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Hepatocellular carcinoma recurrence after liver transplant:An Australian single-centre study

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World Journal of Transplantation 2025年第1期15卷 105-114页

作者： Matthew G Garas Luis Calzadilla-Bertot Briohny W Smith Luc Delriviere Byron Jaques Lingjun Mou Leon A Adams Gerry C MacQuillan George Garas Gary p jeffrey Michael C Wallace Medical School University of Western AustraliaNedlands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Surgery Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia

BACKGROUND Hepatocellular carcinoma(HCC)is a leading cause of cancer-related deaths *** transplantation(LT)offers the most effective *** recurrence is the strongest risk factor that decreases post-LT survival in patients transplanted for *** rate of HCC recurrence is generally reported as 8%-20%in the *** predictors of HCC have already been researched,however,to our knowledge there are no published studies on this topic using Australian *** To determine the rate and identify predictors of HCC recurrence in a contemporary Western Australian LT *** We performed a retrospective cohort study of all liver transplants in patients with HCC at Sir Charles Gairdner Hospital between 2006 and *** was collected from various health record databases and included recipient demographics,serum biochemistry,radiology,operation notes,explant histopathology and details of *** survival of HCC patients post-LT,stratified for recurrence,was calculated by Kaplan Meier *** and multivariate Cox regression was used to determine predictors of HCC recurrence *** Between 1/1/2006 and 12/31/2021,119 patients were transplanted with HCC.8.4%of subjects developed recurrent HCC after LT with median follow-up time of 5.4 *** median time to recurrence was 2.9 years±0.75 *** comparing baseline characteristics,a greater proportion of subjects with recurrence had common characteristics on explant histopathology,including>3 viable nodules(p=0.001),vascular invasion(p=0.003)and poorly differentiated HCC(p=0.03).Unadjusted survival curves showed lower 1-year,3-year,5-year and 10-year survival rates in subjects with HCC recurrence compared to those without HCC recurrence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respectively;log rank pporary Australian cohort,however it significantly impacted post-LT *** studies are requir

关键词： Liver cancer Recurrence Liver transplantation Hepatocellular carcinoma predictors post-transplant survival Australian data

COHESIVE ZONE FINITE ELEMENT-BASED MODELING OF HYDRAULIC FRACTURES

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Acta Mechanica Solida Sinica 2009年第5期22卷 443-452页

作者： A.p.Bunger Robert G.jeffrey CSIRO petroleum Resources Bayview AvenueClaytonVIC 3168Australia

Hydraulic fracturing is a powerful technology used to stimulate fluid production from reservoirs. The fully 3-D numerical simulation of the hydraulic fracturing process is of great importance to the efficient application of this technology, but is also a great challenge because of the strong nonlinear coupling between the viscous flow of fluid and fracture propagation. By taking advantage of a cohesive zone method to simulate the fracture process, a finite element model based on the existing pore pressure cohesive finite elements has been established to investigate the propagation of a penny-shaped hydraulic fracture in an infinite elastic medium. The effect of cohesive material parameters and fluid viscosity on the hydraulic fracture behaviour has been investigated. Excellent agreement between the finite element results and analytical solutions for the limiting case where the fracture process is dominated by rock fracture toughness demonstrates the ability of the cohesive zone finite element model in simulating the hydraulic fracture growth for this case.

关键词： hydraulic fracture cohesive zone model finite element method

prostate cancer:a presentation of climcopathologic prognosticators among Filipino and American men at radical prostatectomy

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Asian Journal of Andrology 2021年第5期23卷 516-519页

作者： Mayen T Grageda Bonnie Choy Gladell p paner jeffrey S So Institute of pathology St.Luke's Medical Center-Global CityTaguigMetro Manila 1634Philippines Department of pathology The University of ChicagoChicagoIL 60637USA lnstitute of pathology St.Luke's Medical Center-Quezon CityMetro Manila 1112Philippines

