphylococcus aureus</i>Biofilm Formation

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Journal of Biosciences and Medicines 2014年第1期2卷 26-32页

作者： Derek T. Kirby Joyce M. savage Balbina J. plotkin Department of Microbiology and Immunology Midwestern University Downers Grove USA

During infection, staphylococcus aureus is exposed to exogenous menaquinone which is essential for the human blood clotting cascade. The effect of exogenous menaquinone on s. aureus phenotypic expression is not known. To test whether menaquinone affects expression of virulence-associated phenotypes, methicillin-sensitive (MssA) and -resistant (MRsA) s. aureus strains (n = 8) were grown in the presence of menaquinone (0.001 - 12 μg/ml). Capsule production, biofilm formation (plastic and fibronectin-coated microtiter plates) and carotenoid levels were determined spectrophotometrically after growth in Mueller Hinton broth (MH;24-hr, 37°C). All experiments were, at minimum, done in triplicate and repeated twice. Menaquinone at physiologic levels (0.01 μg/ml MH) significantly increased (p 0.05) biofilm formation on plastic in a manner that was bacterial population size dependent. In addition, menaquinone (0.05 - 4 μg/ml) significantly increased (p 0.05) biofilm formation on fibronectin-coated surfaces for four MssA strains and one MRsA strain by two to six-fold as compared to medium controls. However, menaquinone had no effect on capsule production or cell-associated carotenoid levels. Menaquinone’s effect on biofilm formation on fibronectin-coated surfaces appears to be regulated by sarA. These findings are the first to demonstrate that a vitamin at concentrations reported in humans affects s. aureus virulence-associated phenotypes.

关键词： Quorum s. aureus Menaquinone Fibronectin Biofilm Capsule Plastic Adherence Carotenoid

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David Foster Wallace's balancing books

David Foster Wallace's balancing books

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作者： jeffrey severs.

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作者： jeffrey Ford.

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McGill Brisbane symptom score for patients with resectable pancreatic head adenocarcinoma

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World Journal of Gastroenterology 2014年第34期20卷 12226-12232页

作者： Mohammed H Jamal suhail A R Doi A James Moser sinziana Dumitra Jad abou Khalil Eve simoneau Prosanto Chaudhury Adedayo A Onitilo Peter Metrakos jeffrey s Barkun Hepato-biliary Pancreatic and Liver Transplant SurgeryMcGill University Health CenterMontreal QCH3A 1A1Canada Department of surgery Kuwait Medical SchoolKuwait CityKuwait 24923Kuwait Clinical Epidemiology Unit School of Population HealthUniversity of QueenslandBrisbane QLD4006Australia Department of surgery Harvard Medical SchoolBeth Israel Deaconess HospitalBostonMA 02215United States Marshfield Clinic Research Foundation Marshfield ClinicMarshfieldWI 54449United States Division of General surgery Department of SurgeryRoyal Victoria HospitalQuébec H3A 1A1Canada

AIM: To evaluate the ability of the McGill Brisbane symptom score (MBss) to predict survival in resectable pancreatic head adenocarcinoma (PHA) patients.

关键词： Pancreatic neoplasms Pancreatic adenocarcinoma Whipple procedure Prognosis survival study Chemotherapy

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定量药理学与儿童药物研发和合理用药

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中国临床药理学与治疗学 2010年第1期15卷 1-10页

作者：史军 jeffrey s.Barrett Daiichi-sankyo Pharma Development Edison The Children's Hospital of Philadelphia Philadelphia

This article provides a comprehensive overview of key issues related to pediatric drug development and rational dosing guidance in pediatrics with an emphasis on how pharmacometrics can improve the efficiency and productivity of pediatric *** pharmacokinetics(PK)and pharmacodynamics(PD)of drugs are often different between adult and pediatric populations which necessitate specific studies in *** aims of this review are to discuss a number of recent methodological developments of modeling and simulation that facilitate the evaluation of drugs in *** focus has been placed on addressing the key issues of PK/PD scaling,sparse sampling,colinearity,covariate evaluation,dose optimization for trial design and label,modeling strategies and validation *** features and potential advantages of Bayesian hierarchical model,physiology-based PK models,and K-PD models are also presented.

