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Plaque herniation after stenting the culprit lesion with myocardial bridging in ST elevation myocardial infarction: A case report

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World Journal of Cardiology 2020年第2期12卷 91-96页

作者： jeffrey ma Gregory m Gustafson Xuming Dai Division of Cardiology Theresa and Eugene M.Lang Center for Research and Education New York Presbyterian–Queens Hospital

BACKGROUND myocardial bridging(mB)is increasingly recognized to stimulate atherogenesis,which may contribute to an acute coronary *** the coronary segment with mB has been recognized to have an increased risk of in-stent restenosis,stent fracture and coronary *** safety and efficacy of stenting the culprit lesion with overlaying mB in ST elevation myocardial infarction(STEmI)as primary reperfusion therapy has not been *** SUmmARY We reported a patient who presented with inferior STEmI with a culprit lesion of an acute thrombotic occlusion in the right coronary artery and thrombolysis and thrombin inhibition in myocardial infarction 0 *** the stent placement during primary percutaneous coronary intervention,intravascular ultrasound revealed mB overlying the stented segment where heavy atherosclerotic plaque were *** due to the combination of plaque herniation or prolapse caused by mB,as well as local increased inflammation and thrombogenicity,acute stent thrombosis occurred at this region,which led to acute stent *** patient required an emergent repeated cardiac catheterization and placing a second layer of stent to enhance the radial strength and reduce the inter-strut *** Plaque herniation or prolapse after stenting a mB segment in STEmI is a potential etiology for acute stent failure.

关键词： Case report ST elevation myocardial infarction myocardial bridging Plaque herniation Plaque prolapse Intravascular ultrasound Acute stent thrombosis

Lessons from a marine Spatial Planning data management process for Ireland

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International Journal of Digital Earth 2021年第2期14卷 139-157页

作者： Sarah Flynn Will meaney Adam m.Leadbetter jeffrey P.Fisher Caitriona Nic Aonghusa marine Institute RinvilleOranmoreCounty GalwayH91 R673Ireland

This paper presents a framework containing ten components to deliver a data management process for the storage and management of data used for marine Spatial Planning(mSP)in *** work includes a data process flow and a recommended solution *** architecture includes a central data catalogue and a spatial storage *** components of the process are presented to maximise the reuse potential of any dataset within an mSP *** terms‘Suitability’and‘Readiness’in the mSP context are offered as both formal and considered assessments of data,as is the applicability of a data stewardship maturity *** data contained in such a storage system can be published externally to potential consumers of these data is also *** process presents a means of managing data and metadata to ensure data lineage is optimised by carrying information about the origin of and the processing applied to the data;to evaluate the quality and relevance of geospatial datasets for use in mSP decisions in *** process was piloted in the National marine Planning Framework for Ireland in the development of draft map products;feedback from the public consultation is ongoing and not presented.

关键词： marine Spatial Planning mSP marine data storage&management data governance reuse&integration

Ultra-high speed holographic shape and displacement measurements in the hearing sciences

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Light(Advanced manufacturing) 2022年第2期3卷 1-14页

作者： Haimi Tang Pavel Psota John J.Rosowski Cosme Furlong jeffrey Tao Cheng Center for Holographic Studies and Laser micro-mechaTronics Worcester Polytechnic InstituteWorcesterMA USA01609 mechanical Engineering Department Worcester Polytechnic InstituteWorcesterMA USA01609 Faculty of mechatronics Informatics and Interdisciplinary StudiesTechnical University of LiberecLiberecCzech Republic46117 Eaton-Peabody Laboratory Massachusetts Eye and EarBostonMA USA02114 Department of Otolaryngology-Head and Neck Surgery Harvard Medical SchoolBostonMAUSA02115

The auditory system of mammals enables the perception of sound from our surrounding *** some of the smallest bones in the body,the ear transduces complex acoustic signals with high-temporal sensitivity to complex mechanical vibrations with magnitudes as small as tens of *** of the shape and acoustically induced motions of different components of the ear are essential if we are to expand our understanding of hearing mechanisms,and also provide quantitative information for the development of numerical ear models that can be used to improve hearing protection,clinical diagnosis,and repair of damaged or diseased *** are developing digital holographic methods and instrumentation using an ultra-high speed camera to measure shape and acoustically-induced motions in the middle *** we study the eardrum,the first structure of the middle ear which initializes the acoustic-mechanical transduction of sound for *** measurement system is capable of performing holographic measurement at rates up to 2.1 m frames per *** shape measurement modalities had previously been implemented into our holographic systems:(1)a multi-wavelength method with a wavelength tunable laser;and(2)a multi-angle illumination method with a single wavelength *** this paper,we present a third method using a miniaturized fringe projection system with a microelectromechanical system(mEmS)***,we optimize the processing of large data sets of holographic displacement measurements using a vectorized Pearson's correlation *** validate and compare the shape and displacement measurements of our methodologies using a National Institute of Standards and Technology(NIST)traceable gauge and sound-activated latex membranes and human eardrums.