Lower incidence and mortality rates from prostate cancer(pCa)have been shown in Asian men in general compared to *** is the first study detailing the clinicopathologic features of resected prostate cancer in Filipino men living in the philippines(pH)_This study investigated the supposed“lower risk”Filipino and“higher risk”American pCa patients from the pH and the United States of America(USA),*** examined 348(176 from pH,172 from USA)radical prostatectomy *** clinicopathologic features of both groups(age at time of diagnosis,preoperative prostate-specific antigen[pre-op pSA]level,Gleason score[GS],Grade groups[GG],margin involvement,extra prostatic extension[EpE],seminal vesicle invasion[SVI],and regional lymph node[RLN]metastasis)were *** of seven prognosticators examined were more strongly associated with Filipinos than with *** were older at diagnosis(pH:64.32±6.56 years vs USA:58.98±8.08 years)and had higher pre-op pSA levels(pH:21.39±46.40 ng ml^(-1) vs USA:7.63±9.19 ng ml^(-1)).Filipino men had more advanced grade,GG 2 with minor pattern 5(pH:6.2%vs USA:2.9%)and GG 5(pH:14.8%vs USA:3.5%).Likewise,other adverse pathological features in margin positivity(pH:52.3%vs USA:23.8%),focal EpE(pH:14.2% vs USA:2.3%),and SVI(pH:17.1%vs USA:5.8%)were more commonly observed in *** study reveals the prognostic disadvantage of Filipinos versus Americans and highlights an important difference of Filipinos from other studied Asian ethnicities that have repeatedly been shown to have lower-risk *** study,the first on Filipino pCa patients with Rp,suggests the need to modify Western-based risk stratification when employed in other countries like the pH.

关键词： clinicopathologic features Filipino prostate cancer radical prostatectomy

The August 14, 2003 blackout andits importance to China

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华东电力 2004年第1期32卷 2-6页

作者： By p. jeffrey palermo Executive Consultant KEMA Inc

本文作者p .jeffreypaleimo先生系美国KEMA公司的资深电力专家 ,2 0 0 4年 1月在上海就美加8·14大停电事故及中国电网的安全运行同我国同行进行了交流、探讨。首篇刊出特邀p jeffreypaleimo就8·14美加大停电原因、涉及的电力体制以及... 详细信息

本文作者p .jeffreypaleimo先生系美国KEMA公司的资深电力专家 ,2 0 0 4年 1月在上海就美加8·14大停电事故及中国电网的安全运行同我国同行进行了交流、探讨。首篇刊出特邀p jeffreypaleimo就8·14美加大停电原因、涉及的电力体制以及中国和亚洲的电力市场应引以为鉴作了专题论述。结合美国国内的各新闻报道和评论 ,以美加大停电特别工作小组的中期报告作为依据 ,归纳了大停电发生的原因 ,特别指出美国现行电力体制中出现的对长距离输电时的地区由于协调控制薄弱 ,增加了发生大停电的可能性。指出 ,在中国东部地区 ,国民经济每年以 10 %以上的速度发展 ,对电力系统发展具有很高的要求是必然的 ,因而对现有电力系统要不断重新评估分析 ,设计中要考虑隔离点 (breakpoints) ,保证必要时以孤岛模式运行。

关键词：电力系统电网安全运行停电事故

Complete loss of RNA editing from the plastid genome and most highly expressed mitochondrial genes of Welwitschia mirabilis

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Science China(Life Sciences) 2019年第4期62卷 498-506页

作者： Weishu Fan Wenhu Guo Lexis Funk jeffrey p.Mower Andan Zhu Germplasm Bank of Wild Species Kunming Institute of Botany Chinese Academy of Sciences Center for plant Science Innovation University of Nebraska Department of Agronomy and Horticulture University of Nebraska School of Biological Sciences University of Nebraska