关键词：儿童合理用药药物研发定量药理学药理学工作者药物试验弱势群体受试者

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Clinical update on the management of pseudopapillary tumor of pancreas

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World Journal of Gastrointestinal Endoscopy 2018年第9期10卷 145-155页

作者： Gandhi Lanke Faisal s Ali jeffrey H Lee Department of Gastroenterology Hepatology and NutritionUniversity of Texas MD Anderson Cancer Center

solid pseudopapillary neoplasm(sPN) is a rare tumor with malignant potential which is generally located in the tail of *** prevalence of sPN has increased with widespread use of cross sectional *** is often misdiagnosed due to nonspecific clinical presentation and accurate diagnosis is essential for optimal *** ultrasound-FNA with immunohistochemistry can help in preoperative *** is the treatment of choice and a successful R0 resection is ***,sPN has a good *** review article focuses on pathogenesis,diagnosis and management of sPN.

关键词： Pancreatectomy Pancreatic cysts Betacatenin Endoscopic ultrasound-fine needle aspiration E-cadherin Immunohistochemistry

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Green Tea Polyphenols Mediated Apoptosis in Intestinal Epithelial Cells by a Fadd-Dependent Pathway

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Journal of Cancer Therapy 2010年第3期1卷 105-113页

作者： Helieh s. Oz jeffrey L. Ebersole Center for Oral Health Research College of Dentistry University of Kentucky Medical Center Lexington KY.

Colorectal cancer is the most common malignant complication in patients with chronic inflammatory bowel disease (IBD). In addition, these patients are at risk for developing painful complications during chemotherapy due to cytotoxic effects of drugs currently in use. Past studies have suggested a protective effect of tea consumption on gastrointestinal (GI) malignancies. Green tea polyphenols (GrTP) inhibited carcinogen-induced GI tumors in rodents and induced apoptosis in various carcinoma cell lines. We hypothesized that GrTP and its polyphenolic compounds regulate apoptosis in the intestinal epithelia. In this study, the effects of GrTP and its polyphenolics on apoptosis was evaluated in intestinal epithelial, IEC-6, cells grown to 85% confluency. GrTP (400-800 mg/ml) induced DNA fragmentation in a dose dependent fashion. Higher concentrations (> 800 mg/ml) induced a mixed apoptosis and cytolysis. Epithelial cells exposed to GrTP and a major polyphenol, EGCG, but not EGC or EC, increased caspase activities in a time and dose dependent manner. The caspase inhibitors rescued cells from GrTP and EGCG-induced cell death. Concomitantly, GrTP resulted in activation of fatty acid synthase (Fas)-associated protein with death domain (FADD) and recruitment to Fas/CD95 domain 30 minutes following treatment. While GrTP also blocked NF-?B activation, an NF-?B inhibitor (MG132) only promoted cytolysis. In conclusion, these data demonstrated GrTP and EGCG induced apoptosis in intestinal epithelia mediated by caspase-8 through a FADD dependent pathway. Future investigation may warrant preventive as well as therapeutic strategies for GrTP in GI malignancy.

关键词： Intestinal Epithelial Cells Green Tea Polyphenols EGCG Apoptosis

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Mineralogical characteristics and photocatalytic properties of natural sphalerite from China

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Journal of Environmental sciences 2020年第3期32卷 156-166页

作者： Can shen Xiangping Gu Bin Yang Dexian Zhang Zhilin Wang Zhengxiang shu jeffrey Dick Anhuai Lu Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of Education Central South UniversityChangsha 410083China school of Geoscience and Info-physics Central South UniversityChangsha 410083China

Different natural sphalerites have a range of photocatalytic properties that can potentially be exploited for environmental remediation *** develop value in the exploitation of sphalerite,samples were collected from 19 ore deposits in China and characterized for their mineralogical and photocatalytic properties.X-ray diffraction(XRD) and electron probe micro analysis(EPMA) measurements indicated that all the natural sphalerites from various localities crystallized in cubic phases with various chemical *** substitution of Fe for Zn ranged from 0.235% to 14.826% by weight,Mn from 0.004% to4.868%,Cu from 0.009% to 5.529% and Cd from 0.133% to 1.576%.As Fe became more abundant,the color of natural sphalerite darkened,becoming almost black;and higher Fe content was associated with stronger visible light *** spectra showed emission mainly related to s-vacancies and progressively decreasing fluorescence intensity with increasing Fe *** of the photocatalytic degradation of methyl orange indicated that the sample with the highest Cd content but moderate Fe content had the highest photocatalytic ***,the degradation of Methyl Orange(30 mg/L)attained 82.11% efficiency under visible light irradiation for 4 hr of natural sphalerite with4.262% Fe and 1.576% ***,the Fe content in sphalerite was found to contribute to the visible light absorption ability and the recombination rate of photo-generated electrons and holes,while substitution by Cd was observed to have a greater effect on the photocatalytic *** findings provide a scientific basis for the profitable utilization of base metal resources like sphalerite.

关键词： Natural sphalerite Mineralogical properties Band gap Photodegradation of Methyl Orange

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