关键词： Ultra-high speed digital holography microelectromechanical systems(mEmS) miniaturized Fringe Projection middle-ear mechanics Shape and displacement measurements.

Functionalized, carbon nanotube material for the catalytic degradation of organophosphate nerve agents

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Nano Research 2014年第3期7卷 390-398页

作者： mark m. Bailey John m. Heddleston jeffrey Davis Jessica L. Staymates Angela R. Hight Walker National Institute of Standards and Technology (NIST) Semiconductor and Dimensional Metrology Division Gaithersburg MD USA National Institute of Standards and Technology (NIST) Materials Measurement Science Division Gaithersburg MD USA Present Address: United States Army medical Research Institute of Infectious Diseases (USAmRIID) Center for Aerobiological Sciences Fort Detrick MD USA

Recent world events have emphasized the need to develop innovative, functional materials that will safely neutralize chemical warfare (CW) agents in situ to protect military personnel and civilians from dermal exposure. Here, we demonstrate the efficacy of a novel, proof-of-concept design for a Cu-containing catalyst, chemically bonded to a single-wall carbon nanotube (SWCNT) structural support, to effectively degrade an organophosphate simulant. SWCNTs have high tensile strength and are flexible and light-weight, which make them a desirable structural component for unique, fabric-like materials. This study aims to develop a self-decontaminating, carbon nanotube-derived material that can ultimately be incorporated into a wearable fabric or protective material to minimize dermal exposure to organophosphate nerve agents and to prevent accidental exposure during decontamination procedures. Carboxylated SWCNTs were functionalized with a polymer, which contained Cu-chelating bipyridine groups, and their catalytic activity against an organophosphate simulant was measured over time. The catalytically active, functionalized nanomaterial was characterized using X-ray fluorescence and Raman spectroscopy. Assuming zeroth-order reaction kinetics, the hydrolysis rate of the organophosphate simulant, as monitored by UV-vis absorption in the presence of the catalytically active nanomaterial, was 63 times faster than the uncatalyzed hydrolysis rate for a sample containing only carboxylated SWCNTs or a control sample containing no added nanotube materials.

关键词：碳纳米管材料有机磷酸酯催化降解神经毒剂单壁碳纳米管功能化 X射线荧光光谱催化活性

Trends with neoadjuvant radiotherapy and clinical staging for those with rectal malignancies

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World Journal of Gastrointestinal Surgery 2017年第4期9卷 97-102页

作者： Sanjay S Reddy Beth Handorf jeffrey m Farma Elin R Sigurdson Department of Surgical Oncology Fox Chase Cancer Center Department of Biostatistics Fox Chase Cancer Center

AIm To see how patterns of care changed over time,and how institution type effected these *** A retrospective analysis was performed using the National Cancer Database,looking at all patients that were diagnosed with rectal cancer from 1998 to 2011. We tested differences in rates of treatment and stage migration using χ~2 tests and logistic regression models. RESULTS A review of ninety thousand five hundred and ninety four subjects underwent multimodality therapy for cancer of the rectum. Staging and response to treatment varied greatly between centers. Forty-six percent of the time staging was missing in academic practices,vs fiftyfour percent of the time in community centers(P mia,whereas only fifteen percent were down-staged and 8% up-staged in community practices(P ment varied greatly. Fifty-one percent received therapy before surgery in academic centers in 1998. Thirty-nine percent followed this pattern in the same year in the community(P mic centers,vs eighty-four percent in the community(P mia,although an increase was seen in both center types. CONCLUSION From the study dates of 1998 to 2011,preoperative treatment with radiation has been on the rise. There is certainly an increased rate of use of radiation in academia,however,this trend is also seen in the community. Practice patterns have evolved over time,although rates of assigning clinical stage are grossly underreported prior to initiation of preoperative therapy.

关键词： Neoadjuvant 治疗社区直肠的癌症学术

microeconomics / 2nd ed.

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Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant *** infection with osseointegration in murine models of implant-associated osteomyelitis

2001年

作者： jeffrey m. Perloff.

来源：畅想之星图书光盘版（南... 评论

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Bone Research 2023年第4期11卷 751-763页

作者： Youliang Ren Jason Weeks Thomas Xue Joshua Rainbolt Karen L.de mesy Bentley Ye Shu Yuting Liu Elysia masters Philip Cherian Charles E.mcKenna jeffrey Neighbors Frank H.Ebetino Edward m.Schwarz Shuting Sun Chao Xie Center for musculoskeletal Research University of Rochester Medical CenterRochesterNY 14642USA Department of Orthopaedics University of Rochester Medical CenterRochesterNY 14642USA Department of Pathology and Center for Advanced Research Technologies University of Rochester Medical CenterRochesterNY 14642USA BioVinc LLCPasadenaCA 91107USA Department of Chemistry University of Southern CaliforniaLos AngelesCA 90089USA Department of Pharmacology Pennsylvania State UniversityHersheyPA 17033USA Department of Chemistry University of RochesterRoche

