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Long-term physical,mental and social health effects of COVID-19 in the pediatric population:a scoping review

World Journal of Pediatrics 2022年第3期18卷 149-159页

作者： Madeline Borel Luyu Xie Olivia Kapera Adrian Mihalcea jeffrey kahn Sarah E.Messiah School of Public Health University of Texas Health Science CenterDallas Campus2777 N Stemmons FwyDallasTX 75207USA Center for Pediatric Population Health University of Texas Health School of Public Health and Children’s Health System of TexasDallasTXUSA School of Public Health University of Texas Health Science CenterAustin CampusAustinTXUSA School of Public Health University of Texas Health Science CenterHouston CampusHoustonTXUSA Department of Pediatrics University of Texas Southwestern Medical CenterDallasTXUSA Children’s Health System of Texas DallasTXUSA

Background The majority of coronavirus disease 2019(COVID-19)symptom presentations in adults and children appear to run their course within a couple of ***,a subgroup of adults has started to emerge with effects lasting several months or more after initial infection,which raises questions about the long-term physical,mental and social health effects of COVID-19 in the pediatric *** purpose of this review was to determine these impacts well into the second year of the *** A search was conducted using PubMed,Web of Science,Science Direct,and Cochrane between 11/1/2019 and 9/1/*** inclusion criteria were as follows:(1)COVID-19 illness and symptoms in children;(2)severe acute respiratory syndrome coronavirus 2 in children;(3)English language;and(4)human studies *** The few studies that have documented long-term physical symptoms in children show that fatigue,difficulty in concentrating(brain fog),sleep disturbances,and sensory problems are the most reported *** studies examining the impact of COVID-19 in pediatric populations have focused on initial clinical presentation,and symptoms,which are similar to those in adult *** addition,COVID-19 has had a moderate impact on children and adolescents’social environment,which may exacerbate current and future physiological,psychological,behavioral,and academic *** There are limited studies reporting long physical symptoms of COVID-19 in the pediatric ***,pediatric COVID-19 cases are underreported due to low rates of testing and symptomatic infection,which calls for more longitudinal *** who have experienced COVID-19 illness should be monitored for long physiological,psychological,behavioral,and academic outcomes.

关键词： Adolescents Children Coronavirus disease 2019(COVID-19) Long-COVID symptoms

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Pramipexole in Treatment Resistant Depression: A Case Review

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Pharmacology & Pharmacy 2023年第7期14卷 223-227页

作者： Nada Abdallah jeffrey kahn Weill Cornell Medicine New York NY USA Department of Psychiatry Weill Cornell Medicine New York NY USA

Pramipexole is a dopamine agonist used in the treatment of Parkinson’s disease and Restless legs syndrome. Although off-label, the use of Pramipexole as an adjunct therapy in treatment resistant depression has recently been documented in the literature with promising results. We present a 75-year-old male with MDD who has failed trials of SSRIs, SNRIs, TCAs, SGA, TMS, Ketamine, and ECT who was initiated on Pramipexole. We discuss, based on existing literature, the probability of a favorable long-term response to Pramipexole and the potential side effects for our patient. We also highlight the need for future studies designed to test the efficacy of Pramipexole in geriatric patients with TRD.

关键词： Pramipexole Treatment Resistant Depression Augmentation Dopamine Agonism Geriatric Psychiatry

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Research Ethics and the Challenges of New Technologies in Biomedical Research

Research Ethics and the Challenges of New Technologies in Bi...