Comparative genomics among gymnosperms suggested extensive loss of mitochondrial RNA editing sites from Welwitschia mirabilis based on predictive analysis. However, empirical or transcriptome data to confirm this massive loss event are lacking,and the potential mechanisms of RNA site loss are unclear. By comparing genomic sequences with transcriptomic and reversetranscription pCR sequencing data, we performed a comprehensive analysis of the pattern of RNA editing in the mitochondrial and plastid genomes(mitogenome and plastome, respectively) of W. mirabilis and a second gymnosperm, Ginkgo biloba. For ***, we found only 99 editing sites located in 13 protein-coding genes in the mitogenome and a complete loss of RNA editing from the plastome. The few genes having high editing frequency in the Welwitschia mitogenome showed a strong negative correlation with gene expression level. Comparative analyses with G. biloba, containing 1,405 mitochondrial and 345 plastid editing sites, revealed that the editing loss from W. mirabilis is mainly due to the substitution of editable cytidines to thymidines at the genomic level, which could be caused by retroprocessing. Our result is the first study to uncover massive editing loss from both the mitogenome and plastome in a single genus. Furthermore, our results suggest that gene expression level and retroprocessing both contributed to the evolution of RNA editing in plant organellar genomes.

关键词： RNA editing massive loss expression levels organelle genomes Welwitschia

Building momentum for sustainable behaviors in developing regions using Locally Managed Decentralized Circular Economy principles

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Chinese Journal of Chemical Engineering 2019年第7期27卷 1566-1571页

作者： Chandni Joshi jeffrey Seay Department of Chemical and Materials Engineering University of Kentucky

Despite the current threat from climate change,plastic collecting in the world's oceans,and the steady loss of biodiversity,the world continually fails to take action with regard to our rapidly changing ***,waiting on governments to act is no longer a viable *** change is needed and the pace of diplomacy is simply too *** governments are reactionary and taking action to solve future problems is not a priority,even as the threat of potential ecological catastrophe draws ever *** is in the hands of individuals,and it is our decisions and behaviors that will influence the future of our planet and our ability to inhabit ***,building momentum for sustainable behavior must begin with *** neoliberal approach to environmental protection posits that individuals are motivated by rational self-interest,and that economic incentives are necessary to achieve environmental ***,recent research suggests that monetary gain alone actually negatively impacts behavior,and often neglects the rural *** a result,models for projects designed to benefit the environment need more than just a monetary incentive,they must incorporate all three pillars of sustainability:environment,economy and *** approach for building momentum for sustainable behavior with regard to municipal solid waste management,particularly in the developing world,is by implementing Locally Managed Decentralized Circular Economy(LMDCE)*** contribution will describe the role behavioral economics plays in the choices made by producers and *** results of a case study on applying LMDCE principles in Uganda to manage waste plastic accumulation by conversion to fuel oil will be presented.

关键词： pyrolysis Fuel pollution Appropriate technology Behavioral economics Municipal solid waste

The kinesin-like proteins, KAC1/2, regulate actin dynamics underlying chloroplast light-avoidance in physcomitrella patens

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Journal of Integrative plant Biology 2015年第1期57卷 106-119页

作者： Zhiyuan Shen Yen-Chen Liu jeffrey p.Bibeau Kyle p.Lemoi Erkan Tüzel Luis Vidali Department of Biology and Biotechnology Worcester Polytechnic Institute Department of physics Worcester Polytechnic Institute

In plants, light determines chloroplast position; these organelles show avoidance and accumulation re- sponses in high and low fluence-rate light, respectively. Chloroplast motility in response to light is driven by cytoskeletal elements. The actin cytoskeleton mediates chloroplast photorelocation responses in Arabidopsis thali- ana. In contrast, in the moss physcomitrella patens, both, actin filaments and microtubules can transport chloroplasts. Because of the surprising evidence that two kinesin-like proteins （called KACs） are important for actin-dependent chloroplast photorelocation in vascular plants, we wanted to determine the cytoskeletal system responsible for the function of these proteins in moss. We performed gene- specific silencing using RNA interference in p. patens. We confirmed existing reports using gene knockouts, that ppKAC1 and ppKAC2 are required for chloroplast dispersion under uniform white light conditions, and that the two proteins are functionally equivalent. To address the specificcytoskeletal elements responsible for motility, this loss-of- function approach was combined with cytoskeleton-targeted drug studies. We found that, in p. patens, these KACs mediate the chloroplast light-avoidance response in an actin filament- dependent, rather than a microtubule-dependent manner. Using correlation-decay analysis of cytoskeletal dynamics, we found that ppKAC stabilizes cortical actin filaments, but has no effect on microtubule dynamics.

