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NKR-p1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections

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Cellular & Molecular Immunology 2019年第11期16卷 868-877页

作者： Elias Abou-Samra Zachary Hickey Oscar A.Aguilar Michal Scur Ahmad Bakur Mahmoud Sergey pyatibrat Megan M.Tu jeffrey Francispillai Arthur Mortha James R.Carlyle Mir Munir A.Rahim Andrew p.Makrigiannis Department of Biochemistry Microbiology and ImmunologyUniversity of Ottawa451 Smyth RoadOttawaON K1H 8M5Canada Department of Immunology University of Toronto1 King’s College CircleTorontoON M5S 1A8Canada Sunnybrook Research Institute 2075 Bayview AvenueTorontoON M4N 3M5Canada Department of Microbiology and Immunology Dalhousie University5850 College StreetHalifaxNS B3H 4R2Canada College of Applied Medical Sciences Taibah UniversityMadinah MunawwarahSaudi Arabia Division of Anatomical pathology Department of Pathology and Laboratory MedicineThe Ottawa HospitalUniversity of Ottawa501 Smyth RoadOttawaON K1H 8L6Canada

Helper-type innate lymphoid cells(ILC)play an important role in intestinal *** of the NKR-p1 gene family are expressed in various innate immune cells,including natural killer(NK)cells,and their cognate Clr ligand family members are expressed in various specialized tissues,including the intestinal epithelium,where they may play an important role in mucosalassociated innate immune *** this study,we show that the inhibitory NKR-p1B receptor,but not the Ly49 receptor,is expressed in gut-resident NK cells,ILC,and a subset ofγδT cells in a tissue-specific ***3 cells constitute the predominant cell subset expressing NKR-p1B in the gut lamina *** known NKR-p1B ligand Clr-b is broadly expressed in gut-associated cells of hematopoietic *** genetic deletion of NKR-p1B results in a higher frequency and number of ILC3 andγδT cells in the gut lamina ***,the function of gut-resident ILC3,NK,andγδT cells in NKR-p1B-deficient mice is impaired during gastrointestinal tract infection by Citrobacter rodentium or Salmonella typhimurium,resulting in increased systemic bacterial dissemination in NKR-p1B-deficient *** findings highlight the role of the NKR-p1B:Clr-b recognition system in the modulation of intestinal innate immune cell functions.

关键词： Innate lymphoid cells Natural killer cells Gut-associated immune cells NKR-p1B receptor Innate immunity

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The Thermoelectric properties of n-Type Bismuth Telluride:Bismuth Selenide Alloys Bi_(2)Te_(3−x)Se_(x)

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Research 2020年第1期2020卷 724-738页

作者： Ian T.Witting Francesco Ricci Thomas C.Chasapis Geoffroy Hautier G.jeffrey Snyder Department of Materials Science and Engineering Northwestern University2220 Campus DriveCook Hall 2036EvanstonIL 60208USA Institute of Condensed Matter and Nanosciences UniversitéCatholique de LouvainLouvain-la-Neuve 1348Belgium

Alloying bismuth telluride with antimony telluride and bismuth selenide for p-and n-type materials,respectively,improves the thermoelectric quality factor for use in room temperature *** the electronic and thermal transports can vary substantially,the alloy composition is a key engineering *** n-type Bi_(2)Te_(3-x)Se_(x)alloy lags its p-type counterpart in thermoelectric performance and does not lend itself as readily to simple transport modeling which complicates *** literature data with recent results across the entire alloy composition range,the complex electronic structure dynamics and trends in lattice thermal conductivity are ***-orbit interaction plays a critical role in determining the position and degeneracy of the various conduction band *** behavior is incorporated into a two-band effective mass model to estimate the transport parameters in each *** alloy scattering model is utilized to demonstrate how phonon scattering behaves differently on either side of the intermediate ordered compound Bi2Te2Se due to chalcogen site occupancy *** parametrization of the electronic and thermal transports presented can be used in future optimization efforts.