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科研伦理培训与伦理审查能力建设专题研讨会

作者： jeffrey kahn Johns Hopkins Berman Institute of Bioethics

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临床试验中的利益冲突:伦理和政策问题

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医学与哲学 2001年第12期22卷 17-20页

作者： jeffrey kahn 吴朝霞美国明尼苏达大学生命伦理学中心北京大学医学部外语部

人们对于研究人员、赞助商和研究机构三者之间的经济利益关系给予越来越多的关注。人体试验研究中的经济利益与其他利益有所不同 ,这种经济利益会导致偏见或诱导不正当的行为 ,尤其是当有从研究中获益的机会存在时 ,将会影响到研究人员... 详细信息

人们对于研究人员、赞助商和研究机构三者之间的经济利益关系给予越来越多的关注。人体试验研究中的经济利益与其他利益有所不同 ,这种经济利益会导致偏见或诱导不正当的行为 ,尤其是当有从研究中获益的机会存在时 ,将会影响到研究人员关于应该选择哪个受试者 ,应该提供给受试者什么样的医疗服务 ,甚至应该如何正确使用受试者保密的健康信息方面的判断。由经济利益引起的明显的风险同样也会威胁公众的学术机构研究使命的支持。从处理临床试验中利益冲突的准则 ,什么样的经济利益是研究中的重大经济利益 ,准则的实施等方面进行了详尽的叙述 ,最后指出没有潜在受试者和公众的信任 ,我们就不能有效地开展研究。

关键词：利益冲突信任风险临床试验伦理政策

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Coupled Inversion of Pressure and Tiltmeter Data for Mapping Hydraulic Fracture Geometry

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Acta Mechanica Solida Sinica 2024年第3期37卷 396-405页

作者： Zuorong Chen Xiaofang Jiang Zhejun Pan Robert G.jeffrey National Key Laboratory of Continental Shale Oil Northeast Petroleum UniversityDaqing163318China SCT Operation Pty.Ltd. PO Box 824WollongongNSW2520Australia

Pressure and tilt data are jointly inverted to simultaneously map the orientation and dimensions of a hydraulic *** deformation induced by a fracture under internal pressure is modeled using the distributed dislocation *** planar fracture is represented by four quarter ellipses,joined at the center and sharing *** configuration provides a straightforward model for characterizing asymmetric fracture *** inverse problem of mapping the fracture geometry is formulated using the Bayesian probabilistic method,combining the a priori information on the fracture model with updated information from pressure and tilt *** the nonlinear inverse problem is achieved by pseudo-randomly sampling the posterior probability distribution through the Markov chain Monte Carlo *** resulting posterior probability distribution is then explored to assess uncertainty,resolution,and correlation between model *** experiments are conducted to verify the accuracy and validity of the proposed analysis method in mapping the fracture geometry using synthetic pressure and tilt data.

关键词： Hydraulic fracture mapping Coupled inversion Tilt Treating pressure

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New insights on the high-corrosion resistance of UHP Mg-Ge alloys tested in a simulated physiological environment

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Journal of Magnesium and Alloys 2024年第3期12卷 1026-1044页

作者： Ting Liu Xingrui Chen jeffrey Venezuela Yuan Wang Zhiming Shi Wenyi Chen Matthew Dargusch Centre for Advanced Materials Processing and Manufacturing(AMPAM) School of Mechanical and Mining Engineeringthe University of QueenslandBrisbaneQLD 4072Australia CSIRO Mineral Resources 1 Technology CourtPullenvaleQLD 4069Australia

UHP Mg-Ge alloys was recently found to provide excellent corrosion *** paper provides new insights on the mechanism of improved corrosion resistance of UHP Mg-Ge alloys in Hanks’*** studied UHP Mg-0.5Ge and UHP Mg-1Ge alloys showed superior corrosion resistance compared to UHP Mg and WE43,with the Mg-1Ge exhibiting the best corrosion *** exceptional corrosion resistance of the UHP alloy is attributed to(i)Mg_(2)Ge’s ability to suppress cathodic kinetics,(ii)Ge’s capability to accelerate the formation of a highly passive layer,and the(iii)low amounts of corrosion-accelerating impurities.

关键词： UHP Mg-Ge alloy Cathodic kinetics suppression Biodegradable metals In vitro corrosion Magnesium corrosion.

