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Advanced bioactive glue tethering Lubricin/PRG4 to promote integrated healing of avascular meniscus tears

Bioactive Materials 2023年第10期28卷 61-73页

作者： Solaiman tarafder Jaskirti Ghataure David Langford Rachel Brooke Ryunhyung Kim Samantha Lewis Eyen Julian Bensadoun jeffrey t.felix James L.Cook Chang H.Lee Regenerative Engineering Laboratory Columbia University Medical Center630 W.168 St.-VC12-212New YorkNY10032USA thompson Laboratory for Regenerative Orthopaedics Missouri Orthopedic InstituteUniversity of Missouri1100 Virginia AvenueColumbi1MO65212USA

Meniscus injuries are extremely common with approximately one million patients undergoing surgical treatment annually in the U.S. alone, but no regenerative therapy exist. Previously, we showed that controlled applications of connective tissue growth factor (CtGF) and transforming growth factor beta 3 (tGFβ3) via fibrin-based bio-glue facilitate meniscus healing by inducing recruitment and stepwise differentiation of synovial mesenchymal stem/progenitor cells. Here, we first explored the potential of genipin, a natural crosslinker, to enhance fibrin-based glue’s mechanical and degradation properties. In parallel, we identified the harmful effects of lubricin on meniscus healing and investigated the mechanism of lubricin deposition on the injured meniscus surface. We found that the pre-deposition of hyaluronic acid (HA) on the torn meniscus surface mediates lubricin deposition. then we implemented chemical modifications with heparin conjugation and CD44 on our bioactive glue to achieve strong initial bonding and integration of lubricin pre-coated meniscal tissues. Our data suggested that heparin conjugation significantly enhances lubricin-coated meniscal tissues. Similarly, CD44, exhibiting a strong binding affinity to lubricin and hyaluronic acid (HA), further improved the integrated healing of HA/lubricin pre-coated meniscus injuries. these findings may represent an important foundation for developing a translational bio-active glue guiding the regenerative healing of meniscus injuries.

关键词： Knee meniscus Bioactive glue Stem cell recruitment Lubricin

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Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness:Lessons from a contemporary single institution radical prostatectomy series

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Asian Journal of Urology 2015年第1期2卷 53-58页

作者： Zachary B.Koloff Daniel A.Hamstra John t.Wei jeffrey S.Montgomery Scott A.tomlins Angela J.Wu todd M.Morgan Javed Siddiqui Kellie Paich Arul M.Chinnaiyan felix Y.Feng Alon Z.Weizer Lakshmi P.Kunju Brent K.Hollenbeck David C.Miller Ganesh S.Palapattu Rohit Mehra Department of Urology University of Michigan Medical SchoolAnn ArborMIUSA Department of Radiation Oncology University of Michigan Medical SchoolAnn ArborMIUSA Department of Pathology University of Michigan Medical SchoolAnn ArborMIUSA

Objective:to better evaluate tertiary Gleason pattern reporting and to evaluate the impact of tertiary Gleason pattern 5(tP5)on prostate cancer pathological features and biochemical recurrence at our large single ***:We retrospectively reviewed 1962 patients who underwent radical prostatectomy(RP)for prostate cancer;tP5 was reported in 159 cases(8.1%).Men with Gleason score(GS)7 and GS 8 disease were divided into subgroups with and without tP5,and histopathological features were *** analyses were conducted to assess the impact on tP5 on biochemical-free survival(BFS).Results:tumors possessing GS 3+4 with tP5 were more likely to exhibit extraprostatic extension(EPE)and had a larger tumor diameter(tD)than GS 3+4 *** 3+4 with tP5 was also associated with positive surgical margins(SM),seminal vesicle involvement(SVI),and higher pre-operative prostate-specific antigen(PSA)values,but without statistical *** 4+3 with tP5 more commonly presented with EPE,positive SM,SVI,and greater tD and pre-operative PSA level than GS 4+3 *** multivariate analysis,Gleason score,EPE,and tP5 were overall independent risk factors for PSA recurrence in this ***,GS 4+3 with tP5 was associated with shorter time to recurrence versus GS 4+3 ***:Our results emphasize the importance of tP5 and suggest that criteria for tertiary pattern reporting in prostate cancer should be *** studies are needed to evaluate the role of tertiary patterns in prognostic models.

关键词： tertiary Gleason pattern Prostate cancer Prostatic neoplasm Gleason score Radical prostatectomy Disease-free survival

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Current landscape and potential future applications of artificial intelligence in medical physics and radiotherapy

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Artificial Intelligence in Medical Imaging 2021年第2期2卷 37-55页

作者： Wing-Yan Ip Fu-Ki Yeung Shang-Peng felix Yung Hong-Cheung jeffrey Yu tsz-Him So Varut Vardhanabhuti Department of Diagnostic Radiology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Medical Physics and Research Department The Hong Kong Sanitorium&HospitalHong Kong SARChina and Department of Diagnostic RadiologyLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Li Ka Shing Faculty of Medicine The University of Hong KongHong Kong SARChina Department of Clinical Oncology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina

Artificial intelligence(AI)has seen tremendous growth over the past decade and stands to disrupts the medical *** medicine,this has been applied in medical imaging and other digitised medical disciplines,but in more traditional fields like medical physics,the adoption of AI is still at an early *** AI is anticipated to be better than human in certain tasks,with the rapid growth of AI,there is increasing concerns for its *** focus of this paper is on the current landscape and potential future applications of artificial intelligence in medical physics and *** on AI for image acquisition,image segmentation,treatment delivery,quality assurance and outcome prediction will be explored as well as the interaction between human and *** will give insights into how we should approach and use the technology for enhancing the quality of clinical practice.

关键词： Artificial intelligence Medical physics Radiotherapy Image acquisition Image segmentation treatment planning treatment delivery Quality assurance

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