关键词： alloy bismuth transport

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Visual Basic 6数据库访问技术

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丛书名：软件开发技术丛书

1999年

作者：（美）（J.p.麦克马纳斯）jeffrey p.McManus 赵军锁等译

Microsoft公司最新推出的

ISBN: (纸本)7111072669

Microsoft公司最新推出的

关键词：数据库管理系统 BASIC语言程序设计

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paths to low-cost hydrogen energy at a scale for transportation applications in the USA and China via liquid-hydrogen distribution networks

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Clean Energy 2020年第1期4卷 26-47页

作者： Xianming Jimmy Li jeffrey D.Allen Jerad A.Stager Anthony Y.Ku NICE America Research 2091 Stierlin CtMountain ViewCA 94043USA National Institute of Clean-and-Low-Carbon Energy PO Box 001Future Science&Technology CityChangping DistrictBeijing 102209P.R.China

The cost of delivered H2 using the liquid-distribution pathway will approach$4.3-8.0/kg in the USA and 26-52 RMB/kg in China by around 2030,assuming large-scale ***,hydrogen as an industrial gas and a chemical feedstock has enjoyed a long and successful ***,it has been slow to take off as an energy carrier for transportation,despite its benefits in energy diversity,security and environmental stewardship.A key reason for this lack of progress is that the cost is currently too high to displace petroleum-based *** paper reviews the prospects for hydrogen as an energy carrier for transportation,clarifies the current drivers for cost in the USA and China,and shows the potential for a liquid-hydrogen supply chain to reduce the costs of delivered *** and economic trade-offs between individual steps in the supply chain(***,transportation,refuelling)are examined and used to show that liquid-H2(LH2)distribution approaches offer a path to reducing the delivery cost of H2 to the point at which it could be competitive with gasoline and diesel fuel.

关键词： fuel hydrogen liquid transportation infrastructure refuelling hydrogen-distribution pathway

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Design of 77GHz Vivaldi Antenna for Millimeter Wave Communication

Design of 77GHz Vivaldi Antenna for Millimeter Wave Communic...

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2002 3rd International Conference on Microwave and Millimeter Wave Technology

作者： L p Chong p T Ng Wen Wang jeffrey S Fu School of Electrical and Electronics Engineering Nanyang Technological University Nanyang Avenue Singapore 639798

＜正＞The antenna was fed by a unilateral fin line and then transmitted to its taper slotline *** design and fabrication of the substrate containing the fin line transmission section and tapered slot rediating section were carried *** waveguides were also designed to house the fin line section of the substrate. Simulations were carried out using XFDTD software to determine the radiating characteristic of the antenna.A set of S-parameter and polarization curves of designed 77GHz were shown.

关键词： Vivaldi antennas Millimeter wave communication Frequency Impedance Millimeter wave technology Slot antennas Slotline Dielectric substrates Dielectric constant Dielectric losses

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Dyslipidemia in Adults with Type 2 Diabetes in a Rural Community in Ganadougou, Mali: A Cross-Sectional Study

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Journal of Diabetes Mellitus 2024年第2期14卷 133-152页

作者： Abdoulaye Diawara Djibril Mamadou Coulibaly Drissa Kone Mama A. Traore Drissa Konaté Dicko S. Bazi Oumar Kassogue Djeneba Sylla Fatoumata Gniné Fofana Oudou Diabaté Mariam Traore Ibrahim Antoine Nieantao Kaly Keїta Mamadou Diarra Olivia Smith Jian Li Cheickna Cisse Talib Yusuf Abbas Crystal Zheng Segun Fatumo Kassim Traore Mamadou Wele Mahamadou Diakité Seydou O. Doumbia jeffrey G. Shaffer University of Sciences Techniques and Technologies of Bamako Bamako Mali National Federation of Community Health Associations Bamako Mali Department of Tropical Medicine Medical Microbiology & Pharmacology John A. Burns School of Medicine University of Hawaii Manoa Honolulu USA Department Biostatistics and Data Science School of Public Health and Tropical Medicine Tulane University New Orleans USA Department of Biotechnology and Computer Science Burhani College Mazgaon Mumbai India School of Medicine Tulane University New Orleans USA Medical Research Council Uganda Virus Research Institute Entebbe Uganda London School of Hygiene and Tropical Medicine London UK Departement of Biochemistry and Genetics Duquesne University College of Medicine Pittsburgh USA