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Back to the drawing board:Overview of the next generation of combination therapy for inflammatory bowel disease

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World Journal of Gastroenterology 2024年第25期30卷 3182-3184页

作者： jeffrey A Lowell Michael J Farber Keith Sultan Department of Medicine Zucker School of Medicine at HofstraNorth Shore University Hospital-Long Island Jewish Medical CenterManhassetNY 11030United States Preclinical Studies New York Institute of Technology College of Osteopathic MedicineGlen HeadNY 11545United States Division of Gastroenterology Northwell HealthNorth Shore University Hospital and Long Island Jewish Medical CenterGreat NeckNY 10021United States

Inflammatory bowel disease(IBD)is entering a potentially new era of combined *** et al provide an insightful review of the current state of combination therapy,with a focus on the use of a combined biologic and immunomodulator,as well as emerging data on the future potential of dual-biologic therapy(DBT).While current evidence for DBT is limited,encouraging safety profiles and ongoing trials suggest a brighter future for this *** importance of controlled trials should be stressed in establishing new treatment *** prospective randomized trials of DBT and perhaps future combinations of biologics and small molecule therapies will hopefully guide the next generation of IBD care.

关键词： Inflammatory bowel disease Biologics Immunomodulators Dual-therapy Combination therapy

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The synergistic interplay of artificial intelligence and digital twin in environmentally planning sustainable smart cities:A comprehensive systematic review

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Environmental Science and Ecotechnology 2024年第4期20卷 79-104页

作者： Simon Elias Bibri jeffrey Huang Senthil Kumar Jagatheesaperumal John Krogstie Swiss Federal Institute of Technology Lausanne(EPFL) Institute of Computer and Communication Sciences(IINFCOM)School of ArchitectureCivil and Environmental Engineering(ENAC)Media and Design Laboratory(LDM)1015LausanneSwitzerland Department of Electronics&Communication Engineering Mepco Schlenk Engineering CollegeSivakasi626005TamilnaduIndia Department of Computer Science Norwegian University of Science and Technology(NTNU)TrondheimNorway

The dynamic landscape of sustainable smart cities is witnessing a significant transformation due to the integration of emerging computational technologies and innovative *** advancements are reshaping data-driven planning strategies,practices,and approaches,thereby facilitating the achievement of environmental sustainability *** transformative wave signals a fundamental shift d marked by the synergistic operation of artificial intelligence(AI),artificial intelligence of things(AIoT),and urban digital twin(UDT)*** previous research has largely explored urban AI,urban AIoT,and UDT in isolation,a significant knowledge gap exists regarding their synergistic interplay,collaborative integration,and collective impact on data-driven environmental planning in the dynamic context of sustainable smart *** address this gap,this study conducts a comprehensive systematic review to uncover the intricate interactions among these interconnected technologies,models,and domains while elucidating the nuanced dynamics and untapped synergies in the complex ecosystem of sustainable smart *** to this study are four guiding research questions:*** theoretical and practical foundations underpin the convergence of AI,AIoT,UDT,data-driven planning,and environmental sustainability in sustainable smart cities,and how can these components be synthesized into a novel comprehensive framework?*** does integrating AI and AIoT reshape the landscape of datadriven planning to improve the environmental performance of sustainable smart cities?*** can AI and AIoT augment the capabilities of UDT to enhance data-driven environmental planning processes in sustainable smart cities?*** challenges and barriers arise in integrating and implementing AI,AIoT,and UDT in data-driven environmental urban planning,and what strategies can be devised to surmount or mitigate them?Methodologically,this study involves a rigorous analysis and synthesis of studies publis

关键词： Sustainable smart cities Artificial intelligence Artificial intelligence of things Urban digital twin Data-driven urban planning Environmental planning Environmental sustainability

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Nano-enhanced solid-state hydrogen storage:Balancing discovery and pragmatism for future energy solutions

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Nano Research 2024年第10期17卷 8729-8753页