Eradication of mRSA osteomyelitis requires elimination of distinct *** overcome this,we developed bisphosphonateconjugated sitafloxacin(BCS,BV600072)and hydroxybisphosphonate-conjugate sitafloxacin(HBCS,BV63072),which achieve“target-and-release”drug delivery proximal to the bone infection and have prophylactic efficacy against mRSA static biofilm in vitro and in *** we evaluated their therapeutic efficacy in a murine 1-stage exchange femoral plate model with bioluminescent mRSA(USA300LAC::lux).Osteomyelitis was confirmed by CFU on the explants and longitudinal bioluminescent imaging(BLI)after debridement and implant exchange surgery on day 7,and mice were randomized into seven groups:1)Baseline(harvested at day7,no treatment);2)HPBP(bisphosphonate control for BCS)+vancomycin;3)HPHBP(hydroxybisphosphonate control for HBCS)+vancomycin;4)vancomycin;5)sitafloxacin;6)BCS+vancomycin;and 7)HBCS+*** confirmed infection persisted in all groups except for mice treated with BCS or HBCS+*** revealed catastrophic femur fractures in all groups except mice treated with BCS or HBCS+vancomycin,which also displayed decreases in peri-implant bone loss,osteoclast numbers,and *** confirm this,we assessed the efficacy of vancomycin,sitafloxacin,and HBCS monotherapy in a transtibial implant *** results showed complete lack of vancomycin efficacy while all mice treated with HBCS had evidence of infection control,and some had evidence of osseous integrated septic implants,suggestive of biofilm *** together these studies demonstrate that HBCS adjuvant with standard of care debridement and vancomycin therapy has the potential to eradicate mRSA osteomyelitis.

关键词： implant infection overcome

Data analytics using canonical correlation analysis and monte Carlo simulation

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npj Computational materials 2017年第1期3卷 234-239页

作者： jeffrey m.Rickman Yan Wang Anthony D.Rollett martin P.Harmer Charles Compson Department of Physics Lehigh UniversityBethlehemPA 18015USA Department of materials Science and Engineering Lehigh UniversityBethlehemPA 18015USA Department of materials Science and Engineering Carnegie Mellon UniversityPittsburghPA 15213USA Almatis Inc. LeetsdalePA 15056USA

A canonical correlation analysis is a generic parametric model used in the statistical analysis of data involving interrelated or interdependent input and output *** is especially useful in data analytics as a dimensional reduction strategy that simplifies a complex,multidimensional parameter space by identifying a relatively few combinations of variables that are maximally *** shortcoming of the canonical correlation analysis,however,is that it provides only a linear combination of variables that maximizes these *** this in mind,we describe here a versatile,monte-Carlo based methodology that is useful in identifying non-linear functions of the variables that lead to strong input/output *** demonstrate that our approach leads to a substantial enhancement of correlations,as illustrated by two experimental applications of substantial interest to the materials science community,namely:(1)determining the interdependence of processing and microstructural variables associated with doped polycrystalline aluminas,and(2)relating microstructural decriptors to the electrical and optoelectronic properties of thin-film solar cells based on CuInSe_(2) ***,we describe how this approach facilitates experimental planning and process control.

关键词： canonical analytic absorber

Capacities in Facing Natural Hazards: A Small Island Perspective

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International Journal of Disaster Risk Science 2014年第4期5卷 247-264页

作者： mercy m.F.Rampengan Agni Klintuni Boedhihartono Lisa Law J.C.Gaillard jeffrey Sayer School of Earth and Environmental Sciences James Cook UniversityQueensland 4870Australia School of Environment The University of AucklandAuckland 1142New Zealand

Isolated communities on small islands are often characterized as vulnerable and marginalized. We studied the recent history of Laingpatehi, a village on Ruang Island off the north coast of Sulawesi, Indonesia to show that the marginalization-vulnerability nexus can be offset by capacity and social cohesion to enable sustainable livelihoods. The island has been impacted by volcanic eruptions,earthquakes, and competition for marine resources from mainland-based fishermen. The community has shown a remarkable ability to cope and prosper in the face of a series of external hazards. We used a sustainable livelihoods approach to identify the assets that enabled the villagers to cope. Strong social cohesion was central to the ability to organize the community and confront hazards. A diversified livelihood strategy drawing on the small island environment and its coastal and marine resources, income generating activities in a distant satellite village, and significant remittances from employment in other parts of Indonesia underpinned people’s capacities to face *** assistance played a supporting role. The case of Laingpatehi demonstrates how remoteness, rather than being a source of vulnerability, can provide access to existing resources and facilitate innovation. Disaster risk reduction strategies should focus more on reinforcing these existing capacities to deal with hazards and less on physical protection and postdisaster responses.

关键词： Human and social resources Indonesia Livelihood diversity Natural hazards Remote marginal communities Small islands