Dyslipidemia is a disorder where abnormally lipid concentrations circulate in the bloodstream. The disorder is common in type 2 diabetics (T2D) and is linked with T2D comorbidities, particularly cardiovascular disease. Dyslipidemia in T2D is typically characterized by elevated plasma triglyceride and low high-density lipoprotein cholesterol (HDL-C) levels. There is a significant gap in the literature regarding dyslipidemia in rural parts of Africa, where lipid profiles may not be captured through routine surveillance. This study aimed to characterize the prevalence and demo-graphic profile of dyslipidemia in T2D in the rural community of Ganadougou, Mali. We performed a cross-sectional study of 104 subjects with T2D in Ganadougou between November 2021 and March 2022. Demographic and lipid profiles were collected through cross-sectional surveys and serological analyses. The overall prevalence of dyslipidemia in T2D patients was 87.5% (91/104), which did not differ by sex (p = .368). High low-density lipoprotein cholesterol (LDL-C) was the most common lipid abnormality (78.9%, [82/104]). Dyslipidemia was associated with age and hypertension status (p = .013 and.036, respectively). High total and high LDL-C parameters were significantly associated with hypertension (p = .029 and .006, respectively). In low-resource settings such as rural Mali, there is a critical need to improve infrastructure for routine dyslipidemia screening to guide its prevention and intervention approaches. The high rates of dyslipidemia observed in Gandadougou, consistent with concomitant increases in cardiovascular diseases in Africa suggest that lipid profile assessments should be incorporated into routine medical care for T2D patients in African rural settings.

关键词： Cholesterol Cross-Sectional Study Dyslipidemia Lipids Mali Type 2 Diabetes

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Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum

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Translational Neurodegeneration 2023年第1期12卷 50-69页

作者： Ting Shen Jacob W.Vogel jeffrey Duda jeffrey S.phillips philip ACook James Gee Lauren Elman Colin Quinn Defne A.Amado Michael Baer Lauren Massimo Murray Grossman David J.Irwin Corey T.McMillan penn Frontotemporal Degeneration Center Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Clinical Sciences SciLifeLabLund University22242 LundSweden penn Image Computing and Science Lab(pICSL) Department of RadiologyPerelman School of MedicineUniversity of Penn-sylvaniaPhiladelphiaPA 19104USA Department of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Digital Neuropathology Laboratory Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA.

Background TDp-43 proteinopathies represent a spectrum of neurological disorders,anchored clinically on either end by amyotrophic lateral sclerosis(ALS)and frontotemporal degeneration(FTD).The ALS-FTD spectrum exhibits a diverse range of clinical presentations with overlapping phenotypes,highlighting its *** study was aimed to use disease progression modeling to identify novel data-driven spatial and temporal subtypes of brain atrophy and its progression in the ALS-FTD *** We used a data-driven procedure to identify 13 anatomic clusters of brain volume for 57 behavioral variant FTD(bvFTD;with either autopsy-confirmed TDp-43 or TDp-43 proteinopathy-associated genetic variants),103 ALS,and 47 ALS-FTD patients with likely TDp-43.A Subtype and Stage Inference(SuStaIn)model was trained to identify subtypes of individuals along the ALS-FTD spectrum with distinct brain atrophy patterns,and we related subtypes and stages to clinical,genetic,and neuropathological features of *** SuStaIn identified three novel subtypes:two disease subtypes with predominant brain atrophy in either prefrontal/somatomotor regions or limbic-related regions,and a normal-appearing group without obvious brain *** limbic-predominant subtype tended to present with more impaired cognition,higher frequencies of pathogenic variants in TBK1 and TARDBp genes,and a higher proportion of TDp-43 types B,E and *** contrast,the prefrontal/somatomotor-predominant subtype had higher frequencies of pathogenic variants in C9orf72 and GRN genes and higher proportion of TDp-43 type *** normal-appearing brain group showed higher frequency of ALS relative to ALS-FTD and bvFTD patients,higher cognitive capacity,higher proportion of lower motor neuron onset,milder motor symptoms,and lower frequencies of genetic pathogenic *** overall SuStaIn stages also correlated with evidence for clinical progression including longer disease duration,higher King’s stage,and cog