作者： Chaochao Dun Xinyi Wang Linfeng Chen Sichi Li Hanna M.Breunig jeffrey J.Urban The Molecular Foundry Lawrence Berkeley National Laboratory BerkeleyBerkeleyCA 94720USA Energy Analysis and Environmental Impacts Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Lawrence Livermore National Laboratory LivermoreCA 94550USA

Nanomaterials have revolutionized the battery industry by enhancing energy storage capacities and charging speeds,and their application in hydrogen(H_(2))storage likewise holds strong potential,though with distinct challenges and mechanisms.H_(2) is a crucial future zero-carbon energy vector given its high gravimetric energy density,which far exceeds that of liquid ***,its low volumetric energy density in gaseous form currently requires storage under high pressure or at low *** review critically examines the current and prospective landscapes of solid-state H_(2) storage technologies,with a focus on pragmatic integration of advanced materials such as metal-organic frameworks(MOFs),magnesium-based hybrids,and novel sorbents into future energy *** materials,enhanced by nanotechnology,could significantly improve the efficiency and capacity of H_(2) storage systems by optimizing H_(2) adsorption at the nanoscale and improving the kinetics of H_(2) uptake and *** discuss various H_(2) storage mechanisms—physisorption,chemisorption,and the Kubas interaction—analyzing their impact on the energy efficiency and scalability of storage *** review also addresses the potential of“smart MOFs”,single-atom catalyst-doped metal hydrides,MXenes and entropy-driven alloys to enhance the performance and broaden the application range of H_(2) storage systems,stressing the need for innovative materials and system integration to satisfy future energy ***-throughput screening,combined with machine learning algorithms,is noted as a promising approach to identify patterns and predict the behavior of novel materials under various conditions,significantly reducing the time and cost associated with experimental *** closing,we discuss the increasing involvement of various companies in solid-state H_(2) storage,particularly in prototype vehicles,from a techno-economic *** forward-looking perspective underscores t

关键词： nanomaterials nanotechnology solid-state H_(2)storage techno-economic analysis model-driven material development processes

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Advances in ground heat exchangers for space heating and cooling:Review and perspectives

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Energy and Built Environment 2024年第2期5卷 255-269页

作者： Ping Cui Weibo Yang Wenke Zhang Ke Zhu jeffrey D.Spitler Mingzhi Yu School of Thermal Engineering Shandong Jianzhu UniversityJinanShandong 250101China College of Electrical Energy and Power EngineeringYangzhou UniversityYangzhouJiangsu 225127China Department of Mechanical Engineering Oklahoma State UniversityStillwaterOKUSA

As a renewable energy source,geothermal energy has been widely used to provide space heating and cooling for *** thermal performance of ground heat exchanger(GHE)is significant for the operating efficiency of the ground source heat pump(GSHP)*** paper presents a comprehensive review of developments and advances of three kinds of GHE,including vertical borehole GHE(VBGHE),Pile GHE(PGHE),and deep borehole GHE(DBGHE)which are currently popular in larger GSHP ***,analytical models proposed to ana-lyze heat transfer process of VBGHE with different geological conditions are summarized,such as homogenous or heterogeneous ground,with or without groundwater *** and short-time step models and measures to improve GHE thermal performance are also ***,a summary of research advances in PGHE is provided,which includes the heat transfer models of PGHE,the effects of geometric structure,oper-ation modes,pile spacing,use of phase change material(PCM),thermal properties of PCM,thermo-mechanical behavior and/or thermal performance of *** effects of groundwater flow direction and velocity on PGHE are also summarized in ***,models of three kinds of DBGHEs,i.e.,deep coaxial GHE(DCGHE),deep U-bend GHE(DUGHE)and super-long gravity heat pipe(SLGHP),are *** physical bases of the dif-ferent analytical models are elaborated and also their advantages and disadvantages are *** in numerical modelling and improving numerical model calculation speed of DCBHE,DCBHE array,and DUBHE are *** review provides a meaningful reference for the further study of GHEs.

关键词： Vertical borehole ground heat exchanger Pile ground heat exchanger Deep borehole ground heat exchanger Modelling

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