关键词： Actin filaments cytoskeleton intracellular transport kinesin-14 light-avoidance response microtubule moss RNAi

Ethanolic extract of puhuang(pollen Typhae) modulates lipopolysaccharide-induced inflammatory response through inducible nitric oxide synthase/cyclooxygenase-2 signaling in RAW 264.7 macrophages

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Journal of Traditional Chinese Medicine 2021年第6期41卷 836-844页

作者： CHEN Tzufan CHEN Chuntzu HUANG Yuanli BASKARAN Rathinasamy TSAI jeffrey J.p. HU Rouhmei Department of Biotechnology Asia UniversityTaichung 41354China Taiwan Department of Bioinformatics and Medical Engineering Asia UniversityTaichung 41354China Taiwan

OBJECTIVE:To evaluate the immune modulatory response of puhuang(pollen Typhae),ethanolic extract of dried pollens(Tp-E)and charcoal activated pollens(CTp-E)were used for their phytochemical evaluation and their modulatory response against lipopolysaccharide(LpS)induced inflammatory activity on RAW264.7 macrophage ***:Biochemical assays were carried out to quantify the 1,1-Diphenyl-2-picrylhydrazyl Radical Scavenging Activity,Reducing power,Ferrous ion chelating ability and total polyphenol content and ***-toxic dose of the extract(Tp-E and CTp-E)was chosen based on 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** of Tp-E and CTp-E on lipopolysaccharides-induced inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2)expression was measured by Western blot and quantitative pCR(q RT-pCR).Expression of inflammatory cytokines,such as interleukins(IL-1βand IL-6)and tumor necrosis factorα(TNF-α),was quantified using q ***-activated protein kinase pathway was analyzed using Western ***:phytochemical analysis revealed that both Tp-E and CTp-E have strong antioxidant activities and high flavonoid and phenolic ***-E and CTp-E effectively inhibit the expression of i NOS and COX-2,thereby inhibiting its downstream proinflammatory regulators,the extracellular signal-related kinase-1/2,that decreases the expression of IL-1β,IL-6 and TNF-α.CONCLUSION:phytochemical constituents present in Typha angustifolia Linn could be used for treating inflammation-related diseases.

关键词： Typha angustifolia lipopolysaccharides inflammation NF-kappa B mitogen-activated protein kinases

Today’s protected areas:supporting a more sustainable future for humanity

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Integrative Zoology 2020年第6期15卷 603-616页

作者： jeffrey A.MCNEELY Society for Conservation Biology Asia Section Cha-AmPetchburiThailand

Nature provides significant benefits to people,especially those living in and around protected *** services from protected areas include producing wild food,supporting biodiversity and water cycles,regulating climate,and providing cultural services like better health,tourism,and legacy for future *** economic terms,the flows of ecosystem services provided by protected areas are worth hundreds of billions of dollars each year,well justifying the costs of managing these sites,but protected areas are suffering from environmental problems such as impacts from human population growth,rural poverty,growing demands for natural resources,land use change that degrades ecosystem productivity,invasive non-native species that harm natural ecosystems,and climate change that is affecting all *** these linked challenges will require mobilizing all parts of the economy,including the protected area *** example,protected areas can take a leadership role in rural development,expand the conservation estate to half of the planet through connectivity and improved management of more of the non-agricultural land,enhance the prominent role of protected areas in contributing to climate change mitigation and adaptation,encourage productive research on applying modern technology to protected areas management,seek broader private sector participation in conserving biodiversity and ecosystem services,and include protected areas as relevant parties in relevant trade and other international *** protected area managers embrace this broader role,they will find enthusiastic public support for this contribution to a sustainable human society.

关键词： Aichi target climate change economic benefit ecosystem service landscape conservation protected area