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Stability of Finite Difference Discretizations of Multi-Physics Interface Conditions

Communications in Computational Physics 2013年第2期13卷 386-410页

作者： Björn Sjögreen jeffrey w.banks Center for Applied Scientific Computing Lawrence Livermore National LaboratoryLivermoreCA 94551USA

we considermulti-physics computationswhere theNavier-Stokes equations of compressible fluid flow on some parts of the computational domain are coupled to the equations of elasticity on other parts of the computational *** different subdomains are separated by well-defined *** consider time accurate computations resolving all time *** such computations,explicit time stepping is very *** address the issue of discrete interface conditions between the two domains of different physics that do not lead to instability,or to a significant reduction of the stable time step *** such interface conditions is *** discretize the problem with high order centered difference approximations with summation by parts boundary *** derive L2 stable interface conditions for the linearized one dimensional discretized ***,we generalize the interface conditions to the full non-linear equations and numerically demonstrate their stable and accurate performance on a simple model *** energy stable interface conditions derived here through symmetrization of the equations contain the interface conditions derived through normal mode analysis by banks and Sj¨ogreen in[8]as a special case.

关键词： Fluid-structure interaction finite difference method summation by parts multiphysics interface condition

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Randomized controlled trials in frontotemporal dementia: cognitive and behavioral outcomes

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Translational Neurodegeneration 2014年第1期3卷 89-97页

作者： Justin B Miller Sarah J banks Gabriel C Léger jeffrey L Cummings Cleveland Clinic Lou Ruvo Center for Brain Health888 W.Bonneville AveLas VegasNevada 89106USA

Progress has been made in understanding the genetics and molecular biology of frontotemporal dementia(FTD).Targets for intervention have been identified,therapies are being developed,and clinical trials are advancing.A major challenge for FTD research is that multiple underlying pathologies can be associated with heterogeneous *** neuropsychological profiles associated with FTD spectrum disorders often include executive dysfunction,language impairments and behavioral *** variant FTD is characterized by an initial presentation of changes in personality,behavior and/or emotion,which are often difficult to objectively capture using traditional neuropsychological *** two principal language variants of FTD are Progressive Nonfluent Aphasia(PNFA)with predominant agrammatic/non-fluent impairments and Semantic Dementia(SD)with semantic impairments and visual *** of appropriate endpoints for clinical trials is critical to ensure that the measures are adequately sensitive to detect change,yet specific enough to isolate signal from noise,and acceptable to regulatory *** the anticipated potential for small effect sizes,measures must be able to identify small incremental changes over *** is also imperative that the measures provide adequate coverage of the constructs or behaviors of *** outcome measures should be suitable for repeat administration,yet relatively robust to practice effects to ensure that observed changes reflect true signal variance and not residual effects due to repeated measurement or poor *** facilitate widespread adoption as an endpoint,measures should be readily *** provide several examples of potential global,composite,and individual cognitive measures,as well as behavioral measures promising for FTD *** and application of appropriate trial outcomes is critically important to success in advancing new treatments for FTD patients.

关键词： Frontotemporal dementia Primary endpoints Secondary endpoints Randomized controlled trial Methods

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Identifying PCR primers to facilitate molecular phylogenetics in Caddisflies(Trichoptera)

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Zoological Systematics 2015年第4期40卷 459-469页

作者： Bonnie S.McCullagh Scott A.wissinger jeffrey M.Marcus Department of Biological Sciences University of Manitoba Departments of Biology and Environmental Science Allegheny College Rocky Mountain Biological Laboratory

The molecular phylogenetics of the Lepidoptera （butterflies and moths） is well studied, but that of Trichoptera （caddisflies）, the sister clade of Lepidoptera, is less studied. The PCR primer libraries developed for lepidopteran phylogenetics might work in Trichoptera. DNA from 8 caddisfly species （Asynarchus nigriculus （banks, 1908）, Grammotaulius lorettae Denning, 1941, Hesperophylax occidentalis （banks, 1908）, Limnephilus externus Hagen, 1861, Limnephilus picturatus McLachlan, 1875, Limnephilus secludens banks, 1914, Limnephilus sublunatus Provancher, 1877 and Agrypnia deflata （Milne, 1931）） was used to screen for amplification. 107 primer pairs for 45 nuclear and 3 mitochondrial genes were tested. Primers for 1 new gene （40S ribosomalprotein $2 （RPS2）） and 8 genes previously used in Trichopteran phylogenetics were recovered （16S rRNA, 18S rRNA, carbamoyl-phosphate synthetase （CAD）, cytoehrome oxidase I （CO1）, cytochrome oxidase 11 （COIl）, elongation factor-1 alpha （EF-1 alpha）, isoeitrate dehydrogenase （IDH）, and RNA polymerase-II （POL-I1））. New primer pairs extended the genomic region sampled for many genes. Evolution rates among loci varied by 2 orders of magnitude. Differences among evolution rates and modes of inheritance offer flexible tools for resolving phylogenetic questions and examining genome evolution in the Trichoptera. Screening libraries of PCR primers is a useful approach for identifying PCR primers in related taxa with limited molecular genetic resources.

关键词： Trichoptera molecular phylogenetics mosaic genome evolution rates ofsequence evolution PCR primer library.

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