关键词： Amyotrophic lateral sclerosis Frontotemporal degeneration Disease heterogeneity SuStaIn model

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Using OD Estimation Techniques to Determine Freight Factors in a Medium Sized Community

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Journal of Transportation Technologies 2013年第1期3卷 39-43页

作者： Michael D. Anderson jeffrey p. Wilson Gregory A. Harris Department of Civil and Environmental Engineering University of Alabama in Huntsville Huntsville USA

Developing an understanding of the socio-economic factors that can be used to generate truck trip productions and attractions in small and medium sized communities can be used to improve travel models and provide better information upon which infrastructure decisions are made. Unfortunately, it is difficult to collect this data in a timely, cost-effective manner. This paper presents a methodology that uses matrix estimation techniques from existing traffic counts to develop origin/destination pairs that can be used to statistically develop truck trip generation models. A case study is presented and a model is presented for one smaller urban community.

关键词： Freight Modeling Origin/Destination Estimating

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合并中的俄亥俄医科大学与图兰朵大学

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复旦教育论坛 2008年第4期6卷 87-93页

作者： McGinnis Ronald A McMillen William Gold jeffrey p 梅人朗(编译) 不详复旦大学公共卫生学院上海200032

本文作者介绍了美国俄亥俄医科大学与图兰朵大学实现历史性合并的过程,提出了两校作出合并决定的背景。作者也评述了合并过程的管理结构和计划结构,讨论了新图兰朵大学面临的挑战。

关键词：大学医学院联合合并

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阿拉斯加东南部温带雨林加氏和肯氏鹿鼠密度与微生境利用的相关性(英文)

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动物学报 2005年第6期51卷 973-988页

作者： Winston p. SMITH Scott M. GENDE jeffrey V. NICHOLS USDA Forest Service Pacific Northwest Research Station Forestry Sciences Laboratory 2770 Sherwood Lane-Suite 2A Juneau Alaska 99801 USA National park Service Glacier Bay Field Station 3100 National Park Road Juneau Alaska 99801 USA Alaska Department of Fish and Game Sport Fish Division 802 Third Street Douglas Alaska 99824 USA

为了验证对阿拉斯加东南部温带雨林中有关栖息地关系的预测,我们于1999年和2000年8-9月以及1999年和2000年4-5月研究了亚历山大群岛加氏(Clethrionomys gapperi)和肯氏鹿鼠(peromyscus keeni)种群。我们测量了26个植被和结构特征以检... 详细信息

为了验证对阿拉斯加东南部温带雨林中有关栖息地关系的预测,我们于1999年和2000年8-9月以及1999年和2000年4-5月研究了亚历山大群岛加氏(Clethrionomys gapperi)和肯氏鹿鼠(peromyscus keeni)种群。我们测量了26个植被和结构特征以检验林隙老龄生长林、多时代老龄生长林、采伐前壮龄(23岁)生长林和泥炭混交针叶林的丰富度与微栖息地利用的相关性。微栖息地利用随季节和栖息地而变化,但加氏与林下落叶灌木覆盖度的正相关最显著。肯氏鹿鼠利用的微环境的林地有较少的苔藓,但是林隙与抓获加氏的概率有直接关系。两种鼠在两个季节的密度与林下腐朽的倒木直接相关。春季的肯氏鹿鼠密度说明加氏密度变化的62%,说明肯氏鹿鼠密度变化的89%。我们的结果印证了早期对阿拉斯加东南部肯氏鹿鼠在各种栖息地尤其早期的演替林中兴旺时的研究;但偏离了西部地貌中肯氏鹿鼠种群在晚期演替针叶林中达到最高密度的普遍结论。与北美西北部其它地区的种群不同,加氏能持久生活在上层被砍伐的雨林板块中。泥炭针叶混交林对两种鼠的繁殖种群几乎没有贡献,因而不可能减轻对多产的老龄生长雨林大规模皆伐所造成的影响。

关键词：阿拉斯加群岛加氏[鼠平] 密度生态相关性栖息地分布微栖息地利用肯氏鹿鼠阿拉斯加东南部温带雨林兰格尔岛

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